IS5140A - Atrópísómerur af 3-arýl-4(3H)-kínasólínónum og notkun þeirra ásamt lyfjablöndum - Google Patents

Atrópísómerur af 3-arýl-4(3H)-kínasólínónum og notkun þeirra ásamt lyfjablöndum

Info

Publication number
IS5140A
IS5140A IS5140A IS5140A IS5140A IS 5140 A IS5140 A IS 5140A IS 5140 A IS5140 A IS 5140A IS 5140 A IS5140 A IS 5140A IS 5140 A IS5140 A IS 5140A
Authority
IS
Iceland
Prior art keywords
quinazolinones
atropisomers
aryl
combination
pharmaceutical preparations
Prior art date
Application number
IS5140A
Other languages
English (en)
Other versions
IS1952B (is
Inventor
Willard Mckowan Welch, Jr.
Michael Devries Keith
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of IS5140A publication Critical patent/IS5140A/is
Publication of IS1952B publication Critical patent/IS1952B/is

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/91Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
IS5140A 1997-02-28 1999-07-30 Atrópísómerur af 3-arýl-4(3H)-kínasólínónum og notkun þeirra ásamt lyfjablöndum IS1952B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3890597P 1997-02-28 1997-02-28
PCT/IB1998/000150 WO1998038173A1 (en) 1997-02-28 1998-02-06 Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as ampa-receptor antagonists

Publications (2)

Publication Number Publication Date
IS5140A true IS5140A (is) 1999-07-30
IS1952B IS1952B (is) 2004-10-13

Family

ID=21902563

Family Applications (1)

Application Number Title Priority Date Filing Date
IS5140A IS1952B (is) 1997-02-28 1999-07-30 Atrópísómerur af 3-arýl-4(3H)-kínasólínónum og notkun þeirra ásamt lyfjablöndum

Country Status (40)

Country Link
US (1) US6306864B1 (is)
EP (1) EP0968194B1 (is)
JP (1) JP2000509731A (is)
KR (1) KR100358636B1 (is)
CN (1) CN1248248A (is)
AP (1) AP859A (is)
AR (1) AR011170A1 (is)
AT (1) ATE267817T1 (is)
AU (1) AU744028B2 (is)
BG (1) BG103689A (is)
BR (1) BR9807872A (is)
CA (1) CA2282277C (is)
DE (1) DE69824157T2 (is)
DK (1) DK0968194T3 (is)
DZ (1) DZ2440A1 (is)
EA (1) EA001963B1 (is)
ES (1) ES2219866T3 (is)
GT (1) GT199800038A (is)
HR (1) HRP980106A2 (is)
HU (1) HUP0000914A3 (is)
ID (1) ID22711A (is)
IL (1) IL130900A0 (is)
IS (1) IS1952B (is)
MA (1) MA24484A1 (is)
NO (1) NO313630B1 (is)
NZ (1) NZ336628A (is)
OA (1) OA11089A (is)
PA (1) PA8447001A1 (is)
PE (1) PE58399A1 (is)
PL (1) PL335418A1 (is)
PT (1) PT968194E (is)
SK (1) SK113299A3 (is)
TN (1) TNSN98035A1 (is)
TR (1) TR199902093T2 (is)
TW (1) TW504508B (is)
UA (1) UA61097C2 (is)
UY (1) UY24897A1 (is)
WO (1) WO1998038173A1 (is)
YU (1) YU41299A (is)
ZA (1) ZA981666B (is)

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SK284108B6 (sk) 1996-05-15 2004-09-08 Pfizer Inc. 2,3-Disubstituované 4(3H)-chinazolinóny, ich použitie a farmaceutické kompozície s ich obsahom
US6323208B1 (en) 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
JPH11279158A (ja) * 1998-02-09 1999-10-12 Pfizer Prod Inc キナゾリン―4―オン誘導体の製造方法
US6667300B2 (en) * 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
DE60144277D1 (de) * 2000-04-25 2011-05-05 Icos Corp Hemmer der menschlichen phosphatidyl-inositol-3-kinase delta
BRPI0111596B8 (pt) 2000-06-12 2022-07-26 Eisai Co Ltd Composto piridona, processo de produção do composto, composição farmacêutica, e uso do dito composto
JP3440469B2 (ja) 2000-08-18 2003-08-25 味の素株式会社 新規フェニルアラニン誘導体
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
US6939968B2 (en) * 2002-12-23 2005-09-06 Bristol-Myers Squibb Company Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives
US20080146562A1 (en) * 2003-08-08 2008-06-19 Ulysses Pharmaceutical Products Inc., Halogenated quinazolinyl nitrofurans as antibacterial agents
BRPI0413372A (pt) * 2003-08-08 2006-10-17 Ulysses Pharmaceutical Product composto e composições de nitrofuranos de quinazolinil halogenados, seus métodos de preparação e usos como agentes antibacterianos
GB0325390D0 (en) * 2003-10-30 2003-12-03 Novartis Ag Organic compounds
US7345049B2 (en) 2003-12-22 2008-03-18 Ajinomoto Co., Inc. Phenylalanine derivatives
CN101031569B (zh) 2004-05-13 2011-06-22 艾科斯有限公司 作为人磷脂酰肌醇3-激酶δ抑制剂的喹唑啉酮
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
GB0416730D0 (en) * 2004-07-27 2004-09-01 Novartis Ag Organic compounds
AU2006311883A1 (en) 2005-11-04 2007-05-18 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
CN101547922B (zh) 2006-10-04 2012-06-20 辉瑞产品公司 作为钙受体拮抗剂的吡啶并[4,3-d]嘧啶-4(3H)-酮衍生物
WO2008140750A1 (en) * 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
CN101429166B (zh) * 2007-11-07 2013-08-21 上海特化医药科技有限公司 喹唑啉酮衍生物及其制备方法和用途
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
AU2009313878B2 (en) 2008-11-13 2016-01-07 Gilead Calistoga Llc Therapies for hematologic malignancies
BRPI1012333A2 (pt) 2009-03-24 2016-03-29 Gilead Calistoga Llc atropisômeros de derivados de 2-purinil-3-tolil-quinazolinonas e métodos de uso
CN102647987A (zh) 2009-07-21 2012-08-22 吉里德卡利斯托加公司 使用pi3k抑制剂治疗肝脏障碍
BR112014021935A2 (pt) 2012-03-05 2019-09-24 Gilead Calistoga Llc formas polimórficas de (s)-2(l-(9h-purin-6-ilamino)propil)-5-fluoro-3-fenilquinazolina-4(3h)ona
CN103275086B (zh) * 2013-05-30 2015-04-15 温州大学 一种6-取代喹唑啉并喹唑啉酮化合物及其合成方法和用途
NZ720867A (en) 2013-12-20 2018-01-26 Gilead Calistoga Llc Process methods for phosphatidylinositol 3-kinase inhibitors
WO2015095605A1 (en) 2013-12-20 2015-06-25 Gilead Calistoga Llc Polymorphic forms of a hydrochloride salt of (s) -2-(9h-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3h) -one
US9533909B2 (en) 2014-03-31 2017-01-03 Corning Incorporated Methods and apparatus for material processing using atmospheric thermal plasma reactor
BR112016028642A2 (pt) 2014-06-13 2017-08-22 Gilead Sciences Inc composto, composição farmacêutica, método de tratamento de uma doença ou condição, método de inibição da atividade de um polipeptídeo de fosfatidilinositol 3-quinase, método de inibição de reações imunes ou crescimento excessivo ou destrutivo ou de proliferação de células cancerosas, kit, e, uso de um composto, de um sal, de um isômero ou de uma mistura farmaceuticamente aceitável do mesmo.
DE102014217021A1 (de) * 2014-08-27 2016-03-03 Skf Lubrication Systems Germany Ag Gehäuse für eine Vorrichtung zum dosierten Verteilen eines Mediums sowie eine Dosiereinrichtung zur Verwendung in dem Gehäuse
JP7177937B2 (ja) 2018-12-14 2022-11-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 1,2-ジヒドロピリジン化合物の水性医薬製剤
JP2023512664A (ja) 2020-01-29 2023-03-28 カマリ ファーマ リミテッド 皮膚障害の治療に使用するための化合物及び組成物

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DE1195321B (de) * 1962-03-16 1965-06-24 Troponwerke Dinklage & Co Verfahren zur Herstellung von substituierten Chinazolon-(4)-derivaten
DE1670416A1 (de) * 1966-12-30 1971-02-11 Chem Fab Von Heyden Gmbh Muenc Verfahren zur Herstellung von aminosubstituierten Chinazolinonderivaten
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SK284108B6 (sk) * 1996-05-15 2004-09-08 Pfizer Inc. 2,3-Disubstituované 4(3H)-chinazolinóny, ich použitie a farmaceutické kompozície s ich obsahom

Also Published As

Publication number Publication date
CA2282277A1 (en) 1998-09-03
PL335418A1 (en) 2000-04-25
HUP0000914A2 (hu) 2001-04-28
ID22711A (id) 1999-12-09
JP2000509731A (ja) 2000-08-02
TW504508B (en) 2002-10-01
YU41299A (sh) 2002-09-19
PA8447001A1 (es) 2000-05-24
BG103689A (bg) 2000-11-30
DZ2440A1 (fr) 2003-01-11
OA11089A (en) 2003-09-22
NO994177L (no) 1999-08-27
BR9807872A (pt) 2000-03-21
EP0968194B1 (en) 2004-05-26
ZA981666B (en) 1999-08-27
AU5676898A (en) 1998-09-18
UA61097C2 (uk) 2003-11-17
EA199900693A1 (ru) 2000-02-28
NZ336628A (en) 2001-03-30
AP9801199A0 (en) 1998-03-31
IL130900A0 (en) 2001-01-28
UY24897A1 (es) 2000-12-29
ES2219866T3 (es) 2004-12-01
CN1248248A (zh) 2000-03-22
TR199902093T2 (xx) 1999-12-21
HRP980106A2 (en) 1999-02-28
PE58399A1 (es) 1999-06-16
KR20000075814A (ko) 2000-12-26
WO1998038173A1 (en) 1998-09-03
HUP0000914A3 (en) 2001-09-28
MA24484A1 (fr) 1998-10-01
NO313630B1 (no) 2002-11-04
EP0968194A1 (en) 2000-01-05
AP859A (en) 2000-07-21
DK0968194T3 (da) 2004-08-16
DE69824157T2 (de) 2004-10-14
CA2282277C (en) 2005-10-11
ATE267817T1 (de) 2004-06-15
US6306864B1 (en) 2001-10-23
PT968194E (pt) 2004-08-31
AU744028B2 (en) 2002-02-14
DE69824157D1 (de) 2004-07-01
IS1952B (is) 2004-10-13
KR100358636B1 (ko) 2002-10-31
TNSN98035A1 (fr) 2005-03-15
AR011170A1 (es) 2000-08-02
SK113299A3 (en) 2001-05-10
GT199800038A (es) 1999-08-13
NO994177D0 (no) 1999-08-27
EA001963B1 (ru) 2001-10-22

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