JP2016521266A5 - - Google Patents
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- JP2016521266A5 JP2016521266A5 JP2016507617A JP2016507617A JP2016521266A5 JP 2016521266 A5 JP2016521266 A5 JP 2016521266A5 JP 2016507617 A JP2016507617 A JP 2016507617A JP 2016507617 A JP2016507617 A JP 2016507617A JP 2016521266 A5 JP2016521266 A5 JP 2016521266A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- ibrutinib
- lymphoma
- relapsed
- refractory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 29
- 239000002177 L01XE27 - Ibrutinib Substances 0.000 claims 22
- XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical compound C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 claims 22
- 229960001507 ibrutinib Drugs 0.000 claims 22
- 208000000429 Leukemia, Lymphocytic, Chronic, B-Cell Diseases 0.000 claims 11
- 210000004027 cells Anatomy 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 9
- 230000002062 proliferating Effects 0.000 claims 9
- 206010012818 Diffuse large B-cell lymphoma Diseases 0.000 claims 8
- LQBVNQSMGBZMKD-UHFFFAOYSA-N 4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide Chemical compound C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C3C=CNC3=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NCC1CCOCC1 LQBVNQSMGBZMKD-UHFFFAOYSA-N 0.000 claims 7
- 206010008958 Chronic lymphocytic leukaemia Diseases 0.000 claims 7
- 229960001183 venetoclax Drugs 0.000 claims 7
- 239000002775 capsule Substances 0.000 claims 4
- 206010026798 Mantle cell lymphomas Diseases 0.000 claims 3
- 208000003950 B-Cell Lymphoma Diseases 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 2
- 208000009899 Burkitt Lymphoma Diseases 0.000 claims 1
- 201000004085 CLL/SLL Diseases 0.000 claims 1
- 210000001280 Germinal Center Anatomy 0.000 claims 1
- 206010024324 Leukaemias Diseases 0.000 claims 1
- 208000006557 Lymphoma, B-Cell, Marginal Zone Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010025310 Other lymphomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010047802 Waldenstrom's macroglobulinaemias Diseases 0.000 claims 1
- 230000001154 acute Effects 0.000 claims 1
- 201000005510 acute lymphocytic leukemia Diseases 0.000 claims 1
- 230000001684 chronic Effects 0.000 claims 1
- 201000009251 multiple myeloma Diseases 0.000 claims 1
- 201000003793 myelodysplastic syndrome Diseases 0.000 claims 1
- 230000000306 recurrent Effects 0.000 claims 1
- IMMOTHDSNAXMDK-NLYMJQDSSA-N tert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-[3-[2-[2-[3-[[2-[2-[2-[2-[3-[2-[2-[3-[3-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethyldisulfanyl]propanoylamino]propoxy]ethoxy]ethoxy]propylamino]-2-oxoethoxy]e Chemical compound C([C@@H]([C@H](O)C[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCCCOCCOCCOCCCNC(=O)COCCOCCOCC(=O)NCCCOCCOCCOCCCNC(=O)CCSSCCNC(=O)CCCC[C@H]1[C@H]2NC(=O)N[C@H]2CS1)CC=1C=CC=CC=1)NC(=O)OC(C)(C)C)C1=CC=CC=C1 IMMOTHDSNAXMDK-NLYMJQDSSA-N 0.000 claims 1
Claims (26)
- Ｂ細胞増殖性障害の処置に使用するための組み合わせであって、該組み合わせは：
ａ．イブルチニブ；及び
ｂ．ＡＢＴ−１９９
を含み、
Ｂ細胞増殖性障害は、慢性リンパ球性白血病（ＣＬＬ）、小リンパ球性リンパ腫（ＳＬＬ）、非ＣＬＬ／ＳＬＬリンパ腫、濾胞性リンパ腫、再発性又は難治性の外套細胞リンパ腫、再発性又は難治性のびまん性大細胞型Ｂ細胞リンパ腫（ＤＬＢＣＬ）、ワルデンストローム・マクログロブリン血症、多発性骨髄腫、辺縁帯リンパ腫、バーキットリンパ腫、非バーキットの高悪性度Ｂ細胞リンパ腫、結節外の辺縁帯Ｂ細胞リンパ腫、急性又は慢性の骨髄性（又は脊髄性）白血病、骨髄異形成症候群、或いは急性リンパ芽球性白血病から選択される
ことを特徴とする組み合わせ。 - Ｂ細胞増殖性障害は再発性又は難治性のＤＬＢＣＬである、ことを特徴とする請求項１に記載の組み合わせ。
- 再発性又は難治性のＤＬＢＣＬは、再発性又は難治性の「活性化Ｂ細胞（ＡＢＣ）」ＤＬＢＣＬである、ことを特徴とする請求項２に記載の組み合わせ。
- 再発性又は難治性のＤＬＢＣＬは、再発性又は難治性の「胚中心Ｂ細胞様（ＧＣＢ）」ＤＬＢＣＬである、ことを特徴とする請求項２に記載の組み合わせ。
- イブルチニブの量は、約１０ｍｇから約１００ｍｇ、１００ｍｇから約２００ｍｇ、又は約２００から約３００ｍｇ、又は約３００から約５００ｍｇ、又は約５００から約８４０ｍｇの間である、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブの量は約１４０ｍｇである、ことを特徴とする請求項５に記載の組み合わせ。
- イブルチニブとＡＢＴ−１９９は、組み合わせた剤形である、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブとＡＢＴ−１９９は、別個の剤形である、ことを特徴とする請求項１に記載の組み合わせ。
- ＡＢＴ−１９９の量は約５ｍｇから約１０００ｍｇである、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブ対ＡＢＴ−１９９の質量比は、約９：１、約４：１、約７：３、約３：２、約１：１、約２：３、約３：７、約１：４、又は約１：９である、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブの量は、約２８０ｍｇ、約４２０ｍｇ、又は約５６０ｍｇである、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブはカプセルの形態である、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブは錠剤の形態である、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブの量は、約１４０ｍｇ、約２８０ｍｇ、約４２０ｍｇ、又は約５６０ｍｇであり、イブルチニブはカプセルの形態である、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブの量は、約１４０ｍｇ、約２８０ｍｇ、約４２０ｍｇ、又は約５６０ｍｇであり、イブルチニブは錠剤の形態である、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブの量は約４２０ｍｇであり、イブルチニブはカプセルの形態である、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブの量は約４２０ｍｇであり、イブルチニブは錠剤の形態である、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブの量は約５６０ｍｇであり、イブルチニブはカプセルの形態である、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブの量は約５６０ｍｇであり、イブルチニブは錠剤の形態である、ことを特徴とする請求項１に記載の組み合わせ。
- イブルチニブ対ＡＢＴ−１９９の質量比は、約３：２、約１：１、又は約２：３である、ことを特徴とする請求項１に記載の組み合わせ。
- ＡＢＴ−１９９は錠剤の形態である、ことを特徴とする請求項１に記載の組み合わせ。
- Ｂ細胞増殖性障害は、慢性リンパ球性白血病（ＣＬＬ）、小リンパ球性リンパ腫（ＳＬＬ）、濾胞性リンパ腫、再発性又は難治性の外套細胞リンパ腫、或いは再発性又は難治性のびまん性大細胞型Ｂ細胞リンパ腫（ＤＬＢＣＬ）である、ことを特徴とする請求項１及び請求項５乃至２１の何れか１つに記載の組み合わせ。
- Ｂ細胞増殖性障害は、再発性又は難治性のＢ細胞増殖性障害である、ことを特徴とする請求項１及び請求項５乃至２１の何れか１つに記載の組み合わせ。
- Ｂ細胞増殖性障害は慢性リンパ球性白血病（ＣＬＬ）である、ことを特徴とする請求項１及び請求項５乃至２１の何れか１つに記載の組み合わせ。
- Ｂ細胞増殖性障害はハイリスクＣＬＬである、ことを特徴とする請求項１及び請求項５乃至２１の何れか１つに記載の組み合わせ。
- Ｂ細胞増殖性障害は再発性又は難治性の外套細胞リンパ腫である、ことを特徴とする請求項１及び請求項５乃至２１の何れか１つに記載の組み合わせ。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361809810P | 2013-04-08 | 2013-04-08 | |
| US61/809,810 | 2013-04-08 | ||
| PCT/US2014/033378 WO2014168975A1 (en) | 2013-04-08 | 2014-04-08 | Ibrutinib combination therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147994A Division JP6871978B2 (ja) | 2013-04-08 | 2019-08-09 | イブルチニブ併用療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016521266A JP2016521266A (ja) | 2016-07-21 |
| JP2016521266A5 true JP2016521266A5 (ja) | 2017-05-25 |
| JP6575952B2 JP6575952B2 (ja) | 2019-09-18 |
Family
ID=51689963
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016507617A Active JP6575952B2 (ja) | 2013-04-08 | 2014-04-08 | イブルチニブ併用療法 |
| JP2019147994A Active JP6871978B2 (ja) | 2013-04-08 | 2019-08-09 | イブルチニブ併用療法 |
| JP2021069171A Pending JP2021119150A (ja) | 2013-04-08 | 2021-04-15 | イブルチニブ併用療法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147994A Active JP6871978B2 (ja) | 2013-04-08 | 2019-08-09 | イブルチニブ併用療法 |
| JP2021069171A Pending JP2021119150A (ja) | 2013-04-08 | 2021-04-15 | イブルチニブ併用療法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20160287592A1 (ja) |
| EP (1) | EP2983670A4 (ja) |
| JP (3) | JP6575952B2 (ja) |
| KR (1) | KR20150141971A (ja) |
| CN (2) | CN111317821A (ja) |
| AU (3) | AU2014251028A1 (ja) |
| BR (1) | BR112015025711A8 (ja) |
| CA (1) | CA2908375A1 (ja) |
| EA (1) | EA201591656A1 (ja) |
| HK (1) | HK1215374A1 (ja) |
| IL (2) | IL241710B (ja) |
| MX (2) | MX369503B (ja) |
| PH (2) | PH12015502337A1 (ja) |
| WO (1) | WO2014168975A1 (ja) |
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2014
- 2014-04-08 MX MX2015013970A patent/MX369503B/es active IP Right Grant
- 2014-04-08 BR BR112015025711A patent/BR112015025711A8/pt not_active Application Discontinuation
- 2014-04-08 EA EA201591656A patent/EA201591656A1/ru unknown
- 2014-04-08 CA CA2908375A patent/CA2908375A1/en not_active Abandoned
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- 2014-04-08 CN CN201911007617.5A patent/CN111317821A/zh active Pending
- 2014-04-08 US US14/778,536 patent/US20160287592A1/en not_active Abandoned
- 2014-04-08 EP EP14782886.7A patent/EP2983670A4/en not_active Withdrawn
- 2014-04-08 CN CN201480025176.0A patent/CN105263496A/zh active Pending
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2015
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2016
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2018
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2019
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2020
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