KR860003012A - (-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물 - Google Patents

(-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물 Download PDF

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Publication number
KR860003012A
KR860003012A KR1019850007328A KR850007328A KR860003012A KR 860003012 A KR860003012 A KR 860003012A KR 1019850007328 A KR1019850007328 A KR 1019850007328A KR 850007328 A KR850007328 A KR 850007328A KR 860003012 A KR860003012 A KR 860003012A
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KR
South Korea
Prior art keywords
amino acid
salt
acid
cis
epoxypropylphosphonic
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KR1019850007328A
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English (en)
Inventor
메올라 스테파니아
Original Assignee
스간지니 카를로
세우레프 에이. 지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 스간지니 카를로, 세우레프 에이. 지 filed Critical 스간지니 카를로
Publication of KR860003012A publication Critical patent/KR860003012A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
    • C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

(-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. (-)시스-1,2-에폭시프로필포스폰산과 아미노산(예, 아르기닌, 오르니틴, 리신, 시스테인)과의 염을 상기 아미노산과 동일하거나 또는 상이한 아미노산의 과량으로 처리함을 특징으로하는, 유효성분으로서 상기 염을 함유하는 수용성 제약 조성물의 제조방법.
  2. 제1항에 있어서, 유효성분이(-)시스-1,2-에폭시프로필포스폰산의 아르기닌 염인 방법.
  3. 제1항 또는 2항에 있어서, 아미노산으로서 아르기닌을 과량으로 사용함을 특징으로 하는 방법.
  4. 제1-3항중 어느 한 항에 있어서, 아미노산을 0.4 내지 0.8, 적합하기로는 0.6의 몰비 과량으로 사용하는 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850007328A 1984-10-05 1985-10-05 (-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물 KR860003012A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH4792/84A CH660306A5 (de) 1984-10-05 1984-10-05 Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren.
CH4792/84-2 1984-10-05

Publications (1)

Publication Number Publication Date
KR860003012A true KR860003012A (ko) 1986-05-19

Family

ID=4282621

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850007328A KR860003012A (ko) 1984-10-05 1985-10-05 (-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물

Country Status (11)

Country Link
JP (1) JPS62223121A (ko)
KR (1) KR860003012A (ko)
AT (1) AT383736B (ko)
BE (1) BE903369A (ko)
CH (1) CH660306A5 (ko)
DE (1) DE3535356A1 (ko)
ES (1) ES8609351A1 (ko)
FR (1) FR2571255B1 (ko)
GB (1) GB2165152B (ko)
IT (1) IT1201479B (ko)
NL (1) NL8502712A (ko)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH310498A (de) * 1951-11-14 1955-10-31 Waldhof Zellstoff Fab Verfahren zur Stabilisierung von Alkalisalzen von Adenosinpolyphosphorsäuren.
DE1767212B1 (de) * 1967-04-13 1971-05-06 Sumitomo Chemical Co Verfahren zur Herstellung injizierbarer Arzneimittel
US3639590A (en) * 1967-07-25 1972-02-01 Merck & Co Inc Antibacterial composition containing (-) (cis-1 2-epoxypropyl) phosphoric acid
BE756953A (fr) * 1969-10-02 1971-04-01 Merck & Co Inc Potentialisation d'antibiotiques
IT1161974B (it) * 1978-02-02 1987-03-18 Italchemi Spa Derivti dell acido cis.i 2 epossipropilfosfonico loro procedimento di preparazione e composizioni farmaceutiche che li contengono
DE2813814A1 (de) * 1978-03-31 1979-10-18 Boehringer Mannheim Gmbh Hochwirksame, enteral resorbierbare pharmazeutische praeparate
IT1112282B (it) * 1978-07-19 1986-01-13 Zambon Spa Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato
IT1097578B (it) * 1978-07-31 1985-08-31 Italchemi Spa Metodo per la preparazione di sali dell'acido (-)
US4235900A (en) * 1978-11-15 1980-11-25 E. R. Squibb & Sons, Inc. Cephradine compositions

Also Published As

Publication number Publication date
GB2165152B (en) 1988-03-16
IT8522367A0 (it) 1985-10-04
DE3535356A1 (de) 1986-04-24
IT1201479B (it) 1989-02-02
NL8502712A (nl) 1986-05-01
JPS62223121A (ja) 1987-10-01
GB8524550D0 (en) 1985-11-06
FR2571255A1 (fr) 1986-04-11
FR2571255B1 (fr) 1988-09-16
BE903369A (nl) 1986-02-03
GB2165152A (en) 1986-04-09
AT383736B (de) 1987-08-10
ATA287185A (de) 1987-01-15
ES547625A0 (es) 1986-09-01
CH660306A5 (de) 1987-04-15
ES8609351A1 (es) 1986-09-01

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