CN114127108A - Il-17拮抗剂治疗自身免疫疾病的方法 - Google Patents

Il-17拮抗剂治疗自身免疫疾病的方法 Download PDF

Info

Publication number
CN114127108A
CN114127108A CN202080051903.6A CN202080051903A CN114127108A CN 114127108 A CN114127108 A CN 114127108A CN 202080051903 A CN202080051903 A CN 202080051903A CN 114127108 A CN114127108 A CN 114127108A
Authority
CN
China
Prior art keywords
patient
weeks
antibody
conjugate
once
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080051903.6A
Other languages
English (en)
Inventor
孙飘扬
张连山
陈建文
许倩
高群杰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of CN114127108A publication Critical patent/CN114127108A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

本公开涉及IL‑17拮抗剂治疗自身免疫疾病的方法。本公开中涉及一种IL‑17A结合物在制备治疗自身免疫***疾病，如类风湿关节炎、强直性脊柱炎、银屑病的药物中的用途，具体而言，提供一种治疗炎症或自身免疫***疾病的方法，包括向患者施用有效量的IL‑17结合物，给药频率低于一周一次。

Description

PCT国内申请，说明书已公开。

Claims (22)

  1. PCT国内申请，权利要求书已公开。
CN202080051903.6A 2019-07-30 2020-07-29 Il-17拮抗剂治疗自身免疫疾病的方法 Pending CN114127108A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201910695261 2019-07-30
CN2019106952612 2019-07-30
CN202010523393 2020-06-10
CN202010523393X 2020-06-10
PCT/CN2020/105510 WO2021018191A1 (zh) 2019-07-30 2020-07-29 Il-17拮抗剂治疗自身免疫疾病的方法

Publications (1)

Publication Number Publication Date
CN114127108A true CN114127108A (zh) 2022-03-01

Family

ID=74228555

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080051903.6A Pending CN114127108A (zh) 2019-07-30 2020-07-29 Il-17拮抗剂治疗自身免疫疾病的方法

Country Status (5)

Country Link
US (1) US20220267432A1 (zh)
EP (1) EP4006053A4 (zh)
CN (1) CN114127108A (zh)
TW (1) TW202114734A (zh)
WO (1) WO2021018191A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022144023A1 (zh) * 2021-01-04 2022-07-07 江苏恒瑞医药股份有限公司 抗il-17抗体治疗自身免疫性疾病和炎症的方法

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009082624A2 (en) * 2007-12-10 2009-07-02 Zymogenetics, Inc. Antagonists of il-17a, il-17f, and il-23 and methods of using the same
CN101646690A (zh) * 2006-08-11 2010-02-10 先灵公司 抗il-17a抗体
CN102905727A (zh) * 2009-10-30 2013-01-30 詹森生物科技公司 Il-17a拮抗剂
CN103298489A (zh) * 2010-10-29 2013-09-11 伊缪诺金公司 新型egfr结合分子及其免疫偶联物
WO2014001368A1 (en) * 2012-06-25 2014-01-03 Orega Biotech Il-17 antagonist antibodies
CN105073775A (zh) * 2013-02-08 2015-11-18 诺华股份有限公司 抗-il-17a抗体及其在治疗自身免疫性和炎性病症中的用途
CN106474470A (zh) * 2015-08-28 2017-03-08 江苏恒瑞医药股份有限公司 一种抗il‑17a抗体的组合物
CN104936981B (zh) * 2013-11-18 2018-02-27 上海恒瑞医药有限公司 Il‑17a结合物及其用途
CN108884161A (zh) * 2015-12-01 2018-11-23 葛兰素史密斯克莱知识产权发展有限公司 联合治疗及其用途和方法
CN109796534A (zh) * 2017-11-16 2019-05-24 北京比洋生物技术有限公司 抗il-17抗体/tnfr ecd融合蛋白及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0417487D0 (en) 2004-08-05 2004-09-08 Novartis Ag Organic compound
HUE039353T2 (hu) 2005-12-13 2018-12-28 Lilly Co Eli Anti-IL-17 ellenanyagok
CN103154031A (zh) 2010-10-08 2013-06-12 诺华有限公司 利用il-17拮抗剂治疗牛皮癣的方法
CN107488227A (zh) * 2016-06-12 2017-12-19 三生国健药业（上海）股份有限公司 抗人白细胞介素‑17a单克隆抗体、其制备方法和应用
US20190194311A1 (en) * 2016-07-19 2019-06-27 Novartis Ag Methods of treating new-onset plaque type psoriasis using il-17 antagonists
US11072651B2 (en) * 2016-09-14 2021-07-27 Beijing Hanmi Pharm. Co., Ltd. Antibody specifically binding to IL-17A, encoding nucleic acid, and method of using the antibody
CN109206515B (zh) * 2017-07-06 2021-10-12 北京伟峰益民科技有限公司 一种全人源抗人白介素17a抗体及其应用
CN109369806B (zh) * 2019-01-14 2019-04-19 迈威(上海)生物科技有限公司 苏金单抗制品中半胱氨酸化变异体的去除方法

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101646690A (zh) * 2006-08-11 2010-02-10 先灵公司 抗il-17a抗体
WO2009082624A2 (en) * 2007-12-10 2009-07-02 Zymogenetics, Inc. Antagonists of il-17a, il-17f, and il-23 and methods of using the same
CN102905727A (zh) * 2009-10-30 2013-01-30 詹森生物科技公司 Il-17a拮抗剂
CN103298489A (zh) * 2010-10-29 2013-09-11 伊缪诺金公司 新型egfr结合分子及其免疫偶联物
WO2014001368A1 (en) * 2012-06-25 2014-01-03 Orega Biotech Il-17 antagonist antibodies
CN105073775A (zh) * 2013-02-08 2015-11-18 诺华股份有限公司 抗-il-17a抗体及其在治疗自身免疫性和炎性病症中的用途
CN104936981B (zh) * 2013-11-18 2018-02-27 上海恒瑞医药有限公司 Il‑17a结合物及其用途
CN106474470A (zh) * 2015-08-28 2017-03-08 江苏恒瑞医药股份有限公司 一种抗il‑17a抗体的组合物
CN108884161A (zh) * 2015-12-01 2018-11-23 葛兰素史密斯克莱知识产权发展有限公司 联合治疗及其用途和方法
CN109796534A (zh) * 2017-11-16 2019-05-24 北京比洋生物技术有限公司 抗il-17抗体/tnfr ecd融合蛋白及其用途

Also Published As

Publication number Publication date
US20220267432A1 (en) 2022-08-25
EP4006053A4 (en) 2022-10-26
EP4006053A1 (en) 2022-06-01
TW202114734A (zh) 2021-04-16
WO2021018191A1 (zh) 2021-02-04

Similar Documents

Publication Publication Date Title
ES2569217T3 (es) Agente para tratar enfermedades
KR20010099807A (ko) 감마 인터페론에 대한 인간화 항체
CN110891971A (zh) 仅有重链的抗bcma抗体
KR20170120616A (ko) 염증성 질환의 치료 방법
TW201917135A (zh) 抗ＴＮＦ／抗ＩＬ-２３ ＩｇＧ雙特異性抗體
US10689434B2 (en) Antibody against hepatitis B surface antigen and use thereof
WO2019076277A1 (zh) 抗pd-1抗体和抗lag-3抗体联合在制备***的药物中的用途
CN114127108A (zh) Il-17拮抗剂治疗自身免疫疾病的方法
AU2019397309A1 (en) Anti-IL-17A antibody and use thereof
WO2021190582A1 (zh) 一种抗ox40抗体药物组合物及其用途
JP4044733B2 (ja) ベロ毒素ｉｉを認識するヒト型化抗体、および該抗体を産生する細胞株
AU2019388931A1 (en) CD40 antibody pharmaceutical composition and use thereof
TW202241505A (zh) 抗il-17抗體治療自體免疫性疾病和炎症的方法
WO2022184114A1 (zh) 抗il-17抗体治疗自身免疫性疾病和炎症的方法
RU2778572C1 (ru) Фармацевтическая композиция на основе антител к cd40 и ее применение
US20230088052A1 (en) Pharmaceutical composition containing anti-il-4r antibody and use thereof
US20230406942A1 (en) Igf1r antibodies
RU2816994C2 (ru) Антитела к bcma, содержащие только тяжелую цепь
TW202302146A (zh) 使用抗baffr抗體治療全身性紅斑狼瘡
TW202144425A (zh) 特異性抗原結合分子，其製備方法及醫藥用途
TWI353852B (en) Methods of administering anti-tnfα antibodies
TWI336258B (en) Methods of administering anti-tnfαantibodies

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination