JPS6445362A - Manufacture of melatonin - Google Patents

Manufacture of melatonin

Info

Publication number
JPS6445362A
JPS6445362A JP63171970A JP17197088A JPS6445362A JP S6445362 A JPS6445362 A JP S6445362A JP 63171970 A JP63171970 A JP 63171970A JP 17197088 A JP17197088 A JP 17197088A JP S6445362 A JPS6445362 A JP S6445362A
Authority
JP
Japan
Prior art keywords
serotonine
acetyl
melatonin
manufacture
diacetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63171970A
Other languages
English (en)
Other versions
JPH0466866B2 (ja
Inventor
Berusore Reimon
Irusuburunaa Pieeru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe des Produits Nestle SA
Nestle SA
Original Assignee
Societe des Produits Nestle SA
Nestle SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe des Produits Nestle SA, Nestle SA filed Critical Societe des Produits Nestle SA
Publication of JPS6445362A publication Critical patent/JPS6445362A/ja
Publication of JPH0466866B2 publication Critical patent/JPH0466866B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • External Artificial Organs (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP63171970A 1983-07-01 1988-07-12 Manufacture of melatonin Granted JPS6445362A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/510,167 US4506080A (en) 1983-07-01 1983-07-01 Preparation of serotonine and derivatives

Publications (2)

Publication Number Publication Date
JPS6445362A true JPS6445362A (en) 1989-02-17
JPH0466866B2 JPH0466866B2 (ja) 1992-10-26

Family

ID=24029637

Family Applications (4)

Application Number Title Priority Date Filing Date
JP59103799A Granted JPS6025966A (ja) 1983-07-01 1984-05-24 セロトニンの分離方法
JP63171971A Granted JPS6445363A (en) 1983-07-01 1988-07-12 Manufacture of mexamine
JP63171969A Granted JPS6445361A (en) 1983-07-01 1988-07-12 Manufacture of n-acetylserotonin
JP63171970A Granted JPS6445362A (en) 1983-07-01 1988-07-12 Manufacture of melatonin

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP59103799A Granted JPS6025966A (ja) 1983-07-01 1984-05-24 セロトニンの分離方法
JP63171971A Granted JPS6445363A (en) 1983-07-01 1988-07-12 Manufacture of mexamine
JP63171969A Granted JPS6445361A (en) 1983-07-01 1988-07-12 Manufacture of n-acetylserotonin

Country Status (10)

Country Link
US (1) US4506080A (ja)
EP (3) EP0197389B1 (ja)
JP (4) JPS6025966A (ja)
AT (2) ATE38513T1 (ja)
DE (1) DE3462794D1 (ja)
ES (4) ES8602653A1 (ja)
GB (3) GB2142622B (ja)
IL (1) IL71737A (ja)
OA (1) OA07734A (ja)
ZM (1) ZM3384A1 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877176A (en) * 1991-12-26 1999-03-02 Cornell Research Foundation, Inc. Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
US6080773A (en) 1997-10-14 2000-06-27 Akzo Nobel, N.V. Benzylamine derivatives which are useful in treating psychiatric disorders
IL155666A (en) * 2003-04-29 2013-12-31 Neurim Pharma 1991 Insomnia treatment
US9119846B2 (en) 2003-04-29 2015-09-01 Neurim Pharmaceuticals (1991) Ltd. Method and composition for enhancing cognition in alzheimer's patients
CN104496882A (zh) * 2014-11-29 2015-04-08 湖北金赛药业有限公司 一种褪黑素的合成方法
US20210238124A1 (en) * 2018-04-20 2021-08-05 The General Hospital Corporation Acetylated prodrugs for delivery across the blood-brain barrier
CN110105261A (zh) * 2018-12-24 2019-08-09 武汉工程大学 一种利用微反应器连续、快速合成及提纯褪黑素的方法
ES1237024Y (es) 2019-09-20 2020-01-30 Normagrup Tech S A Dispositivo de iluminacion autonomo para la regulacion de ciclos circadianos
CN113402437B (zh) * 2021-06-29 2023-07-14 河北维达康生物科技有限公司 一种合成膳食补充剂褪黑素的新方法
CN113788780B (zh) * 2021-10-15 2023-06-16 河北维达康生物科技有限公司 一种n-乙酰基-5-甲氧基色胺的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2156944C3 (de) * 1971-11-16 1974-10-17 Hag Ag, 2800 Bremen Verfahren zur Gewinnung von Serotonin aus Kaffeewachs
CH568719A5 (en) * 1973-08-22 1975-11-14 Haco Ag Extracting carboxylic acid 5-hydroxy-tryptamide irritants - from coffee without caffeine extn. by using caffeine - enriched solvents
DE2435365A1 (de) * 1973-12-31 1976-01-29 Luigi Di Bella Pharmazeutisches mittel fuer die behandlung von allen leukaemieformen und neurotischen syndromen
CH601227A5 (ja) * 1975-05-30 1978-06-30 Nestle Sa
CH608790A5 (en) * 1976-11-18 1979-01-31 Nestle Sa Process for separating serotonin from coffee waxes

Also Published As

Publication number Publication date
ES545232A0 (es) 1986-01-01
ES533890A0 (es) 1985-12-16
ES8603411A1 (es) 1986-01-01
JPH0466866B2 (ja) 1992-10-26
ATE38514T1 (de) 1988-11-15
EP0197390A3 (en) 1986-12-03
EP0197389B1 (en) 1988-11-09
US4506080A (en) 1985-03-19
GB8411197D0 (en) 1984-06-06
ATE38513T1 (de) 1988-11-15
EP0130303B1 (en) 1987-03-25
JPS6025966A (ja) 1985-02-08
IL71737A (en) 1987-07-31
JPS6445363A (en) 1989-02-17
ZM3384A1 (en) 1984-12-21
GB8521543D0 (en) 1985-10-02
ES545231A0 (es) 1986-01-16
OA07734A (fr) 1985-08-30
JPS6445361A (en) 1989-02-17
EP0197389A2 (en) 1986-12-03
GB2142622B (en) 1987-04-01
JPH0438748B2 (ja) 1992-06-25
GB2165838A (en) 1986-04-23
IL71737A0 (en) 1984-09-30
ES8603410A1 (es) 1986-01-01
GB2165837A (en) 1986-04-23
ES8602653A1 (es) 1985-12-16
GB8521544D0 (en) 1985-10-02
EP0197389A3 (en) 1986-12-03
ES8604142A1 (es) 1986-01-16
JPS6410511B2 (ja) 1989-02-22
GB2165837B (en) 1987-04-01
GB2142622A (en) 1985-01-23
JPH0438747B2 (ja) 1992-06-25
ES545230A0 (es) 1986-01-01
EP0197390A2 (en) 1986-12-03
DE3462794D1 (en) 1987-04-30
EP0130303A1 (en) 1985-01-09
EP0197390B1 (en) 1988-11-09
GB2165838B (en) 1987-04-01

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