JP2019043861A - 乳酸/ピルビン酸比の改善用組成物 - Google Patents
乳酸/ピルビン酸比の改善用組成物 Download PDFInfo
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- JP2019043861A JP2019043861A JP2017165644A JP2017165644A JP2019043861A JP 2019043861 A JP2019043861 A JP 2019043861A JP 2017165644 A JP2017165644 A JP 2017165644A JP 2017165644 A JP2017165644 A JP 2017165644A JP 2019043861 A JP2019043861 A JP 2019043861A
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Landscapes
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Abstract
Description
本実施形態に係る組成物は、有効成分としてトリプトファンを含み、血液中の乳酸/ピルビン酸比の改善に用いられる。トリプトファンを含む組成物を、例えば経口投与することで、飲酒等に起因して上昇する乳酸/ピルビン酸比を改善することができる。これは例えば、トリプトファンを含む組成物を投与することで血液中のピルビン酸濃度が上昇するためと考えることができる。ここで、本明細書における乳酸/ピルビン酸比の改善とは、何らかの要因によって正常な状態から逸脱した乳酸/ピルビン酸比を正常な値に近づけることを意味する。乳酸/ピルビン酸比は対象動物(例えば、哺乳動物、特にヒト)の血液サンプルついて、常法により測定することができる。
飲食品は、上述したトリプトファンを含む乳酸/ピルビン酸比の改善用組成物を含む。飲食品を摂取することで、上述した組成物の効果を得ることができる。本発明の乳酸/ピルビン酸比の改善用組成物を含有する飲食品には、健康飲食品、機能性飲食品、病者用飲食品などの他、上記乳酸/ピルビン酸比の改善用組成物を配合できる全ての飲食品が含まれる。なかでも、機能性飲食品はとりわけ好ましい。「機能性飲食品」は、生体に対して一定の機能性を有する飲食品を意味し、例えば、特定保健用飲食品(条件付きトクホ[特定保健用食品]を含む)及び栄養機能飲食品を含む保健機能飲食品、特別用途飲食品、栄養補助飲食品、健康補助飲食品、サプリメント(例えば、錠剤、被覆錠、糖衣錠、カプセル及び液剤などの各種剤形のもの)及び美容飲食品(例えばダイエット飲食品)などのいわゆる健康飲食品全般を包含する。機能性飲食品はまた、コーデックス(FAO/WHO合同食品規格委員会)の食品規格に基づく健康強調表示(Health claim)が適用される健康飲食品を包含する。
アルデヒド、ターピネオール、δ−デカラクトン、デカナール、ノナナール、γ―ノナラクトン、バニリン、フェニルエチルアルコール、フラネオール、フルフリルメルカプタン、2−ヘキセナール、3−ヘキセノール、ヘリオトロピン、ペリラアルデヒド、ベンズアルデヒド、マルトール、メチルアンスラニレート、メチルサリシレート、メントール、α−ヨノン、リナロール等が挙げられる。
Wistar系ラット(雄性、6週齢以上)に、エチルアルコール(Alc)を1g/kg、2g/kgまたは3g/kgの投与量で強制胃内投与し、3時間後に採血して、血中ピルビン酸濃度(mg/dl)を測定した。結果を図1に示す。
Wistar系ラット(雄性、6週齢以上)に、各種アミノ酸(グリシン以外はすべてL型)及び糖類を1.5g/kg(但し、オルニチンとタウリンは0.5g/kg)投与し、30分後にアルコール3g/kgを強制胃内投与した。アルコール投与の3時間後に採血して、血中ピルビン酸濃度(mg/dl)を測定した。結果を図2に示す。なお、図2中の略語は以下の通りである。アルコール非投与(Alc(−))、アルコール投与(Alc)、グリシン(Gly)、アラニン(Ala)、グルタミン(Gln)、アルギニン(Arg)、セリン(Ser)、システイン(Cys)、トレオニン(Thr)、フェニルアラニン(Phe)、プロリン(Pro)、アスパラギン(Asn)、アスパラギン酸(Asp)、メチオニン(Met)、ヒスチジン(His)、イソロイシン(Ile)、シトルリン(Cit)、グルタミン酸(Glu)、オルニチン(Orn)、テアニン(Tea)、タウリン(Tau)、チロシン(Tyr)。また図2中、左下がり斜線は対照(Alc(−)、Alc)を示し、右下がり斜線は対照と有意差があったことを示す。
Wistar系ラット(雄性、6週齢以上)に、グリシン単独、トリプトファン単独、またはグリシンとトリプトファンの混合物をそれぞれ投与し、30分後にアルコール3g/kgを強制胃内投与した。アルコール投与の3時間後に採血して、血中ピルビン酸濃度(mg/dl)を測定した。結果を図3に示す。なお、グリシンの投与量は1.5g/kgであり、トリプトファンの投与量は0.125g/kgであった。
Wistar系ラット(雄性、6週齢以上)に、フルクトース単独、トリプトファン単独、またはフルクトースとトリプトファンの混合物をそれぞれ投与し、30分後にアルコール3g/kgを強制胃内投与した。アルコール投与の3時間後に採血して、血中ピルビン酸濃度(mg/dl)を測定した。結果を図4に示す。なお、フルクトースの投与量は1.5g/kgであり、トリプトファンの投与量は0.125g/kgであった。
健康な成人男女を被験者として、書面でのインフォームドコンセントに同意を得た後に飲酒試験を実施した。対照としての難溶性デキストリン6g(n=7)、グリシン6g(n=7)、グリシン6gとトリプトファン0.1gを含む組成物(n=5)、グリシン6gとトリプトファン0.2gを含む組成物(n=7)、又はグリシン6gとトリプトファン0.4gを含む組成物(n=7)のいずれかを経口投与し、その30分後に甲類焼酎をアルコール量0.32g/kgで摂取させた。甲類焼酎を摂取前、摂取から60分後、120分後、及び180分後に採血して、血中ピルビン酸濃度(mg/dl)、血中乳酸/ピルビン酸比、及び血中アルコール消失速度(mg/ml/hr)を測定した。血中ピルビン酸濃度の測定結果を図5及び図6、血中乳酸/ピルビン酸比の測定結果を図7及び図8、血中アルコール消失速度の測定結果を図9に示す。なお、血中アルコール消失速度は、血中アルコール濃度経時変化における最高血中アルコール濃度到達以降の濃度低下、すなわち消失相の傾きから算出した。
Claims (8)
- トリプトファンを含む乳酸/ピルビン酸比の改善用組成物。
- グリシン、アラニン、グルタミン、アルギニン、セリン、システイン、トレオニン、フェニルアラニン、プロリン、アスパラギン、アスパラギン酸、メチオニン、ヒスチジン、イソロイシン、シトルリン、グルタミン酸、オルニチン、テアニン、タウリン、チロシン及びバリンからなる群から選択されるアミノ酸、並びにフルクトース、スクロース及びグルコースからなる群から選択される糖類の少なくとも1種を更に含む請求項1に記載の組成物。
- 前記アミノ酸がグリシン、アラニン及びグルタミンからなる群から選択され、前記糖類がフルクトース及びスクロースからなる群から選択される請求項2に記載の組成物。
- 前記アミノ酸又は糖類のトリプトファンに対する重量基準の含有比が5以上100以下である請求項2又は3に記載の組成物。
- アルコール代謝促進に用いられる請求項1から4のいずれか1項に記載の組成物。
- 請求項1から5のいずれか1項に記載の組成物を含む飲食品。
- 請求項1から5のいずれか1項に記載の組成物を含むアルコール代謝促進剤。
- 請求項1から5のいずれか1項に記載の組成物を含む二日酔い防止剤。
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020080398A1 (ja) | 2018-10-16 | 2020-04-23 | 日本ケミファ株式会社 | アルコール飲料摂取による悪酔い又は二日酔いの抑制剤 |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61162159A (ja) * | 1985-01-09 | 1986-07-22 | イペツクス・ゲトレンケ−ヘルシユテルンクス−ウント・フアトリ−ブスゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 飲料 |
JPS6330425A (ja) * | 1986-07-18 | 1988-02-09 | ジヨ−ゼフ・アントニイ・ハクリツチ | 無毒性酔いざまし飲料 |
JPH0640901A (ja) * | 1992-07-28 | 1994-02-15 | Suntory Ltd | アセトアルデヒド毒性の抑制剤 |
JPH08169831A (ja) * | 1994-12-16 | 1996-07-02 | Itouen:Kk | 体内アルコール代謝促進剤及びその製造方法 |
JP2000204038A (ja) * | 1999-01-12 | 2000-07-25 | Masatsugu Tanaka | ピルビン酸欠乏症及び/または高乳酸血症の予防及び/または治療剤 |
JP2002187839A (ja) * | 2000-12-19 | 2002-07-05 | Masatsugu Tanaka | アルコール代謝促進剤 |
JP2003116504A (ja) * | 2001-10-18 | 2003-04-22 | Asahi Soft Drinks Co Ltd | グリシン含有飲料 |
WO2005102321A1 (ja) * | 2004-04-19 | 2005-11-03 | Kirin Beer Kabushiki Kaisha | 糖新生によりアルコール代謝を促進又は疲労を改善する組成物 |
WO2005107734A1 (ja) * | 2004-05-06 | 2005-11-17 | Taiyokagaku Co., Ltd. | アルコール代謝促進組成物、及びこの組成物を含有する飲食物 |
JP2007020432A (ja) * | 2005-07-13 | 2007-02-01 | Asahi Breweries Ltd | アルコール代謝促進飲料 |
WO2007023931A1 (ja) * | 2005-08-25 | 2007-03-01 | Kyowa Hakko Kogyo Co., Ltd. | 血中アルコール濃度上昇抑制用組成物 |
KR100903690B1 (ko) * | 2007-12-18 | 2009-06-18 | 주식회사 엠에이치투 바이오케미칼 | 오르니친을 포함하는 것을 특징으로 하는 숙취해소용조성물 및 알코올 음료 |
KR20130086660A (ko) * | 2012-01-26 | 2013-08-05 | 이정민 | 저장공간에 숙취해소용 내용물이 든 이종물질 수용장치 시스템 |
WO2016085735A1 (en) * | 2014-11-24 | 2016-06-02 | Entrinsic Health Solutions, Llc | Amino acid compositions for the treatment of symptoms of disease |
JP2017043610A (ja) * | 2015-08-26 | 2017-03-02 | 株式会社東洋新薬 | 二日酔いの予防又は改善剤、肝機能改善剤 |
-
2017
- 2017-08-30 JP JP2017165644A patent/JP2019043861A/ja active Pending
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61162159A (ja) * | 1985-01-09 | 1986-07-22 | イペツクス・ゲトレンケ−ヘルシユテルンクス−ウント・フアトリ−ブスゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 飲料 |
JPS6330425A (ja) * | 1986-07-18 | 1988-02-09 | ジヨ−ゼフ・アントニイ・ハクリツチ | 無毒性酔いざまし飲料 |
JPH0640901A (ja) * | 1992-07-28 | 1994-02-15 | Suntory Ltd | アセトアルデヒド毒性の抑制剤 |
JPH08169831A (ja) * | 1994-12-16 | 1996-07-02 | Itouen:Kk | 体内アルコール代謝促進剤及びその製造方法 |
JP2000204038A (ja) * | 1999-01-12 | 2000-07-25 | Masatsugu Tanaka | ピルビン酸欠乏症及び/または高乳酸血症の予防及び/または治療剤 |
JP2002187839A (ja) * | 2000-12-19 | 2002-07-05 | Masatsugu Tanaka | アルコール代謝促進剤 |
JP2003116504A (ja) * | 2001-10-18 | 2003-04-22 | Asahi Soft Drinks Co Ltd | グリシン含有飲料 |
WO2005102321A1 (ja) * | 2004-04-19 | 2005-11-03 | Kirin Beer Kabushiki Kaisha | 糖新生によりアルコール代謝を促進又は疲労を改善する組成物 |
WO2005107734A1 (ja) * | 2004-05-06 | 2005-11-17 | Taiyokagaku Co., Ltd. | アルコール代謝促進組成物、及びこの組成物を含有する飲食物 |
JP2007020432A (ja) * | 2005-07-13 | 2007-02-01 | Asahi Breweries Ltd | アルコール代謝促進飲料 |
WO2007023931A1 (ja) * | 2005-08-25 | 2007-03-01 | Kyowa Hakko Kogyo Co., Ltd. | 血中アルコール濃度上昇抑制用組成物 |
KR100903690B1 (ko) * | 2007-12-18 | 2009-06-18 | 주식회사 엠에이치투 바이오케미칼 | 오르니친을 포함하는 것을 특징으로 하는 숙취해소용조성물 및 알코올 음료 |
KR20130086660A (ko) * | 2012-01-26 | 2013-08-05 | 이정민 | 저장공간에 숙취해소용 내용물이 든 이종물질 수용장치 시스템 |
WO2016085735A1 (en) * | 2014-11-24 | 2016-06-02 | Entrinsic Health Solutions, Llc | Amino acid compositions for the treatment of symptoms of disease |
JP2017043610A (ja) * | 2015-08-26 | 2017-03-02 | 株式会社東洋新薬 | 二日酔いの予防又は改善剤、肝機能改善剤 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020080398A1 (ja) | 2018-10-16 | 2020-04-23 | 日本ケミファ株式会社 | アルコール飲料摂取による悪酔い又は二日酔いの抑制剤 |
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