JPH10506406A - 治療用ビヒクルとしての噴霧乾燥させた微細粒子 - Google Patents
治療用ビヒクルとしての噴霧乾燥させた微細粒子Info
- Publication number
- JPH10506406A JPH10506406A JP8511495A JP51149596A JPH10506406A JP H10506406 A JPH10506406 A JP H10506406A JP 8511495 A JP8511495 A JP 8511495A JP 51149596 A JP51149596 A JP 51149596A JP H10506406 A JPH10506406 A JP H10506406A
- Authority
- JP
- Japan
- Prior art keywords
- fine particles
- water
- particles
- microcapsules
- soluble substance
- Prior art date
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- Ceased
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
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- Radiology & Medical Imaging (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 滑らかで球形の粒子であって、その少なくとも90%が1〜10μmの 質量メジアン粒子サイズを有している、治療もしくは診断に用いる為の水溶性物 質の微細粒子。 2. 滑らかで球形での粒子あって、その少なくとも90%の1〜10μmの 質量メジアン粒子サイズを有している、治療用もしくは診断用の薬剤を運ぶ水溶 性物質の微細粒子。 3. 該水溶性物質の水溶液と、治療用もしくは診断用の薬剤とを噴霧乾燥さ せて得ることのできる、請求項2に記載の微細粒子。 4. 該粒子サイズが1〜5μmである、先行する請求項のいずれか一項に記 載の微細粒子。 5. 最大四分位範囲が3μmである、先行する請求項のいずれか一項に記載 の微細粒子。 6. 最大四分位範囲が2μmである、請求項5に記載の微細粒子。 7. 無菌である、先行する請求項のいずれか一項に記載の微細粒子。 8. 水に不溶な物質で少なくとも部分的にコートされている、先行する請求 項のいずれか一項に記載の微細粒子。 9. 受容体結合成分を付加的に担持する、先行する請求項のいずれか一項に 記載の微細粒子。 10. 水溶性物質が炭水化物である、先行する請求項のいずれか一項に記載 の微細粒子。 11. 水溶性物質がアミノ酸、もしくはポリアミノ酸である、請求項1〜9 のいずれか一項に記載の微細粒子。 12. 水溶性物質が脂肪酸、もしくはそのエステルである、請求項1〜9の いずれか一項に記載の微細粒子。 13. 水溶性物質が蛋白質、ペプチド、もしくは酵素である、請求項1〜9 のいずれか一項に記載の微細粒子。 14. 水溶性物質が天然もしくは組換え型の形態の、ヒトの蛋白質もしくは 断片である、請求項13に記載の微細粒子。 15. 水溶性物質がヒト血清アルブミンである、請求項14に記載の微細粒 子。 16. 水溶性物質を、微細粒子を形成する前に化学的もしくは酵素的に変性 する、先行する請求項のいずれか一項に記載の微細粒子。 17. 先行する請求項のいずれか一項に記載の微細粒子の形態の治療用薬剤 で構成される、治療用薬剤を肺の気道を経て送るのに適した吸入器。 18. 肺の気道を経ての投与により作用する治療用薬剤の、愁訴治療用薬物 の製造への使用であって、治療用薬剤が、請求項1〜16のいずれか一項に記載 の微細粒子の形態であることを特徴とするもの。 19. 肺の気道を経ての投与により作用する治療用薬剤を有効量、患者に投 与することによる愁訴の治療方法に於いて、請求項1〜16のいずれか一項に記 載の微細粒子の形態にある治療用薬剤を投与することからなる改良。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94307126 | 1994-09-29 | ||
AT94307126.6 | 1994-09-29 | ||
PCT/GB1995/002279 WO1996009814A1 (en) | 1994-09-29 | 1995-09-26 | Spray-dried microparticles as therapeutic vehicles |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH10506406A true JPH10506406A (ja) | 1998-06-23 |
Family
ID=8217866
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8511495A Ceased JPH10506406A (ja) | 1994-09-29 | 1995-09-26 | 治療用ビヒクルとしての噴霧乾燥させた微細粒子 |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0783298A1 (ja) |
JP (1) | JPH10506406A (ja) |
KR (1) | KR970705979A (ja) |
AU (1) | AU701440B2 (ja) |
BR (1) | BR9509171A (ja) |
CA (1) | CA2199954A1 (ja) |
CZ (1) | CZ92497A3 (ja) |
FI (1) | FI971332A (ja) |
HU (1) | HUT77373A (ja) |
MX (1) | MX9702357A (ja) |
NO (1) | NO971438L (ja) |
NZ (1) | NZ292980A (ja) |
PL (1) | PL319600A1 (ja) |
RU (1) | RU2147226C1 (ja) |
WO (1) | WO1996009814A1 (ja) |
ZA (1) | ZA958239B (ja) |
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-
1995
- 1995-09-26 CA CA002199954A patent/CA2199954A1/en not_active Abandoned
- 1995-09-26 KR KR1019970702043A patent/KR970705979A/ko not_active Application Discontinuation
- 1995-09-26 BR BR9509171A patent/BR9509171A/pt not_active Application Discontinuation
- 1995-09-26 RU RU97106769A patent/RU2147226C1/ru not_active IP Right Cessation
- 1995-09-26 EP EP95932122A patent/EP0783298A1/en not_active Ceased
- 1995-09-26 PL PL95319600A patent/PL319600A1/xx unknown
- 1995-09-26 CZ CZ97924A patent/CZ92497A3/cs unknown
- 1995-09-26 AU AU35302/95A patent/AU701440B2/en not_active Ceased
- 1995-09-26 MX MX9702357A patent/MX9702357A/es unknown
- 1995-09-26 NZ NZ292980A patent/NZ292980A/xx not_active IP Right Cessation
- 1995-09-26 WO PCT/GB1995/002279 patent/WO1996009814A1/en not_active Application Discontinuation
- 1995-09-26 JP JP8511495A patent/JPH10506406A/ja not_active Ceased
- 1995-09-26 HU HU9702161A patent/HUT77373A/hu unknown
- 1995-09-29 ZA ZA958239A patent/ZA958239B/xx unknown
-
1997
- 1997-03-26 NO NO971438A patent/NO971438L/no not_active Application Discontinuation
- 1997-04-01 FI FI971332A patent/FI971332A/fi not_active IP Right Cessation
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JP2012527924A (ja) * | 2009-05-28 | 2012-11-12 | プロフィブリックス ビー.ヴイ. | フィブリンシーラント |
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Also Published As
Publication number | Publication date |
---|---|
CA2199954A1 (en) | 1996-04-04 |
CZ92497A3 (en) | 1997-08-13 |
WO1996009814A1 (en) | 1996-04-04 |
BR9509171A (pt) | 1997-09-16 |
FI971332A0 (fi) | 1997-04-01 |
NO971438D0 (no) | 1997-03-26 |
MX9702357A (es) | 1997-06-28 |
AU701440B2 (en) | 1999-01-28 |
NZ292980A (en) | 1999-02-25 |
HUT77373A (hu) | 1998-03-30 |
PL319600A1 (en) | 1997-08-18 |
RU2147226C1 (ru) | 2000-04-10 |
NO971438L (no) | 1997-03-26 |
FI971332A (fi) | 1997-04-01 |
EP0783298A1 (en) | 1997-07-16 |
AU3530295A (en) | 1996-04-19 |
KR970705979A (ko) | 1997-11-03 |
ZA958239B (en) | 1996-09-30 |
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