JP2011529942A5 - - Google Patents
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- Publication number
- JP2011529942A5 JP2011529942A5 JP2011521561A JP2011521561A JP2011529942A5 JP 2011529942 A5 JP2011529942 A5 JP 2011529942A5 JP 2011521561 A JP2011521561 A JP 2011521561A JP 2011521561 A JP2011521561 A JP 2011521561A JP 2011529942 A5 JP2011529942 A5 JP 2011529942A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline form
- compound
- formula
- methylbenzenesulfonate
- xrpd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000634 powder X-ray diffraction Methods 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 229940126214 compound 3 Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
Claims (9)
- 結晶形態が無水型である、結晶形態の式(I)の化合物の4−メチルベンゼンスルホン酸塩。
- 結晶形態が水和物である、結晶形態の式(I)の化合物の4−メチルベンゼンスルホン酸塩。
- 結晶形態が図1に示す粉末X線回折(XRPD)パターンと実質的に同じパターンを示すことを特徴とする無水結晶形態1である、請求項1または2に記載の結晶形態の式(I)の化合物の4−メチルベンゼンスルホン酸塩。
- 結晶形態が図3に示す粉末X線回折(XRPD)パターンと実質的に同じパターンを示すことを特徴とする無水結晶形態2である、請求項1または2に記載の結晶形態の式(I)の化合物の4−メチルベンゼンスルホン酸塩。
- 結晶形態が図5に示す粉末X線回折(XRPD)パターンと実質的に同じパターンを示すことを特徴とする水和物1である、請求項1または3に記載の結晶形態の式(I)の化合物の4−メチルベンゼンスルホン酸塩。
- 請求項1〜6のいずれか一項に記載の結晶形態の式(I)の化合物の4−メチルベンゼンスルホン酸塩またはその溶媒和物を含んでなる、医薬組成物。
- 1種以上の薬学上許容される担体または希釈剤を更に含んでなる、請求項7に記載の医薬組成物。
- 精神病性障害、うつ病、気分障害、不安、睡眠障害、および物質関連障害の治療または予防のために用いられる、請求項7または8に記載の医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0814340.6 | 2008-08-05 | ||
GBGB0814340.6A GB0814340D0 (en) | 2008-08-05 | 2008-08-05 | Anhydrous crystol form fo a pyridine derivative |
PCT/EP2009/060089 WO2010015626A1 (en) | 2008-08-05 | 2009-08-04 | Crystalline forms of a pyridine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011529942A JP2011529942A (ja) | 2011-12-15 |
JP2011529942A5 true JP2011529942A5 (ja) | 2012-09-27 |
Family
ID=39767571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011521561A Withdrawn JP2011529942A (ja) | 2008-08-05 | 2009-08-04 | ピリジン誘導体の結晶体 |
Country Status (14)
Country | Link |
---|---|
US (1) | US8093242B2 (ja) |
EP (1) | EP2321324A1 (ja) |
JP (1) | JP2011529942A (ja) |
KR (1) | KR20110052686A (ja) |
CN (1) | CN102171219A (ja) |
AU (1) | AU2009279135B2 (ja) |
BR (1) | BRPI0917224A2 (ja) |
CA (1) | CA2733235A1 (ja) |
EA (1) | EA201170300A1 (ja) |
GB (1) | GB0814340D0 (ja) |
IL (1) | IL210777A0 (ja) |
MX (1) | MX2011001414A (ja) |
WO (1) | WO2010015626A1 (ja) |
ZA (1) | ZA201100426B (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102639536B (zh) | 2009-08-27 | 2015-03-18 | 尼尔医疗有限公司 | 吡啶衍生物的无水晶型 |
EP3297631B1 (en) * | 2015-05-18 | 2019-09-04 | NeRRe Therapeutics Limited | Nk-1/nk-3 receptor antagonist for the treatment of hot flushes |
GEP20237503B (en) | 2018-03-14 | 2023-04-25 | Kandy Therapeutics Ltd | Novel pharmaceutical formulation comprising dual nk-1/nk-3 receptor antagonists |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998002158A1 (en) | 1996-07-17 | 1998-01-22 | Merck & Co., Inc. | Alteration of circadian rhythmicity with a tachykinin antagonist |
DK1394150T3 (da) | 1999-02-24 | 2011-03-21 | Hoffmann La Roche | 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister |
WO2001030348A1 (en) | 1999-10-25 | 2001-05-03 | Janssen Pharmaceutica N.V. | Use of substance p antagonists for influencing the circadian timing system |
GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
GB0203022D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
DK1643998T3 (da) * | 2003-07-03 | 2007-12-27 | Hoffmann La Roche | NK1/NK3-antagonister til behandling af skizofreni |
DE602006021323D1 (de) * | 2005-09-09 | 2011-05-26 | Glaxosmithkline Llc | Pyridinderivate und ihre verwendung bei der behandlung psychotischer erkrankungen |
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2008
- 2008-08-05 GB GBGB0814340.6A patent/GB0814340D0/en not_active Ceased
-
2009
- 2009-08-04 WO PCT/EP2009/060089 patent/WO2010015626A1/en active Application Filing
- 2009-08-04 KR KR1020117005159A patent/KR20110052686A/ko not_active Application Discontinuation
- 2009-08-04 AU AU2009279135A patent/AU2009279135B2/en not_active Ceased
- 2009-08-04 CN CN2009801393221A patent/CN102171219A/zh active Pending
- 2009-08-04 MX MX2011001414A patent/MX2011001414A/es unknown
- 2009-08-04 CA CA2733235A patent/CA2733235A1/en not_active Abandoned
- 2009-08-04 JP JP2011521561A patent/JP2011529942A/ja not_active Withdrawn
- 2009-08-04 US US13/056,775 patent/US8093242B2/en active Active
- 2009-08-04 EA EA201170300A patent/EA201170300A1/ru unknown
- 2009-08-04 EP EP09781468A patent/EP2321324A1/en not_active Withdrawn
- 2009-08-04 BR BRPI0917224A patent/BRPI0917224A2/pt not_active IP Right Cessation
-
2011
- 2011-01-17 ZA ZA2011/00426A patent/ZA201100426B/en unknown
- 2011-01-20 IL IL210777A patent/IL210777A0/en unknown