ES8603411A1 - Un procedimiento para la preparacion de mexamina - Google Patents

Un procedimiento para la preparacion de mexamina

Info

Publication number
ES8603411A1
ES8603411A1 ES545232A ES545232A ES8603411A1 ES 8603411 A1 ES8603411 A1 ES 8603411A1 ES 545232 A ES545232 A ES 545232A ES 545232 A ES545232 A ES 545232A ES 8603411 A1 ES8603411 A1 ES 8603411A1
Authority
ES
Spain
Prior art keywords
wax
prepn
water
soln
coffee
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545232A
Other languages
English (en)
Other versions
ES545232A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe des Produits Nestle SA
Nestle SA
Original Assignee
Societe des Produits Nestle SA
Nestle SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe des Produits Nestle SA, Nestle SA filed Critical Societe des Produits Nestle SA
Publication of ES545232A0 publication Critical patent/ES545232A0/es
Publication of ES8603411A1 publication Critical patent/ES8603411A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • External Artificial Organs (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE LA MEXAMINA. CONSISTENTE EN: A) DESACETILIZAR MELATONINA EN UNA SOLUCION ALCALINA CALIENTE A TEMPERATURA DE REFLUJO, QUE CONTIENE PREFERENTEMENTE HIDROXIDO SODICO Y UN ALCOHOL ACUOINSOLUBLE DE 4 A 8 ATOMOS DE CARBONO SELECCIONADO ENTRE ISOBUTANOL, UN PENTANOL Y OTROS; B) ENFRIAR HASTA TEMPERATURA AMBIENTE EL PRODUCTO RESULTANTE DE A); C) LAVAR CON AGUA; D) SEPARAR LA FASE ALCOHOLICA DE LA FASE ACUOSA Y ACIDIFICAR CON ACIDO CLORHIDRICO HASTA UN PH INFERIOR A 3; Y E) CONCENTRAR EL RESULTADO DE D) HASTA OBTENER LA MEXAMINA CRISTALIZADA QUE SE SEPARA POR METODOS CONVENCIONALES. SE UTILIZA COMO SEDANTE Y COMO AGENTE RADIOPROTECTOR.
ES545232A 1983-07-01 1985-07-16 Un procedimiento para la preparacion de mexamina Expired ES8603411A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/510,167 US4506080A (en) 1983-07-01 1983-07-01 Preparation of serotonine and derivatives

Publications (2)

Publication Number Publication Date
ES545232A0 ES545232A0 (es) 1986-01-01
ES8603411A1 true ES8603411A1 (es) 1986-01-01

Family

ID=24029637

Family Applications (4)

Application Number Title Priority Date Filing Date
ES533890A Expired ES8602653A1 (es) 1983-07-01 1984-06-30 Un procedimiento para la separacion de serotonina
ES545230A Granted ES545230A0 (es) 1983-07-01 1985-07-16 Un procedimiento para la preparacion de n-acetil serotonina
ES545232A Expired ES8603411A1 (es) 1983-07-01 1985-07-16 Un procedimiento para la preparacion de mexamina
ES545231A Expired ES8604142A1 (es) 1983-07-01 1985-07-16 Un procedimiento para la preparacion de melatonina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES533890A Expired ES8602653A1 (es) 1983-07-01 1984-06-30 Un procedimiento para la separacion de serotonina
ES545230A Granted ES545230A0 (es) 1983-07-01 1985-07-16 Un procedimiento para la preparacion de n-acetil serotonina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES545231A Expired ES8604142A1 (es) 1983-07-01 1985-07-16 Un procedimiento para la preparacion de melatonina

Country Status (10)

Country Link
US (1) US4506080A (es)
EP (3) EP0197389B1 (es)
JP (4) JPS6025966A (es)
AT (2) ATE38513T1 (es)
DE (1) DE3462794D1 (es)
ES (4) ES8602653A1 (es)
GB (3) GB2142622B (es)
IL (1) IL71737A (es)
OA (1) OA07734A (es)
ZM (1) ZM3384A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877176A (en) * 1991-12-26 1999-03-02 Cornell Research Foundation, Inc. Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
US6080773A (en) 1997-10-14 2000-06-27 Akzo Nobel, N.V. Benzylamine derivatives which are useful in treating psychiatric disorders
IL155666A (en) * 2003-04-29 2013-12-31 Neurim Pharma 1991 Insomnia treatment
US9119846B2 (en) 2003-04-29 2015-09-01 Neurim Pharmaceuticals (1991) Ltd. Method and composition for enhancing cognition in alzheimer's patients
CN104496882A (zh) * 2014-11-29 2015-04-08 湖北金赛药业有限公司 一种褪黑素的合成方法
US20210238124A1 (en) * 2018-04-20 2021-08-05 The General Hospital Corporation Acetylated prodrugs for delivery across the blood-brain barrier
CN110105261A (zh) * 2018-12-24 2019-08-09 武汉工程大学 一种利用微反应器连续、快速合成及提纯褪黑素的方法
ES1237024Y (es) 2019-09-20 2020-01-30 Normagrup Tech S A Dispositivo de iluminacion autonomo para la regulacion de ciclos circadianos
CN113402437B (zh) * 2021-06-29 2023-07-14 河北维达康生物科技有限公司 一种合成膳食补充剂褪黑素的新方法
CN113788780B (zh) * 2021-10-15 2023-06-16 河北维达康生物科技有限公司 一种n-乙酰基-5-甲氧基色胺的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2156944C3 (de) * 1971-11-16 1974-10-17 Hag Ag, 2800 Bremen Verfahren zur Gewinnung von Serotonin aus Kaffeewachs
CH568719A5 (en) * 1973-08-22 1975-11-14 Haco Ag Extracting carboxylic acid 5-hydroxy-tryptamide irritants - from coffee without caffeine extn. by using caffeine - enriched solvents
DE2435365A1 (de) * 1973-12-31 1976-01-29 Luigi Di Bella Pharmazeutisches mittel fuer die behandlung von allen leukaemieformen und neurotischen syndromen
CH601227A5 (es) * 1975-05-30 1978-06-30 Nestle Sa
CH608790A5 (en) * 1976-11-18 1979-01-31 Nestle Sa Process for separating serotonin from coffee waxes

Also Published As

Publication number Publication date
ES545232A0 (es) 1986-01-01
ES533890A0 (es) 1985-12-16
JPH0466866B2 (es) 1992-10-26
ATE38514T1 (de) 1988-11-15
EP0197390A3 (en) 1986-12-03
JPS6445362A (en) 1989-02-17
EP0197389B1 (en) 1988-11-09
US4506080A (en) 1985-03-19
GB8411197D0 (en) 1984-06-06
ATE38513T1 (de) 1988-11-15
EP0130303B1 (en) 1987-03-25
JPS6025966A (ja) 1985-02-08
IL71737A (en) 1987-07-31
JPS6445363A (en) 1989-02-17
ZM3384A1 (en) 1984-12-21
GB8521543D0 (en) 1985-10-02
ES545231A0 (es) 1986-01-16
OA07734A (fr) 1985-08-30
JPS6445361A (en) 1989-02-17
EP0197389A2 (en) 1986-12-03
GB2142622B (en) 1987-04-01
JPH0438748B2 (es) 1992-06-25
GB2165838A (en) 1986-04-23
IL71737A0 (en) 1984-09-30
ES8603410A1 (es) 1986-01-01
GB2165837A (en) 1986-04-23
ES8602653A1 (es) 1985-12-16
GB8521544D0 (en) 1985-10-02
EP0197389A3 (en) 1986-12-03
ES8604142A1 (es) 1986-01-16
JPS6410511B2 (es) 1989-02-22
GB2165837B (en) 1987-04-01
GB2142622A (en) 1985-01-23
JPH0438747B2 (es) 1992-06-25
ES545230A0 (es) 1986-01-01
EP0197390A2 (en) 1986-12-03
DE3462794D1 (en) 1987-04-30
EP0130303A1 (en) 1985-01-09
EP0197390B1 (en) 1988-11-09
GB2165838B (en) 1987-04-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001