MX340756B - Compuestos de quinazolina como inhibidores de serina/treonina quinasa. - Google Patents

Compuestos de quinazolina como inhibidores de serina/treonina quinasa.

Info

Publication number
MX340756B
MX340756B MX2014001389A MX2014001389A MX340756B MX 340756 B MX340756 B MX 340756B MX 2014001389 A MX2014001389 A MX 2014001389A MX 2014001389 A MX2014001389 A MX 2014001389A MX 340756 B MX340756 B MX 340756B
Authority
MX
Mexico
Prior art keywords
serine
kinase inhibitors
threonine kinase
quinazoline compounds
compounds
Prior art date
Application number
MX2014001389A
Other languages
English (en)
Other versions
MX2014001389A (es
Inventor
F Blake James
M Wallace Eli
Chen Huifen
Joseph Chicarelli Mark
Demeese Jason
Ferdinand Garrey Rustam
Gaudino John
Gazzard Lewis
J Kaus Robert
Klintz Samuel
J Mohr Peter
a moreno David
Schwarz Jacob
S Siedem Christopher
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of MX2014001389A publication Critical patent/MX2014001389A/es
Publication of MX340756B publication Critical patent/MX340756B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

Abstract

Se describen compuestos que tienen la fórmula (I), en donde R1, R2, R3 y Ar son como se define aquí y son inhibidores de ERK quinasa. También se describen composiciones y métodos para tratar trastornos hiperproliferativos.
MX2014001389A 2011-08-04 2012-08-03 Compuestos de quinazolina como inhibidores de serina/treonina quinasa. MX340756B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161515165P 2011-08-04 2011-08-04
PCT/US2012/049551 WO2013020062A1 (en) 2011-08-04 2012-08-03 Quinazoline compounds as serine/threonine kinase inhibitors

Publications (2)

Publication Number Publication Date
MX2014001389A MX2014001389A (es) 2014-11-13
MX340756B true MX340756B (es) 2016-07-25

Family

ID=47003195

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014001389A MX340756B (es) 2011-08-04 2012-08-03 Compuestos de quinazolina como inhibidores de serina/treonina quinasa.

Country Status (12)

Country Link
US (1) US9187462B2 (es)
EP (1) EP2739618B1 (es)
JP (1) JP6097289B2 (es)
KR (1) KR101979042B1 (es)
CN (1) CN103958502B (es)
BR (1) BR112014002675A2 (es)
CA (1) CA2844058A1 (es)
ES (1) ES2552989T3 (es)
HK (2) HK1199021A1 (es)
MX (1) MX340756B (es)
RU (1) RU2014108140A (es)
WO (1) WO2013020062A1 (es)

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Also Published As

Publication number Publication date
MX2014001389A (es) 2014-11-13
HK1199248A1 (zh) 2015-06-26
CA2844058A1 (en) 2013-02-07
JP2014521696A (ja) 2014-08-28
BR112014002675A2 (pt) 2017-02-21
ES2552989T3 (es) 2015-12-03
KR20140062057A (ko) 2014-05-22
EP2739618A1 (en) 2014-06-11
KR101979042B1 (ko) 2019-05-15
WO2013020062A1 (en) 2013-02-07
EP2739618B1 (en) 2015-09-16
US9187462B2 (en) 2015-11-17
JP6097289B2 (ja) 2017-03-15
RU2014108140A (ru) 2015-09-10
US20150087664A1 (en) 2015-03-26
HK1199021A1 (en) 2015-06-19
CN103958502A (zh) 2014-07-30
CN103958502B (zh) 2016-02-10

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