JP2011518833A5 - - Google Patents
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- Publication number
- JP2011518833A5 JP2011518833A5 JP2011506415A JP2011506415A JP2011518833A5 JP 2011518833 A5 JP2011518833 A5 JP 2011518833A5 JP 2011506415 A JP2011506415 A JP 2011506415A JP 2011506415 A JP2011506415 A JP 2011506415A JP 2011518833 A5 JP2011518833 A5 JP 2011518833A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- pharmaceutically acceptable
- acceptable salt
- following formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 13
- 239000011780 sodium chloride Substances 0.000 claims 13
- 201000004384 alopecia Diseases 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 0 CCCCC(c(cc1)ccc1N([C@@](COCc1ccc(*)[s]1)CC1)C1=O)O Chemical compound CCCCC(c(cc1)ccc1N([C@@](COCc1ccc(*)[s]1)CC1)C1=O)O 0.000 description 48
- ZDTRMJAWAIZCSV-UHFFFAOYSA-N CC(OCCN1CCOCC1)=O Chemical compound CC(OCCN1CCOCC1)=O ZDTRMJAWAIZCSV-UHFFFAOYSA-N 0.000 description 1
Claims (15)
- 下記構造より選ばれる式の化合物
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 下記式の請求項1に記載の化合物、又はその医薬的に許容され得る塩。
- 脱毛症の治療用組成物を製造するための、請求項１〜１４のいずれか一項に記載の化合物の使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4750108P | 2008-04-24 | 2008-04-24 | |
| US61/047,501 | 2008-04-24 | ||
| PCT/US2009/041389 WO2009132088A1 (en) | 2008-04-24 | 2009-04-22 | Substituted gamma lactams as therapeutic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011518833A JP2011518833A (ja) | 2011-06-30 |
| JP2011518833A5 true JP2011518833A5 (ja) | 2012-06-14 |
| JP5524181B2 JP5524181B2 (ja) | 2014-06-18 |
Family
ID=40852537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506415A Expired - Fee Related JP5524181B2 (ja) | 2008-04-24 | 2009-04-22 | 治療剤としての置換ガンマラクタム |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7820661B2 (ja) |
| EP (1) | EP2291368B1 (ja) |
| JP (1) | JP5524181B2 (ja) |
| KR (1) | KR20110008263A (ja) |
| CN (1) | CN102076681A (ja) |
| AU (1) | AU2009239372B2 (ja) |
| BR (1) | BRPI0911347A2 (ja) |
| CA (1) | CA2722529A1 (ja) |
| CO (1) | CO6321273A2 (ja) |
| DK (1) | DK2291368T3 (ja) |
| ES (1) | ES2399314T3 (ja) |
| IL (1) | IL208899A0 (ja) |
| MX (1) | MX2010011636A (ja) |
| MY (1) | MY150518A (ja) |
| PL (1) | PL2291368T3 (ja) |
| RU (1) | RU2543379C2 (ja) |
| UA (1) | UA103616C2 (ja) |
| WO (1) | WO2009132088A1 (ja) |
| ZA (1) | ZA201007553B (ja) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9216183B2 (en) | 2002-02-04 | 2015-12-22 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US7351404B2 (en) | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| US8758733B2 (en) | 2002-02-04 | 2014-06-24 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| EP2113246B1 (en) | 2003-08-07 | 2016-06-22 | Allergan, Inc. | Compositions for delivery of therapeutics into the eyes and methods for making and using the same |
| US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
| US8673341B2 (en) | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
| US8377984B2 (en) * | 2008-01-29 | 2013-02-19 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
| US7842714B2 (en) * | 2008-03-03 | 2010-11-30 | Allergan, Inc. | Ketorolac tromethamine compositions for treating ocular pain |
| US9192571B2 (en) * | 2008-03-03 | 2015-11-24 | Allergan, Inc. | Ketorolac tromethamine compositions for treating or preventing ocular pain |
| EP2288385A2 (en) * | 2008-04-16 | 2011-03-02 | Allergan, Inc. | Combination therapy for glaucoma |
| EP2291367A1 (en) * | 2008-04-24 | 2011-03-09 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
| WO2009142969A1 (en) * | 2008-05-20 | 2009-11-26 | Allergan, Inc. | Therapeutic lactams |
| US20100204335A1 (en) * | 2008-12-01 | 2010-08-12 | Allergan, Inc. | Kit and composition for eyelash growth |
| US20120322882A1 (en) | 2009-11-09 | 2012-12-20 | Allergan, Inc. | Compositions And Methods For Stimulating Hair Growth |
| US9149484B2 (en) | 2009-11-09 | 2015-10-06 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| US20110136872A1 (en) * | 2009-12-09 | 2011-06-09 | Burk Robert M | Stable aqueous compositions of prostglandin agonist prodrugs and methods for use thereof |
| CA2882138C (en) * | 2012-08-21 | 2020-10-27 | Allergan, Inc. | Process for the synthesis of substituted gamma lactams |
| US9540357B1 (en) | 2014-07-31 | 2017-01-10 | Allergan, Inc. | 15-aryl prostaglandins as EP4 agonists, and methods of use thereof |
| CA2962766A1 (en) * | 2014-10-02 | 2016-04-07 | Allergan, Inc. | Ester prodrugs of gamma-lactams and their use |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US395798A (en) * | 1889-01-08 | reason | ||
| US4007210A (en) | 1973-04-27 | 1977-02-08 | American Cyanamid Company | Novel 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenyl-methoxy-1-trans-alkenyl-dialkyl-alanates |
| US3985798A (en) | 1975-01-27 | 1976-10-12 | American Cyanamid Company | 11α-HOMO-PROSTANOIC ACIDS AND ESTERS |
| US4060540A (en) | 1975-09-18 | 1977-11-29 | American Cyanamid Company | Novel 3-triphenylmethoxy-1-alkynes, 3-triphenyl-methoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| ES2052735T3 (es) | 1987-09-18 | 1994-07-16 | R Tech Ueno Ltd | Un metodo para producir un agente hipotensor ocular. |
| CA2021316C (en) | 1989-07-27 | 2000-10-24 | Ming Fai Chan | Intraocular pressure reducing 11-acyl prostaglandins |
| US4994274A (en) | 1989-07-27 | 1991-02-19 | Allergan, Inc. | Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using |
| US5034413A (en) | 1989-07-27 | 1991-07-23 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
| US5028624A (en) | 1989-07-27 | 1991-07-02 | Allergan, Inc. | Intraocular pressure reducing 9,15-diacyl prostaglandins |
| US5288754A (en) | 1992-02-04 | 1994-02-22 | Allergan, Inc. | Polar C-1 esters of prostaglandins |
| US5721273A (en) | 1993-12-15 | 1998-02-24 | Alcon Laboratories, Inc. | Use of certain 9-halo-13,14-dihydroprostaglandins to treat glaucoma and ocular hypertension |
| US5462968A (en) | 1994-01-19 | 1995-10-31 | Allergan, Inc. | EP2 -receptor agonists as agents for lowering intraocular pressure |
| US6034413A (en) * | 1997-02-27 | 2000-03-07 | Texas Instruments Incorporated | High speed biCMOS gate power for power MOSFETs incorporating improved injection immunity |
| US6437146B1 (en) | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
| AU2002328855B2 (en) * | 2001-07-16 | 2005-11-24 | F. Hoffmann-La Roche Ag | Prostaglandin Analogues As EP4 Receptor Agonists |
| ATE305463T1 (de) | 2001-11-05 | 2005-10-15 | Allergan Inc | Omega-zykloalkyl 17-heteroaryl prostaglandin-e2- analoga als ep2-rezeptoragonisten |
| NZ535024A (en) * | 2002-03-05 | 2006-10-27 | Ono Pharmaceutical Co | 8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient |
| US6573294B1 (en) | 2002-05-14 | 2003-06-03 | Allergan, Inc. | 8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| AU2003237520B2 (en) | 2002-06-10 | 2009-01-08 | Laboratoires Serono Sa | Gamma lactams as prostaglandin agonists and use thereof |
| AU2003275838A1 (en) | 2002-10-25 | 2004-05-13 | Beunard, Jean-Luc | Pyrrolidin-2-on derivatives as ep4 receptor agonists |
| US7015243B2 (en) | 2003-08-28 | 2006-03-21 | Allergan, Inc. | Cyclohexyl prostaglandin analogs as EP4-receptor agonists |
| US7091231B2 (en) | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
| DE602005014671D1 (de) * | 2004-12-22 | 2009-07-09 | Janssen Pharmaceutica Nv | Tricyclische delta-opioid-modulatoren |
| DK1856042T3 (da) | 2005-03-10 | 2012-09-17 | Allergan Inc | Substituerede gamma-lactamer som terapeutiske midler |
| US8039507B2 (en) | 2005-06-29 | 2011-10-18 | Allergan, Inc. | Therapeutic substituted gamma lactams |
| US7592364B2 (en) | 2006-02-28 | 2009-09-22 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
| AU2007226957B2 (en) | 2006-03-20 | 2013-08-15 | Allergan, Inc. | Substituted gamma lactams as prostaglandin EP2 agonists |
| US7482475B2 (en) | 2006-08-11 | 2009-01-27 | Allergan, Inc. | Therapeutic lactams |
| US7507817B2 (en) | 2006-11-17 | 2009-03-24 | Allergan, Inc. | Prostaglandin prodrugs |
| BRPI0808377B8 (pt) * | 2007-01-31 | 2021-05-25 | Allergan Inc | composto, composição e uso de um composto |
| US7589213B2 (en) | 2007-04-27 | 2009-09-15 | Old David W | Therapeutic substituted lactams |
| EP2291367A1 (en) * | 2008-04-24 | 2011-03-09 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
-
2009
- 2009-04-22 BR BRPI0911347A patent/BRPI0911347A2/pt not_active IP Right Cessation
- 2009-04-22 RU RU2010144637/04A patent/RU2543379C2/ru active
- 2009-04-22 EP EP09734653A patent/EP2291368B1/en active Active
- 2009-04-22 CN CN2009801242132A patent/CN102076681A/zh active Pending
- 2009-04-22 PL PL09734653T patent/PL2291368T3/pl unknown
- 2009-04-22 CA CA2722529A patent/CA2722529A1/en not_active Abandoned
- 2009-04-22 UA UAA201013802A patent/UA103616C2/ru unknown
- 2009-04-22 WO PCT/US2009/041389 patent/WO2009132088A1/en active Application Filing
- 2009-04-22 MY MYPI20105007 patent/MY150518A/en unknown
- 2009-04-22 KR KR1020107026219A patent/KR20110008263A/ko not_active Application Discontinuation
- 2009-04-22 JP JP2011506415A patent/JP5524181B2/ja not_active Expired - Fee Related
- 2009-04-22 ES ES09734653T patent/ES2399314T3/es active Active
- 2009-04-22 US US12/427,968 patent/US7820661B2/en active Active
- 2009-04-22 AU AU2009239372A patent/AU2009239372B2/en active Active
- 2009-04-22 DK DK09734653.0T patent/DK2291368T3/da active
- 2009-04-22 MX MX2010011636A patent/MX2010011636A/es active IP Right Grant
-
2010
- 2010-10-22 ZA ZA2010/07553A patent/ZA201007553B/en unknown
- 2010-10-24 IL IL208899A patent/IL208899A0/en unknown
- 2010-11-22 CO CO10145796A patent/CO6321273A2/es active IP Right Grant