IN2014MN01521A - - Google Patents

Info

Publication number
IN2014MN01521A
IN2014MN01521A IN1521MUN2014A IN2014MN01521A IN 2014MN01521 A IN2014MN01521 A IN 2014MN01521A IN 1521MUN2014 A IN1521MUN2014 A IN 1521MUN2014A IN 2014MN01521 A IN2014MN01521 A IN 2014MN01521A
Authority
IN
India
Prior art keywords
formula
compound
preparation
disclosed
eribulin
Prior art date
Application number
Other languages
English (en)
Inventor
Fabio E S Souza
Alena Rudolph
Ming Pan
Boris Gorin
Dino Alberico
Original Assignee
Alphora Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alphora Res Inc filed Critical Alphora Res Inc
Publication of IN2014MN01521A publication Critical patent/IN2014MN01521A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/366Lactones having six-membered rings, e.g. delta-lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02Acyclic radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
IN1521MUN2014 2011-12-29 2012-12-24 IN2014MN01521A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161581164P 2011-12-29 2011-12-29
PCT/CA2012/050939 WO2013097042A1 (fr) 2011-12-29 2012-12-24 Dérivés de 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-méthoxy-3-(phénylsulfonylméthyl)tétrahydrofurane-2-yl)acétaldéhyde et procédé pour leur préparation

Publications (1)

Publication Number Publication Date
IN2014MN01521A true IN2014MN01521A (fr) 2015-05-01

Family

ID=48696142

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1521MUN2014 IN2014MN01521A (fr) 2011-12-29 2012-12-24

Country Status (9)

Country Link
US (1) US9062020B2 (fr)
EP (1) EP2797945B1 (fr)
JP (1) JP6300030B2 (fr)
CN (1) CN104080793B (fr)
AU (1) AU2012363334B2 (fr)
CA (1) CA2860446C (fr)
IN (1) IN2014MN01521A (fr)
SI (1) SI2797945T1 (fr)
WO (1) WO2013097042A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013078559A1 (fr) 2011-11-30 2013-06-06 Alphora Research Inc. Procédé de préparation de (3r)-2,4-di-groupe partant-3-méthylbut-1-ène
EP2791123B1 (fr) 2011-12-16 2018-07-18 Sandoz AG Procédé de préparation de dérivés de 3-((2s,5s)-4-méthylène-5- (3-oxopropyl)tétrahydrofuran-2-yl)propanol et d'intermédiaires utiles à leur préparation
JP6531911B2 (ja) 2012-03-30 2019-06-19 サンド アーゲー ハリコンドリンbの大環状c1−ケト類似体を調製するための合成プロセスおよびそれに有用な中間体
TW201617326A (zh) 2014-03-06 2016-05-16 Alphora研發股份有限公司 (s)-1-((2r,3r,4s,5s)-5-烯丙-3-甲氧-4-(對甲苯磺醯甲基)四氫呋喃-2-基)-3-氨基丙-2-醇之結晶衍生物
JP2017520586A (ja) 2014-06-30 2017-07-27 プレジデント アンド フェローズ オブ ハーバード カレッジ ハリコンドリン類似体の合成およびその使用
US10147463B2 (en) 2014-12-10 2018-12-04 Nxp Usa, Inc. Video processing unit and method of buffering a source video stream
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
HUE054726T2 (hu) 2016-03-02 2021-09-28 Eisai R&D Man Co Ltd Eribulinalapú antitest-gyógyszer konjugátumok és alkalmazási eljárások
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
PL3606928T3 (pl) 2017-04-05 2023-02-06 President And Fellows Of Harvard College Związek makrocykliczny i jego zastosowania
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
IL271660B (en) 2017-07-06 2022-09-01 Harvard College Synthesis of the Lichondrins
CN111566113B (zh) 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436238A (en) 1992-03-12 1995-07-25 President And Fellows Of Harvard College Halichondrins and related compounds
US5338865A (en) 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
CA2166898C (fr) 1993-07-09 2004-09-07 Roger Bouillon Nouveaux analogues structurels de la vitamine d
PT1087960E (pt) 1998-06-17 2011-06-17 Eisai R&D Man Co Ltd Análogos macrocíclicos e métodos de sua utilização e preparação
US7001982B2 (en) 2003-03-31 2006-02-21 Council Of Scientific And Industrial Research Non-natural C-linked carbo-β-peptides with robust secondary structures
EP2949652B1 (fr) * 2004-06-03 2019-08-07 Eisai R&D Management Co., Ltd. Intermédiaires pour la préparation d'halichondrine B
CN1993342A (zh) * 2004-06-03 2007-07-04 卫材株式会社 用于制备软海绵素b的中间体
US8598373B2 (en) * 2008-04-04 2013-12-03 Eisai R&D Management Co., Ltd. Halichondrin B analogs
WO2013078559A1 (fr) 2011-11-30 2013-06-06 Alphora Research Inc. Procédé de préparation de (3r)-2,4-di-groupe partant-3-méthylbut-1-ène
EP2791123B1 (fr) 2011-12-16 2018-07-18 Sandoz AG Procédé de préparation de dérivés de 3-((2s,5s)-4-méthylène-5- (3-oxopropyl)tétrahydrofuran-2-yl)propanol et d'intermédiaires utiles à leur préparation
JP6531911B2 (ja) 2012-03-30 2019-06-19 サンド アーゲー ハリコンドリンbの大環状c1−ケト類似体を調製するための合成プロセスおよびそれに有用な中間体
WO2014183211A1 (fr) 2013-05-15 2014-11-20 Alphora Research Inc. Dérivés de 3-((2s,5s)-4-méthylène-5-(3-oxopropyl)tétrahydrofuran-2-yl)propanol, leur préparation et intermédiaires utiles correspondants

Also Published As

Publication number Publication date
CN104080793B (zh) 2017-09-19
US9062020B2 (en) 2015-06-23
EP2797945A1 (fr) 2014-11-05
AU2012363334B2 (en) 2017-02-02
AU2012363334A1 (en) 2014-08-21
JP2015503525A (ja) 2015-02-02
JP6300030B2 (ja) 2018-03-28
CA2860446A1 (fr) 2013-07-04
CN104080793A (zh) 2014-10-01
US20150011776A1 (en) 2015-01-08
EP2797945A4 (fr) 2015-06-03
CA2860446C (fr) 2017-01-10
SI2797945T1 (sl) 2016-07-29
EP2797945B1 (fr) 2016-03-16
WO2013097042A1 (fr) 2013-07-04

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