JP2006503850A5 - - Google Patents
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- Publication number
- JP2006503850A5 JP2006503850A5 JP2004540164A JP2004540164A JP2006503850A5 JP 2006503850 A5 JP2006503850 A5 JP 2006503850A5 JP 2004540164 A JP2004540164 A JP 2004540164A JP 2004540164 A JP2004540164 A JP 2004540164A JP 2006503850 A5 JP2006503850 A5 JP 2006503850A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- mammal
- pharmaceutically acceptable
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 241000124008 Mammalia Species 0.000 claims 5
- 208000002193 Pain Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 102000037275 μ-opioid receptors Human genes 0.000 claims 2
- 108020001612 μ-opioid receptors Proteins 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N Hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 1
- 230000002730 additional Effects 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000005284 excitation Effects 0.000 claims 1
- 229960001410 hydromorphone Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (11)
- 下記式Ｉ：
を有する化合物又はその医薬的に許容可能な塩。 - Ｒが、Ｃ1〜4アルキルである、請求項１に記載の化合物。
- Ｒが、メチル又はエチルである、請求項２に記載の化合物。
- 前記化合物が、N-メチルヒドロモルホン又はその医薬的に許容可能な塩である、請求項１に記載の化合物。
- 前記化合物が、ヒドロモルホンメチオダイドである、請求項４に記載の化合物。
- 請求項１から５のいずれか一項に記載の１若しくはそれ以上の化合物、及び医薬的に許容可能な担体又は希釈剤を含む医薬組成物。
- 約5mg〜約350mgの前記１又はそれ以上の化合物を含む、請求項６に記載の組成物。
- μオピオイド受容体の興奮に反応する疾患に罹患している哺乳動物の治療のために、当該治療が必要な哺乳動物に有効量の請求項１〜５のいずれか一項に記載の化合物が投与されることを特徴とする、μオピオイド受容体の興奮に反応する疾患の治療剤。
- 疼痛に罹患している哺乳動物において疼痛を治療、改善又は予防するために、当該治療が必要な哺乳動物に有効量の請求項１〜５のいずれか一項に記載の化合物が投与されることを特徴とする、疼痛の治療、改善又は予防剤。
- 慢性疼痛を治療、予防又は改善するためのものである、請求項９に記載の治療剤。
- 当該化合物、又は等量のその医薬的に許容可能な塩が、治療を受ける哺乳動物の体重あたり約0.1〜約5mg/kgの用量で、４時間ごとに経口投与されることを特徴とする、請求項９又は請求項１０に記載の治療剤。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41325402P | 2002-09-25 | 2002-09-25 | |
| US60/413,254 | 2002-09-25 | ||
| PCT/US2003/029876 WO2004029059A1 (en) | 2002-09-25 | 2003-09-24 | N-substituted hydromorphones and the use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010242645A Division JP2011042681A (ja) | 2002-09-25 | 2010-10-28 | Ｎ−置換ヒドロモルホン及びそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006503850A JP2006503850A (ja) | 2006-02-02 |
| JP2006503850A5 true JP2006503850A5 (ja) | 2006-06-29 |
| JP4806190B2 JP4806190B2 (ja) | 2011-11-02 |
Family
ID=32043224
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004540164A Expired - Fee Related JP4806190B2 (ja) | 2002-09-25 | 2003-09-24 | Ｎ−置換ヒドロモルホン及びそれらの使用 |
| JP2010242645A Withdrawn JP2011042681A (ja) | 2002-09-25 | 2010-10-28 | Ｎ−置換ヒドロモルホン及びそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010242645A Withdrawn JP2011042681A (ja) | 2002-09-25 | 2010-10-28 | Ｎ−置換ヒドロモルホン及びそれらの使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6825205B2 (ja) |
| EP (2) | EP1803724A1 (ja) |
| JP (2) | JP4806190B2 (ja) |
| KR (1) | KR20050074462A (ja) |
| CN (1) | CN100387600C (ja) |
| AT (1) | ATE360633T1 (ja) |
| AU (1) | AU2003272642B2 (ja) |
| BR (1) | BR0314488A (ja) |
| CA (1) | CA2500118C (ja) |
| CY (1) | CY1106697T1 (ja) |
| DE (1) | DE60313478T2 (ja) |
| DK (1) | DK1543010T3 (ja) |
| ES (1) | ES2286461T3 (ja) |
| HK (1) | HK1080456A1 (ja) |
| MX (1) | MXPA05003104A (ja) |
| NZ (1) | NZ538726A (ja) |
| PT (1) | PT1543010E (ja) |
| WO (1) | WO2004029059A1 (ja) |
| ZA (1) | ZA200502174B (ja) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
| US20070185145A1 (en) * | 2006-02-03 | 2007-08-09 | Royds Robert B | Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same |
| AU2007297827B2 (en) | 2006-09-20 | 2012-09-20 | Mallinckrodt Llc | Preparation of substituted morphinan-6-ones and salts and intermediates thereof |
| CA2670342A1 (en) * | 2006-11-22 | 2008-06-12 | Progenics Pharmaceuticals, Inc. | N-oxides of 4,5-epoxy-morphinanium analogs |
| JP2010510329A (ja) * | 2006-11-22 | 2010-04-02 | プロジェニックス ファーマスーティカルス インコーポレーテッド | ７，８−飽和−４，５−エポキシ−モルフィナニウム類似体 |
| EP2137189B1 (en) * | 2007-03-06 | 2015-05-06 | Mallinckrodt LLC | Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
| US9040726B2 (en) | 2007-03-06 | 2015-05-26 | Mallinckrodt Llc | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
| MX2010001371A (es) * | 2007-08-09 | 2010-03-10 | Rensselaer Polytech Inst | Carboxamidas opioides cuaternarias. |
| JP2011500686A (ja) * | 2007-10-18 | 2011-01-06 | アイコ バイオテクノロジー | オピオイドと中性アンタゴニストを用いる組合せ鎮痛剤 |
| US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
| US20110112129A2 (en) * | 2007-11-26 | 2011-05-12 | Pharmacofore, Inc. | Peripheral Phenolic Opioid Antagonist |
| EP2285780B1 (en) | 2008-05-27 | 2015-08-26 | Mallinckrodt LLC | Processes and compounds for the preparation of normorphinans |
| WO2010028004A2 (en) | 2008-09-03 | 2010-03-11 | Mallinckrodt Inc. | Substituted berbines and processes for their synthesis |
| EA201390422A1 (ru) | 2010-09-21 | 2014-01-30 | Пердью Фарма Л.П. | Бупренорфиновые аналоги |
| CA2890655A1 (en) | 2012-11-09 | 2014-05-15 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| EP2951160B1 (en) | 2013-01-31 | 2019-04-24 | Purdue Pharma LP | Benzomorphan analogs and the use thereof |
| US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| US9862726B2 (en) | 2013-12-26 | 2018-01-09 | Purdue Pharma L.P. | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| JP6353543B2 (ja) | 2013-12-26 | 2018-07-04 | パーデュー、ファーマ、リミテッド、パートナーシップ | 環縮小モルフィナン及びその使用 |
| WO2015097548A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 7-beta-alkyl analogs of orvinols |
| WO2015097547A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
| US10550088B2 (en) | 2013-12-27 | 2020-02-04 | Purdue Pharma L.P. | 6-substituted and 7-substituted morphinan analogs and the use thereof |
| EP3148535A4 (en) | 2014-05-27 | 2017-11-29 | Purdue Pharma LP | Spirocyclic morphinans and use thereof |
| MA40171A (fr) | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés d'azamophinan et leur utilisation |
| MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
| US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4176186A (en) * | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| EP0306575B1 (en) * | 1987-09-10 | 1992-07-29 | The University Of Chicago | Quaternary derivatives of noroxymorphone which relieve nausea and emesis |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| ATE359076T1 (de) * | 1996-11-25 | 2007-05-15 | Toray Industries | Mittel gegen juckreiz |
| WO2001014382A1 (fr) * | 1999-08-23 | 2001-03-01 | Toray Industries, Inc. | Analgesiques contenant des derives sel d'ammonium quaternaire comme principe actif |
-
2003
- 2003-09-24 AT AT03754837T patent/ATE360633T1/de active
- 2003-09-24 EP EP07007240A patent/EP1803724A1/en not_active Withdrawn
- 2003-09-24 CA CA2500118A patent/CA2500118C/en not_active Expired - Fee Related
- 2003-09-24 EP EP03754837A patent/EP1543010B1/en not_active Expired - Lifetime
- 2003-09-24 KR KR1020057005255A patent/KR20050074462A/ko not_active Application Discontinuation
- 2003-09-24 JP JP2004540164A patent/JP4806190B2/ja not_active Expired - Fee Related
- 2003-09-24 PT PT03754837T patent/PT1543010E/pt unknown
- 2003-09-24 NZ NZ538726A patent/NZ538726A/en not_active IP Right Cessation
- 2003-09-24 AU AU2003272642A patent/AU2003272642B2/en not_active Ceased
- 2003-09-24 CN CNB038229587A patent/CN100387600C/zh not_active Expired - Fee Related
- 2003-09-24 DE DE60313478T patent/DE60313478T2/de not_active Expired - Lifetime
- 2003-09-24 WO PCT/US2003/029876 patent/WO2004029059A1/en active IP Right Grant
- 2003-09-24 US US10/668,326 patent/US6825205B2/en not_active Expired - Lifetime
- 2003-09-24 ES ES03754837T patent/ES2286461T3/es not_active Expired - Lifetime
- 2003-09-24 DK DK03754837T patent/DK1543010T3/da active
- 2003-09-24 MX MXPA05003104A patent/MXPA05003104A/es active IP Right Grant
- 2003-09-24 BR BR0314488-7A patent/BR0314488A/pt not_active IP Right Cessation
-
2005
- 2005-03-15 ZA ZA200502174A patent/ZA200502174B/en unknown
- 2005-12-22 HK HK05111890A patent/HK1080456A1/xx not_active IP Right Cessation
-
2007
- 2007-07-03 CY CY20071100881T patent/CY1106697T1/el unknown
-
2010
- 2010-10-28 JP JP2010242645A patent/JP2011042681A/ja not_active Withdrawn
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