JP2014516634A - 自動式注射装置 - Google Patents
自動式注射装置 Download PDFInfo
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- JP2014516634A JP2014516634A JP2014506591A JP2014506591A JP2014516634A JP 2014516634 A JP2014516634 A JP 2014516634A JP 2014506591 A JP2014506591 A JP 2014506591A JP 2014506591 A JP2014506591 A JP 2014506591A JP 2014516634 A JP2014516634 A JP 2014516634A
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Abstract
Description
(i)米国特許出願公開第2006/0040358号明細書(2006年2月23日公開)、米国特許出願公開第2005/0008642号明細書(2005年1月13日公開)、米国特許出願公開第2004/0228859号明細書(2004年11月18日公開)。これら抗体は、限定されないが、例えば、抗体1A(DSMZ寄託番号DSMACC2586)、抗体8(DSMZ寄託番号DSMACC2589)、抗体23(DSMZ寄託番号DSMACC2588)及び上記公報に記載されたような抗体18を含む。
(ii)国際公開第06/138729号(2006年12月28日公開)、国際公開第05/0169709号(2005年2月24日公開)、及びLuなどの2004, J Biol. Chem. 279: 2856 - 65。これら抗体は、限定されないが、上記文献に記載されたような抗体2F8、A12及びIMC−A12を含む。
(iii)国際公開第07/012614号(2007年2月1日公開)、国際公開第07/000328号(2007年1月4日公開)、国際公開第06/013472号(2006年2月9日公開)、国際公開第05/058967号(2005年6月30日公開)及び国際公開第03/059951号(2003年7月24日公開)。
(iv)米国特許出願公開第2005/0084906号明細書(2005年4月21日公開)。これら抗体は、限定されないが、公報に記載されているように、抗体7C10、キメラ抗体C7C10、抗体h7C10、抗体7H2M、キメラ抗体*7C10、抗体GM607、ヒト化抗体7C10バージョン1、ヒト化抗体7C10バージョン2、ヒト化抗体7C10バージョン3、及び、抗体7H2HMを含む。
(v)米国特許出願公開第2005/0249728(2005年11月10日公開)、米国特許出願公開第2005/0186203(2005年8月25日公開)、米国特許出願公開第2004/0265307(2004年12月30日公開)、及び、米国特許出願公開第2003/0235582(2003年12月25日公開)、並びにMaloney等の2003, Cancer Res. 63: 5073 - 83。これら抗体は、文献に記載されているように、限定されないが、抗体EM164、表面再構成されたEM164、ヒト化EM164、huEM164バージョン1.0、huEM164バージョン1.1、huEM164バージョン1.2、及び、huEM164バージョン1.3、を含む。
(vi)米国特許第7037498(2006年5月2日発行)、米国特許出願公開第2005/0244408号明細書(2005年11月30日公開)、米国特許出願公開第2004/0086503号明細書(2004年5月6日)、及び、Cohen等のClinicalCancerRes.11:2063-73、例えば、抗体CP−751、871。これら抗体は、文献に記載されているように、限定されないが、ATCC寄託番号PTA−2792、PTA−2788、PTA−2790、PTA−2791、PTA−2789、PTA−2793を有するハイブリドーマにより生成された抗体、並びに、抗体2.12.1、2.13.2、2.14.3、3.1.1、4.9.2及び4.17.3、のいずれかを含む。
(vii)米国特許出願公開第2005/0136063号明細書(2005年6月23日公開)及び米国特許出願公開第2004/0018191号明細書(2004年1月29日公開)。これら抗体は、公報に記載されているように、限定されないが、抗体19D12と、ATCCの下の番号PTA−5214で寄託されたプラスミド15H12/19D12HCA(γ4)におけるポリヌクレオチドによってコード化された重鎖及びATCCの下の番号PTA−5220で寄託されたプラスミド15H12/19D12LCF(κ)におけるポリヌクレオチドによってコード化された軽鎖を含む抗体と、を含む。
(vii)米国特許出願公開第2004/0202655号明細書(2004年10月14日)。これら抗体は、公報に記載されているように、限定されないが、抗体PINT−6A1、PINT−7A2、PINT−7A4、PINT−7A5、PINT−7A6、PINT−8A1、PINT−9A2、PINT−11A1、PINT−11A2、PINT−11A3、PINT−11A4、PINT−11A5、PINT−11A7、PINT−11A12、PINT−12A1、PINT−12A2、PINT−12A3、PINT−12A4、及びPINT−12A5を含む。
これらそれぞれ及びこれらすべては、その全体を、特にIGF−1受容体を標的とする上記抗体、ペプチボディ及び関連タンパク質などに関して、参考として本願に組み込まれる。
33(抗IFNAR);抗CD38mAb(HuMaxCD38);抗CD40LmAb;抗CriptomAb;抗CTGF特発性肺線維症フェーズIフィブリノゲン(FG−3019);抗CTLA4mAb;抗eotaxin1mAb(CAT−213);抗FGF8mAb;抗ガングリオシドGD2mAb;抗ガングリオシドGM2mAb;抗GDF−8ヒトmAb(MYO−029);抗GM−CSF受容体mAb(CAM−3001);抗HepCmAb(HuMaxHepC);抗IFNαmAb(MEDI−545,MDX−1103);抗IGF1RmAb;抗IGF−1RmAb(HuMax−Inflam);抗IL12mAb(ABT−874);抗IL12/IL23mAb(CNTO1275);抗IL13mAb(CAT−354);抗IL2RamAb(HuMax−TAC);抗IL5受容体mAb;抗インテグリン受容体mAb(MDX−018,CNTO95);抗IP10潰瘍性大腸炎mAb(MDX−1100);抗LLY抗体;BMS−66513;抗マンノース受容体/hCGβmAb(MDX−1307);抗メソテリンdsFv−PE38接合体(CAT−5001);抗PD1mAb(MDX−1106(ONO−4538));抗PDGFRα抗体(IMC−3G3);抗TGFβmAb(GC−1008);抗ヒトTRAIL受容体−2mAb(HGS−ETR2);抗TWEAKmAb;抗VEGFR/Flt−1mAb;抗ZP3mAb(HuMax−ZP3);NVS抗体♯1;及び、NVS抗体♯2、である。
A)、アルファ−フェトタンパク質(AFP)、腫瘍壊死因子(TNF)、CTLA−4(細胞傷害性のT細胞関連抗原である)、Fc−γ−1受容体、HLA−DR10ベータ、HLA−DA抗原、L−セレクチン、呼吸系発疹ウイルス、ヒト免疫不全ウイルス(HIV)、B型肝炎ウイルス(HBV)、ミュータンス連鎖球菌、並びに、黄色ブドウ球菌、である。
Claims (38)
- 自動式注射器と共に使用するための使い捨てのカセットであって、
筐体と、
前記筐体内に配置され、第1及び第2位置間で移動可能であるスリーブであって、当該スリーブが当該スリーブ内にシリンジを配置することが可能である、スリーブと、
前記シリンジを前記スリーブ内に固定するためのロックキャップであって、当該ロックキャップが、前記スリーブの先端部に付けられており、前記シリンジの前記先端部と接触可能である、ロックキャップと、
を備えることを特徴とするカセット。 - 前記ロックキャップが、前記シリンジの前記先端部と接触可能である弾性バンパを備えることを特徴とする請求項1に記載のカセット。
- 内側の前記スリーブが、当該スリーブの前記先端部において少なくとも1つの受容部を備え、前記ロックキャップが、前記受容部内に挿入される少なくとも1つの腕部材を備えることを特徴とする請求項1に記載のカセット。
- 前記ロックキャップの少なくとも1つの前記腕部材が、内側の前記スリーブの前記受容部の内面を把持するための鉤状手段を備えることを特徴とする請求項3に記載のカセット。
- 前記スリーブ内に配置されるバレル及び注射針をさらに備えることを特徴とする請求項1に記載のカセット。
- 当該カセットが、針シールドを前記シリンジから取り外すために筐体の基端部にある開口部を通して延在するシールド取外器をさらに備えることを特徴とする請求項1に記載のカセット。
- 前記シールド取外器が、バネ付勢式のタブを備え、
前記タブが、前記筐体の壁部に画成されたアパーチャ内に配置されることを特徴とする請求項6に記載のカセット。 - 前記シールド取外器が、基端部及び先端部を有する細長い本体を備え、
前記先端部が、少なくとも1つの舌部を備え、
前記舌部が、前記シールド取外器を当該カセットから取り外すときに径方向外側に広がり、前記シールド取外器が当該カセット内に再び挿入されることを防止することを特徴とする請求項6に記載のカセット。 - バレル及び注射針をさらに備えることを特徴とする請求項1に記載のカセット。
- 前記シリンジ内にある治療薬をさらに備えることを特徴とする請求項1に記載のカセット。
- 前記治療薬が、エポジェン(登録商標)、アラネスプ(登録商標)、エンブレル(登録商標)、ニューラスタ(登録商標)、ニューポジェン(登録商標)、エヌプレート(登録商標)、ベクティビックス(登録商標)、センシパー(登録商標)、ザイゲバ(登録商標)及びプロリア(登録商標)からなるグループから選択されていることを特徴とする請求項10に記載のカセット。
- 前記治療薬が、IL−17受容体Aへの抗体であることを特徴とする請求項10に記載のカセット。
- 前記治療薬が、アンジオポエチン-2の抑制因子であることを特徴とする請求項10に記載のカセット。
- 前記治療薬が、TNFブロッカまたは抑制剤であることを特徴とする請求項10に記載のカセット。
- 前記TNFブロッカまたは前記抑制剤が、エタネルセプトであることを特徴とする請求項14に記載のカセット。
- 前記TNFブロッカまたは前記抑制剤が、アダリムマブ、セルトリズマブ、ゴリムマブまたはインフリキシマブであることを特徴とする請求項14に記載のカセット。
- 前記筐体の表面にあるカセット識別手段をさらに備え、前記自動式注射器が当該カセットを識別可能とすることを特徴とする請求項1に記載のカセット。
- 前記カセット識別手段が、少なくとも1つの突出部を備えることを特徴とする請求項17に記載のカセット。
- 治療薬を注射するための装置であって、
自動式注射器と、
前記自動式注射器を用いて使用するための使い捨てのカセットであって、
筐体と、
前記筐体内に配置され、第1及び第2位置間で移動可能であるスリーブと、
前記スリーブ内に配置されたシリンジと、
前記シリンジを前記スリーブ内に固定するためのロックキャップであって、前記スリーブの先端部に付けられ、前記シリンジの前記先端部と接触する、ロックキャップと、
を備えるカセットと、
を備えることを特徴とする装置。 - 前記ロックキャップが、前記シリンジの前記先端部に接触する弾性バンパを備えることを特徴とする請求項19に記載の装置。
- 内側の前記スリーブが、その先端部に少なくとも1つの受容部を備え、
前記ロックキャップが、前記受容部内へ挿入される少なくとも1つの腕部材を備えることを特徴とする請求項19に記載の装置。 - 前記ロックキャップの少なくとも1つの前記腕部材が、内側の前記スリーブの前記受容部の内面を把持するための鉤状手段を備えることを特徴とする請求項21に記載の装置。
- 前記カセットが、針シールドを前記シリンジから取り外すために前記筐体の基端部にある開口部を通して延在するシールド取外器をさらに備えることを特徴とする請求項19に記載の装置。
- 前記シールド取外器が、バネ付勢式のタブを備え、
前記筐体の壁部に画成されたアパーチャ内に配置された前記タブが、前記カセットから前記シールド取外器を取り外すことを防止することを特徴とする請求項23に記載の装置。 - 前記自動式注射器が、前記カセットが当該自動式注射器内に配置されると、前記筐体の前記壁部に画成された前記アパーチャから外に前記タブを押し付けるためのピンを備え、これにより、前記シールド取外器を前記カセットから取り外すことを可能とすることを特徴とする請求項24に記載の装置。
- 前記シールド取外器が、基端部及び先端部を有する細長い本体を有し、
前記先端部が、少なくとも1つの可撓性を有する舌部を備え、
前記舌部が、前記シールド取外器を前記カセットから取り外すと外側へ広がり、前記シールド取外器を前記カセット内へ再び挿入することを防止することを特徴とする請求項23に記載の装置。 - 前記シリンジ内にある治療薬をさらに備えることを特徴とする請求項19に記載の装置。
- 前記治療薬が、エポジェン(登録商標)、アラネスプ(登録商標)、エンブレル(登録商標)、ニューラスタ(登録商標)、ニューポジェン(登録商標)、エヌプレート(登録商標)、ベクティビックス(登録商標)、センシパー(登録商標)、ザイゲバ(登録商標)及びプロリア(登録商標)からなるグループから選択されていることを特徴とする請求項27に記載の装置。
- 前記治療薬が、IL−17受容体Aへの抗体であることを特徴とする請求項27に記載の装置。
- 前記治療薬が、アンジオポエチン-2の抑制因子であることを特徴とする請求項27に記載の装置。
- 前記治療薬が、TNFブロッカまたは抑制剤であることを特徴とする請求項27に記載の装置。
- 前記TNFブロッカまたは抑制剤が、エタネルセプトであることを特徴とする請求項31に記載の装置。
- 前記TNFブロッカまたは抑制剤が、アダリムマブ、セルトリズマブ、ゴリムマブまたはインフリキシマブであることを特徴とする請求項31に記載の装置。
- 前記筐体の表面にあるカセット識別手段をさらに備え、前記自動式注射器が前記カセットを識別可能とすることを特徴とする請求項19に記載の装置。
- 前記カセット識別手段が、少なくとも1つの突出部を備えることを特徴とする請求項34に記載の装置。
- 前記自動式注射器が、前記カセット識別手段を読み込むための検出器を備え、前記カセットを識別することを特徴とする請求項34に記載の装置。
- 治療薬を注射するための装置であって、
自動式注射器と、
前記自動式注射器と共に使用するための使い捨てのカセットであって、
筐体と、
前記筐体内に配置され、第1及び第2位置間で移動可能なスリーブと、
前記スリーブ内に配置されたシリンジと、
を備えるカセットと、
針シールドを前記シリンジから取り外すために前記筐体の基端部にある開口部を通して延在するシールド取外器と、
を備えることを特徴とする装置。 - 自動式注射器と共に使用するための使い捨てのカセットであって、
筐体と、
前記筐体内に配置され、第1及び第2位置間で移動可能なスリーブであって、当該スリーブがシリンジを当該スリーブ内に配置することができる、スリーブと、
針シールドを前記シリンジから取り外すために前記筐体の基端部にある開口部を通して延在するシールド取外器と、
を備えることを特徴とする装置。
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