JPH11509523A - オメガ−3ポリ不飽和酸の経口投与剤を用いた炎症性腸疾患の治療方法 - Google Patents
オメガ−3ポリ不飽和酸の経口投与剤を用いた炎症性腸疾患の治療方法Info
- Publication number
- JPH11509523A JPH11509523A JP8534539A JP53453996A JPH11509523A JP H11509523 A JPH11509523 A JP H11509523A JP 8534539 A JP8534539 A JP 8534539A JP 53453996 A JP53453996 A JP 53453996A JP H11509523 A JPH11509523 A JP H11509523A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- omega
- oral
- oral preparation
- polyunsaturated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.有効成分としてオメガ3−ポリ不飽和酸を遊離酸として又は薬学的に受容可 能なその塩として含有する経口製剤において、該酸を回腸内において放出するこ とを特徴とする前記経口製剤。 2.該オメガ3−ポリ不飽和酸が回腸中央部で放出される、請求項1において記 載された経口製剤。 3.該オメガ3−ポリ不飽和酸の放出が、前記有効成分を含有するカプセルの表 面に設けた外部コ−ティング膜で制御される、請求項1又は請求項2において記 載された経口製剤。 4.該コ−ティング膜の溶解遅延が、時間依存性であって、pH依存性ではない 、請求項3において記載された経口製剤。 5.該コ−ティング膜が,pH5.5において30ないし60分の時間溶解しな いものである、請求項4において記載された経口製剤。 6.該コ−ティング膜が,中性のポリアクリル酸エステルである、請求項4又は 請求項5において記載された経口製剤。 7.該コ−ティング膜が,ポリ(アクリル酸エチル−メタアクリル酸メチル)で ある、請求項6において記載された経口製剤。 8.前記酸が、DHA、EPA又はその混合物である、前記請求項の内のいずれ か一項において記載された経口製剤。 9.前記酸が、単一の有効成分として含有される、前記請求項の内のいずれか一 項において記載された経口製剤。 10.オメガ3−ポリ不飽和酸を遊離酸として又は薬学的に受容可能なその塩と して、炎症性腸疾患の治療を行うため該酸を回腸内において放出する医薬品の製 造に使用する用途。 11.該医薬品が、請求項2ないし請求項9の内のいずれか一項において定義さ れた経口製剤である、請求項13において記載された用途。 12.請求項1ないし請求項9の内のいずれか一項において記載された経口製剤 を炎症性腸炎の治療に使用する用途。 13.請求項1ないし請求項9の内のいずれか一項において記載された経口製剤 の有効量を患者に投与することから成る、炎症性腸炎を治療する方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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GB9509764.8 | 1995-05-15 | ||
GBGB9509764.8A GB9509764D0 (en) | 1995-05-15 | 1995-05-15 | Treatment of inflammatory bowel disease using oral dosage forms of omega-3 polyunsaturated acids |
PCT/EP1996/002038 WO1996036329A1 (en) | 1995-05-15 | 1996-05-13 | Treatment of inflammatory bowel disease using oral dosage forms of omega-3 polyunsaturated acids |
Publications (1)
Publication Number | Publication Date |
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JPH11509523A true JPH11509523A (ja) | 1999-08-24 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP8534539A Pending JPH11509523A (ja) | 1995-05-15 | 1996-05-13 | オメガ−3ポリ不飽和酸の経口投与剤を用いた炎症性腸疾患の治療方法 |
Country Status (23)
Country | Link |
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US (2) | US5792795A (ja) |
EP (1) | EP0825858B1 (ja) |
JP (1) | JPH11509523A (ja) |
KR (1) | KR100427112B1 (ja) |
CN (1) | CN1104237C (ja) |
AT (1) | ATE294575T1 (ja) |
AU (1) | AU702692B2 (ja) |
BR (1) | BR9608785A (ja) |
CA (1) | CA2221356C (ja) |
CZ (1) | CZ288560B6 (ja) |
DE (1) | DE69634693T2 (ja) |
DK (1) | DK0825858T3 (ja) |
ES (1) | ES2240995T3 (ja) |
GB (1) | GB9509764D0 (ja) |
HU (1) | HU227282B1 (ja) |
IL (1) | IL118240A (ja) |
NO (1) | NO320780B1 (ja) |
PL (1) | PL184085B1 (ja) |
PT (1) | PT825858E (ja) |
SK (1) | SK282062B6 (ja) |
TW (1) | TW397683B (ja) |
WO (1) | WO1996036329A1 (ja) |
ZA (1) | ZA963854B (ja) |
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- 1996-05-13 US US08/687,329 patent/US5792795A/en not_active Expired - Lifetime
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- 1996-05-13 PL PL96323362A patent/PL184085B1/pl unknown
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JP2013508348A (ja) * | 2009-10-23 | 2013-03-07 | プロノヴァ・バイオファーマ・ノルゲ・アーエス | 脂肪酸油混合物の被覆型カプセル剤および錠剤 |
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JP2017193555A (ja) * | 2009-10-23 | 2017-10-26 | プロノヴァ・バイオファーマ・ノルゲ・アーエスPronova BioPharma Norge AS | 脂肪酸油混合物の被覆型カプセル剤および錠剤 |
JP2013525349A (ja) * | 2010-04-20 | 2013-06-20 | エルセリクス セラピューティクス インコーポレイテッド | 化学感覚受容体リガンドに基づく治療法 |
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