JP2013514818A - 吸入活動をシミュレートするための装置及び方法 - Google Patents
吸入活動をシミュレートするための装置及び方法 Download PDFInfo
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- JP2013514818A JP2013514818A JP2012537973A JP2012537973A JP2013514818A JP 2013514818 A JP2013514818 A JP 2013514818A JP 2012537973 A JP2012537973 A JP 2012537973A JP 2012537973 A JP2012537973 A JP 2012537973A JP 2013514818 A JP2013514818 A JP 2013514818A
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Abstract
【選択図】なし
Description
図13は、取りはずし可能な検知監視装置1000の底面図を描いており、センサーワイヤー1302に結合されたセンサー1202及びデジタル−アナログ変換器に接続するためのワイヤー接続916を示している。
57歳の2型糖尿病患者は、ヘモグロビンA1cが上昇しコントロール不能と考えられたため、乾燥粉末吸入システムからのインスリンに吸入を受けるよう指示された。この患者は、センサーが組み込まれた、図9Bに示す装置を用いて吸入の訓練を受けた。この患者は装置を与えられ、この訓練装置を使用する際は深く速い息をするよう求められた。
59歳の2型糖尿病患者は、乾燥粉末吸入システムからのインスリンに吸入を受けるよう指示された。この患者は、センサーが組み込まれた、図9Aに示す装置を用いて吸入の訓練を受けた。この患者は、図12に示すのと同様な取り付け可能なセンサーが装着された状態の装置を与えられ、この訓練装置を使用する際は深く速い息をするよう求められた。
45歳の2型糖尿病患者は、乾燥粉末吸入システムからのインスリンに吸入を受けるよう指示された。この患者は、利便性上の理由から吸入システムをリクエストしたものである。この患者は、図9Aに示す装置を用いて適切な吸入操作の訓練を受けた。この患者は、図12に示すのと同様な、吸入器に取り付け可能なジャケットの中に配置された取り付け可能な無線センサー装置が装着された状態の装置を与えられた。この患者は、この吸入器を訓練装置とともに使用する際につき、吸入を実行している間にこのシステムにおける標準の特性と比較してモニターに表示しているときは、患者が望ましい吸入特性を達成するまで深く速い息をするよう求められた。
本願は、2009年11月3日に出願された米国仮出願61/257,813号に由来する、米国特許法第119条(e)に基づいた利益を主張し、参照のためその開示全体をここに援用する。
Claims (21)
- 吸入器と、
前記吸入器と通信するセンサーであって、前記乾燥粉末吸入器から生成された少なくとも1種類の信号を検出し、当該少なくとも1種類の信号を、解析、記録、印刷または表示のための少なくとも1個の装置へと送信するよう構成されているセンサーと、
実質的に正確な上気道を備える人工的な解剖学的頭部と、
真空源と、
電源と、
マイクロプロセッサー、アルゴリズム及び表示装置を備えるコンピューターと、
を備える吸入シミュレーションシステム。 - 前記センサーは前記吸入器の内部に配置され、又は、前記吸入器に取り付けられるように配置する、
請求項1に記載の吸入シミュレーションシステム。 - 前記乾燥粉末吸入器は、センサーと、当該吸入器の内部に組み込まれ又は当該吸入器に取り付け可能な装置に設けられたマイクロプロセッサとを備える、息により駆動される乾燥粉末吸入器である、
請求項1に記載の吸入シミュレーションシステム。 - 前記少なくとも1種類の信号は、音声信号の振幅、当該音声信号の周波数、又はこれらの組み合わせである、
請求項1に記載の吸入シミュレーションシステム。 - 前記センサーは、前記吸入器から生成された前記少なくとも1個の信号をさらに計測し、当該信号をマイクロプロセッサ内又はコンピュータ内の受信器へと送信するよう構成されている、
請求項1に記載の吸入シミュレーションシステム。 - 前記センサーはマイクロホンである、
請求項1に記載の吸入シミュレーションシステム。 - 前記乾燥粉末吸入器装置は、肺に供給するための乾燥粉末を備えたカートリッジを備える、
請求項3に記載の吸入シミュレーションシステム。 - 前記乾燥粉末は、ジケトピペラジン微粒子からなる、
請求項7に記載の吸入シミュレーションシステム。 - 前記乾燥粉末は、少なくとも1個の活性成分からなる、
請求項7に記載の吸入シミュレーションシステム。 - 前記少なくとも1個の活性成分は、インスリン、GLP−1、成長ホルモン、スマトリプタン、パラチロイドホルモン、又はこれらの類似体からなる、
請求項9に記載の吸入シミュレーションシステム。 - 前記乾燥粉末吸入器は、約0.065(√kPa)/リットル毎分と約0.200(√kPa)/リットル毎分との間である抵抗値を有する、
請求項3に記載の吸入シミュレーションシステム。 - 前記センサーは、前記音声信号を有線又は無線通信モードで前記少なくとも1個の装置へと送信するよう構成されている、
請求項1に記載の吸入シミュレーションシステム。 - アナログ−デジタル変換器が、前記少なくとも1個の音声信号を、当該少なくとも1個の音声信号を解析及び処理するよう構成されたマイクロプロセッサへと伝送する、
請求項3に記載の吸入シミュレーションシステム。 - 前記少なくとも1個の装置はアナログ−デジタル変換器である、
請求項1に記載の吸入シミュレーションシステム。 - 前記少なくとも1個の装置は表示装置である、
請求項1に記載の吸入シミュレーションシステム。 - 前記表示装置は,コンピューターモニター、PDA、又はプリンターである、
請求項15に記載の吸入シミュレーションシステム。 - 前記真空源は、校正されたシリンジポンプ、又はピストン/シリンダー装置である、
請求項1に記載の吸入シミュレーションシステム。 - 第1のセンサー及び第1のラジオ送信器に取り付けられた第1の吸入器を被験者に提供し、
前記吸入器ないし吸入を通じた圧力差を生成するため、信号受信器と、第1のセンサーから生成された信号を解析及び処理するよう構成されたアルゴリズムと、を備えるマイクロプロセッサを有するコンピュータと、コントローラーと、モーターと、校正されたシリンジポンプと、人工的な実質的に正確な解剖学的な上気道と、前記人工的な実質的に正確な解剖学的な上気道に取り付けられており、第2のセンサーと、第2のラジオ送信器と、乾燥粉末処方物とを備える第2の吸入器と、を備える吸入シミュレーション装置の近傍で、前記被験者に、前記吸入器を通じて吸入を行わせ、
少なくとも1種類の信号を、前記第1の吸入器内で生成された流れから収集し、前記コンピュータないしマイクロプロセッサにおいて前記アルゴリズムを用い、信号を、前記第1のセンサーにより供給された前記被験者の吸引からの第1のデータのセットへと変換し、
前記コンピューターにおいて、前記被験者の吸入により生成された前記圧力差に等しい圧力差を生成するため前記モーターに前記シリンジポンプを駆動させるよう前記コントローラーに命令するための第2の信号の組を生成する、
被験者による吸入操作をシミュレートする方法。 - 前記シリンジポンプは、前記第2の吸入器に接続された口部が配置されている前記人工的な実質的に正確な解剖学的な上気道に接続されている、
請求項18に記載の方法。 - 前記第2の吸入器は、センサー及びラジオ送信器が取り付けられた乾燥粉末吸入器である、
請求項18に記載の方法。 - 前記第2の吸入器は、音声信号を電気的インパルスに変換できコンピューター又はマイクロプロセッサー内のラジオ信号受信器と通信するよう構成されたマイクロホンを備える無線又は有線のジャケットが取り付けられている、
請求項18に記載の方法。
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EP2496295A1 (en) | 2012-09-12 |
US20150196724A1 (en) | 2015-07-16 |
US9016147B2 (en) | 2015-04-28 |
JP5784622B2 (ja) | 2015-09-24 |
WO2011056889A1 (en) | 2011-05-12 |
CA2778698A1 (en) | 2011-05-12 |
US9706944B2 (en) | 2017-07-18 |
JP2015226814A (ja) | 2015-12-17 |
US20120247235A1 (en) | 2012-10-04 |
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