DE69903953D1 - 2-substituierte-1-piperidyl-benzimidazolverbindungen als orl1 rezeptor agonisten - Google Patents

2-substituierte-1-piperidyl-benzimidazolverbindungen als orl1 rezeptor agonisten

Info

Publication number
DE69903953D1
DE69903953D1 DE69903953T DE69903953T DE69903953D1 DE 69903953 D1 DE69903953 D1 DE 69903953D1 DE 69903953 T DE69903953 T DE 69903953T DE 69903953 T DE69903953 T DE 69903953T DE 69903953 D1 DE69903953 D1 DE 69903953D1
Authority
DE
Germany
Prior art keywords
piperidyl
substituted
receptor agonists
benzimidazole compounds
orl1 receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69903953T
Other languages
English (en)
Other versions
DE69903953T2 (de
Inventor
Fumitaka Ito
Hirohide Noguchi
Hiroshi Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE69903953D1 publication Critical patent/DE69903953D1/de
Publication of DE69903953T2 publication Critical patent/DE69903953T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Addiction (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69903953T 1998-08-06 1999-07-05 2-substituierte-1-piperidyl-benzimidazolverbindungen als orl1 rezeptor agonisten Expired - Fee Related DE69903953T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IBPCT/IB98/01206 1998-08-06
PCT/IB1999/001239 WO2000008013A2 (en) 1998-08-06 1999-07-05 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Publications (2)

Publication Number Publication Date
DE69903953D1 true DE69903953D1 (de) 2002-12-19
DE69903953T2 DE69903953T2 (de) 2003-03-27

Family

ID=11004738

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69903953T Expired - Fee Related DE69903953T2 (de) 1998-08-06 1999-07-05 2-substituierte-1-piperidyl-benzimidazolverbindungen als orl1 rezeptor agonisten

Country Status (44)

Country Link
US (1) US6172067B1 (de)
EP (1) EP1102762B1 (de)
JP (1) JP3367945B2 (de)
CN (1) CN1317968A (de)
AP (1) AP2001002063A0 (de)
AR (1) AR018686A1 (de)
AT (1) ATE227716T1 (de)
AU (1) AU749166B2 (de)
BG (1) BG105301A (de)
BR (1) BR9912778A (de)
CA (1) CA2339621C (de)
CZ (1) CZ2001397A3 (de)
DE (1) DE69903953T2 (de)
DK (1) DK1102762T3 (de)
EA (1) EA200100104A1 (de)
EE (1) EE200100075A (de)
ES (1) ES2185357T3 (de)
GE (1) GEP20033000B (de)
GT (1) GT199900125A (de)
HK (1) HK1040188A1 (de)
HN (1) HN1999000105A (de)
HR (1) HRP20010089B1 (de)
HU (1) HUP0103567A3 (de)
ID (1) ID27212A (de)
IL (1) IL141029A0 (de)
IS (1) IS5812A (de)
MA (1) MA26659A1 (de)
NO (1) NO20010603L (de)
NZ (1) NZ509299A (de)
OA (1) OA11590A (de)
PA (1) PA8477701A1 (de)
PE (1) PE20000868A1 (de)
PL (1) PL346211A1 (de)
PT (1) PT1102762E (de)
SI (1) SI1102762T1 (de)
SK (1) SK1602001A3 (de)
SV (1) SV1999000099A (de)
TN (1) TNSN99142A1 (de)
TR (1) TR200100403T2 (de)
TW (1) TW513424B (de)
UY (1) UY25659A1 (de)
WO (1) WO2000008013A2 (de)
YU (1) YU8201A (de)
ZA (1) ZA200100900B (de)

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SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
ES2249237T3 (es) * 2000-01-05 2006-04-01 Pfizer Inc. Compuestos de bencimidazol como antagonistas del receptor orl1.
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
EP1342717A4 (de) * 2000-11-15 2005-02-16 Banyu Pharma Co Ltd Benzimidazolderivate
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
DE60229736D1 (de) 2001-04-18 2008-12-18 Euro Celtique Sa Spiroinden- und spiroindan-verbindungen
AU2002307416B2 (en) * 2001-04-18 2005-08-11 Euro-Celtique S.A. Nociceptin analogs
BR0209127A (pt) 2001-04-18 2006-03-21 Euro Celtique Sa compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos
HUP0402510A3 (en) 2001-04-18 2012-08-28 Euro Celtique Sa Nociceptin analogs and pharmaceutical compositions containing them
US6872733B2 (en) * 2001-04-18 2005-03-29 Euro-Celtique S.A. Benzimidazolone compounds
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
EP1406629A1 (de) * 2001-07-02 2004-04-14 Omeros Corporation Verfahren zur induzierung von analgesie beinhaltend die verabreichung alternativ eines opiat-rezeptoragonists und eines opiat-rezeptor ähnlichen-1 rezeptoragonists und eine implantierbare infusionspumpe
SE0102716D0 (sv) * 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
SE0103818D0 (sv) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
AU2002360561A1 (en) * 2001-12-11 2003-06-23 Sepracor, Inc. 4-substituted piperidines, and methods of use thereof
WO2003082333A1 (fr) 2002-03-29 2003-10-09 Mitsubishi Pharma Corporation Remede contre les troubles du sommeil
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
DE10252666A1 (de) * 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
AR045939A1 (es) 2003-09-25 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolona y quinazolinona como agonistas de los receptores orl 1 humanos
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
WO2006038738A1 (ja) * 2004-10-08 2006-04-13 Takeda Pharmaceutical Company Limited 受容体機能調節剤
WO2006074991A1 (en) 2005-01-11 2006-07-20 Neurosearch A/S Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels
AU2007271243A1 (en) * 2006-07-03 2008-01-10 Neurosearch A/S Combinations of monoamine reuptake inhibitors and potassium channel activators
PT2076506E (pt) 2007-01-16 2010-12-10 Purdue Pharma Lp Compostos de piperidina substituídos nos grupos heterocíclicos como ligandos orl-1
ES2593706T3 (es) * 2007-08-31 2016-12-12 Purdue Pharma Lp Compuestos de piperidina, de tipo quinoxalina sustituida, y usos de los mismos
US8119661B2 (en) * 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
AR072578A1 (es) 2008-07-21 2010-09-08 Purdue Pharma Lp Compuestos de piperidina puenteada tipo quinoxalina sustituida y los usos de los mismos
SG187209A1 (en) 2010-08-05 2013-03-28 Amgen Inc Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase
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JO3300B1 (ar) 2012-06-06 2018-09-16 Novartis Ag مركبات وتركيبات لتعديل نشاط egfr
CN107753462B (zh) 2012-07-12 2021-01-08 诺华丝国际股份有限公司 用于保护生物活性剂的基质和层组合物
US9085561B2 (en) * 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
US9656994B2 (en) 2013-03-22 2017-05-23 The Scripps Research Institute Substituted benzimidazoles as nociceptin receptor modulators
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ATE276242T1 (de) 1997-05-30 2004-10-15 Banyu Pharma Co Ltd 2-oxoimidazol-derivate
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US5929035A (en) 1998-04-14 1999-07-27 Regents Of The University Of Michigan Methods of treating intestinal disorders
ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1

Also Published As

Publication number Publication date
AU4385999A (en) 2000-02-28
JP3367945B2 (ja) 2003-01-20
SK1602001A3 (en) 2002-09-10
JP2002522431A (ja) 2002-07-23
DK1102762T3 (da) 2002-12-16
US6172067B1 (en) 2001-01-09
NO20010603L (no) 2001-04-05
DE69903953T2 (de) 2003-03-27
ZA200100900B (en) 2002-08-28
CA2339621C (en) 2005-04-05
EP1102762A2 (de) 2001-05-30
MA26659A1 (fr) 2004-12-20
AU749166B2 (en) 2002-06-20
PE20000868A1 (es) 2000-08-31
EE200100075A (et) 2002-06-17
UY25659A1 (es) 2000-02-23
PA8477701A1 (es) 2000-09-29
HN1999000105A (es) 2000-11-11
YU8201A (sh) 2003-07-07
GEP20033000B (en) 2003-06-25
ATE227716T1 (de) 2002-11-15
EP1102762B1 (de) 2002-11-13
NO20010603D0 (no) 2001-02-05
BR9912778A (pt) 2001-09-25
GT199900125A (es) 2001-01-27
HUP0103567A2 (hu) 2002-02-28
HUP0103567A3 (en) 2003-01-28
SI1102762T1 (en) 2003-04-30
AP2001002063A0 (en) 2001-03-31
ID27212A (id) 2001-03-08
CZ2001397A3 (cs) 2002-05-15
TW513424B (en) 2002-12-11
EA200100104A1 (ru) 2001-08-27
PT1102762E (pt) 2003-02-28
HK1040188A1 (zh) 2002-05-31
HRP20010089A2 (en) 2002-02-28
NZ509299A (en) 2003-05-30
SV1999000099A (es) 2000-09-05
HRP20010089B1 (en) 2003-04-30
ES2185357T3 (es) 2003-04-16
PL346211A1 (en) 2002-01-28
WO2000008013A3 (en) 2000-03-23
AR018686A1 (es) 2001-11-28
OA11590A (en) 2004-08-18
IL141029A0 (en) 2002-02-10
CA2339621A1 (en) 2000-02-17
CN1317968A (zh) 2001-10-17
IS5812A (is) 2001-01-16
TNSN99142A1 (fr) 2005-11-10
WO2000008013A2 (en) 2000-02-17
BG105301A (en) 2001-12-29
TR200100403T2 (tr) 2001-07-23

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8339 Ceased/non-payment of the annual fee