KR100257619B1 - Azole compounds, their production and use - Google Patents

Azole compounds, their production and use Download PDF

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Publication number
KR100257619B1
KR100257619B1 KR1019930007244A KR930007244A KR100257619B1 KR 100257619 B1 KR100257619 B1 KR 100257619B1 KR 1019930007244 A KR1019930007244 A KR 1019930007244A KR 930007244 A KR930007244 A KR 930007244A KR 100257619 B1 KR100257619 B1 KR 100257619B1
Authority
KR
South Korea
Prior art keywords
group
optionally substituted
independently
azole compounds
lower alkyl
Prior art date
Application number
KR1019930007244A
Other languages
English (en)
Other versions
KR940005616A (ko
Inventor
Itoh Katsumi
Okonogi Kenji
Tamura Norikazu
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of KR940005616A publication Critical patent/KR940005616A/ko
Application granted granted Critical
Publication of KR100257619B1 publication Critical patent/KR100257619B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymerization Catalysts (AREA)
  • Coloring (AREA)
  • Lubricants (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019930007244A 1992-04-28 1993-04-28 Azole compounds, their production and use KR100257619B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP92-110400 1992-04-28
JP11040092 1992-04-28
JP93-22623 1993-02-10
JP2262393 1993-02-10

Publications (2)

Publication Number Publication Date
KR940005616A KR940005616A (ko) 1994-03-21
KR100257619B1 true KR100257619B1 (en) 2000-07-01

Family

ID=26359882

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930007244A KR100257619B1 (en) 1992-04-28 1993-04-28 Azole compounds, their production and use

Country Status (18)

Country Link
US (2) US5371101A (ko)
EP (1) EP0567982B1 (ko)
JP (1) JP2818097B2 (ko)
KR (1) KR100257619B1 (ko)
CN (1) CN1040433C (ko)
AT (1) ATE167857T1 (ko)
AU (1) AU655544B2 (ko)
CA (1) CA2094962A1 (ko)
DE (1) DE69319380T2 (ko)
DK (1) DK0567982T3 (ko)
ES (1) ES2118160T3 (ko)
FI (1) FI931901A (ko)
HU (2) HUT64327A (ko)
NO (1) NO303284B1 (ko)
NZ (1) NZ247488A (ko)
PH (1) PH31082A (ko)
SG (1) SG48939A1 (ko)
TW (1) TW218017B (ko)

Families Citing this family (52)

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HU212458B (en) * 1993-09-23 1996-06-28 Richter Gedeon Vegyeszet New silyloxypropane derivatives substituted with triazole or imidazole pharmaceutical compositions containing them and process for producing them
TW297813B (ko) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd
CA2134417A1 (en) * 1993-12-22 1995-06-23 Katsumi Itoh Optically active azole derivatives, their production and use
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
CA2182698A1 (en) * 1994-02-25 1995-08-31 Jun Sato Injectable emulsions containing antifungal triazole derivatives
US5677464A (en) * 1994-05-31 1997-10-14 Takeda Chemical Industries, Ltd. Production of optically active triazole compounds and their intermediates
US5639754A (en) * 1994-07-12 1997-06-17 Janssen Pharmaceutica N.V. Urea and thiourea derivatives of azolones
US5637592A (en) * 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
TW318841B (ko) * 1995-02-17 1997-11-01 Takeda Pharm Industry Co Ltd
AU4675596A (en) * 1995-02-17 1996-09-04 Takeda Chemical Industries Ltd. Azole compounds, their production and use
US6060604A (en) 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
DE19520597A1 (de) * 1995-06-06 1996-12-12 Bayer Ag Mercapto-bis-triazole
ES2107376B1 (es) * 1995-08-02 1998-07-01 Uriach & Cia Sa J Nuevos derivados de pirimidona con actividad antifungica.
ES2120885B1 (es) * 1996-03-15 1999-06-16 Uriach & Cia Sa J Nuevas tienopirimidonas con actividad antifungica.
EP0783502A1 (en) * 1995-08-02 1997-07-16 J. URIACH & CIA. S.A. New carboxamides with antifungal activity
ATE198593T1 (de) * 1995-08-02 2001-01-15 Uriach & Cia Sa J Pyrimidonderivate mit antifungaler wirkung
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
CA2250353A1 (en) * 1996-04-03 1997-10-09 Christopher J. Dinsmore Inhibitors of farnesyl-protein transferase
US6001835A (en) * 1996-04-03 1999-12-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU6119798A (en) * 1997-03-05 1998-09-22 Takeda Chemical Industries Ltd. Crystalline form of a bis 1,2,4-triazole compound
CA2281875A1 (en) 1997-03-31 1998-10-08 Takeda Chemical Industries, Ltd. Azole compounds, their production and their use
EP0884311A3 (en) * 1997-06-06 1999-01-27 Takeda Chemical Industries, Ltd. Triazole Derivatives and their production
US6133485A (en) * 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
CA2345612A1 (en) * 1998-09-29 2000-04-06 Masao Nagao Anti-fungal composition
ES2159488B1 (es) 2000-03-07 2002-04-16 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.
RU2002126272A (ru) * 2000-03-07 2004-08-10 Рэнбакси Лабораториз Лимитед (In) Производные азолов в качестве терапевтических агентов против грибковых инфекций
IN191188B (ko) 2000-03-07 2003-10-04 Ranbaxy Lab Ltd
MXPA03005899A (es) 2000-12-26 2004-01-26 Ranbaxy Lab Ltd Compuestos azoles como agentes anti-micoticos.
ES2252209T3 (es) * 2001-03-23 2006-05-16 Richter Gedeon Vegyeszeti Gyar R.T. Proceso para preparar fluconazol y sus modificaciones cristalinas.
IN191819B (ko) * 2001-07-19 2004-01-03 Ranbaxy Lab Ltd
IN192526B (ko) * 2001-09-25 2004-04-24 Ranbaxy Lab
US7028055B2 (en) * 2002-03-22 2006-04-11 Sun Microsystems, Inc. Method and apparatus for improving transaction specification by marking application states
WO2003087106A1 (en) * 2002-04-12 2003-10-23 Ranbaxy Laboratories Limited Derivatives of 2,2,4-trisubstituted tetrahydrofuran as antifungal agents
US8039452B2 (en) * 2002-06-18 2011-10-18 Pola Pharma Inc. Antifungal medicinal compositions
WO2004018485A1 (en) * 2002-08-26 2004-03-04 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
KR100572996B1 (ko) * 2003-08-12 2006-04-25 한국화학연구원 불소화 비닐 에테르 측쇄기를 갖는 아졸계 살균제 화합물및 그의 제조방법
KR101374553B1 (ko) * 2004-11-18 2014-03-17 신타 파마슈티칼스 코프. Ｈｓｐ90 활성을 조절하는 트리아졸 화합물
CN1304376C (zh) * 2005-03-04 2007-03-14 清华大学 一种卤化烷基咪唑型离子液体的制备方法
AU2006279794B2 (en) * 2005-08-12 2011-04-07 Synta Pharmaceuticals Corp. Pyrazole compounds that modulate HSP90 activity
JP5118039B2 (ja) * 2005-08-18 2013-01-16 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するトリアゾール化合物
SI2035396T1 (sl) 2006-05-25 2014-08-29 Synta Pharmaceuticals Corp. Triazolne spojine, ki modulirajo aktivnost HSP90
TW200804313A (en) * 2006-05-25 2008-01-16 Synta Pharmaceuticals Corp Triazole compounds that modulate HSP90 activity
US8183384B2 (en) * 2006-05-25 2012-05-22 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
US20080027047A1 (en) * 2006-05-25 2008-01-31 Weiwen Ying Compounds that modulate HSP90 activity and methods for identifying same
CA2658843A1 (en) 2006-08-07 2008-02-21 Stiefel Laboratories, Inc. Crystalline antifungal compounds
JP5079011B2 (ja) * 2006-10-19 2012-11-21 エフ．ホフマン−ラ ロシュ アーゲー 糖尿病のための１１β−ＨＳＤ１阻害剤としてのイミダゾロン及びイミダゾリジノン誘導体
EP2560640A1 (en) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
CN102824342B (zh) * 2011-06-17 2016-03-30 全哲山 一类用作抗癫痫药的化合物及其可药用盐
EP2773345A1 (en) 2011-11-02 2014-09-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
EP2776025A1 (en) 2011-11-02 2014-09-17 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with platinum-containing agents
AU2012339679A1 (en) 2011-11-14 2014-06-12 Synta Pharmaceuticals Corp. Combination therapy of Hsp90 inhibitors with BRAF inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8306351D0 (en) * 1983-03-08 1983-04-13 Ici Plc Azole fungicides
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
IE58738B1 (en) * 1984-09-05 1993-11-03 Ici Plc Antifungal azole compounds
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
NO171272C (no) * 1988-03-04 1993-02-17 Sankyo Co Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,4-triazolforbindelser
DE3837463A1 (de) * 1988-11-04 1990-05-10 Bayer Ag Substituierte bisazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
US5371101A (en) 1994-12-06
NO303284B1 (no) 1998-06-22
AU3822193A (en) 1993-11-04
JP2818097B2 (ja) 1998-10-30
US5466820A (en) 1995-11-14
KR940005616A (ko) 1994-03-21
CN1040433C (zh) 1998-10-28
AU655544B2 (en) 1994-12-22
EP0567982A1 (en) 1993-11-03
EP0567982B1 (en) 1998-07-01
NZ247488A (en) 1995-02-24
DK0567982T3 (da) 1999-04-12
DE69319380T2 (de) 1998-10-29
PH31082A (en) 1998-02-05
HUT64327A (en) 1993-12-28
HU9301226D0 (en) 1993-07-28
HU211474A9 (en) 1995-11-28
SG48939A1 (en) 1998-05-18
TW218017B (ko) 1993-12-21
FI931901A (fi) 1993-10-29
NO931533L (no) 1993-10-29
CA2094962A1 (en) 1993-10-29
FI931901A0 (fi) 1993-04-27
JPH06293740A (ja) 1994-10-21
NO931533D0 (no) 1993-04-27
ATE167857T1 (de) 1998-07-15
ES2118160T3 (es) 1998-09-16
DE69319380D1 (de) 1998-08-06
CN1079467A (zh) 1993-12-15

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Legal Events

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A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee