MA28982B1 - Anticorps antagonistes de il-17 - Google Patents

Anticorps antagonistes de il-17

Info

Publication number
MA28982B1
MA28982B1 MA29710A MA29710A MA28982B1 MA 28982 B1 MA28982 B1 MA 28982B1 MA 29710 A MA29710 A MA 29710A MA 29710 A MA29710 A MA 29710A MA 28982 B1 MA28982 B1 MA 28982B1
Authority
MA
Morocco
Prior art keywords
antagonist antibodies
antibody
human
usable
diseases
Prior art date
Application number
MA29710A
Other languages
English (en)
Inventor
Padova Franco E Di
Hermann Gram
Hans Hofstetter
Margit Jeschke
Jean-Michel Rondeau
Den Berg Wim Van
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32982602&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA28982(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA28982B1 publication Critical patent/MA28982B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

L'invention prévoit une molécule de liaison IL-17, plus particulièrement un anticorps envers l'IL-17 humain, de préférence un anticorps humain envers l'IL-17, caractérisée en ce que les régions hypervariables des chaînes lourde: légères possèdent des séquences des acides aminés telles que définies, utilisables pour le traitement de maladies ou troubles provoqués par l'intermédiaire de l'IL-17, p.ex. l'arthrite rhumatoïde.
MA29710A 2004-08-05 2007-02-22 Anticorps antagonistes de il-17 MA28982B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0417487.6A GB0417487D0 (en) 2004-08-05 2004-08-05 Organic compound

Publications (1)

Publication Number Publication Date
MA28982B1 true MA28982B1 (fr) 2007-11-01

Family

ID=32982602

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29710A MA28982B1 (fr) 2004-08-05 2007-02-22 Anticorps antagonistes de il-17

Country Status (39)

Country Link
US (8) US7807155B2 (fr)
EP (5) EP1776142B9 (fr)
JP (1) JP4682200B2 (fr)
KR (2) KR100852523B1 (fr)
CN (1) CN101001645B (fr)
AR (1) AR050200A1 (fr)
AT (1) ATE517924T1 (fr)
AU (2) AU2005268857C1 (fr)
BR (3) BRPI0513078C1 (fr)
CA (1) CA2573586C (fr)
CY (6) CY1111963T1 (fr)
DK (4) DK1776142T6 (fr)
EC (1) ECSP077198A (fr)
ES (4) ES2367440T7 (fr)
FR (1) FR15C0048I2 (fr)
GB (1) GB0417487D0 (fr)
HK (3) HK1101277A1 (fr)
HR (3) HRP20110758T4 (fr)
HU (4) HUE038187T2 (fr)
IL (1) IL180717A (fr)
LT (3) LT2902039T (fr)
LU (2) LU92768I2 (fr)
MA (1) MA28982B1 (fr)
MX (1) MX2007001338A (fr)
MY (1) MY144925A (fr)
NL (1) NL300749I2 (fr)
NO (9) NO336279B1 (fr)
NZ (1) NZ552658A (fr)
PE (1) PE20060418A1 (fr)
PL (4) PL2364729T6 (fr)
PT (4) PT2366405E (fr)
RU (2) RU2426741C3 (fr)
SG (1) SG155186A1 (fr)
SI (4) SI2364729T1 (fr)
TN (1) TNSN07034A1 (fr)
TR (1) TR201808057T4 (fr)
TW (1) TWI359153B (fr)
WO (1) WO2006013107A1 (fr)
ZA (1) ZA200700242B (fr)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
GB0417487D0 (en) * 2004-08-05 2004-09-08 Novartis Ag Organic compound
GB0425569D0 (en) 2004-11-19 2004-12-22 Celltech R&D Ltd Biological products
JP2009507023A (ja) * 2005-09-01 2009-02-19 シェーリング コーポレイション 自己免疫性眼炎症性疾患を処置するためのil−23およびil−17のアンタゴニストの使用
PL2481753T3 (pl) 2005-12-13 2018-09-28 Eli Lilly And Company Przeciwciała anty-IL-17
EP1964852B1 (fr) 2005-12-20 2013-04-17 SBI Biotech Co., Ltd. Anticorps anti-ilt7
AR060017A1 (es) 2006-01-13 2008-05-21 Novartis Ag Composiciones y metodos de uso para anticuerpos de dickkopf -1
WO2007117749A2 (fr) * 2006-01-31 2007-10-18 Novartis Ag Anticorps antagonistes il-17
US7910703B2 (en) 2006-03-10 2011-03-22 Zymogenetics, Inc. Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
US7790862B2 (en) 2006-06-13 2010-09-07 Zymogenetics, Inc. IL-17 and IL-23 antagonists and methods of using the same
TW200815469A (en) * 2006-06-23 2008-04-01 Astrazeneca Ab Compounds
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
JP5118699B2 (ja) * 2006-08-11 2013-01-16 メルク・シャープ・アンド・ドーム・コーポレーション Il−17aに対する抗体
GB0620729D0 (en) 2006-10-18 2006-11-29 Ucb Sa Biological products
TWI426918B (zh) 2007-02-12 2014-02-21 Merck Sharp & Dohme Il-23拮抗劑於治療感染之用途
NZ579297A (en) 2007-02-28 2012-03-30 Schering Corp Combination therapy comprising an il-23 antagonist and a cytokine antagonist for treatment of immune disorders
RU2009148597A (ru) 2007-05-29 2011-07-10 Новартис АГ (CH) Новые показания к применению при лечении антителами против il-1-бета
US20100239590A1 (en) * 2007-06-20 2010-09-23 Schering Corporation Joint destruction biomarkers for anti-il-17a therapy of inflammatory joint disease
ES2614735T3 (es) * 2007-07-23 2017-06-01 Janssen Biotech, Inc. Métodos y composiciones para tratar los trastornos relacionados con fibrosis usando antagonistas de la IL-17
US20110195509A1 (en) * 2007-09-06 2011-08-11 Drew Pardoll Treatment of th17-mediated autoimmune disease via inhibition of stat 3
WO2009072802A2 (fr) * 2007-12-03 2009-06-11 Amorepacific Corporation Composition amincissante
WO2009082624A2 (fr) * 2007-12-10 2009-07-02 Zymogenetics, Inc. Antagonistes de il-17a, il-17f et il-23 et procédés d'utilisation de ceux-ci
US9309313B2 (en) * 2008-01-09 2016-04-12 The Schepens Eye Research Institute, Inc. Therapeutic compositions for treatment of ocular inflammatory disorders
GB0807413D0 (en) 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
WO2009133103A1 (fr) * 2008-04-29 2009-11-05 Micromet Ag Inhibiteurs de gm-csf et il-17 pour thérapie
CA2722466A1 (fr) 2008-04-29 2009-11-05 Tariq Ghayur Immunoglobulines a double domaine variable et utilisations
WO2009136286A2 (fr) 2008-05-05 2009-11-12 Novimmune Sa Anticorps à réaction croisée anti-il-17a/il-17f et leurs procédés d'utilisation
AU2009256250B2 (en) 2008-06-03 2013-05-30 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
CA2725666A1 (fr) 2008-06-03 2009-12-10 Abbott Laboratories Immunoglobulines a double domaine variable et leurs utilisations
NZ590074A (en) 2008-07-08 2012-12-21 Abbott Lab Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
ES2493042T3 (es) 2008-09-29 2014-09-11 Roche Glycart Ag Anticuerpos contra la IL-17 humana y usos de los mismos
NZ594514A (en) 2009-03-05 2013-06-28 Abbott Lab Interleukin-17 BINDING PROTEINS
SI2424895T1 (en) * 2009-04-27 2018-01-31 Novartis Ag Ingredients and procedures for increasing muscle growth
WO2010128407A2 (fr) 2009-05-05 2010-11-11 Novimmune S.A. Anticorps anti-il-17f et leurs méthodes d'utilisation
IN2012DN02737A (fr) 2009-09-01 2015-09-11 Abbott Lab
AU2010303166A1 (en) * 2009-10-10 2012-05-24 Eleven Biotherapeutics, Inc. IL-17 family cytokine compositions and uses
KR20140015139A (ko) 2009-10-15 2014-02-06 애브비 인코포레이티드 이원 가변 도메인 면역글로불린 및 이의 용도
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
ES2728115T3 (es) 2009-10-30 2019-10-22 Janssen Biotech Inc Antagonistas de IL-17A
EP3546483A1 (fr) 2010-05-20 2019-10-02 Ablynx N.V. Matériaux biologiques associés à her3
CA2807014A1 (fr) 2010-08-03 2012-02-09 Abbvie Inc. Immunoglobulines a double domaine variable et utilisations associees
JP2013537414A (ja) * 2010-08-05 2013-10-03 アナプティスバイオ インコーポレイティッド Il−17に対する抗体
EP2600901B1 (fr) 2010-08-06 2019-03-27 ModernaTX, Inc. Compositions pharmaceutiques a base d'acides nucléiques modifiés et leur utilisation medicale
TW201211252A (en) 2010-08-26 2012-03-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
ES2737960T3 (es) 2010-10-01 2020-01-17 Modernatx Inc Nucleósidos, nucleótidos y ácidos nucleicos modificados y sus usos
EP4137514A1 (fr) * 2010-10-08 2023-02-22 Novartis AG Procédés de traitement du psoriasis à l'aide des antagonistes il-17
KR20180129991A (ko) * 2010-11-05 2018-12-05 노파르티스 아게 Il-17 길항제를 사용한 류마티스성 관절염의 치료 방법
AU2014259523B2 (en) * 2010-11-05 2016-02-04 Novartis Ag Methods of treating psoriatic arthritis using IL-17 antagonists
TW201307845A (zh) 2010-12-13 2013-02-16 Novartis Ag 預測方法及利用il-17拮抗劑治療關節炎的方法
US10208349B2 (en) 2011-01-07 2019-02-19 Ucb Biopharma Sprl Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy
JP5947041B2 (ja) * 2011-01-07 2016-07-06 第一三共ヘルスケア株式会社 安全なil−17産生抑制剤
GB201100282D0 (en) 2011-01-07 2011-02-23 Ucb Pharma Sa Biological methods
US20140004540A1 (en) * 2011-01-13 2014-01-02 Universite Paris Descartes Methods and kits for predicting the risk of having a cardiovascular event in a subject
ME02734B (fr) 2011-01-14 2017-10-20 Ucb Biopharma Sprl Molécules d'anticorps se liant à il-17a et il-17f
WO2012125680A1 (fr) 2011-03-16 2012-09-20 Novartis Ag Méthodes de traitement de vascularite à l'aide d'un molécule de liaison à l'il-17
ES2784628T3 (es) 2011-03-29 2020-09-29 Glaxosmithkline Llc Sistema de tampón para purificación de proteína
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
UA117218C2 (uk) 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3682905B1 (fr) 2011-10-03 2021-12-01 ModernaTX, Inc. Nucléosides, nucléotides et acides nucléiques modifiés et leurs utilisations
CA2856252A1 (fr) * 2011-11-21 2013-05-30 Novartis Ag Procedes de traitement du rhumatisme psoriasique (psa) utilisant des antagonistes d'il-17 et des alleles repondeurs ou non repondeurs a psa
WO2013082282A1 (fr) 2011-12-02 2013-06-06 lNOVARTIS AG Thérapie prophylactique à base d'anticorps anti-il-1bêta (interleukine-1bêta) pour prévenir des complications conduisant à une vaso-occlusion dans une drépanocytose
EP2791160B1 (fr) 2011-12-16 2022-03-02 ModernaTX, Inc. Compositions de mrna modifiés
US9580501B2 (en) 2011-12-16 2017-02-28 Synthon Biopharmaceuticals B.V. Anti-TNF alpha monoclonal secretory IgA antibodies and methods for treating inflammatory diseases
UY34558A (es) 2011-12-30 2013-07-31 Abbvie Inc Proteínas de unión específicas duales dirigidas contra il-13 y/o il-17
WO2013116682A1 (fr) 2012-02-02 2013-08-08 Ensemble Therapeutics Corporation Composés macrocycliques pour une modulation d'il-17
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9303079B2 (en) 2012-04-02 2016-04-05 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
AU2013243948A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins associated with human disease
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
BR112014024903A2 (pt) 2012-04-05 2017-07-11 Hoffmann La Roche anticorpos biespecíficos contra tweak humanao e il17 humana e seus usos
KR20150010709A (ko) 2012-04-20 2015-01-28 노파르티스 아게 Il-17 길항제를 사용하는 강직성 척추염의 치료 방법
US9708401B2 (en) 2012-05-22 2017-07-18 Bristol-Myers Squibb Company IL-17A/F cross-reactive monoclonal antibodies and methods of using the same
US9833410B2 (en) 2012-10-31 2017-12-05 Takeda Gmbh Lyophilized formulation comprising GM-CSF neutralizing compound
AR093297A1 (es) 2012-10-31 2015-05-27 Amgen Res (Munich) Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
AU2013337775B2 (en) 2012-11-01 2017-03-30 Abbvie Inc. Anti-VEGF/DLL4 dual variable domain immunoglobulins and uses thereof
EP4074834A1 (fr) 2012-11-26 2022-10-19 ModernaTX, Inc. Arn à terminaison modifiée
WO2014107737A2 (fr) 2013-01-07 2014-07-10 Eleven Biotherapeutics, Inc. Administration locale d'inhibiteurs de l'il-17 en vue du traitement d'affections oculaires
CA3185317A1 (fr) 2013-02-08 2014-08-14 Novartis Ag Anticorps anti-il-17a et leur utilisation dans le traitement de troubles auto-immuns et inflammatoires
CN105324396A (zh) 2013-03-15 2016-02-10 艾伯维公司 针对IL-1β和/或IL-17的双重特异性结合蛋白
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2014155278A2 (fr) * 2013-03-26 2014-10-02 Novartis Ag Méthodes de traitement de maladies auto-immunes à l'aide d'antagonistes de l'il -17
WO2014161570A1 (fr) 2013-04-03 2014-10-09 Roche Glycart Ag Anticorps dirigés contre l'il17 humaine et ses utilisations
US9707154B2 (en) 2013-04-24 2017-07-18 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US9603882B2 (en) 2013-08-13 2017-03-28 Industrial Technology Research Institute Method for modulating Th17 cells and method for treating a disease related to modulation of Th17 cells
EP4223312A1 (fr) 2013-08-15 2023-08-09 Novartis AG Procédés de traitement du psoriasis en plaques à l'aide d'antagonistes de l'il-17
US10745475B2 (en) 2013-08-30 2020-08-18 Takeda Gmbh Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics
WO2015048744A2 (fr) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucléotides codant des polypeptides de modulation immunitaire
CA2926218A1 (fr) 2013-10-03 2015-04-09 Moderna Therapeutics, Inc. Polynucleotides codant pour un recepteur de lipoproteines de faible densite
AU2014350758B2 (en) 2013-11-18 2019-07-25 Jiangsu Hengrui Medicine Co., Ltd. IL-17A binding agent and uses thereof
KR20160113268A (ko) * 2014-01-28 2016-09-28 베이징 한미 파마슈티컬 컴퍼니 리미티드 이기능 융합단백질,이의 제조방법 및 용도
TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
CA2960754A1 (fr) 2014-09-10 2016-03-17 Novartis Ag Utilisation d'antagonistes d'il-17 pour inhiber la progression d'une lesion structurelle chez des patients atteints d'une polyarthrite psoriasique
RU2609627C2 (ru) 2014-09-26 2017-02-02 Закрытое Акционерное Общество "Биокад" Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
CU20170052A7 (es) 2014-10-14 2017-11-07 Dana Farber Cancer Inst Inc Moléculas de anticuerpo que se unen a pd-l1
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
AR103172A1 (es) 2014-12-22 2017-04-19 Novartis Ag Reducción selectiva de residuos de cisteina en anticuerpos il-17
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
MX2017008660A (es) 2015-01-12 2017-11-17 Affibody Ab Polipeptidos enlazados a il-17a.
JP2018506275A (ja) 2015-01-28 2018-03-08 ジェネンテック, インコーポレイテッド 多発性硬化症の遺伝子発現マーカー及び治療
CN105315371B (zh) * 2015-03-05 2018-05-29 北京百特美博生物科技有限公司 抗人il-17单克隆抗体
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗vegf、pdgf及/或其受體之結合蛋白
EP3322725A1 (fr) 2015-07-16 2018-05-23 Eli Lilly and Company Traitement du prurit
SI3317301T1 (sl) 2015-07-29 2021-10-29 Novartis Ag Kombinirane terapije, ki obsegajo molekule protitelesa na LAG-3
WO2017019897A1 (fr) 2015-07-29 2017-02-02 Novartis Ag Polythérapies comprenant des molécules d'anticorps contre tim -3
IL297775A (en) 2015-10-19 2022-12-01 Novartis Ag Methods for the treatment of non-radiographic sclerosing spondylitis with the help of interleukin-17 (il-17) antagonists
JP2019503349A (ja) 2015-12-17 2019-02-07 ノバルティス アーゲー Pd−1に対する抗体分子およびその使用
RU2756109C2 (ru) 2016-03-10 2021-09-28 Виела Байо, Инк. Связывающие ilt7 молекулы и способы их применения
JP6987072B2 (ja) 2016-03-10 2021-12-22 アクセレロン ファーマ インコーポレーテッド アクチビン2型受容体結合タンパク質及びその使用
RU2680011C2 (ru) 2016-04-29 2019-02-14 Закрытое Акционерное Общество "Биокад" Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы
FR3051673B1 (fr) * 2016-05-24 2018-06-22 Assistance Publique - Hopitaux De Paris Inhibiteurs de la voie de l'interleukine 17 pour le traitement des infections chroniques dues a hpv
CN107488227A (zh) * 2016-06-12 2017-12-19 三生国健药业(上海)股份有限公司 抗人白细胞介素‑17a单克隆抗体、其制备方法和应用
WO2017221174A1 (fr) 2016-06-22 2017-12-28 Novartis Ag Méthodes de traitement du vitiligo à l'aide d'anticorps de l'interleukine-17 (il -17)
CN109476733A (zh) 2016-07-19 2019-03-15 诺华股份有限公司 使用il-17拮抗剂治疗新发斑块型银屑病的方法
CA3036913C (fr) 2016-09-14 2023-05-16 Beijing Hanmi Pharm. Co., Ltd. Anticorps se liant specifiquement a il -17 a et fragment fonctionnel de celui-ci
WO2018096467A1 (fr) 2016-11-28 2018-05-31 Novartis Ag Méthodes de traitement de l'acné à l'aide d'antagonistes de l'interleukine-17 (il -17)
RU2771485C2 (ru) 2017-02-10 2022-05-04 Дженентек, Инк. Антитела против триптазы, их композиции и применения
WO2018158741A1 (fr) 2017-03-03 2018-09-07 Novartis Ag Modification de la maladie du psoriasis suite à un traitement à long terme avec un antagoniste de l'il-17
US10676522B2 (en) 2017-05-05 2020-06-09 Novartis Ag Methods of selectively treating asthma using IL-17 antagonists
CN108359011B (zh) 2017-07-21 2019-06-25 华博生物医药技术(上海)有限公司 靶向于白介素17a的抗体、其制备方法和应用
JP2021501752A (ja) 2017-11-02 2021-01-21 ノバルティス アーゲー インターロイキン−17(il−17)アンタゴニストを使用して腱障害を治療する方法
US20200277369A1 (en) 2017-11-20 2020-09-03 Novartis Ag Method of treating hidradentitis suppurativa with il-17 antagonists
EP3717907A1 (fr) 2017-11-30 2020-10-07 Novartis AG Récepteur d'antigène chimérique ciblant le bcma et ses utilisations
CN112203685A (zh) * 2018-03-29 2021-01-08 瑞美德生物医药科技有限公司 使用结合白细胞介素-17a(il-17a)的抗体的自身免疫紊乱和炎性紊乱的治疗
CA3098420A1 (fr) 2018-06-01 2019-12-05 Novartis Ag Molecules de liaison dirigees contre bcma et leurs utilisations
US20210309735A1 (en) * 2018-07-31 2021-10-07 Weiqun SHEN Anti-il-17a antibodies and use thereof
US20220033486A1 (en) 2018-09-25 2022-02-03 Inserm (Institut National De La Santè Et De La Recherch Médicale) Use of antagonists of th17 cytokines for the treatment of bronchial remodeling in patients suffering from allergic asthma
KR20210122243A (ko) 2019-01-31 2021-10-08 누맙 세러퓨틱스 아게 TNFα 및 IL-17A에 대한 특이성을 가지는 다중 특이적 항체, IL-17A를 표적화하는 항체, 그리고 이의 사용 방법
EP3689907A1 (fr) 2019-01-31 2020-08-05 Numab Therapeutics AG Anticorps dirigés contre il-17a et leurs procédés d'utilisation
MX2021009851A (es) 2019-02-18 2021-09-10 Lilly Co Eli Formulacion de anticuerpos terapeuticos.
CN110179746A (zh) * 2019-05-17 2019-08-30 通化东宝生物科技有限公司 一种稳定的苏金单抗注射剂及其制备方法
US11878037B2 (en) 2019-05-31 2024-01-23 Figene, Llc Concurrent activation of regenerative and tolerogenic processes by fibroblast-based compositions for the treatment of multiple sclerosis
CN110343666B (zh) * 2019-07-10 2023-05-30 通化东宝药业股份有限公司 一种cho细胞培养的补料培养基及其制备方法和应用
JP7214921B2 (ja) 2019-07-26 2023-01-30 神州細胞工程有限公司 ヒト化抗il17a抗体及びその使用
CN114127108A (zh) 2019-07-30 2022-03-01 江苏恒瑞医药股份有限公司 Il-17拮抗剂治疗自身免疫疾病的方法
CN114981302A (zh) 2019-09-20 2022-08-30 诺华股份有限公司 使用白细胞介素-17(il-17)拮抗剂治疗自身免疫性疾病的方法
CN114729943A (zh) 2019-09-30 2022-07-08 詹森药业有限公司 用大分子调节剂进行il-17靶接合测定的组合物和方法
AU2020386669A1 (en) 2019-11-19 2022-06-02 Novartis Ag Methods of treating Lupus Nephritis using interleukin-17 (IL-17) antagonists
WO2021111377A2 (fr) 2019-12-06 2021-06-10 Novartis Ag Procédés de traitement de lichen plan à l'aide d'antagonistes de l'interleukine 17 (il-17)
CN114805577B (zh) * 2019-12-31 2023-11-21 南京融捷康生物科技有限公司 针对il-17ra蛋白的抗体及其制备方法和应用
CN115812079A (zh) 2020-06-23 2023-03-17 诺华股份有限公司 使用白细胞介素-17(il-17)拮抗剂治疗甲状腺眼病和格雷夫斯眼眶病的方法
UY39484A (es) 2020-11-02 2022-06-30 Novartis Ag Inhibidores de interleucina-17
KR20230104651A (ko) 2020-11-06 2023-07-10 노파르티스 아게 Cd19 결합 분자 및 이의 용도
CA3202877A1 (fr) 2020-12-02 2022-06-09 Fresenius Kabi Deutschland Gmbh Methodes de reduction selective d'anticorps
IL303951A (en) 2020-12-22 2023-08-01 Novartis Ag Methods for reducing the oxidation level of cysteine residues in recombinantly secreted protein during cell culture
WO2023209519A1 (fr) 2022-04-25 2023-11-02 Novartis Ag Formes cristallines d'un inhibiteur d'il-17
WO2023223211A1 (fr) 2022-05-16 2023-11-23 Novartis Ag Méthodes de traitement de l'artérite à cellules géantes à l'aide d'antagonistes de l'interleukine-17 (il-17)
WO2023223263A1 (fr) 2022-05-18 2023-11-23 Novartis Ag Procédés de traitement sélectif de la tendinopathie à l'aide d'antagonistes de l'interleukine-17 (il-17)

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
ATE87659T1 (de) 1986-09-02 1993-04-15 Enzon Lab Inc Bindungsmolekuele mit einzelpolypeptidkette.
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
WO1991010741A1 (fr) 1990-01-12 1991-07-25 Cell Genesys, Inc. Generation d'anticorps xenogeniques
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US6562333B1 (en) 1993-06-14 2003-05-13 Schering Corporation Purified mammalian CTLA-8 antigens and related reagents
US6274711B1 (en) 1993-06-14 2001-08-14 Inserm, Institut National De La Sante Et De La Recherche Medicale Purified mammalian CTLA-8 antigens and related reagents
JP4373495B2 (ja) 1995-03-23 2009-11-25 イミュネックス・コーポレーション Il−17受容体
WO1997004097A2 (fr) * 1995-07-19 1997-02-06 Genetics Institute, Inc. Proteines humaines ctla-8 et utilisation de proteines apparentees aux proteines ctla-8
US6074849A (en) 1995-07-19 2000-06-13 Genetics Institute, Inc. Polynucleotides encoding human CTLA-8 related proteins
ES2181915T3 (es) 1995-10-27 2003-03-01 Schering Corp Ctla-8 en combinacionpn con g-csf y il-6, y uso de ctla-8 para tratar infecciones.
DE69739375D1 (de) 1996-11-27 2009-06-04 Immunex Corp Verfahren zur regulierung der stickstoffmonoxid-erzeugung
US6635443B1 (en) 1997-09-17 2003-10-21 Human Genome Sciences, Inc. Polynucleotides encoding a novel interleukin receptor termed interleukin-17 receptor-like protein
US6482923B1 (en) 1997-09-17 2002-11-19 Human Genome Sciences, Inc. Interleukin 17-like receptor protein
US6849719B2 (en) 1997-09-17 2005-02-01 Human Genome Sciences, Inc. Antibody to an IL-17 receptor like protein
CA2309604C (fr) 1997-11-10 2010-01-12 Cytimmune Sciences, Inc. Compositions et procedes d'administration ciblee de facteurs
US6562578B1 (en) 1999-01-11 2003-05-13 Schering Corporation IL-17-like cytokine binding compounds and antibodies
WO1999032632A1 (fr) 1997-12-19 1999-07-01 Millennium Pharmaceuticals, Inc. Nouvelles molecules d'un facteur apparente a l'interleukine issu d'un embryon (edirf) et leurs utilisations
AU2031399A (en) 1998-01-09 1999-07-26 Immunex Corporation Human and murine il-17d, cytokine related to interleukin-17: dna and polypeptides
WO1999035263A2 (fr) 1998-01-09 1999-07-15 Immunex Corporation Adn codant il-17rh et polypeptides il-17rh
JP2002503478A (ja) 1998-02-11 2002-02-05 マキシジェン, インコーポレイテッド 遺伝子ワクチンベクターの標的化
JP3577586B2 (ja) 1998-05-15 2004-10-13 ジェネンテック・インコーポレーテッド Il−17相同的ポリペプチドとその治療用途
CA2343569C (fr) 1998-09-17 2010-09-14 Zymogenetics, Inc. Facteur de croissance transformant beta - 9 mammaliens
AU6277799A (en) 1998-10-02 2000-04-26 Eli Lilly And Company Il-17 homolog nucleic acids, polypeptides, vectors, host cells, methods and usesthereof
JP2000186046A (ja) * 1998-10-14 2000-07-04 Snow Brand Milk Prod Co Ltd 慢性関節リウマチ治療剤及び診断方法
WO2000022909A2 (fr) 1998-10-19 2000-04-27 Biotech Australia Pty. Limited Systemes d'administration orale
DE29820466U1 (de) 1998-11-16 1999-04-08 Reutter Werner Prof Dr Med Rekombinante Glycoproteine und sie enthaltende Arzneimittel
US6734172B2 (en) 1998-11-18 2004-05-11 Pacific Northwest Research Institute Surface receptor antigen vaccines
EP1141297B1 (fr) 1999-01-11 2009-09-30 Schering Corporation Cytokines de mammiferes liees a l'interleukin-17, polynucleotides les codant et leurs utilisations
AU3207000A (en) 1999-01-11 2000-08-01 Schering Corporation Interleukin-17 related mammalian cytokine (il-171). polynucleotides encoding them. uses
SI1031346T1 (en) 1999-01-27 2002-08-31 Idea Ag Noninvasive vaccination through the skin
DK1156823T3 (da) 1999-02-12 2009-01-19 Scripps Research Inst Fremgangsmåder til behandling af tumorer og metastaser ved anvendelse af en kombination af anti-angiogene terapier og immunoterapier
EP1053751A1 (fr) * 1999-05-17 2000-11-22 Institut National De La Sante Et De La Recherche Medicale (Inserm) Compositions et méthodes pour le traitement des désordres de la prolifération cellulaire
US6036128A (en) 1999-05-17 2000-03-14 Common Ground Recycling, Inc. Tire shredding machine and method of using the same
WO2001015728A1 (fr) 1999-08-27 2001-03-08 University Health Network Procede d'activation de lymphocytes t cytotoxiques (ctls) in vivo: composition comprenant un anticorps anti cd40 (ou cd40l ou une proteine liant le cd40) et un antigene
JP2001086046A (ja) * 1999-09-09 2001-03-30 Nec Corp カメラ付き携帯電話装置
US7220840B2 (en) 2000-06-16 2007-05-22 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator protein
NZ522700A (en) 2000-06-16 2006-02-24 Human Genome Sciences Inc Antibodies that immunospecifically bind to blys
AU2001296229A1 (en) 2000-10-13 2002-04-29 Eli Lilly And Company Methods of using a human il-17-related polypeptide to treat disease
EP1326626B1 (fr) * 2000-10-18 2020-04-01 Immunex Corporation Methodes de traitement de la polyarthrite rhumatoide a l'aide d'antagonistes de l'il-17
CA2435151A1 (fr) 2001-01-25 2002-12-27 Zymogenetics, Inc. Methode de traitement du psoriasis
CA2658221C (fr) * 2001-04-27 2012-11-27 Kyowa Hakko Kirin Co., Ltd. Anticorps monoclonal anti-cd40
EP1456347A4 (fr) 2001-11-16 2006-08-02 Human Genome Sciences Inc Anticorps se liant a blys selon un mode immunospecifique
US20040136992A1 (en) 2002-08-28 2004-07-15 Burton Paul B. J. Compositions and method for treating cardiovascular disease
MXPA05012571A (es) * 2003-05-21 2006-02-08 Medarex Inc Anticuerpos monoclonales humanos contra el antigeno protector de bacillus anthracis.
EP1983000B1 (fr) 2003-11-21 2015-09-02 UCB Biopharma SPRL Procédé pour le traitement de la sclérose en plaque par l'inhibition d'activité IL-17
JP2007535930A (ja) 2004-05-03 2007-12-13 シェーリング コーポレイション 皮膚の炎症を予測するためのil−17発現の使用;処置方法
GB0417487D0 (en) * 2004-08-05 2004-09-08 Novartis Ag Organic compound
JP2009507023A (ja) 2005-09-01 2009-02-19 シェーリング コーポレイション 自己免疫性眼炎症性疾患を処置するためのil−23およびil−17のアンタゴニストの使用

Also Published As

Publication number Publication date
IL180717A0 (en) 2007-06-03
KR20080029018A (ko) 2008-04-02
US20090280131A1 (en) 2009-11-12
HUS1500037I1 (hu) 2017-10-30
TW200617025A (en) 2006-06-01
RU2426741C3 (ru) 2017-11-15
SI2366405T1 (sl) 2015-07-31
NO20150065L (no) 2007-03-30
NO20171697A1 (no) 2007-03-30
CY2015030I2 (el) 2017-11-14
PL2364729T6 (pl) 2016-06-30
NL300749I2 (nl) 2017-11-02
CA2573586A1 (fr) 2006-02-09
TNSN07034A1 (en) 2008-06-02
AR050200A1 (es) 2006-10-04
SI1776142T1 (sl) 2011-11-30
NO2015023I2 (no) 2015-10-26
NO341384B1 (no) 2017-10-30
HK1207559A1 (en) 2016-02-05
HK1256639A1 (zh) 2019-09-27
RU2011113153A (ru) 2012-10-20
PL1776142T6 (pl) 2016-06-30
NZ552658A (en) 2009-11-27
LTC1776142I2 (lt) 2022-07-11
SI2902039T1 (en) 2018-07-31
BRPI0513078C1 (pt) 2021-05-25
TR201808057T4 (tr) 2018-06-21
EP2366405B1 (fr) 2015-02-25
PL2364729T3 (pl) 2014-10-31
PT2902039T (pt) 2018-07-17
US20230235038A1 (en) 2023-07-27
EP2366405A2 (fr) 2011-09-21
HRP20181069T1 (hr) 2018-09-07
NO337129B1 (no) 2016-01-25
HUS1800040I1 (hu) 2018-11-28
KR100852523B1 (ko) 2008-08-14
PE20060418A1 (es) 2006-06-15
HRP20110758T1 (en) 2011-11-30
PL1776142T3 (pl) 2011-12-30
ZA200700242B (en) 2008-08-27
AU2005268857B8 (en) 2010-05-27
HUE038187T2 (hu) 2018-10-29
CY2018027I1 (el) 2020-05-29
NO337286B1 (no) 2016-02-29
US7807155B2 (en) 2010-10-05
US10344084B2 (en) 2019-07-09
US20170355762A1 (en) 2017-12-14
IL180717A (en) 2012-07-31
EP1776142B1 (fr) 2011-07-27
EP2902039B1 (fr) 2018-04-11
CY1111963T1 (el) 2015-11-04
AU2005268857C1 (en) 2012-01-19
PL2366405T3 (pl) 2015-08-31
CY1120723T1 (el) 2019-12-11
ES2677245T3 (es) 2018-07-31
PT2364729E (pt) 2014-09-01
LU92768I2 (fr) 2015-11-03
DK1776142T6 (en) 2015-07-06
DK2366405T3 (en) 2015-05-11
DK2902039T3 (en) 2018-07-16
AU2010201689A1 (en) 2010-05-20
SI2364729T1 (sl) 2014-08-29
CY2018027I2 (el) 2020-05-29
MY144925A (en) 2011-11-30
ES2487533T7 (es) 2015-07-14
ES2536228T3 (es) 2015-05-21
RU2426741C2 (ru) 2011-08-20
EP1776142A1 (fr) 2007-04-25
AU2010201689B2 (en) 2011-09-29
LTPA2018515I1 (lt) 2018-10-25
KR20070036166A (ko) 2007-04-02
NO2016017I1 (no) 2016-08-23
US20190270804A1 (en) 2019-09-05
US8119131B2 (en) 2012-02-21
ES2367440T3 (es) 2011-11-03
BR122017009404B1 (pt) 2022-02-22
NO2015023I1 (no) 2015-11-02
NO336279B1 (no) 2015-07-06
LTPA2015029I1 (lt) 2022-07-11
US8617552B2 (en) 2013-12-31
TWI359153B (en) 2012-03-01
DK2364729T3 (da) 2014-07-21
SG155186A1 (en) 2009-09-30
PT2366405E (pt) 2015-06-30
PT1776142E (pt) 2011-10-06
EP3409288A1 (fr) 2018-12-05
AU2005268857B2 (en) 2010-01-28
ES2367440T9 (es) 2021-04-28
EP2364729B1 (fr) 2014-05-14
PL1776142T4 (pl) 2018-04-30
BR122018075556B1 (pt) 2022-10-18
CN101001645B (zh) 2012-09-05
FR15C0048I1 (fr) 2015-08-28
HUE025815T2 (en) 2016-04-28
US20140079719A1 (en) 2014-03-20
CY1116256T1 (el) 2017-02-08
AU2005268857A1 (en) 2006-02-09
NO20070985L (no) 2007-03-30
NO20151787L (no) 2006-02-06
EP2364729A2 (fr) 2011-09-14
JP2008507988A (ja) 2008-03-21
NO20150064L (no) 2007-03-30
PL2902039T3 (pl) 2018-09-28
EP2364729B3 (fr) 2015-06-24
CN101001645A (zh) 2007-07-18
US20100215666A1 (en) 2010-08-26
HK1101277A1 (en) 2007-10-12
CY1115444T1 (el) 2017-01-04
US20120107325A1 (en) 2012-05-03
LUC00088I2 (fr) 2018-12-17
CY2015030I1 (el) 2015-11-04
EP2364729A3 (fr) 2012-01-18
NO2018007I1 (no) 2018-02-14
US20150152178A1 (en) 2015-06-04
US9765140B2 (en) 2017-09-19
ATE517924T1 (de) 2011-08-15
HRP20150480T1 (hr) 2015-07-17
EP1776142B9 (fr) 2016-09-07
BRPI0513078A (pt) 2008-04-22
DK1776142T3 (da) 2011-10-31
GB0417487D0 (en) 2004-09-08
EP2366405A3 (fr) 2012-01-18
ES2367440T7 (es) 2015-07-14
DK2364729T6 (en) 2015-07-06
CA2573586C (fr) 2013-06-25
ECSP077198A (es) 2007-02-28
BRPI0513078B8 (pt) 2019-08-27
NO2022026I1 (no) 2022-06-24
RU2007108067A (ru) 2008-09-10
HRP20110758T4 (hr) 2015-07-31
EP2902039A1 (fr) 2015-08-05
FR15C0048I2 (fr) 2015-11-20
ES2487533T3 (es) 2014-08-21
WO2006013107A1 (fr) 2006-02-09
MX2007001338A (es) 2008-03-11
BRPI0513078B1 (pt) 2019-02-19
JP4682200B2 (ja) 2011-05-11
EP1776142B3 (fr) 2015-06-24
LT2902039T (lt) 2018-06-25

Similar Documents

Publication Publication Date Title
MA28982B1 (fr) Anticorps antagonistes de il-17
EA201000245A1 (ru) Человеческие нейтрализующие антитела к фактору роста нервов (ngf) в качестве селективных ингибиторов метаболического пути ngf
MA31225B1 (fr) Anticorps neutralisants des cytomegalovirus humains et leur utilisation
ATE520416T1 (de) Menschliche anti-ifn-gamma-neutralisierende antikörper als selektive inhibitoren des ifn- gamma-wegs
EA200800355A1 (ru) Нейтрализующие антитела человека против b7rp1
UA108066C2 (uk) Білки, що зв'язуються з cgrp-рецепторами людини
EA200970262A1 (ru) Композиции и способы, относящиеся к антителам к глюкагоновым рецепторам
MA32928B1 (fr) Anticorps anti-cxcr4 et leur utilisation pour le traitement du cancer
EA200500441A1 (ru) Терапевтическое человеческое моноклональное антитело против il-1r1
NO963280L (no) Anvendelse av anti-TNF antistoffer som legemidler i behandling av sykdommer som involverer forhöyede interleukin-6 serumnivåer
PE20140231A1 (es) Proteinas de union a antigeno contra proproteina converstasa subtilisina/kexina tipo 9 (pcsk9)
MA32621B1 (fr) Traitement de maladie auto-immune et inflammatoire
MA30353B1 (fr) Anticorps se liant à la protéine tyrosine phosphatase bêta humaine (hptpbêta) et utilisations correspondantes.
EA200600735A1 (ru) Нуклеиновые кислоты, специфично связывающие биоактивный грелин
MA33381B1 (fr) Proteine de liaison a il-13
MA34175B1 (fr) Anticorps anti-cxcr4 humanisés pour le traitement de cancer
MA29625B1 (fr) Immunoglobulines
ATE402958T1 (de) Antagonisten des ige-rezeptors
BR0313307A (pt) Antagonistas do receptor de mcp-1 e método para a sua utilização
UA108734C2 (uk) Моноклональне антитіло, що специфічно зв'язується з протеїнконвертазою субтілізин кексин типу 9 (pcsk9)
MA37523A1 (fr) Protéines de liaison à l'antigène st2
EA202190387A1 (ru) Антитело к cd38 человека и его применение