IN2015DN01119A - - Google Patents

Info

Publication number
IN2015DN01119A
IN2015DN01119A IN1119DEN2015A IN2015DN01119A IN 2015DN01119 A IN2015DN01119 A IN 2015DN01119A IN 1119DEN2015 A IN1119DEN2015 A IN 1119DEN2015A IN 2015DN01119 A IN2015DN01119 A IN 2015DN01119A
Authority
IN
India
Prior art keywords
compounds
disclosed
methods
intermediates
synthesis
Prior art date
Application number
Other languages
English (en)
Inventor
Ende Christopher William Am
Michael Eric Green
Douglas Scott Johnson
Gregory Wayne Kauffman
Christopher John Odonnell
Nandini Chaturbhai Patel
Martin Youngjin Pettersson
Antonia Friederike Stepan
Cory Michael Stiff
Chakrapani Subramanyam
Tuan Phong Tran
Patrick Robert Verhoest
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IN2015DN01119A publication Critical patent/IN2015DN01119A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
IN1119DEN2015 2012-09-21 2013-09-06 IN2015DN01119A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261703969P 2012-09-21 2012-09-21
PCT/IB2013/058347 WO2014045156A1 (fr) 2012-09-21 2013-09-06 Nouvelles pyridinones bicycliques

Publications (1)

Publication Number Publication Date
IN2015DN01119A true IN2015DN01119A (fr) 2015-06-26

Family

ID=49585452

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1119DEN2015 IN2015DN01119A (fr) 2012-09-21 2013-09-06

Country Status (47)

Country Link
US (3) US8916564B2 (fr)
EP (1) EP2897956B1 (fr)
JP (1) JP5844018B2 (fr)
KR (1) KR101725696B1 (fr)
CN (1) CN104662021B (fr)
AP (1) AP2015008277A0 (fr)
AR (1) AR092628A1 (fr)
AU (1) AU2013319845B2 (fr)
BR (1) BR112015006436A2 (fr)
CA (1) CA2882386C (fr)
CL (1) CL2015000717A1 (fr)
CR (1) CR20150053A (fr)
CU (1) CU20150021A7 (fr)
CY (1) CY1118662T1 (fr)
DK (1) DK2897956T3 (fr)
DO (1) DOP2015000069A (fr)
EA (1) EA026668B1 (fr)
EC (1) ECSP15015594A (fr)
ES (1) ES2609987T3 (fr)
GE (1) GEP201706659B (fr)
GT (1) GT201500069A (fr)
HK (1) HK1206013A1 (fr)
HR (1) HRP20161558T1 (fr)
HU (1) HUE031248T2 (fr)
IL (1) IL237163A (fr)
IN (1) IN2015DN01119A (fr)
LT (1) LT2897956T (fr)
MA (1) MA37886B1 (fr)
MD (1) MD4583B1 (fr)
ME (1) ME02571B (fr)
MX (1) MX360599B (fr)
MY (1) MY181891A (fr)
NI (1) NI201500038A (fr)
NZ (1) NZ704863A (fr)
PE (1) PE20150686A1 (fr)
PH (1) PH12015500376B1 (fr)
PL (1) PL2897956T3 (fr)
PT (1) PT2897956T (fr)
RS (1) RS55426B1 (fr)
SG (1) SG11201501074WA (fr)
SI (1) SI2897956T1 (fr)
TN (1) TN2015000084A1 (fr)
TW (1) TWI500616B (fr)
UA (1) UA110688C2 (fr)
UY (1) UY35039A (fr)
WO (1) WO2014045156A1 (fr)
ZA (1) ZA201501195B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
EP2953949B1 (fr) 2012-12-20 2016-09-28 Janssen Pharmaceutica NV Nouveaux dérivés tricycliques 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione utilisés comme modulateurs de la gamma sécrétase
KR102171710B1 (ko) 2013-01-17 2020-10-30 얀센 파마슈티카 엔.브이. 감마 세크레타제 조절 인자로서의 신규 치환 피리도-피페라지논 유도체
WO2015049616A1 (fr) * 2013-10-04 2015-04-09 Pfizer Inc. Nouvelles pyridinones bicycliques utilisées comme modulateurs de gamma-sécrétase
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
BR112016022519A8 (pt) * 2014-04-01 2018-03-06 Pfizer cromeno e 1,1a,2,7b-tetra-hidrociclopropa[c]cromeno piridopirazinadionas como moduladores de gama-secretase
KR102000382B1 (ko) * 2015-02-03 2019-07-15 화이자 인코포레이티드 신규 시클로프로파벤조푸라닐 피리도피라진디온
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
CN109311876B (zh) 2016-06-16 2022-05-03 豪夫迈·罗氏有限公司 杂芳基***受体调节剂及其用途
US10925872B2 (en) 2016-12-16 2021-02-23 Pipeline Therapeutics, Inc. Methods of treating cochlear synaptopathy
BR112021006092A2 (pt) 2018-10-02 2021-07-20 Frequency Therapeutics, Inc. composições farmacêuticas que compreendem agentes terapêuticos óticos e métodos relacionados
MX2021012258A (es) 2019-04-08 2022-01-04 Frequency Therapeutics Inc Combinacion de chir99021 y acido valproico para tratar la perdida auditiva.
CR20220316A (es) 2019-12-06 2022-10-07 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio
CN113402490B (zh) * 2021-03-29 2023-01-03 白银京宇新药业有限公司 一种1,2,6,7-四氢-8H-茚并[5,4-b]呋喃-8-酮的制备方法
US11827627B2 (en) 2021-06-04 2023-11-28 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
CN114034792A (zh) * 2021-11-09 2022-02-11 山东新华制药股份有限公司 检测氯酮含量的液相色谱分析方法

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419788A (en) 1972-08-02 1975-12-31 Pfizer Herbicidal method using 2-trifuluromethyl-4-quinolinols
WO1992000075A1 (fr) 1990-06-29 1992-01-09 Pfizer Inc. Derives de pyridopyrazine utilises dans le traitement de l'abus et de la dependance de substances
ATE161530T1 (de) 1992-09-04 1998-01-15 Takeda Chemical Industries Ltd Kondensierte heterozyklische verbindungen, deren herstellung und verwendung
EP0683234B2 (fr) 1993-01-25 2007-06-06 Takeda Chemical Industries, Ltd. Anticorps dirige contre le beta-amyloide ou un derive de ce dernier et son utilisation
TW394773B (en) 1995-03-24 2000-06-21 Takeda Chemical Industries Ltd Cyclic compounds for antagonizing tachykinin receptor, substance p receptor and neurokinin a receptor, their production and pharmaceutical composition
DE19709877A1 (de) 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
US8173127B2 (en) 1997-04-09 2012-05-08 Intellect Neurosciences, Inc. Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
WO1998044955A1 (fr) 1997-04-09 1998-10-15 Mindset Ltd. Anticorps recombines specifiques contre les terminaisons beta-amyloide, codage par molecule d'adn, et leurs procedes d'utilisation
GB9722520D0 (en) 1997-10-24 1997-12-24 Pfizer Ltd Compounds
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6743427B1 (en) 1997-12-02 2004-06-01 Neuralab Limited Prevention and treatment of amyloidogenic disease
RU2209788C2 (ru) 1998-03-03 2003-08-10 Ппг Индастриз Огайо, Инк. Пропитанные стекловолоконные пряди и содержащие их изделия
US20020132817A1 (en) 1998-03-19 2002-09-19 Hideaki Natsugari Heterocyclic compounds, their production and use
EP1145714A4 (fr) 1998-11-27 2004-12-15 Takeda Chemical Industries Ltd Medicaments
CZ306683B6 (cs) 2000-02-24 2017-05-03 Washington University Léčivo pro prevenci nebo léčení preklinické nebo klinické Alzheimerovy nemoci
DE10045112A1 (de) 2000-09-11 2002-03-21 Merck Patent Gmbh Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
EP1335738A4 (fr) 2000-11-03 2004-09-08 Proteotech Inc Procedes d'isolement de composes inhibiteurs d'amyloide, et utilisation de composes utilises a partir d'uncaria tomentosa et de plantes parentes
US20040192898A1 (en) 2001-08-17 2004-09-30 Jia Audrey Yunhua Anti-abeta antibodies
US20030195205A1 (en) 2001-11-02 2003-10-16 Pfizer Inc. PDE9 inhibitors for treating cardiovascular disorders
DE10238724A1 (de) 2002-08-23 2004-03-04 Bayer Ag Alkyl-substituierte Pyrazolpyrimidine
DE10238723A1 (de) 2002-08-23 2004-03-11 Bayer Ag Phenyl-substituierte Pyrazolyprimidine
EP1549315A4 (fr) 2002-09-11 2007-05-23 Merck & Co Inc Composes de dihydroxypyridopyrazine-1,6-diones utiles en tant qu'inhibiteurs de l'integrase du vih
US20040146512A1 (en) 2002-10-09 2004-07-29 Arnon Rosenthal Methods of treating Alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof
EP1551809A1 (fr) 2002-10-09 2005-07-13 Pfizer Products Inc. Composes pyrazole pour le traitement de maladies neurodegeneratives
AU2003301439A1 (en) 2002-10-16 2004-05-04 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
US20040220186A1 (en) 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
EP1638935A1 (fr) 2003-06-19 2006-03-29 Pfizer Products Inc. Antagoniste de nk1
BRPI0413709A (pt) 2003-08-21 2006-10-17 Pfizer Prod Inc compostos para o tratamento de distúrbios neurodegenerativos
CA2538220A1 (fr) 2003-09-09 2005-03-24 Takeda Pharmaceutical Company Limited Utilisation d'un anticorps
GB0327319D0 (en) 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
JP2007519734A (ja) 2004-01-28 2007-07-19 メルク エンド カムパニー インコーポレーテッド アミノシクロペンチルピリドピラジノン系ケモカイン受容体活性調節剤
BRPI0507374A (pt) 2004-02-02 2007-07-10 Pfizer Prod Inc moduladores do receptor de histamina-3
AU2005227258A1 (en) 2004-03-09 2005-10-06 Merck & Co., Inc. HIV integrase inhibitors
AU2005225635B2 (en) 2004-03-23 2010-06-24 Pfizer Products Inc. Imidazole compounds for the treatment of neurodegenerative disorders
JP2007532665A (ja) 2004-04-14 2007-11-15 ギリアード サイエンシーズ, インコーポレイテッド Hivインテグラーゼ阻害剤化合物のホスホネート類似物
US7456164B2 (en) 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
EP1595881A1 (fr) 2004-05-12 2005-11-16 Pfizer Limited Dérivés de tetrahydronaphthyridine en tant que ligands de récepteur H3 d'histamine
US7807165B2 (en) 2004-07-30 2010-10-05 Rinat Neuroscience Corp. Antibodies directed against amyloid-beta peptide and methods using same
GB0423356D0 (en) 2004-10-21 2004-11-24 Merck Sharp & Dohme Therapeutic agents
FR2877015B1 (fr) 2004-10-21 2007-10-26 Commissariat Energie Atomique Revetement nanostructure et procede de revetement.
US20090074775A1 (en) 2004-12-22 2009-03-19 David Michael Holtzman Use Of Anti-AB Antibody To Treat Traumatic Brain Injury
MY148086A (en) 2005-04-29 2013-02-28 Rinat Neuroscience Corp Antibodies directed against amyloid-beta peptide and methods using same
WO2006121831A2 (fr) 2005-05-10 2006-11-16 Merck & Co., Inc. Inhibiteurs de l'intégrase du vih
ATE493413T1 (de) 2005-05-12 2011-01-15 Pfizer Wasserfreie kristalline formen von n-ä1,2- ethoxyethyl)-5-(n-ethyl-n-methylaminoü-7-(4- methylpyridin-2-yl-aminoü-1h-pyrazoloä4,3-
WO2006126083A1 (fr) 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Composes de pyridine [3 , 4-b] pyrazinones utilises comme inhibiteurs de pde-5
WO2006126081A2 (fr) 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [2,3-b] pyrazinones
WO2006126082A2 (fr) 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3,4-b] pyrazinones
JP2008543923A (ja) 2005-06-22 2008-12-04 ファイザー・プロダクツ・インク ヒスタミン−3受容体アンタゴニスト
US20070060534A1 (en) 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
US8158673B2 (en) 2005-10-27 2012-04-17 Pfizer Inc. Histamine-3 receptor antagonists
WO2007052124A1 (fr) 2005-11-04 2007-05-10 Pfizer Limited Dérivé de tétrahydronaphtyridine
WO2007062332A2 (fr) 2005-11-18 2007-05-31 Glaxo Group Limited Nouveaux intermédiaires et leur utilisation
JP2009515997A (ja) 2005-11-18 2009-04-16 タケダ サン ディエゴ インコーポレイテッド グルコキナーゼ活性剤
US20070117839A1 (en) 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
KR20080069221A (ko) 2005-11-24 2008-07-25 에자이 알앤드디 매니지먼트 가부시키가이샤 모르폴린 타입의 신나미드 화합물
WO2007063385A2 (fr) 2005-12-01 2007-06-07 Pfizer Products Inc. Antagonistes des recepteurs de l'histamine 3 pour des amines spirocycliques
WO2007069053A1 (fr) 2005-12-14 2007-06-21 Pfizer Products Inc. Antagonistes benzimidazoliques du récepteur h-3
KR20080095885A (ko) 2006-01-20 2008-10-29 쉐링 코포레이션 벤젠설포닐-크로만, 티오크로만, 테트라하이드로나프탈렌 및 관련된 감마 세크라타제 억제제
WO2007088462A1 (fr) 2006-02-01 2007-08-09 Pfizer Products Inc. Antagonistes du récepteur du h-3 à base de spirochromane
WO2007088450A2 (fr) 2006-02-01 2007-08-09 Pfizer Products Inc. Chromane antagoniste du récepteur h-3
WO2007099423A1 (fr) 2006-03-02 2007-09-07 Pfizer Products Inc. Dérivés de 1-pyrrolidine indane en tant qu'antagonistes du récepteur d'histamine 3
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
US20090163482A1 (en) 2006-03-13 2009-06-25 Mchardy Stanton Furst Tetralines antagonists of the h-3 receptor
MX2008012456A (es) 2006-04-21 2008-10-10 Pfizer Prod Inc Piridin[3,4-b]pirazinonas.
US7442808B2 (en) 2006-05-15 2008-10-28 Merck & Co., Inc. Antidiabetic bicyclic compounds
US8008287B2 (en) 2006-05-16 2011-08-30 Gilead Sciences, Inc. Integrase inhibitors
KR20090018963A (ko) 2006-05-19 2009-02-24 에자이 알앤드디 매니지먼트 가부시키가이샤 우레아계 신나미드 유도체
WO2007138431A2 (fr) 2006-05-30 2007-12-06 Pfizer Products Inc. Antagonistes de l'éther histamine-3 azabicyclique
JP4585610B2 (ja) 2007-01-22 2010-11-24 ファイザー・プロダクツ・インク 治療用化合物のトシル酸塩およびその医薬組成物
JP2010518083A (ja) 2007-02-12 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション ピペリジン誘導体
JP2010518064A (ja) 2007-02-12 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション Adおよび関連状態の治療のためのピペラジン誘導体
TW200848054A (en) 2007-02-28 2008-12-16 Eisai R&D Man Co Ltd Two cyclic oxomorpholine derivatives
WO2008137102A2 (fr) 2007-05-04 2008-11-13 Torreypines Therapeutics, Inc. Procédés de modulation de la bêta-amyloïde et composés utiles pour cette modulation
WO2008137139A1 (fr) 2007-05-07 2008-11-13 Schering Corporation Modulateurs de gamma sécrétase
RU2009140182A (ru) 2007-05-11 2011-06-20 Ф. Хоффманн-Ля Рош Аг (Ch) Гетариланилины в качестве модуляторов для бета-амилоида
TW200908968A (en) 2007-05-29 2009-03-01 Sgx Pharmaceuticals Inc Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators
WO2008153792A2 (fr) 2007-06-01 2008-12-18 Schering Corporation Modulateurs de sécrétase gamma
JP5495331B2 (ja) 2007-06-01 2014-05-21 メルク・シャープ・アンド・ドーム・コーポレーション γセクレターゼ修飾因子
WO2008156580A1 (fr) 2007-06-13 2008-12-24 Merck & Co., Inc. Dérivés du triazole destinés au traitement de la maladie d'alzheimer et d'états associés
WO2009005729A1 (fr) 2007-06-29 2009-01-08 Schering Corporation Modulateurs de la gamma-sécrétase
CA2695543A1 (fr) 2007-08-06 2009-02-12 Schering Corporation Modulateurs de la gamma-secretase
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
AR068121A1 (es) 2007-08-31 2009-11-04 Eisai R&D Man Co Ltd Compuestos multiciclicos para tratar enfermedades neurodegenerativas
CA2698341A1 (fr) 2007-09-06 2009-03-12 Schering Corporation Modulateurs de la gamma secretase
EP2205567A1 (fr) 2007-09-28 2010-07-14 Schering Corporation Modulateurs de gamma secrétase
GB0720444D0 (en) 2007-10-18 2007-11-28 Glaxo Group Ltd Novel compounds
CN101910178A (zh) 2007-11-05 2010-12-08 先灵公司 γ分泌酶调节剂
EP2229375A1 (fr) * 2007-12-06 2010-09-22 Schering Corporation Modulateurs de la gamma sécrétase
MX2010006378A (es) 2007-12-11 2010-09-07 Schering Corp Moduladores de gamma secretasa.
EP2268636A1 (fr) 2007-12-11 2011-01-05 Schering Corporation Modulateurs de la gamma sécrétase
CA2707492A1 (fr) 2007-12-13 2009-06-18 Amgen Inc. Modulateurs de la gamma-secretase
KR101244517B1 (ko) 2008-01-11 2013-03-18 에프. 호프만-라 로슈 아게 아밀로이드 베타에 대한 조절제
JP5328816B2 (ja) 2008-02-22 2013-10-30 エフ.ホフマン−ラ ロシュ アーゲー アミロイドβの調節薬
US20110027264A1 (en) 2008-02-29 2011-02-03 Xianhai Huang Gamma secretase modulators for the treatment of alzheimer's disease
US20100137320A1 (en) 2008-02-29 2010-06-03 Schering Corporation Gamma secretase modulators
JP2011520809A (ja) 2008-05-05 2011-07-21 アムジエン・インコーポレーテツド γセクレターゼモジュレーターとしての尿素化合物
FR2933700B1 (fr) * 2008-07-08 2010-07-30 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
TW201006801A (en) 2008-07-18 2010-02-16 Lilly Co Eli Imidazole carboxamides
US8685972B2 (en) 2008-08-13 2014-04-01 Merck Sharp & Dohme Corp. Pyrimidine derivatives for treatment of alzheimer's disease
US20110251172A1 (en) 2008-08-13 2011-10-13 Rivkin Alexey A Purine derivatives for treatment of alzheimer's disease
MX2011002002A (es) 2008-08-27 2011-03-29 Eisai R&D Man Co Ltd Proceso para preparar ciertos compuestos de cinnamida.
WO2010040661A1 (fr) 2008-10-09 2010-04-15 F. Hoffmann-La Roche Ag Modulateurs pour l'amyloïde bêta
JP2012507512A (ja) 2008-11-06 2012-03-29 アストラゼネカ・アクチエボラーグ アミロイドβのモジュレーター
CA2742602A1 (fr) 2008-11-06 2010-05-14 Schering Corporation Modulateurs de secretase gamma
US20110263529A1 (en) 2008-11-06 2011-10-27 Ruo Xu Gamma secretase modulators
JP5378532B2 (ja) 2008-11-10 2013-12-25 エフ.ホフマン−ラ ロシュ アーゲー 複素環γ−セクレターゼモジュレーター
US20110313001A1 (en) 2008-12-16 2011-12-22 Christian Fischer Triazole derivatives for treatment of alzheimer's disease
WO2010071741A1 (fr) 2008-12-16 2010-06-24 Merck Sharp & Dohme Corp. Dérivés du triazole pour traitement de la maladie d'alzheimer
PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
DK2379525T3 (en) 2008-12-19 2015-10-19 Boehringer Ingelheim Int Cyclic pyrimidin-4-carboxamides, as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD
TW201035103A (en) 2008-12-22 2010-10-01 Schering Corp Gamma secretase modulators
CA2747744A1 (fr) 2008-12-22 2010-07-01 Theodros Asberom Modulateurs de gamma secretase
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
ES2481715T3 (es) 2009-02-06 2014-07-31 Janssen Pharmaceuticals, Inc. Compuestos heterocíclicos bicíclicos sustituidos novedosos como moduladores de gamma-secretasa
TWI461425B (zh) * 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
JP2012051805A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd テトラヒドロトリアゾロピリジン誘導体の製造方法
AU2010218667A1 (en) 2009-02-26 2011-07-21 Eisai R&D Management Co., Ltd. Salt of tetrahydrotriazolopyridine derivative and crystal thereof
JP2012121809A (ja) 2009-02-26 2012-06-28 Eisai R & D Management Co Ltd 多環式化合物の製造法およびその中間体
JP2012051807A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
JP2012051806A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
CA2751534A1 (fr) 2009-03-03 2010-09-10 Pfizer Inc. Nouveaux phenyl imidazoles et phenyl triazoles en tant que modulateurs de la gamma secretase
IN2012DN00548A (fr) 2009-08-07 2015-06-12 Dow Agrosciences Llc
JP2013508350A (ja) * 2009-10-20 2013-03-07 ファイザー・インク ガンマ−セクレターゼモジュレーターとしての新規なヘテロアリールイミダゾールおよびヘテロアリールトリアゾール
RU2573569C2 (ru) * 2009-12-22 2016-01-20 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы фосфатидилинозитол-3-киназы на основе изоиндолинона
EP2691393B1 (fr) 2011-03-31 2016-09-14 Pfizer Inc Nouvelles pyridones bicycliques
US9181245B2 (en) * 2012-05-16 2015-11-10 Janssen Pharmaceuticals, Inc. Substituted pyrido[1,2-a]pyrazines and substituted pyrido[1,2-a][1,4]diazepines for the treatment of (inter alia) Alzheimer's disease
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
TWI614238B (zh) 2012-09-21 2018-02-11 必治妥美雅史谷比公司 雙(氟烷基)-1,4-苯并二氮呯酮化合物及其前藥
EP2953949B1 (fr) 2012-12-20 2016-09-28 Janssen Pharmaceutica NV Nouveaux dérivés tricycliques 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione utilisés comme modulateurs de la gamma sécrétase
KR102171710B1 (ko) 2013-01-17 2020-10-30 얀센 파마슈티카 엔.브이. 감마 세크레타제 조절 인자로서의 신규 치환 피리도-피페라지논 유도체
WO2015049616A1 (fr) 2013-10-04 2015-04-09 Pfizer Inc. Nouvelles pyridinones bicycliques utilisées comme modulateurs de gamma-sécrétase
EP3119347B1 (fr) 2014-03-21 2023-06-07 Align Technology, Inc. Appareil orthodontique segmenté doté d'élastiques
BR112016022519A8 (pt) 2014-04-01 2018-03-06 Pfizer cromeno e 1,1a,2,7b-tetra-hidrociclopropa[c]cromeno piridopirazinadionas como moduladores de gama-secretase

Also Published As

Publication number Publication date
AU2013319845B2 (en) 2017-09-14
TN2015000084A1 (fr) 2016-06-29
DK2897956T3 (en) 2017-01-16
AP2015008277A0 (en) 2015-02-28
LT2897956T (lt) 2017-01-10
HK1206013A1 (zh) 2015-12-31
ECSP15015594A (es) 2017-08-31
NI201500038A (es) 2015-06-05
US20160024088A1 (en) 2016-01-28
ME02571B (me) 2017-06-20
JP2015529238A (ja) 2015-10-05
CY1118662T1 (el) 2017-07-12
UY35039A (es) 2014-04-30
HRP20161558T1 (hr) 2016-12-30
KR20150044948A (ko) 2015-04-27
PE20150686A1 (es) 2015-05-23
MA37886A1 (fr) 2016-02-29
EA026668B1 (ru) 2017-05-31
DOP2015000069A (es) 2015-05-15
BR112015006436A2 (pt) 2017-07-04
CA2882386A1 (fr) 2014-03-27
MD4583B1 (ro) 2018-07-31
MX2015003637A (es) 2015-06-05
EA201590319A1 (ru) 2015-09-30
CL2015000717A1 (es) 2015-06-19
CR20150053A (es) 2015-03-25
US9751877B2 (en) 2017-09-05
CN104662021A (zh) 2015-05-27
KR101725696B1 (ko) 2017-04-10
AR092628A1 (es) 2015-04-29
IL237163A0 (en) 2015-04-30
CN104662021B (zh) 2016-08-24
TWI500616B (zh) 2015-09-21
PH12015500376A1 (en) 2015-04-20
MX360599B (es) 2018-11-08
MY181891A (en) 2021-01-12
CU20150021A7 (es) 2015-08-27
GEP201706659B (en) 2017-04-25
SG11201501074WA (en) 2015-05-28
PL2897956T3 (pl) 2017-05-31
EP2897956A1 (fr) 2015-07-29
UA110688C2 (uk) 2016-01-25
EP2897956B1 (fr) 2016-11-09
CA2882386C (fr) 2017-11-28
PH12015500376B1 (en) 2015-04-20
MA37886B1 (fr) 2016-09-30
US9193726B2 (en) 2015-11-24
PT2897956T (pt) 2017-01-13
TW201425311A (zh) 2014-07-01
IL237163A (en) 2016-12-29
HUE031248T2 (en) 2017-06-28
WO2014045156A1 (fr) 2014-03-27
AU2013319845A1 (en) 2015-02-26
SI2897956T1 (sl) 2017-02-28
US20150072990A1 (en) 2015-03-12
US8916564B2 (en) 2014-12-23
ZA201501195B (en) 2016-01-27
ES2609987T3 (es) 2017-04-25
GT201500069A (es) 2016-03-01
NZ704863A (en) 2017-03-31
RS55426B1 (sr) 2017-04-28
MD20150023A2 (ro) 2015-07-31
US20140088111A1 (en) 2014-03-27
JP5844018B2 (ja) 2016-01-13

Similar Documents

Publication Publication Date Title
IN2015DN01119A (fr)
IN2014MN02598A (fr)
PH12014501514A1 (en) New azetidine derivatives, pharmaceutical compositions and uses thereof
IN2015DN01156A (fr)
PH12014501542B1 (en) Substituted pyrrolidine -2- carboxamides
IN2014DN09434A (fr)
IN2014DN09352A (fr)
IN2012DN03182A (fr)
UA109010C2 (en) MORPHOLINOPYRIMIDINES AND THEIR APPLICATIONS IN THERAPY
MX345928B (es) Composiciones terapeuticamente activas y metodos de uso de las mismas.
IN2014DN09348A (fr)
MX2016006336A (es) Compuestos pirazolopirimidina.
MX343706B (es) Derivados heterocíclicos novedosos.
IN2014CN04530A (fr)
EA201390381A1 (ru) Триазиноксадиазолы
WO2014045162A8 (fr) Composés d'hexahydropyrano[3,4-d][1,3]thiazine-2-amine alkyl-substitués
EA201500298A1 (ru) Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы
MX2012013274A (es) Novedosos derivados de la pirimidina.
IN2015DN01151A (fr)
IN2014DN09347A (fr)
WO2012135615A3 (fr) Enopeptines, utilisations de celles-ci, et procédés de synthèse de celles-ci
GB201209587D0 (en) Therapeutic compounds
MX340574B (es) Imidazo pirazinas.
MX2013008340A (es) Novedosas 4-amino-n-hidroxi-benzamidas para el tratamiento de cancer.
IN2013DN02555A (fr)