CA2199954A1 - Spray-dried microparticles as therapeutic vehicles - Google Patents

Spray-dried microparticles as therapeutic vehicles

Info

Publication number: CA2199954A1
Authority: CA; Canada
Prior art keywords: microparticles; microparticles according; water; soluble material; microcapsules
Prior art date: 1994-09-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002199954A

Other languages

English (en)

French (fr)

Inventor

Andrew Derek Sutton

Richard Alan Johnson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Quadrant Holdings Cambridge Ltd

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-29

Filing date

1995-09-26

Publication date

1996-04-04

1995-09-26 Application filed by Individual filed Critical Individual

1996-04-04 Publication of CA2199954A1 publication Critical patent/CA2199954A1/en

Status Abandoned legal-status Critical Current

Links

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239000003550 marker Substances 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
244000005700 microbiome Species 0.000 description 1
238000002156 mixing Methods 0.000 description 1
235000019426 modified starch Nutrition 0.000 description 1
238000011587 new zealand white rabbit Methods 0.000 description 1
238000012856 packing Methods 0.000 description 1
239000000199 parathyroid hormone Substances 0.000 description 1
229960001319 parathyroid hormone Drugs 0.000 description 1
238000005192 partition Methods 0.000 description 1
239000008188 pellet Substances 0.000 description 1
239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
230000002572 peristaltic effect Effects 0.000 description 1
102000013415 peroxidase activity proteins Human genes 0.000 description 1
108040007629 peroxidase activity proteins Proteins 0.000 description 1
229920000747 poly(lactic acid) Polymers 0.000 description 1
239000001259 polydextrose Substances 0.000 description 1
235000013856 polydextrose Nutrition 0.000 description 1
229940035035 polydextrose Drugs 0.000 description 1
229920000656 polylysine Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000012545 processing Methods 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
238000002731 protein assay Methods 0.000 description 1
238000000163 radioactive labelling Methods 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000004366 reverse phase liquid chromatography Methods 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
229960001860 salicylate Drugs 0.000 description 1
238000000926 separation method Methods 0.000 description 1
238000007873 sieving Methods 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000011343 solid material Substances 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
238000000527 sonication Methods 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
230000001839 systemic circulation Effects 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
239000002753 trypsin inhibitor Substances 0.000 description 1
238000013385 tryptic peptide mapping Methods 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
210000005166 vasculature Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Physics & Mathematics (AREA)
Acoustics & Sound (AREA)
Radiology & Medical Imaging (AREA)
Otolaryngology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002199954A 1994-09-29 1995-09-26 Spray-dried microparticles as therapeutic vehicles Abandoned CA2199954A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP94307126.6		1994-09-29
EP94307126		1994-09-29

Publications (1)

Publication Number	Publication Date
CA2199954A1 true CA2199954A1 (en)	1996-04-04

Family

ID=8217866

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002199954A Abandoned CA2199954A1 (en)	1994-09-29	1995-09-26	Spray-dried microparticles as therapeutic vehicles

Country Status (16)

Country	Link
EP (1)	EP0783298A1 (ja)
JP (1)	JPH10506406A (ja)
KR (1)	KR970705979A (ja)
AU (1)	AU701440B2 (ja)
BR (1)	BR9509171A (ja)
CA (1)	CA2199954A1 (ja)
CZ (1)	CZ92497A3 (ja)
FI (1)	FI971332A0 (ja)
HU (1)	HUT77373A (ja)
MX (1)	MX9702357A (ja)
NO (1)	NO971438D0 (ja)
NZ (1)	NZ292980A (ja)
PL (1)	PL319600A1 (ja)
RU (1)	RU2147226C1 (ja)
WO (1)	WO1996009814A1 (ja)
ZA (1)	ZA958239B (ja)

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1995
- 1995-09-26 AU AU35302/95A patent/AU701440B2/en not_active Ceased
- 1995-09-26 JP JP8511495A patent/JPH10506406A/ja not_active Ceased
- 1995-09-26 CZ CZ97924A patent/CZ92497A3/cs unknown
- 1995-09-26 HU HU9702161A patent/HUT77373A/hu unknown
- 1995-09-26 WO PCT/GB1995/002279 patent/WO1996009814A1/en not_active Application Discontinuation
- 1995-09-26 CA CA002199954A patent/CA2199954A1/en not_active Abandoned
- 1995-09-26 MX MX9702357A patent/MX9702357A/es unknown
- 1995-09-26 EP EP95932122A patent/EP0783298A1/en not_active Ceased
- 1995-09-26 NZ NZ292980A patent/NZ292980A/xx not_active IP Right Cessation
- 1995-09-26 BR BR9509171A patent/BR9509171A/pt not_active Application Discontinuation
- 1995-09-26 KR KR1019970702043A patent/KR970705979A/ko not_active Application Discontinuation
- 1995-09-26 RU RU97106769A patent/RU2147226C1/ru not_active IP Right Cessation
- 1995-09-26 PL PL95319600A patent/PL319600A1/xx unknown
- 1995-09-29 ZA ZA958239A patent/ZA958239B/xx unknown
1997
- 1997-03-26 NO NO971438A patent/NO971438D0/no not_active Application Discontinuation
- 1997-04-01 FI FI971332A patent/FI971332A0/fi not_active IP Right Cessation

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Also Published As

Publication number	Publication date
KR970705979A (ko)	1997-11-03
WO1996009814A1 (en)	1996-04-04
RU2147226C1 (ru)	2000-04-10
BR9509171A (pt)	1997-09-16
AU701440B2 (en)	1999-01-28
HUT77373A (hu)	1998-03-30
EP0783298A1 (en)	1997-07-16
NZ292980A (en)	1999-02-25
ZA958239B (en)	1996-09-30
FI971332A (fi)	1997-04-01
PL319600A1 (en)	1997-08-18
NO971438L (no)	1997-03-26
AU3530295A (en)	1996-04-19
CZ92497A3 (en)	1997-08-13
JPH10506406A (ja)	1998-06-23
MX9702357A (es)	1997-06-28
NO971438D0 (no)	1997-03-26
FI971332A0 (fi)	1997-04-01

Legal Events

Date	Code	Title	Description
2002-07-15	EEER	Examination request
2006-04-18	FZDE	Discontinued

Publication	Publication Date	Title
AU701440B2 (en)	1999-01-28	Spray-dried microparticles as therapeutic vehicles
US5993805A (en)	1999-11-30	Spray-dried microparticles and their use as therapeutic vehicles
MXPA97002357A (en)	1997-06-01	Microparticles dried by aspersion as vehicles therapeuti
US6416739B1 (en)	2002-07-09	Microparticles and their therapeutic or diagnostic use
JP4416325B2 (ja)	2010-02-17	安定な噴霧乾燥タンパク質製剤
CA2216828C (en)	2002-03-26	Controlled release insufflation carrier for medicaments
US5707644A (en)	1998-01-13	Small particle compositions for intranasal drug delivery
DE69907456T2 (de)	2004-03-25	Grosse poröse partikel ausgestossen von einem inhalator
CA2277801C (en)	2002-10-15	Preparation of particles for inhalation
CN101090714A (zh)	2007-12-19	通过吸入伊洛前列素和微粒制剂治疗肺动脉高血压症
JP2006503865A (ja)	2006-02-02	吸入のための徐放性の多孔性微粒子
JP2002524535A (ja)	2002-08-06	乾燥粉末活性薬剤肺性送達
KR20020060218A (ko)	2002-07-16	개선된 분산성을 갖는 건조 분말 조성물
CN1164186A (zh)	1997-11-05	用作治疗载体的经喷雾干燥的微颗粒
MXPA01002649A (en)	2001-12-04	Dry powder active agent pulmonary delivery

CA2199954A1 - Spray-dried microparticles as therapeutic vehicles - Google Patents

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