KR930012023A - 환원된 형태의 비글리코실화 재조합 인체 il2의 안정화된 제약 조성물 및 그의 제조방법 - Google Patents

환원된 형태의 비글리코실화 재조합 인체 il2의 안정화된 제약 조성물 및 그의 제조방법 Download PDF

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Publication number
KR930012023A
KR930012023A KR1019920023909A KR920023909A KR930012023A KR 930012023 A KR930012023 A KR 930012023A KR 1019920023909 A KR1019920023909 A KR 1019920023909A KR 920023909 A KR920023909 A KR 920023909A KR 930012023 A KR930012023 A KR 930012023A
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KR
South Korea
Prior art keywords
dextran
recombinant human
composition
reduced form
mannitol
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Application number
KR1019920023909A
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English (en)
Inventor
로우셀-우크라프
Original Assignee
장-끌로드 비에이으포스
로우셀-우크라프
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 장-끌로드 비에이으포스, 로우셀-우크라프 filed Critical 장-끌로드 비에이으포스
Publication of KR930012023A publication Critical patent/KR930012023A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

본 발명은 개선된 안정성을 갖는 환원된 형태, 특히 동결건조된 형태의 비글리코실화 재조합 인체 IL2의 제약 조성물 및 의약으로서의 그의 용도에 관한 것이다.

Description

환원된 형태의 비글리코실화 재조합 인체 IL2의 안정화된 제약 조성물 및 그이 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 시트르산 및 만리톨을 함유하고, 덱스트란 및 EDTA 칼슘염을 함유하는 것을 특징으로 하는, 환원된 형태의 비글리코실화 재조합 인체 IL2의 안정화된 제약 조성물.
  2. 제1항에 있어서, 덱스트란의 평균 분자량이 약 40,000 내지 110,000 임을 특징으로 하는 조성물.
  3. 제2항에 있어서, 덱스트란의 평균 분자량이 약 70,000 임을 특징으로 하는 조성물.
  4. 제3항에 있어서, 덱스트란 : IL2의 중량비가 약 20 내지 약 80 임을 특징으로 하는 조성물.
  5. 제4항에 있어서, 덱스트란 : IL2의 중량비가 약 40 임을 특징으로 하는 조성물.
  6. 제5항에 있어서, IL2 : 시트르산 : 만니톨 : 텍스트란 : EDTA 칼슘염의 중량비가 약 1 : 10 : 50 : 40 : 0.01임을 특징으로 하는 조성물.
  7. 제1항 내지 제6항 중 어느 한 항에 있어서, 필수적으로 IL2 이량체가 없음을 특징으로 하는 조성물.
  8. 덱스트란, EDTA 칼슘염 및 만니틀을 함유하는 용액을 시트르산을 함유하는 IL2의 수용액에 첨가하여 용액을 동결건조시킴을 특징으로 하는, 환원된 형태의 비글리코실화 재조합 인체 IL2의 안정화된 동결건조된 제약 조성물의 제조 방법.
  9. 시트르산 및 만니톨을 함유하는 환원된 형태의 비글리코실화 재조합 인체 IL2의 제약 조성물을 안정화시키기 위한 덱스트란 및 EDTA칼슘염의 용도.
  10. 덱스트란 및 EDTA칼슘염을 첨가함을 특징으로 하는 스트르산 및 만니톨을 함유하는 환원된 형태의 비글리코실화 재조합 인체 IL2의 제약 조성물의 안정화 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920023909A 1991-12-12 1992-12-11 환원된 형태의 비글리코실화 재조합 인체 il2의 안정화된 제약 조성물 및 그의 제조방법 KR930012023A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR91-15418 1991-12-12
FR9115418A FR2684878B1 (fr) 1991-12-12 1991-12-12 Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation.

Publications (1)

Publication Number Publication Date
KR930012023A true KR930012023A (ko) 1993-07-20

Family

ID=9419958

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920023909A KR930012023A (ko) 1991-12-12 1992-12-11 환원된 형태의 비글리코실화 재조합 인체 il2의 안정화된 제약 조성물 및 그의 제조방법

Country Status (18)

Country Link
US (1) US5340574A (ko)
EP (1) EP0554634B1 (ko)
JP (1) JP3291340B2 (ko)
KR (1) KR930012023A (ko)
AT (1) ATE135917T1 (ko)
AU (1) AU662940B2 (ko)
CA (1) CA2085142A1 (ko)
DE (1) DE69209486T2 (ko)
DK (1) DK0554634T3 (ko)
ES (1) ES2084965T3 (ko)
FR (1) FR2684878B1 (ko)
GR (1) GR3019440T3 (ko)
HU (1) HU218103B (ko)
IL (1) IL103862A (ko)
MX (1) MX9207199A (ko)
RU (1) RU2107511C1 (ko)
UA (1) UA26898C2 (ko)
ZA (1) ZA929627B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9280798A (en) * 1997-10-03 1999-04-27 Shionogi & Co., Ltd. Process for freeze-drying proteins
HUP0203133A3 (en) * 1999-10-04 2005-07-28 Chiron Corp Emeryville Stabilized liquid polypeptide-containing pharmaceutical compositions
EP2174663A1 (en) 2003-01-08 2010-04-14 Novartis Vaccines and Diagnostics, Inc. Stabilized aqueous compositions comprising tissue factor pathway inhibitor (TFPI) or tissue factor pathway inhibitor variant
JP2008501639A (ja) * 2004-04-23 2008-01-24 ノベシン リミテッド タンパク質を安定化、保護及び可溶化させるための方法及びキット
WO2011134979A2 (en) * 2010-04-27 2011-11-03 Scil Technology Gmbh Stable mia/cd-rap formulation

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DE251001C (ko) *
FR353150A (fr) * 1905-04-08 1905-09-04 Gerardo Caffaro Compteurs à gaz
FR452598A (fr) * 1912-12-26 1913-05-19 Lanston Monotype Corp Ltd Perfectionnements apportés aux machines servant à la composition typographique
WO1985004328A1 (en) * 1984-03-28 1985-10-10 Cetus Corporation Pharmaceutical compositions of microbially produced interleukin-2
EP0158487B1 (en) * 1984-04-09 1991-08-28 Takeda Chemical Industries, Ltd. Stable composition of interleukin-2
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JPH0645551B2 (ja) * 1986-01-07 1994-06-15 塩野義製薬株式会社 インタ−ロイキン−２組成物
US4933433A (en) * 1986-01-31 1990-06-12 E. I. Du Pont De Nemours And Company Recombinant interleukin-2 composition and process for making it
DE3621828A1 (de) * 1986-06-28 1988-01-14 Biotest Pharma Gmbh Stabilisierung eines fuer therapeutische zwecke, insbesondere beim menschen, bestimmten interleukin-2-praeparates sowie dieses praeparat enthaltende stabilisierte waessrige loesung oder feststoff
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FR2635527B1 (fr) * 1988-07-28 1992-06-12 Roussel Uclaf Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament
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Also Published As

Publication number Publication date
JP3291340B2 (ja) 2002-06-10
EP0554634B1 (fr) 1996-03-27
RU2107511C1 (ru) 1998-03-27
EP0554634A1 (fr) 1993-08-11
AU662940B2 (en) 1995-09-21
CA2085142A1 (fr) 1993-06-13
DK0554634T3 (da) 1996-07-01
MX9207199A (es) 1993-07-01
HUT63575A (en) 1993-09-28
FR2684878B1 (fr) 1994-02-11
DE69209486T2 (de) 1996-09-12
IL103862A (en) 1997-02-18
ZA929627B (en) 1993-12-13
AU3004192A (en) 1993-06-17
HU9203925D0 (en) 1993-03-29
FR2684878A1 (fr) 1993-06-18
IL103862A0 (en) 1993-04-04
GR3019440T3 (en) 1996-06-30
JPH05345728A (ja) 1993-12-27
DE69209486D1 (de) 1996-05-02
HU218103B (hu) 2000-06-28
ATE135917T1 (de) 1996-04-15
UA26898C2 (uk) 1999-12-29
ES2084965T3 (es) 1996-05-16
US5340574A (en) 1994-08-23

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