IT8522933A0 - Procedimento per la preparazione di silibinina esente da isosilibina e medicamenti contenenti dilibinina. - Google Patents

Procedimento per la preparazione di silibinina esente da isosilibina e medicamenti contenenti dilibinina.

Info

Publication number: IT8522933A0
Authority: IT; Italy
Prior art keywords: dilibinin; isosilibin; silibinin; procedure; preparation
Prior art date: 1984-11-22

Application number

IT8522933A

Other languages

English (en)

Other versions

IT1207508B (it

Inventor

Rolf Madaus

Klaus Gorler

Hartwig Soicke

Original Assignee

Madaus & Co Dr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-22

Filing date

1985-11-21

Publication date

1985-11-21

1985-11-21 Application filed by Madaus & Co Dr filed Critical Madaus & Co Dr

1985-11-21 Publication of IT8522933A0 publication Critical patent/IT8522933A0/it

1989-05-25 Application granted granted Critical

1989-05-25 Publication of IT1207508B publication Critical patent/IT1207508B/it

Links

SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 title 1
229950000628 silibinin Drugs 0.000 title 1
235000014899 silybin Nutrition 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L59/00—Thermal insulation in general
- F16L59/04—Arrangements using dry fillers, e.g. using slag wool which is added to the object to be insulated by pouring, spreading, spraying or the like

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Mechanical Engineering (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)

IT8522933A 1984-11-22 1985-11-21 Procedimento per la preparazione di silibinina esente da isosilibina e medicamenti contenenti dilibinina. IT1207508B (it)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3442641		1984-11-22
DE19853537656 DE3537656A1 (de)	1984-11-22	1985-10-23	Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin

Publications (2)

Publication Number	Publication Date
IT8522933A0 true IT8522933A0 (it)	1985-11-21
IT1207508B IT1207508B (it)	1989-05-25

Family

ID=25826741

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8522933A IT1207508B (it)	1984-11-22	1985-11-21	Procedimento per la preparazione di silibinina esente da isosilibina e medicamenti contenenti dilibinina.

Country Status (26)

Country	Link
US (1)	US4871763A (it)
JP (1)	JPH0678228B2 (it)
AR (1)	AR241268A1 (it)
AT (1)	AT391315B (it)
BE (1)	BE903694A (it)
CA (1)	CA1337125C (it)
CH (1)	CH660008A5 (it)
CS (1)	CS271321B2 (it)
DE (1)	DE3537656A1 (it)
DK (3)	DK166541B1 (it)
EG (1)	EG17710A (it)
ES (2)	ES8609312A1 (it)
FI (1)	FI84065C (it)
FR (1)	FR2573426B1 (it)
GB (1)	GB2167746B (it)
HU (1)	HU195504B (it)
IE (1)	IE59209B1 (it)
IT (1)	IT1207508B (it)
LU (1)	LU86164A1 (it)
MX (1)	MX172175B (it)
NL (1)	NL192204C (it)
NO (1)	NO160206C (it)
PL (1)	PL146889B1 (it)
PT (1)	PT81531B (it)
SE (1)	SE457957B (it)
YU (1)	YU43690B (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3357383B2 (ja) *	1991-08-14	2002-12-16	昌宏黒田	低分子化植物性組成物
DE4401902C2 (de) *	1994-01-24	2000-02-03	Madaus Ag	Verwendung von Flavolignanen als Adjuvans in der Tumortherapie
FR2719451B1 (fr) *	1994-05-04	1996-07-26	Apcis Sa	Utilisation de la silybinine dans le gavage des palmipèdes, en vue de l'obtention d'un foie gras de meilleure qualité.
DE19501266A1 (de) *	1995-01-18	1996-07-25	Madaus Ag	Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln
US6379714B1 (en)	1995-04-14	2002-04-30	Pharmaprint, Inc.	Pharmaceutical grade botanical drugs
DE69824223T2 (de)	1997-03-19	2004-09-30	Unilever N.V.	Vorrichtung zum Handhaben von Gegenständen
GB2327607B8 (en) *	1997-07-31	2005-03-30	Litton Internat Company Ltd	A process for producing a herbal extract composition
DE10053384A1 (de) *	2000-10-27	2002-05-08	Bionorica Arzneimittel Gmbh	Pharmazeutische Zubereitung aus Mariendistel und Terpenen
US6699900B2 (en) *	2001-04-07	2004-03-02	Jan E. Zielinski	Hydrophilic and lipophilic silibinin pro-forms
DE10360954B3 (de) *	2003-12-23	2005-08-18	Esparma Gmbh	Verwendung von Silibinin, dessen Salzen und/oder dessen Prodrugs zusammen mit α-Liponsäure zur Behandlung chronisch obstruktiver Lungenerkrankungen
BG65997B1 (bg) *	2005-03-29	2010-09-30	"Софарма" Ад	Метод за получаване на силибинин
MX2010005107A (es) *	2007-11-15	2010-05-27	Madaus Gmbh	Componente de silibinina para tratamiento contra hepatitis.
PT2430017T (pt) *	2009-05-14	2016-10-12	Madaus Gmbh	Método para a preparação de silibinina amorfa
WO2011051742A1 (en)	2009-10-28	2011-05-05	Modutech S.A.	Preparation comprising amino acids and plants and its activity in the alcohol detoxification
CN103408539B (zh) *	2013-08-28	2016-04-06	天津泰阳制药有限公司	高纯度水飞蓟宾的生产方法
EP3402788A1 (en) *	2016-01-15	2018-11-21	Universität Hamburg	Flavonoide-type compounds bearing an o-rhamnosyl residue
US20240024399A1 (en)	2020-09-29	2024-01-25	Munisekhar Medasani	Bioactive compounds extraction from plant matters of silybum marianum and usage

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3773932A (en) *	1968-06-01	1973-11-20	Madaus & Co Dr	Method for recovering silymarin comprising polyhydroxyphenyl chromanones
DE1767666C3 (de) *	1968-06-01	1986-07-31	Dr. Madaus & Co, 5000 Koeln	Pharmazeutische Zubereitung gegen Lebererkrankungen
DE1923082C3 (de) *	1969-05-06	1985-08-22	Dr. Madaus & Co, 5000 Koeln	Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch
DE2416302B2 (de) *	1974-04-04	1978-02-02	Dr. Madaus & Co, 5000 Köln	Dimeres sowie trimeres silybin und deren n-methylglucaminsalz und verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
BE885558A (fr) *	1980-10-07	1981-04-07	Madaus & Co Dr	Procede pour l'extraction de silymarine a partir des plantes silymarine ainsi obtenue et son utilisation en therapeutique
DE3225688A1 (de) *	1982-07-09	1984-01-12	Suschnik Matthias Dr	Verfahren zur gewinnung von silymarin aus silybum marianum

1985
- 1985-10-23 DE DE19853537656 patent/DE3537656A1/de active Granted
- 1985-11-11 GB GB08527809A patent/GB2167746B/en not_active Expired
- 1985-11-12 CH CH4854/85A patent/CH660008A5/de not_active IP Right Cessation
- 1985-11-13 LU LU86164A patent/LU86164A1/de unknown
- 1985-11-14 NL NL8503136A patent/NL192204C/nl not_active IP Right Cessation
- 1985-11-18 FI FI854536A patent/FI84065C/fi not_active IP Right Cessation
- 1985-11-19 AT AT0337285A patent/AT391315B/de not_active IP Right Cessation
- 1985-11-20 CS CS858379A patent/CS271321B2/cs unknown
- 1985-11-20 CA CA000495805A patent/CA1337125C/en not_active Expired - Fee Related
- 1985-11-20 YU YU1812/85A patent/YU43690B/xx unknown
- 1985-11-20 SE SE8505488A patent/SE457957B/sv not_active IP Right Cessation
- 1985-11-21 IE IE292785A patent/IE59209B1/en not_active IP Right Cessation
- 1985-11-21 EG EG741/85A patent/EG17710A/xx active
- 1985-11-21 DK DK537685A patent/DK166541B1/da not_active IP Right Cessation
- 1985-11-21 IT IT8522933A patent/IT1207508B/it active
- 1985-11-21 HU HU854449A patent/HU195504B/hu not_active IP Right Cessation
- 1985-11-21 PL PL1985256373A patent/PL146889B1/pl unknown
- 1985-11-21 NO NO854657A patent/NO160206C/no unknown
- 1985-11-21 ES ES549119A patent/ES8609312A1/es not_active Expired
- 1985-11-21 PT PT81531A patent/PT81531B/pt not_active IP Right Cessation
- 1985-11-22 MX MX009231A patent/MX172175B/es unknown
- 1985-11-22 AR AR85302358A patent/AR241268A1/es active
- 1985-11-22 FR FR8517320A patent/FR2573426B1/fr not_active Expired
- 1985-11-22 BE BE2/60851A patent/BE903694A/fr not_active IP Right Cessation
1986
- 1986-04-16 ES ES554022A patent/ES8704482A1/es not_active Expired
1988
- 1988-03-18 US US07/171,176 patent/US4871763A/en not_active Expired - Fee Related
1991
- 1991-01-29 JP JP3009169A patent/JPH0678228B2/ja not_active Expired - Lifetime
- 1991-11-20 DK DK189491A patent/DK164866C/da not_active IP Right Cessation
1992
- 1992-09-17 DK DK199201145A patent/DK172879B1/da active

Also Published As

Publication number	Publication date
IT1207508B (it)	1989-05-25
SE8505488L (sv)	1986-05-23
GB2167746A (en)	1986-06-04
ES549119A0 (es)	1986-09-01
CH660008A5 (de)	1987-03-13
DK172879B1 (da)	1999-09-06
NL192204B (nl)	1996-11-01
FI84065C (fi)	1991-10-10
FI84065B (fi)	1991-06-28
PL146889B1 (en)	1989-03-31
GB2167746B (en)	1989-01-11
US4871763A (en)	1989-10-03
DK114592A (da)	1992-09-17
NO854657L (no)	1986-05-23
ES554022A0 (es)	1987-04-01
CS271321B2 (en)	1990-09-12
DK189491A (da)	1991-11-20
DK164866B (da)	1992-08-31
IE852927L (en)	1986-05-22
PT81531B (pt)	1987-11-11
DK537685D0 (da)	1985-11-21
NL8503136A (nl)	1986-06-16
AR241268A1 (es)	1992-04-30
YU43690B (en)	1989-10-31
NO160206C (no)	1989-03-22
HU195504B (en)	1988-05-30
FI854536A (fi)	1986-05-23
CS837985A2 (en)	1990-02-12
MX172175B (es)	1993-12-07
JPH05271071A (ja)	1993-10-19
SE8505488D0 (sv)	1985-11-20
DK114592D0 (da)	1992-09-17
JPH0678228B2 (ja)	1994-10-05
NL192204C (nl)	1997-03-04
LU86164A1 (de)	1986-03-24
SE457957B (sv)	1989-02-13
IE59209B1 (en)	1994-01-26
DE3537656C2 (it)	1989-03-16
PT81531A (de)	1985-12-01
FR2573426A1 (fr)	1986-05-23
GB8527809D0 (en)	1985-12-18
DK166541B1 (da)	1993-06-07
FI854536A0 (fi)	1985-11-18
PL256373A1 (en)	1986-12-02
NO160206B (no)	1988-12-12
HUT40115A (en)	1986-11-28
EG17710A (en)	1990-10-30
CA1337125C (en)	1995-09-26
BE903694A (fr)	1986-05-22
YU181285A (en)	1987-12-31
ES8609312A1 (es)	1986-09-01
AT391315B (de)	1990-09-25
DK537685A (da)	1986-05-23
ES8704482A1 (es)	1987-04-01
DK164866C (da)	1993-01-18
DK189491D0 (da)	1991-11-20
DE3537656A1 (de)	1986-05-22
FR2573426B1 (fr)	1988-06-10
ATA337285A (de)	1990-03-15

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19971030

Publication	Publication Date	Title
NO871791D0 (no)	1987-04-29	Fremgangsmaate for fremstilling av farmasoeytiske preparater inneholdende syrelabile stoffer for oral anvendelse.
NO854194L (no)	1986-04-23	Fremgangsmaate for fremstilling av farmasoeytiske preparater inneholdende antracyklinglykosider.
DE3784594D1 (de)	1993-04-15	Mikrokapseln enthaltende pharmazeutische zusammensetzungen.
DE3676248D1 (de)	1991-01-31	Ubidecarenon enthaltende arzneimittel.
NO874873D0 (no)	1987-11-23	Innretning for autoadministrering av fysiologisk aktive stoffer.
IT8522933A0 (it)	1985-11-21	Procedimento per la preparazione di silibinina esente da isosilibina e medicamenti contenenti dilibinina.
IT1183060B (it)	1987-10-05	Procedimento di preparazione. cefem composti ad azione farmaceutica e relativo
DE3583765D1 (de)	1991-09-19	Hydantoinderivate und diese enthaltende pharmazeutische zusammensetzungen.
IT8521322A0 (it)	1985-06-27	Composti e composizioni farmaceutiche per la terapia di retinopatie e neuropatie diabetiche.
IT8522365A0 (it)	1985-10-04	Procedimento per la preparazione di l-alfa-glicerilfosforilcolina, l-alfa-glicerilfosforiletanolommina e l-alfa-glicerilfosforilinositolo da lecitine grezze e/o deoleate.
IT1230068B (it)	1991-10-05	Procedimento per la preparazione di n sulfoniluree.
NO873514L (no)	1988-02-22	Fremgangsmaate for fremstilling av farmasoeytisk aktive forbindelser.
FI863657A (fi)	1987-03-12	Foerfarande foer framstaellning av n-sulfamyl-3-(2-guanidino-tiazol-4-yl-metyltio)-propionamidin.
NO891574L (no)	1989-10-20	Fremgangsmaate for fremstilling av farmasoeytisk anvendbareforbindelser.
IT8820194A0 (it)	1988-04-13	Procedimento di dosaggio di sostanze liquide o pastose e impianto per la realizzazione ditale procedimento.
IT1157058B (it)	1987-02-11	Procedimento per la preparazione di acril e metaacrilamidi n.sostituite
IT8621526A0 (it)	1986-08-26	Loro preparazione e medicinali che derivati di metilendiossifenantrene li contengono. e stilbene, procedimento per la
IT8620761A0 (it)	1986-06-11	Procedimento per la preparazione di 2-bromo-alfa-ergocriptina.
IT8722055A0 (it)	1987-09-28	Procedimento per la preparazione di idantoine 5-ariliden e alchilidensostituite.
IT8520591A0 (it)	1985-05-06	Formulazione farmaceutica.
DE3889327D1 (de)	1994-06-01	Platinkomplexe enthaltende arzneimittel.
IT8723035A0 (it)	1987-12-16	Procedimento per la preparazione di n acilaniline.
IT8620135A0 (it)	1986-04-18	Procedimento per la preparazione di derivati della eburnamenina e composizioni farmaceutiche che licontengono.
IT8619751A0 (it)	1986-03-14	Composizioni farmaceutiche contenenti vinburnina e loro procedimento di preparazione.
IT8719426A0 (it)	1987-02-19	Preparazione di amoxicillina iniettabile famraceutica.