JP5559309B2 - γ分泌酵素調節物質としての新規置換インダゾールおよびアザインダゾール誘導体 - Google Patents

γ分泌酵素調節物質としての新規置換インダゾールおよびアザインダゾール誘導体 Download PDF

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Publication number: JP5559309B2
Authority: JP; Japan
Prior art keywords: alkyl; formula; compound; hydrogen; phenyl
Prior art date: 2009-05-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2012509024A

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English (en)

Japanese (ja)

Other versions

JP2012526078A (ja

Inventor

ビシヨフ，フランソワ・ポール

ギーセン，ヘンリクス・ヤコブス・マリア

ピータース，セルジユ・マリア・アロイシウス

マイン，ギヤレツト・ベルロンド

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceuticals Inc

Original Assignee

Janssen Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-05-07

Filing date

2010-05-05

Publication date

2014-07-23

2010-05-05 Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc

2012-10-25 Publication of JP2012526078A publication Critical patent/JP2012526078A/ja

2014-07-23 Application granted granted Critical

2014-07-23 Publication of JP5559309B2 publication Critical patent/JP5559309B2/ja

Status Expired - Fee Related legal-status Critical Current

2030-05-05 Anticipated expiration legal-status Critical

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

JP2012509024A 2009-05-07 2010-05-05 γ分泌酵素調節物質としての新規置換インダゾールおよびアザインダゾール誘導体 Expired - Fee Related JP5559309B2 (ja)

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PCT/EP2010/056074 WO2010145883A1 (en)	2009-05-07	2010-05-05	Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators

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JP (1)	JP5559309B2 (zh)
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CN (1)	CN102439005B (zh)
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AU (1)	AU2010262036B2 (zh)
BR (1)	BRPI1011190A8 (zh)
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SG (1)	SG175317A1 (zh)
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UA (1)	UA105377C2 (zh)
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AP2011005779A0 (en)	2009-02-06	2011-08-31	Ortho Mcneil Janssen Pharm	Novel susbstituted bicyclic heterocyclic compoundsas gamma secretase modulators.
TWI461425B (zh)	2009-02-19	2014-11-21	Janssen Pharmaceuticals Inc	作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
NZ596843A (en)	2009-05-07	2012-12-21	Janssen Pharmaceuticals Inc	Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators
EP2454239B1 (en)	2009-07-15	2014-08-13	Janssen Pharmaceuticals Inc.	Substituted triazole and imidazole derivatives as gamma secretase modulators
BR112012017310A2 (pt)	2010-01-15	2016-04-19	Janssen Pharmaceuticals Inc	derivados de triazol substituídos como moduladores de gama secretase
KR20140047032A (ko)	2011-03-24	2014-04-21	얀센 파마슈티칼즈, 인코포레이티드	감마 세크레타제 조정제로서의 신규 치환 트리아졸릴 피페라진 및 트리아졸릴 피페리딘 유도체
IN2014MN00258A (zh)	2011-07-15	2015-09-25	Janssen Pharmaceuticals Inc
AU2013261023B2 (en)	2012-05-16	2016-11-24	Cellzome Limited	Substituted 3, 4 - dihydro - 2H - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) Alzheimer's disease
CA2889249C (en)	2012-12-20	2021-02-16	Francois Paul Bischoff	Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators
EP2945944B1 (en)	2013-01-17	2016-11-09	Janssen Pharmaceutica, N.V.	Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
EP2958918B1 (en) *	2013-02-21	2016-12-07	Boehringer Ingelheim International GmbH	Dihydropteridinones ii
US10562897B2 (en)	2014-01-16	2020-02-18	Janssen Pharmaceutica Nv	Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
CN103880683B (zh) *	2014-02-26	2018-06-22	南通大学	一种3-溴-2-硝基苯甲醛的化学合成方法
EP3347363B1 (en) *	2015-09-09	2020-01-01	H. Hoffnabb-La Roche Ag	N-(3-azabicyclo[3.2.1]octan-8-yl)-8-(4-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[l,5-a]pyridin-2-amine derivatives as gamma-secretase modulators for treating alzheimer's disease
CN105585547A (zh) *	2016-03-09	2016-05-18	中国科学院广州生物医药与健康研究院	一种4-五氟化硫苯酚类化合物及制备方法以及五氟化硫取代苯并吡喃类化合物的制备方法
CN114195702A (zh) *	2020-09-18	2022-03-18	瑞博(杭州)医药科技有限公司	一种用于合成抗肿瘤药物尼拉帕利的中间体及其制备方法

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US20120095036A1 (en)	2012-04-19
IL216113A0 (en)	2012-01-31
MX2011011753A (es)	2011-11-29
IL216113A (en)	2015-02-26
KR20120024555A (ko)	2012-03-14
WO2010145883A1 (en)	2010-12-23
MY152998A (en)	2014-12-31
EP2427453A1 (en)	2012-03-14
AR076850A1 (es)	2011-07-13
CN102439005A (zh)	2012-05-02
SG175317A1 (en)	2011-11-28
CA2755467A1 (en)	2010-12-23
AU2010262036B2 (en)	2014-10-30
BRPI1011190A2 (pt)	2016-03-15
ZA201108117B (en)	2015-06-24
JP2012526078A (ja)	2012-10-25
UA105377C2 (uk)	2014-05-12
TWI461419B (zh)	2014-11-21
US8835482B2 (en)	2014-09-16
EP2427453B1 (en)	2013-07-17
EA019702B1 (ru)	2014-05-30
NZ596843A (en)	2012-12-21
EA201171363A1 (ru)	2012-04-30
ES2431619T3 (es)	2013-11-27
CN102439005B (zh)	2015-07-22
BRPI1011190A8 (pt)	2016-11-16
TW201105658A (en)	2011-02-16
AU2010262036A1 (en)	2011-09-22

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