IS2566B - Aðferð til að ákvarða stig metýleringar afmarkaðra sýtósína í genamengi DNA í raðasamhenginu 5'-CPG-3' - Google Patents

Aðferð til að ákvarða stig metýleringar afmarkaðra sýtósína í genamengi DNA í raðasamhenginu 5'-CPG-3'

Info

Publication number
IS2566B
IS2566B IS6705A IS6705A IS2566B IS 2566 B IS2566 B IS 2566B IS 6705 A IS6705 A IS 6705A IS 6705 A IS6705 A IS 6705A IS 2566 B IS2566 B IS 2566B
Authority
IS
Iceland
Prior art keywords
methylation
degree
determining
cpg
classes
Prior art date
Application number
IS6705A
Other languages
English (en)
Other versions
IS6705A (is
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
David Gutig
Original Assignee
Epigenomics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10044543A external-priority patent/DE10044543C2/de
Application filed by Epigenomics Ag filed Critical Epigenomics Ag
Publication of IS6705A publication Critical patent/IS6705A/is
Publication of IS2566B publication Critical patent/IS2566B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
IS6705A 2000-09-01 2003-01-31 Aðferð til að ákvarða stig metýleringar afmarkaðra sýtósína í genamengi DNA í raðasamhenginu 5'-CPG-3' IS2566B (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10043826 2000-09-01
DE10044543A DE10044543C2 (de) 2000-09-05 2000-09-05 Verfahren zur Bestimmung des Methylierungsgrades von bestimmten Cytosinen in genomischer DNA im Sequenzkontext 5'-CpG-3'
PCT/EP2001/010074 WO2002018632A2 (de) 2000-09-01 2001-09-01 Verfahren zur bestimmung des methylierungsgrades von bestimmten cytosinen in genomischer dna im sequenzkontext 5'-cpg-3'

Publications (2)

Publication Number Publication Date
IS6705A IS6705A (is) 2003-01-31
IS2566B true IS2566B (is) 2009-12-15

Family

ID=26006939

Family Applications (1)

Application Number Title Priority Date Filing Date
IS6705A IS2566B (is) 2000-09-01 2003-01-31 Aðferð til að ákvarða stig metýleringar afmarkaðra sýtósína í genamengi DNA í raðasamhenginu 5'-CPG-3'

Country Status (16)

Country Link
US (2) US20040234960A1 (is)
EP (2) EP1423528B1 (is)
JP (1) JP2004516821A (is)
KR (1) KR100870486B1 (is)
AT (1) ATE382711T1 (is)
AU (2) AU1218802A (is)
CA (1) CA2420840A1 (is)
DE (1) DE50113454D1 (is)
DK (1) DK1423528T3 (is)
EA (1) EA007028B1 (is)
ES (1) ES2299520T3 (is)
IL (2) IL154663A0 (is)
IS (1) IS2566B (is)
MX (1) MXPA03001834A (is)
NZ (1) NZ524229A (is)
WO (1) WO2002018632A2 (is)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
DE19951189C2 (de) * 1999-10-15 2003-11-06 Epigenomics Ag Verfahren zur Unterscheidung von 5-Position-Methylierungsänderungen von Cytosin-Basen und Cytosin-zu-Thymin-Mutationen und zum Nachweis von single nucleotide polymorphisms (SNPs) oder Punktmutation in genomischer DNA
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
DE10061348C2 (de) * 2000-12-06 2002-10-24 Epigenomics Ag Verfahren zur Quantifizierung von Cytosin-Methylierungen in komplex amplifizierter genomischer DNA
DE10061338A1 (de) * 2000-12-06 2002-06-20 Epigenomics Ag Diagnose von mit Angiogenese assoziierten Krankheiten
US7459539B2 (en) 2000-12-15 2008-12-02 Agensys, Inc. Antibody that binds zinc transporter protein 108P5H8
US7736654B2 (en) 2001-04-10 2010-06-15 Agensys, Inc. Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers
JP2003144172A (ja) * 2001-11-16 2003-05-20 Nisshinbo Ind Inc メチル化検出用オリゴヌクレオチド固定化基板
JPWO2003068973A1 (ja) * 2002-02-13 2005-06-02 暉勝 有馬 肝炎の診断に有用なｄｎａ配列とコードされたポリペプタイド
EP1340818A1 (en) * 2002-02-27 2003-09-03 Epigenomics AG Method and nucleic acids for the analysis of a colon cell proliferative disorder
EP1488003A1 (en) * 2002-03-25 2004-12-22 Epigenomics AG Method for the analysis of methylation patterns within nucleic acids by means of mass spectrometry
DE10214232A1 (de) * 2002-03-25 2003-10-23 Epigenomics Ag Verfahren und Vorrichtung für die DNA Methylierungsanalyse
DE10392538B4 (de) * 2002-04-09 2010-02-18 Epigenomics Ag Verfahren zur Analyse von methylierten Nukleinsäuren
US20040053304A1 (en) 2002-06-05 2004-03-18 Case Western Reserve University Methods and compositions for detecting cancers
JP2005532067A (ja) * 2002-07-03 2005-10-27 コーリー ファーマシューティカル グループ，インコーポレイテッド 刺激性免疫応答用の核酸組成物
US7569553B2 (en) * 2002-07-03 2009-08-04 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AU2003243151A1 (en) 2002-08-16 2004-03-03 Agensys, Inc. Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
AU2003257587A1 (en) * 2002-08-23 2004-03-11 Japan As Represented By President Of National Cancer Center Method of evaluating degree of canceration of human-origin specimen
WO2004046310A2 (en) * 2002-11-15 2004-06-03 Five Prime Therapeutics, Inc. Novel mouse polypeptides encoded by polynucleotides and methods of their use
WO2004048565A1 (ja) * 2002-11-22 2004-06-10 Takeda Pharmaceutical Company Limited アポトーシス関連蛋白質およびその用途
JP4488720B2 (ja) * 2002-11-22 2010-06-23 武田薬品工業株式会社 アポトーシス関連蛋白質およびその用途
ATE462017T1 (de) * 2002-12-02 2010-04-15 Illumina Cambridge Ltd Bestimmung der methylierung von nukleinsäuresequenzen
AU2003290433A1 (en) * 2002-12-25 2004-07-22 Combimatrix K.K. Nucleic acid methylation detection process using an internal reference sample
US7485418B2 (en) * 2003-03-17 2009-02-03 The Johns Hopkins University Aberrantly methylated genes in pancreatic cancer
EP2354249A1 (en) * 2003-06-23 2011-08-10 Epigenomics AG Methods and nucleic acids for analyses of colorectal cell proliferative disorders
JP4955385B2 (ja) * 2003-06-23 2012-06-20 エピゲノミクス アクチェンゲゼルシャフト 結腸直腸細胞増殖障害の分析のための方法及び核酸
JP4781267B2 (ja) 2003-08-14 2011-09-28 ケース ウエスタン リザーブ ユニバーシティ 大腸癌を検出する方法及び組成物
US8415100B2 (en) 2003-08-14 2013-04-09 Case Western Reserve University Methods and compositions for detecting gastrointestinal and other cancers
JP5116938B2 (ja) * 2003-09-16 2013-01-09 独立行政法人国立がん研究センター 哺乳動物由来の検体の癌化度を評価する方法
JP5116935B2 (ja) * 2003-09-16 2013-01-09 独立行政法人国立がん研究センター 哺乳動物由来の検体の癌化度を評価する方法
JP2005087050A (ja) * 2003-09-16 2005-04-07 National Cancer Center-Japan 哺乳動物由来の検体の癌化度を評価する方法
JP4917891B2 (ja) * 2003-10-21 2012-04-18 オリオン ゲノミクス エルエルシー 差次的酵素的断片化の方法
EP1689889B1 (en) * 2003-12-01 2017-08-30 Epigenomics AG Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
US7157281B2 (en) * 2003-12-11 2007-01-02 Monsanto Technology Llc High lysine maize compositions and event LY038 maize plants
WO2006008128A2 (en) * 2004-07-18 2006-01-26 Epigenomics Ag Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
KR20060026595A (ko) 2004-09-21 2006-03-24 (주)지노믹트리 제한효소와 ｄｎａ 칩을 이용한 프로모터의 메틸화 검출방법
US8679745B2 (en) 2004-09-30 2014-03-25 Epigenomics Ag Method for providing DNA fragments derived from an archived sample
US20060134650A1 (en) * 2004-12-21 2006-06-22 Illumina, Inc. Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis
WO2006084699A1 (en) * 2005-02-11 2006-08-17 Roche Diagnostics Gmbh New methylation marker
WO2006088978A1 (en) 2005-02-16 2006-08-24 Epigenomics, Inc. Method for determining the methylation pattern of a polynucleic acid
US7932027B2 (en) 2005-02-16 2011-04-26 Epigenomics Ag Method for determining the methylation pattern of a polynucleic acid
DK1871912T3 (da) 2005-04-15 2012-05-14 Epigenomics Ag Fremgangsmåde til bestemmelse af DNA-methylering i blod- eller urinprøver
CN107663538B (zh) * 2005-04-15 2022-03-18 Epi基因组股份公司 分析细胞增殖性病症的方法和核酸
EP2386654A1 (en) * 2005-05-02 2011-11-16 University of Southern California DNA Methylation markers associated with the CpG island methylator phenotype (cimp) in human colorectal cancer
US9556430B2 (en) * 2005-05-27 2017-01-31 Dana-Farber Cancer Institute, Inc. Gene methylation and expression
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
WO2007019670A1 (en) * 2005-07-01 2007-02-22 Graham, Robert Method and nucleic acids for the improved treatment of breast cancers
WO2007032748A1 (en) * 2005-09-15 2007-03-22 Agency For Science, Technology & Research Method for detecting dna methylation
EP1969139A1 (en) 2005-11-17 2008-09-17 Epigenomics AG Method for the determination of the dna methylation level of a cpg position in identical cells within a tissue sample
KR100817444B1 (ko) * 2006-03-10 2008-03-27 포천중문의과대학교 산학협력단 5'-말단 ｘｉｓｔ 유전자 서열에 존재하는 메틸화 정도측정방법과 이를 이용한 암 진단 방법, 항암활성을측정하는 방법 및 메틸화 측정 키트
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
KR100761031B1 (ko) * 2006-05-27 2007-10-04 김연수 디엔에이 메틸화 현상을 이용한 암 진단용 키트
WO2007143037A2 (en) * 2006-05-31 2007-12-13 Orion Genomics Llc Gene methylation in cancer diagnosis
GB0700374D0 (en) * 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20090075264A1 (en) * 2007-02-02 2009-03-19 Orion Genomics Llc Gene methylation in liver cancer diagnosis
WO2008096146A1 (en) 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
CN104846092A (zh) * 2007-02-21 2015-08-19 奥斯陆大学医院Hf 新型癌症标记物
PL2479289T3 (pl) 2007-06-08 2016-10-31 Sposób analizy metylacji
EP2193209B1 (en) * 2007-09-17 2014-11-12 Koninklijke Philips N.V. Method for the analysis of breast cancer disorders
KR200449398Y1 (ko) * 2007-11-22 2010-07-07 고영길 컴퓨터 책상
WO2009108917A2 (en) * 2008-02-29 2009-09-03 Oncomethylome Sciences, S.A. Markers for improved detection of breast cancer
EP2108705A1 (en) * 2008-04-08 2009-10-14 Universität Duisburg-Essen Method for analysing the epigenetic status of the HtrA 1 gene in a biological sample
KR100986960B1 (ko) * 2008-07-23 2010-10-11 재단법인 아산사회복지재단 유전자의 메틸화 여부 및 비율의 분석방법
WO2010048337A2 (en) 2008-10-22 2010-04-29 Illumina, Inc. Preservation of information related to genomic dna methylation
SI2759306T1 (sl) * 2008-12-09 2016-05-31 Coley Pharmaceutical Group, Inc. Imunostimulacijski oligonukleotidi
EP3327139A1 (en) * 2009-04-06 2018-05-30 The Johns Hopkins University Digital quantification of dna methylation
JP6013910B2 (ja) * 2009-06-26 2016-10-25 エピゲノミクス アーゲー 膀胱細胞増殖性障害の分析のための方法及び核酸
US20110046009A1 (en) * 2009-08-24 2011-02-24 Perkinelmer Health Sciences, Inc. Methods for detecting dna methylation using encoded particles
US10428388B2 (en) * 2009-11-05 2019-10-01 Genomictree, Inc. Method for detecting the methylation of colorectal-cancer-specific methylation marker genes for colorectal cancer diagnosis
ES2633111T3 (es) 2010-03-26 2017-09-19 Hongzhi Zou Métodos y materiales para detectar neoplasia colorrectal
US9290807B2 (en) * 2011-07-29 2016-03-22 Cambridge Epigenetix Limited Methods for detection of nucleotide modification
CN102618645B (zh) * 2012-03-30 2014-07-09 中国人民解放军第四军医大学 基于荧光偏振的egfr基因启动子甲基化状态均相检测法
SG11201501115VA (en) * 2012-08-28 2015-04-29 Istat Biomedical Co Ltd Test composition for screening cancers
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
EP2971179B1 (en) 2013-03-14 2019-01-09 Mayo Foundation for Medical Education and Research Detecting neoplasm
ES2524194B1 (es) * 2013-06-03 2015-09-09 Universitat De Barcelona Métodos y kits para el diagnóstico de la diabetes tipo 2
CN106460046A (zh) 2014-03-31 2017-02-22 梅奥医学教育和研究基金会 检测结直肠赘生物
US11352672B2 (en) * 2014-09-15 2022-06-07 Garvan Institute Of Medical Research Methods for diagnosis, prognosis and monitoring of breast cancer and reagents therefor
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
AU2015360352B2 (en) * 2014-12-12 2022-01-27 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
WO2016094839A2 (en) 2014-12-12 2016-06-16 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
AU2015374019B2 (en) * 2014-12-31 2022-03-10 Case Western Reserve University Methods and compositions for detecting esophageal neoplasias and/or metaplasias in the esophagus
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
EP3344784A4 (en) 2015-08-31 2019-07-10 Mayo Foundation for Medical Education and Research PROOF OF GASTRIC NEOPLASMS
AU2016343937B2 (en) 2015-10-30 2023-01-19 Exact Sciences Corporation Multiplex amplification detection assay and isolation and detection of DNA from plasma
HUE054225T2 (hu) * 2016-01-29 2021-08-30 Epigenomics Ag Módszerek a daganatból származó DNA CPG-metilációjának kimutatására vérmintákban
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
CN116024334A (zh) 2016-04-14 2023-04-28 梅约医学教育与研究基金会 检测DMR试剂筛选IPMN-HGD、PanIN-3或PDAC的用途及试剂盒
KR102436270B1 (ko) 2016-05-05 2022-08-25 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 폐 종양의 검출
KR101883631B1 (ko) * 2016-05-27 2018-08-01 전남대학교산학협력단 심장 질환 후 우울증 진단을 위한 정보 제공 방법 및 진단용 키트
CN116445593A (zh) 2016-08-10 2023-07-18 格里尔公司 测定一生物样品的一甲基化图谱的方法
DK3336197T3 (da) 2016-12-16 2022-07-11 Eurofins Genomics Europe Sequencing GmbH Epigenetiske markører og relaterede fremgangsmåder og midler til detektion og behandling af ovariekræft
WO2018140781A1 (en) * 2017-01-27 2018-08-02 Exact Sciences Development Company, Llc Detection of colon neoplasia by analysis of methylated dna
JP7356349B2 (ja) 2017-02-28 2023-10-04 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 前立腺癌検出
US20190092817A1 (en) * 2017-03-13 2019-03-28 Base Pair Biotechnologies, Inc. Functional ligands to peptides
US10934594B2 (en) 2017-11-30 2021-03-02 Mayo Foundation For Medical Education And Research Detecting breast cancer
JP6924335B2 (ja) * 2017-12-01 2021-08-25 バイオチェーン（ペキン）サイエンス アンド テクノロジー、インコーポレイテッドＢｉｏｃｈａｉｎ （Ｂｅｉｊｉｎｇ） Ｓｃｉｅｎｃｅ ＆ Ｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． 食道癌を検出するための組成物及びその使用
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
SG11202009866XA (en) * 2018-04-12 2020-11-27 Singlera Genomics Inc Compositions and methods for cancer or neoplasia assessment
CN110511997A (zh) * 2018-05-22 2019-11-29 广州市康立明生物科技有限责任公司 肿瘤标志物、甲基化试剂、试剂盒及其应用
SG11202010208YA (en) * 2018-05-23 2020-11-27 Hangzhou New Horizon Health Tech Co Ltd The kit for screening colorectal cancer and advanced adenoma and its application
CN108660209B (zh) * 2018-05-23 2020-01-14 杭州诺辉健康科技有限公司 基于bmp3基因甲基化制备结直肠癌早期检测的产品
JP2022500087A (ja) * 2018-09-14 2022-01-04 元 篠崎 エピジェネティックマーカーを使用してせん妄危険性を検出するためのシステムおよび方法
CN115315529A (zh) * 2020-01-17 2022-11-08 小利兰·斯坦福大学董事会 用于诊断肝细胞癌的方法
CN112195243A (zh) * 2020-09-22 2021-01-08 北京华大吉比爱生物技术有限公司 一种检测多基因甲基化的试剂盒及其应用
EP4234720A1 (en) * 2022-02-25 2023-08-30 Consejo Superior de Investigaciones Cientificas Epigenetic biomarkers for the diagnosis of thyroid cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
WO1995011995A1 (en) * 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US6027880A (en) 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
JP2001524808A (ja) 1996-12-10 2001-12-04 ジーントレイス・システムズ・インコーポレイテッド 放出可能な不揮発性の質量標識分子
DE19754482A1 (de) * 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
DE19817948A1 (de) * 1998-04-17 1999-10-21 Metagen Gesellschaft Fuer Genomforschung Mbh Menschliche Nukleinsäuresequenzen aus Endometrium-Tumor
DE19853398C1 (de) * 1998-11-19 2000-03-16 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischer DNA
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben
JP2004507214A (ja) * 2000-03-15 2004-03-11 エピゲノミクス　アーゲー 腫瘍抑制遺伝子と腫瘍遺伝子に関連する疾患の診断

Also Published As

Publication number Publication date
EA007028B1 (ru) 2006-06-30
DK1423528T3 (da) 2008-05-13
US20110136687A1 (en) 2011-06-09
US20040234960A1 (en) 2004-11-25
CA2420840A1 (en) 2003-02-27
WO2002018632A2 (de) 2002-03-07
KR100870486B1 (ko) 2008-12-11
JP2004516821A (ja) 2004-06-10
MXPA03001834A (es) 2003-08-01
EP1942197A1 (de) 2008-07-09
EP1423528B1 (de) 2008-01-02
WO2002018632A3 (de) 2004-02-05
AU1218802A (en) 2002-03-13
AU2002212188B2 (en) 2008-02-28
US9719131B2 (en) 2017-08-01
IL154663A0 (en) 2003-09-17
DE50113454D1 (de) 2008-02-14
EP1423528A2 (de) 2004-06-02
IS6705A (is) 2003-01-31
KR20040015705A (ko) 2004-02-19
NZ524229A (en) 2006-01-27
EA200300330A1 (ru) 2004-06-24
IL154663A (en) 2009-12-24
ATE382711T1 (de) 2008-01-15
ES2299520T3 (es) 2008-06-01

Similar Documents

Publication Publication Date Title
IS2566B (is) Aðferð til að ákvarða stig metýleringar afmarkaðra sýtósína í genamengi DNA í raðasamhenginu 5'-CPG-3'
CN107849603B (zh) 利用有限核苷酸组成的引物扩增
CA2226542C (en) Glycosylase mediated detection of nucleotide sequences at candidate loci
US5744308A (en) Chimera oligonucleotide and its utilization for obtaining transcripts of a nucleic acid
US8673567B2 (en) Method and kit for nucleic acid sequence detection
EP1322782B1 (en) Method of nucleic acid typing or sequencing
CA2662837C (en) Methods and substances for isolation and detection of small polynucleotides
US7846693B2 (en) Nucleic acid detection assay
AU772002B2 (en) Method for relative quantification of methylation of cytosin-type bases in DNA samples
US20100209932A1 (en) MicroRNA and Messenger RNA Detection On Arrays
US20060211030A1 (en) Methods and compositions for assay readouts on multiple analytical platforms
NZ506333A (en) An assay for detecting and quantifying the presence of particular nucleic acid (DNA or RNA) sequences
US20020127575A1 (en) Partially double-stranded nucleic acids, methods of making, and use thereof
CN106574304B (zh) 基于链侵入的dna扩增方法
KR20100124705A (ko) 핵산 하이브리드화 방법
JP2003517303A (ja) 複合ｐｃｒ増幅の制御可能な実施方法
EP3027769A1 (en) Compositions and methods for bisulfite converted sequence capture
WO2002061124A3 (en) Analysis of methylation patterns in genomic dna using bisulfite treatment and fluorescence polarisation assay techniques
US20020031776A1 (en) Enzymatic labeling and detection of DNA hybridization probes
WO2002034937A2 (en) Methods for detection of differences in nucleic acids
AU2004270756B2 (en) Nucleic acid detection assay