ATE198593T1 - Pyrimidonderivate mit antifungaler wirkung - Google Patents
Pyrimidonderivate mit antifungaler wirkungInfo
- Publication number
- ATE198593T1 ATE198593T1 AT96929201T AT96929201T ATE198593T1 AT E198593 T1 ATE198593 T1 AT E198593T1 AT 96929201 T AT96929201 T AT 96929201T AT 96929201 T AT96929201 T AT 96929201T AT E198593 T1 ATE198593 T1 AT E198593T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- pyrimidone derivatives
- fungal effect
- sec
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9501564A ES2107376B1 (es) | 1995-08-02 | 1995-08-02 | Nuevos derivados de pirimidona con actividad antifungica. |
| ES9600646A ES2120885B1 (es) | 1996-03-15 | 1996-03-15 | Nuevas tienopirimidonas con actividad antifungica. |
| PCT/EP1996/003420 WO1997005130A1 (en) | 1995-08-02 | 1996-08-02 | New pyrimidone derivatives with antifungal activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE198593T1 true ATE198593T1 (de) | 2001-01-15 |
Family
ID=26154906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96929201T ATE198593T1 (de) | 1995-08-02 | 1996-08-02 | Pyrimidonderivate mit antifungaler wirkung |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5807854A (de) |
| EP (1) | EP0783501B9 (de) |
| JP (1) | JP4049207B2 (de) |
| KR (1) | KR100423590B1 (de) |
| AT (1) | ATE198593T1 (de) |
| AU (1) | AU6870396A (de) |
| BR (1) | BR9606547A (de) |
| CA (1) | CA2201477C (de) |
| DE (1) | DE69611512T2 (de) |
| DK (1) | DK0783501T3 (de) |
| ES (1) | ES2153975T3 (de) |
| GR (1) | GR3035621T3 (de) |
| MX (1) | MX9702382A (de) |
| NO (1) | NO312898B1 (de) |
| PT (1) | PT783501E (de) |
| WO (1) | WO1997005130A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2371728C (en) * | 1999-06-11 | 2009-06-02 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
| US7094885B2 (en) * | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
| ES2159488B1 (es) * | 2000-03-07 | 2002-04-16 | Uriach & Cia Sa J | Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica. |
| WO2002000647A1 (en) | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Heteroaryl-phenyl substituted factor xa inhibitors |
| CA2434302A1 (en) | 2001-01-08 | 2002-08-15 | Neorx Corporation | Therapeutic and diagnostic compounds, compositions, and methods |
| PA8539401A1 (es) * | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
| HUP0303249A3 (en) | 2001-02-22 | 2007-03-28 | Sankyo Co | Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them |
| PL208713B1 (pl) * | 2001-06-11 | 2011-05-31 | Virochem Pharma Inc | Związek stanowiący pochodną tiofenu, kompozycja farmaceutyczna zawierająca taki związek i jego zastosowanie |
| US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
| US7045116B2 (en) | 2001-12-13 | 2006-05-16 | Dow Global Technologies Inc. | Treatment of osteomyelitis with radiopharmaceuticals |
| CA2495923A1 (en) * | 2002-08-20 | 2004-03-04 | Doren M. Pinnell | Methods for treating fungal infections |
| PT1569929E (pt) | 2002-12-10 | 2010-06-18 | Virochem Pharma Inc | Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus |
| EP1871766A4 (de) * | 2005-03-30 | 2010-07-21 | Dae Woong Pharma | Triazolderivate mit antipilzwirkung |
| JP5132069B2 (ja) * | 2006-03-31 | 2013-01-30 | 三井化学アグロ株式会社 | ３−（ジヒドロ（又はテトラヒドロ）イソキノリン−１−イル）キノリン化合物を含む医薬用抗真菌剤 |
| EP2650291B1 (de) * | 2006-08-07 | 2017-10-04 | Palau Pharma, S.A. | Antifungale Kristallverbindungen |
| EP2009009A1 (de) * | 2007-06-26 | 2008-12-31 | Palau Pharma, S.A. | Antifungale Kristallverbindungen |
| EP1887004A1 (de) * | 2006-08-07 | 2008-02-13 | Palau Pharma, S.A. | Kristalline Formen von (1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]chinazolin-4(3H)-on |
| RS52874B (en) | 2006-11-15 | 2013-12-31 | Vertex Pharmaceuticals Incorporated | THYOPHEN ANALYSIS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS |
| UY30892A1 (es) * | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
| US20080255161A1 (en) * | 2007-04-11 | 2008-10-16 | Dmitry Koltun | 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS |
| EP2257555B1 (de) | 2008-03-03 | 2012-07-04 | National Chemical Laboratory | Thieno[2,3-d]-pyrimidin-4(3h)-on-verbindungen mit antimykotischen eigenschaften und verfahren dafür |
| CA2763911C (en) * | 2009-05-29 | 2018-01-30 | Palau Pharma, S.A. | Azole antifungal compositions |
| TW201441215A (zh) * | 2013-02-04 | 2014-11-01 | Syngenta Participations Ag | 新穎殺微生物劑 |
| MX2020003488A (es) | 2015-02-02 | 2022-05-24 | Forma Therapeutics Inc | Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac). |
| AR103598A1 (es) | 2015-02-02 | 2017-05-24 | Forma Therapeutics Inc | Ácidos bicíclicos[4,6,0]hidroxámicos como inhibidores de hdac |
| EA025187B1 (ru) * | 2015-04-17 | 2016-11-30 | Тагир Аббасели оглы Сулейманов | Производное дитиокарбамата 2-((4-(4-метилпиперазин-1-ил)фенил)амино)-2-оксоетил4-этилпиперазин-1-карбодитиоат, обладающее антифунгальной активностью |
| WO2017009751A1 (en) | 2015-07-15 | 2017-01-19 | Pfizer Inc. | Pyrimidine derivatives |
| EP3472131B1 (de) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- und 6-hydroxamsäureindane als hdac-inhibitoren |
| WO2019031240A1 (ja) | 2017-08-10 | 2019-02-14 | 住友化学株式会社 | エポキシアルコール化合物の製造方法 |
| CN111018839B (zh) * | 2019-12-02 | 2022-12-23 | 中国人民解放军第二军医大学 | 三氮唑醇类衍生物及其制备方法和应用 |
| WO2023118082A1 (en) | 2021-12-22 | 2023-06-29 | Palau Pharma, S.L.U. | Multiparticulate albaconazole composition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4482558A (en) * | 1982-06-18 | 1984-11-13 | Pfizer Inc. | Antifungal amide and urea derivatives of (3-amino-2-aryl-2-hydroxyprop-1-yl)-1H-1,2,4-triazoles |
| EP0293500A1 (de) * | 1987-06-01 | 1988-12-07 | American Cyanamid Company | 3-Heteroalkyl-2,4-quinazolinedione, 3-Heteroaryl-1,2,3-benzotriazin-4(3H)-one, 3-Heteroarylalkyl-4-quinazolinon |
| GB8819308D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Triazole antifungal agents |
| TW218017B (de) * | 1992-04-28 | 1993-12-21 | Takeda Pharm Industry Co Ltd |
-
1996
- 1996-08-02 KR KR1019970701515A patent/KR100423590B1/ko not_active IP Right Cessation
- 1996-08-02 CA CA002201477A patent/CA2201477C/en not_active Expired - Lifetime
- 1996-08-02 DE DE69611512T patent/DE69611512T2/de not_active Expired - Lifetime
- 1996-08-02 AT AT96929201T patent/ATE198593T1/de active
- 1996-08-02 PT PT96929201T patent/PT783501E/pt unknown
- 1996-08-02 US US08/809,967 patent/US5807854A/en not_active Expired - Lifetime
- 1996-08-02 DK DK96929201T patent/DK0783501T3/da active
- 1996-08-02 BR BR9606547A patent/BR9606547A/pt not_active IP Right Cessation
- 1996-08-02 MX MX9702382A patent/MX9702382A/es unknown
- 1996-08-02 EP EP96929201A patent/EP0783501B9/de not_active Expired - Lifetime
- 1996-08-02 JP JP50725497A patent/JP4049207B2/ja not_active Expired - Lifetime
- 1996-08-02 WO PCT/EP1996/003420 patent/WO1997005130A1/en active IP Right Grant
- 1996-08-02 ES ES96929201T patent/ES2153975T3/es not_active Expired - Lifetime
- 1996-08-02 AU AU68703/96A patent/AU6870396A/en not_active Abandoned
-
1997
- 1997-04-01 NO NO19971470A patent/NO312898B1/no not_active IP Right Cessation
-
2001
- 2001-03-23 GR GR20010400466T patent/GR3035621T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0783501B9 (de) | 2001-07-25 |
| EP0783501A1 (de) | 1997-07-16 |
| GR3035621T3 (en) | 2001-06-29 |
| JPH10508317A (ja) | 1998-08-18 |
| KR100423590B1 (ko) | 2004-09-10 |
| CA2201477C (en) | 2005-05-03 |
| DE69611512T2 (de) | 2001-05-31 |
| WO1997005130A1 (en) | 1997-02-13 |
| MX9702382A (es) | 1998-02-28 |
| BR9606547A (pt) | 1997-10-14 |
| EP0783501B1 (de) | 2001-01-10 |
| NO971470D0 (no) | 1997-04-01 |
| DE69611512D1 (de) | 2001-02-15 |
| NO312898B1 (no) | 2002-07-15 |
| US5807854A (en) | 1998-09-15 |
| CA2201477A1 (en) | 1997-02-13 |
| AU6870396A (en) | 1997-02-26 |
| DK0783501T3 (da) | 2001-01-29 |
| ES2153975T3 (es) | 2001-03-16 |
| NO971470L (no) | 1997-04-01 |
| JP4049207B2 (ja) | 2008-02-20 |
| KR970705558A (ko) | 1997-10-09 |
| PT783501E (pt) | 2001-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner |