IN2014DN09346A - - Google Patents

Info

Publication number
IN2014DN09346A
IN2014DN09346A IN9346DEN2014A IN2014DN09346A IN 2014DN09346 A IN2014DN09346 A IN 2014DN09346A IN 9346DEN2014 A IN9346DEN2014 A IN 9346DEN2014A IN 2014DN09346 A IN2014DN09346 A IN 2014DN09346A
Authority
IN
India
Prior art keywords
compounds
methods
general formula
provides novel
compositions including
Prior art date
Application number
Other languages
English (en)
Inventor
Daniel Hunziker
Patrizio Mattei
Harald Mauser
Marco Prunotto
Christoph Ullmer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IN2014DN09346A publication Critical patent/IN2014DN09346A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
IN9346DEN2014 2012-06-13 2013-06-10 IN2014DN09346A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12171839 2012-06-13
PCT/EP2013/061890 WO2013186159A1 (fr) 2012-06-13 2013-06-10 Nouveaux composés diazaspirocycloalcane et azaspirocycloalcane

Publications (1)

Publication Number Publication Date
IN2014DN09346A true IN2014DN09346A (fr) 2015-07-17

Family

ID=48692428

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9346DEN2014 IN2014DN09346A (fr) 2012-06-13 2013-06-10

Country Status (35)

Country Link
US (3) US9493486B2 (fr)
EP (1) EP2861566B1 (fr)
JP (1) JP6258928B2 (fr)
KR (1) KR20150023373A (fr)
CN (1) CN104364239B (fr)
AR (1) AR091416A1 (fr)
AU (1) AU2013276617B9 (fr)
BR (1) BR112014030473A2 (fr)
CA (1) CA2872213A1 (fr)
CL (1) CL2014003136A1 (fr)
CO (1) CO7121325A2 (fr)
CR (1) CR20140501A (fr)
CY (1) CY1118860T1 (fr)
DK (1) DK2861566T3 (fr)
EA (1) EA201492223A1 (fr)
ES (1) ES2618703T3 (fr)
HK (1) HK1202545A1 (fr)
HR (1) HRP20161774T1 (fr)
HU (1) HUE030526T2 (fr)
IL (1) IL235826A (fr)
IN (1) IN2014DN09346A (fr)
LT (1) LT2861566T (fr)
MA (1) MA37756B1 (fr)
MX (1) MX358310B (fr)
MY (1) MY180688A (fr)
NZ (1) NZ702334A (fr)
PE (1) PE20150230A1 (fr)
PH (1) PH12014502697A1 (fr)
PL (1) PL2861566T3 (fr)
PT (1) PT2861566T (fr)
RS (1) RS55717B1 (fr)
SG (1) SG11201407534PA (fr)
SI (1) SI2861566T1 (fr)
TW (1) TWI633087B (fr)
WO (1) WO2013186159A1 (fr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013276617B9 (en) 2012-06-13 2018-03-29 F. Hoffmann-La Roche Ag New diazaspirocycloalkane and azaspirocycloalkane
LT2900669T (lt) * 2012-09-25 2019-11-11 Hoffmann La Roche Heksahidropirol[3,4-c]pirolo dariniai ir susiję junginai kaip autotaksino (atx) inhibitoriai ir kaip lizofosfatidinės rūgšties (lpa) gamybos inhibitoriai, skirti gydyti pvz., inkstų ligas
JP6363616B2 (ja) 2012-12-19 2018-07-25 ノバルティス アーゲー オートタキシン阻害剤
US9409895B2 (en) 2012-12-19 2016-08-09 Novartis Ag Autotaxin inhibitors
AR095079A1 (es) * 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
US20160039825A1 (en) 2013-03-15 2016-02-11 Biogen Ma Inc. S1p and/or atx modulating agents
WO2015048567A1 (fr) * 2013-09-26 2015-04-02 Sanford-Burnham Medical Research Institute Modulateurs ebi2 spirocycliques
HUE055213T2 (hu) 2013-11-22 2021-11-29 Sabre Therapeutics Llc Autotaxin inhibitor vegyületek
MX2016005186A (es) * 2013-11-26 2016-07-08 Hoffmann La Roche Nuevo octahidro-ciclobuta[1,2-c;3,4-c']dipirrol-2-ilo.
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
WO2015140132A1 (fr) 2014-03-17 2015-09-24 Remynd Nv Composés de 2,7-diazaspiro[3.5]nonane
RS59477B1 (sr) * 2014-03-26 2019-12-31 Hoffmann La Roche Biciklička jedinjenja kao inhibitori proizvodnje autotaksina (atx) i lizofosfatidne kiseline (lpa)
EA032357B1 (ru) 2014-03-26 2019-05-31 Ф. Хоффманн-Ля Рош Аг Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
EA201691840A1 (ru) 2014-04-04 2017-03-31 Икс-Рикс, Инк. Замещенные спироциклические ингибиторы аутотаксина
TW201613917A (en) 2014-06-06 2016-04-16 Biogen Ma Inc ATX modulating agents
US9051320B1 (en) 2014-08-18 2015-06-09 Pharmakea, Inc. Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor
CN104530046B (zh) * 2014-12-10 2016-08-24 广东东阳光药业有限公司 二氮杂螺类化合物及其在药物中的应用
EA201791643A1 (ru) * 2015-01-20 2017-11-30 Новартис Аг Средства визуализации для пэт
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
CN106146483A (zh) * 2015-04-23 2016-11-23 上海迪诺医药科技有限公司 杂环类法尼酯衍生物x受体调节剂
MX2017015225A (es) 2015-05-27 2018-02-19 Pharmakea Inc Inhibidores de la autotaxina y sus usos.
US10118904B2 (en) 2015-06-05 2018-11-06 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of Demyelinating Diseases
EP3344619B1 (fr) 2015-09-04 2020-10-28 H. Hoffnabb-La Roche Ag Dérivés phénoxyméthyles
KR20180053408A (ko) 2015-09-24 2018-05-21 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서의 신규한 이환형 화합물
JP6846414B2 (ja) 2015-09-24 2021-03-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ａｔｘ阻害剤としての二環式化合物
JP6876685B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ａｔｘ阻害剤としての二環式化合物
CR20180057A (es) 2015-09-24 2018-04-02 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca.
RU2744988C2 (ru) 2016-06-14 2021-03-17 Новартис Аг Соединения и композиции для подавления активности shp2
WO2018106641A1 (fr) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles pour le traitement de maladies démyélinisantes
WO2018106643A1 (fr) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Azoles hétérocycliques pour le traitement de maladies de démyélinisation
WO2018106646A1 (fr) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles pour traiter des maladies démyélinisantes
CN108456208B (zh) * 2017-02-22 2021-04-16 广州市恒诺康医药科技有限公司 氮杂螺环类化合物及其制备方法和应用
KR20190129924A (ko) * 2017-03-16 2019-11-20 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물
EP3596060B1 (fr) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG Nouveaux composés bicycliques utilisés en tant qu'inhibiteurs d'atx
US10961242B2 (en) 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
KR101798840B1 (ko) 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
AU2018360575A1 (en) 2017-11-01 2020-06-18 Bristol-Myers Squibb Company Alkene spirocyclic compounds as farnesoid X receptor modulators
SG11202003827YA (en) 2017-11-01 2020-05-28 Bristol Myers Squibb Co Bridged bicyclic compounds as farnesoid x receptor modulators
US11370785B2 (en) 2017-11-01 2022-06-28 Bristol-Myers Squibb Company Multicyclic compounds as farnesoid X receptor modulators
WO2019089670A1 (fr) 2017-11-01 2019-05-09 Bristol-Myers Squibb Company Composés d'alcène utilisés en tant que modulateurs du récepteur farnésoïde x
TW201922737A (zh) 2017-11-01 2019-06-16 美商必治妥美雅史谷比公司 作為法尼醇x受體調節劑之螺環化合物
UY37957A (es) * 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
JP2021501785A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
WO2019147662A1 (fr) * 2018-01-23 2019-08-01 Bristol-Myers Squibb Company Composés 2,8-diacyle -2,8-diazaspiro [5,5] undécane utiles comme immunomodulateurs
JP2022513745A (ja) * 2018-12-11 2022-02-09 エフ．ホフマン－ラ ロシュ アーゲー アミノアジンアミド
WO2020119896A1 (fr) * 2018-12-11 2020-06-18 F. Hoffmann-La Roche Ag Inhibiteurs hétérocycliques d'atx
AR118050A1 (es) 2019-02-15 2021-09-15 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos como moduladores del receptor farnesoide x
JP2022116370A (ja) * 2019-06-13 2022-08-10 アグロカネショウ株式会社 新規な１－ベンジルアミン誘導体及びこれを有効成分とする農園芸用薬剤
TW202211917A (zh) * 2020-08-21 2022-04-01 南韓商治納輔醫藥科技有限公司 對***素e2受體具有抑制活性的新穎化合物及其用途
WO2022149010A1 (fr) * 2021-01-05 2022-07-14 Cadila Healthcare Limited Nouveaux inhibiteurs de l'autotaxine

Family Cites Families (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1252898B (de) * 1965-06-12 1967-10-26 Bayer Ag Verfahren zur Herstellung von Copolymerisaten des Trioxans
US5240928A (en) 1989-07-03 1993-08-31 Merck & Co., Inc. Substituted quinazolinones as angiotensin II antagonists
DE3930262A1 (de) * 1989-09-11 1991-03-21 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
CA2037630C (fr) 1990-03-07 2001-07-03 Akira Morimoto Composes heterocycliques renfermant de l'azote, methode de production et applications correspondantes
US5470975A (en) 1990-10-16 1995-11-28 E.R. Squibb & Sons, Inc. Dihydropyrimidine derivatives
US5290780A (en) 1991-01-30 1994-03-01 American Cyanamid Co. Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
US5238942A (en) 1991-05-10 1993-08-24 Merck & Co., Inc. Substituted quinazolinones bearing acidic functional groups as angiotensin ii antagonists
US5202322A (en) 1991-09-25 1993-04-13 Merck & Co., Inc. Quinazolinone and pyridopyrimidine a-II antagonists
US5532243A (en) 1992-02-14 1996-07-02 The Dupont Merck Pharmaceutical Company Antipsychotic nitrogen-containing bicyclic compounds
US5358951A (en) 1993-04-23 1994-10-25 American Cyanamid Company Angiotensin II receptor blocking 2, 3, 6 substituted quinazolinones
DE4407047A1 (de) 1994-03-03 1995-09-07 Merck Patent Gmbh Acetamide
US20010016657A1 (en) 1997-03-18 2001-08-23 Smithkline Beecham P.L.C. Substituted isoquinoline derivatives and their use as anticonvulsants
DE69922494T2 (de) * 1998-02-04 2005-05-25 Banyu Pharmaceutical Co., Ltd. Zyklische n-acylamin-derivate
JP2001039950A (ja) * 1999-07-30 2001-02-13 Banyu Pharmaceut Co Ltd Ｎ−アシル環状アミン誘導体
JP2003514777A (ja) * 1999-10-27 2003-04-22 シーオーアール セラピューティクス インコーポレイテッド フィブリノゲン依存性血小板凝集の阻害剤としてのピリジル含有スピロ環化合物
EP1368354A1 (fr) 2001-03-07 2003-12-10 Pfizer Products Inc. Modulateurs de l'activite du recepteur de la chimiokine
CA2481313A1 (fr) 2002-04-12 2003-10-23 Merck & Co., Inc. Amides bicycliques
GB0303852D0 (en) 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
WO2005023762A1 (fr) 2003-09-04 2005-03-17 Abbott Laboratories Derives de pyrrolidine-2-carbonitrile et leur utilisation comme inhibiteurs de la dipeptidyle peptidase-iv (dpp-iv)
SE0302811D0 (sv) * 2003-10-23 2003-10-23 Astrazeneca Ab Novel compounds
GB0324790D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Amide derivatives
US7226951B2 (en) 2003-12-17 2007-06-05 Allergan, Inc. Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same
US7435830B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
EP1761542B1 (fr) 2004-06-09 2008-01-02 F.Hoffmann-La Roche Ag Dérivés octahydropyrrolo[3,4-c]pyrrole et leur utilisation comme agents antiviraux
AU2005271161B2 (en) 2004-08-10 2011-05-12 Janssen Pharmaceutica N.V. HIV inhibiting 1,2,4-triazin-6-one derivatives
US7410949B2 (en) 2005-01-18 2008-08-12 Hoffmann-La Roche Inc. Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
CN101166736B (zh) 2005-04-28 2013-02-06 惠氏公司 他那普戈特的多晶型ⅱ
US7737279B2 (en) 2005-05-10 2010-06-15 Bristol-Myers Squibb Company 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same
TW200800999A (en) * 2005-09-06 2008-01-01 Astrazeneca Ab Novel compounds
ES2427989T3 (es) * 2005-10-28 2013-11-05 Ono Pharmaceutical Co., Ltd. Compuesto que contiene un grupo básico y uso del mismo
WO2007058322A1 (fr) * 2005-11-18 2007-05-24 Ono Pharmaceutical Co., Ltd. Composé contenant un groupe basique et son utilisation
US20070208001A1 (en) * 2006-03-03 2007-09-06 Jincong Zhuo Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
JP2008031064A (ja) 2006-07-27 2008-02-14 Astellas Pharma Inc ジアシルピペラジン誘導体
CA2663161C (fr) 2006-09-11 2014-10-28 N.V. Organon Derives d'acetamide de quinazolinone et d'isoqiinolinone
AR062790A1 (es) * 2006-09-15 2008-12-03 Schering Corp Derivados de azetidina utiles en el tratamiento del dolor, diabetes y trastornos del metabolismo de los lipidos
US8735411B2 (en) * 2006-10-02 2014-05-27 Abbvie Inc. Macrocyclic benzofused pyrimidine derivatives
WO2008059026A1 (fr) 2006-11-15 2008-05-22 High Point Pharmaceuticals, Llc Nouveaux 2-(2-hydroxyphényl)benzimidazoles utilisés pour traiter l'obésité et le diabète
TW200831085A (en) 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
EP1975165A1 (fr) 2007-03-27 2008-10-01 Boehringer Ingelheim Pharma GmbH & Co. KG Pyrrolidinamide substituée, sa fabrication et son utilisation en tant que médicament
WO2008119662A1 (fr) 2007-03-29 2008-10-09 F. Hoffmann-La Roche Ag Inhibiteurs non nucléosidiques de la transcriptase inverse
CL2008001002A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
ATE489389T1 (de) 2007-04-27 2010-12-15 Sanofi Aventis 2 -heteroaryl- pyrrolo ä3, 4-cüpyrrol- derivate und deren verwendung als scd inhibitoren
DE102007047737A1 (de) 2007-10-05 2009-04-30 Merck Patent Gmbh Piperidin- und Piperazinderivate
CN101873797A (zh) 2007-10-19 2010-10-27 萨可德公司 用于治疗糖尿病性视网膜病的组合物和方法
PE20091017A1 (es) 2007-10-31 2009-07-16 Janssen Pharmaceutica Nv Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa
JP2009161449A (ja) * 2007-12-28 2009-07-23 Lion Corp Ｐｐａｒ活性促進剤並びに美容用飲食品、皮膚外用剤及び医薬
EP2301936A1 (fr) * 2008-06-19 2011-03-30 Banyu Pharmaceutical Co., Ltd. Dérivé de spirodiamine-diarylcétoxime
US8673917B2 (en) 2008-09-09 2014-03-18 Sanofi 2-heteroaryl-pyrrolo [3,4-C]pyrrole derivatives, and use thereof as SCD inhibitors
TW201020247A (en) * 2008-11-06 2010-06-01 Gruenenthal Gmbh Substituierte disulfonamide
CN102216273A (zh) * 2008-11-17 2011-10-12 霍夫曼-拉罗奇有限公司 用作crth2拮抗剂或部分激动剂的萘乙酸
DE102008059578A1 (de) 2008-11-28 2010-06-10 Merck Patent Gmbh Benzo-Naphtyridin Verbindungen
JP5697601B2 (ja) 2008-12-01 2015-04-08 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 癌に対するオータキシン阻害剤としての２，５−ジアミノ−置換ピリド［４，３−ｄ］ピリミジン
TW201035102A (en) * 2009-03-04 2010-10-01 Gruenethal Gmbh Sulfonylated tetrahydroazolopyrazines and their use as medicinal products
TW201038572A (en) * 2009-03-25 2010-11-01 Gruenenthal Gmbh Substituted spiro-amide compounds
EA201101399A1 (ru) 2009-04-02 2012-08-30 Мерк Патент Гмбх Гетероциклические соединения в качестве ингибиторов аутотаксина
US8822476B2 (en) * 2009-04-02 2014-09-02 Merck Patent Gmbh Piperidine and piperazine derivatives as autotaxin inhibitors
SG174518A1 (en) 2009-04-02 2011-10-28 Merck Patent Gmbh Autotaxin inhibitors
FR2945534B1 (fr) 2009-05-12 2012-11-16 Sanofi Aventis DERIVES DE CYCLOPENTAL[c]PYRROLE-2-CARBOXYLATES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
WO2010135524A1 (fr) * 2009-05-22 2010-11-25 Exelixis, Inc. Inhibiteurs de pi3k/mtor à base de benzoxazépines pour lutter contre les maladies prolifératives
WO2010141817A1 (fr) * 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Modulateurs d'amide d'acide gras hydrolase de type diamine urée spirocyclique substituée par un groupe hétéroaryle
DE102009033392A1 (de) 2009-07-16 2011-01-20 Merck Patent Gmbh Heterocyclische Verbindungen als Autotaxin-Inhibitoren II
CN102574822A (zh) 2009-08-04 2012-07-11 阿米拉制药公司 作为溶血磷脂酸受体拮抗剂的化合物
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
AR079022A1 (es) 2009-11-02 2011-12-21 Sanofi Aventis Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion
MX2012007935A (es) 2010-01-07 2012-08-15 Du Pont Compuestos heterociclicos fungicidas.
WO2011115813A1 (fr) * 2010-03-18 2011-09-22 Abbott Laboratories Acétamides de lactame en tant que bloqueurs des canaux calciques
MX2012010772A (es) * 2010-03-19 2012-11-06 Pfizer Derivados de 2,3-dihidro-1h-inden-1-il-2,7-diazaspiro[3,5]nonano y su uso como antagonistas o agonistas inversos del receptor de grelina.
WO2011116867A1 (fr) 2010-03-26 2011-09-29 Merck Patent Gmbh Benzonaphthyridinamines en tant qu'inhibiteurs d'autotaxine
GB201008005D0 (en) 2010-05-13 2010-06-30 Sentinel Oncology Ltd Pharmaceutical compounds
EP2575794A2 (fr) 2010-06-04 2013-04-10 B.S.R.C. "Alexander Fleming" Modulation de la voie autotaxine et utilisations correspondantes
AR082590A1 (es) * 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
US9000025B2 (en) 2010-08-20 2015-04-07 Amira Pharmaceuticals, Inc. Autotaxin inhibitors and uses thereof
AU2011297961B2 (en) 2010-09-02 2015-07-02 Merck Patent Gmbh Pyrazolopyridinone derivatives as LPA receptor antagonists
US20140018540A1 (en) 2010-12-14 2014-01-16 Electrophoretics Limited Casein kinase 1delta (ck 1delta) inhibitors
WO2012166415A1 (fr) 2011-05-27 2012-12-06 Amira Pharmaceuticals, Inc. Inhibiteurs hétérocycliques d'autotaxine et leurs utilisations
EP2751118B1 (fr) * 2011-08-29 2016-10-12 Bristol-Myers Squibb Company Dérivés spiraniques de diamine bicyclique utilisés en tant qu'inhibiteurs de la fixation du vih
WO2013054185A1 (fr) 2011-10-13 2013-04-18 Pfizer, Inc. Dérivés de pyrimidine et de pyridine utiles en thérapie
JPWO2013065712A1 (ja) * 2011-10-31 2015-04-02 東レ株式会社 ジアザスピロウレア誘導体及びその医薬用途
US8809552B2 (en) * 2011-11-01 2014-08-19 Hoffmann-La Roche Inc. Azetidine compounds, compositions and methods of use
WO2013079223A1 (fr) 2011-12-02 2013-06-06 Phenex Pharmaceuticals Ag Pyrrolocarboxamides en tant que modulateurs de l'activité d'un récepteur orphelin gamma (rorϒ, nr1f3) apparenté au récepteur nucléaire orphelin rar et destinés au traitement de maladies inflammatoires chroniques et auto-immunes
TWI638802B (zh) 2012-05-24 2018-10-21 芬蘭商奧利安公司 兒茶酚ｏ－甲基轉移酶活性抑制化合物
IL289834B1 (en) 2012-06-13 2024-03-01 Incyte Holdings Corp Conversion of tricyclic compounds as FGFR inhibitors
AU2013276617B9 (en) 2012-06-13 2018-03-29 F. Hoffmann-La Roche Ag New diazaspirocycloalkane and azaspirocycloalkane
CN104684560B (zh) 2012-07-27 2018-08-17 比奥根艾迪克Ma公司 作为s1p调节剂和/或atx调节剂的化合物
WO2014018881A1 (fr) 2012-07-27 2014-01-30 Biogen Idec Ma Inc. Agents de modulation d'atx
LT2900669T (lt) 2012-09-25 2019-11-11 Hoffmann La Roche Heksahidropirol[3,4-c]pirolo dariniai ir susiję junginai kaip autotaksino (atx) inhibitoriai ir kaip lizofosfatidinės rūgšties (lpa) gamybos inhibitoriai, skirti gydyti pvz., inkstų ligas
PT2900269T (pt) 2012-09-25 2018-10-22 Bayer Pharma AG Combinação de regorafenib e ácido acetilsalicílico para o tratamento de cancro colorretal
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
FR2996608A1 (fr) 2012-10-05 2014-04-11 Turbomeca Couvercle de compresseur centrifuge, assemblage de couvercle et de compresseur centrifuge, et turbomachine comportant un tel assemblage
NZ705881A (en) 2012-10-25 2018-04-27 Tetra Discovery Partners Llc Heteroaryl inhibitors of pde4
US20160002247A1 (en) 2013-03-01 2016-01-07 The University Of Tokyo 8-substituted imidazopyrimidinone derivative having autotaxin inhibitory activity
TWI593692B (zh) 2013-03-12 2017-08-01 美國禮來大藥廠 四氫吡咯并噻嗪化合物
EP2970330B1 (fr) 2013-03-12 2019-04-17 AbbVie Inc. Inhibiteurs de bromodomaines tétracycliques
EP2970099A4 (fr) 2013-03-12 2016-12-21 Acucela Inc Dérivés de 3-phénylpropylamine substitués pour le traitement des maladies et des troubles ophtalmiques
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
US20160039825A1 (en) 2013-03-15 2016-02-11 Biogen Ma Inc. S1p and/or atx modulating agents
WO2015008230A1 (fr) 2013-07-18 2015-01-22 Novartis Ag Inhibiteurs de l'autotaxine contenant un noyau à cycle benzyle-amide cyclique hétéroaromatique
CN105636958B (zh) 2013-10-17 2018-01-05 沃泰克斯药物股份有限公司 Dna‑pk抑制剂
HUE055213T2 (hu) 2013-11-22 2021-11-29 Sabre Therapeutics Llc Autotaxin inhibitor vegyületek
MX2016005186A (es) 2013-11-26 2016-07-08 Hoffmann La Roche Nuevo octahidro-ciclobuta[1,2-c;3,4-c']dipirrol-2-ilo.
AR098475A1 (es) 2013-11-26 2016-06-01 Bayer Cropscience Ag Compuestos pesticidas y usos
RS59477B1 (sr) 2014-03-26 2019-12-31 Hoffmann La Roche Biciklička jedinjenja kao inhibitori proizvodnje autotaksina (atx) i lizofosfatidne kiseline (lpa)
EA032357B1 (ru) 2014-03-26 2019-05-31 Ф. Хоффманн-Ля Рош Аг Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
CN106132935A (zh) 2014-03-26 2016-11-16 巴斯夫欧洲公司 作为杀真菌剂的取代的[1,2,4]***和咪唑化合物
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
EA201691840A1 (ru) 2014-04-04 2017-03-31 Икс-Рикс, Инк. Замещенные спироциклические ингибиторы аутотаксина
CN107074852B (zh) 2014-10-14 2019-08-16 生命医药有限责任公司 ROR-γ的二氢吡咯并吡啶抑制剂
EP3256463B1 (fr) 2015-02-15 2019-10-09 F. Hoffmann-La Roche AG Dérivés de 1-(het)arylsulfonyl-(pyrrolidine ou piperidine)-2-carboxamide et leur utilisation en tant qu'antagonistes de trpa1
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
CN104927727B (zh) 2015-07-06 2017-01-11 香山红叶建设有限公司 一种玻璃幕墙用结构密封胶及其制备方法
PL415078A1 (pl) 2015-09-04 2017-03-13 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków
EP3344619B1 (fr) 2015-09-04 2020-10-28 H. Hoffnabb-La Roche Ag Dérivés phénoxyméthyles
JP6876685B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ａｔｘ阻害剤としての二環式化合物
CR20180057A (es) 2015-09-24 2018-04-02 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca.
KR20180053408A (ko) 2015-09-24 2018-05-21 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서의 신규한 이환형 화합물
JP6846414B2 (ja) 2015-09-24 2021-03-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ａｔｘ阻害剤としての二環式化合物
BR112018009798A8 (pt) 2015-11-25 2019-02-26 Dana Farber Cancer Inst Inc inibidores de bromodomínio bivalentes e usos dos mesmos
JP6577051B2 (ja) 2015-12-01 2019-09-18 日本農薬株式会社 ３ｈ‐ピロロピリジン化合物若しくはそのｎ‐オキサイド、又はそれらの塩類及び該化合物を含有する農園芸用殺虫剤並びにその使用方法
WO2017139978A1 (fr) 2016-02-19 2017-08-24 吴伟东 Procédé et système d'actualisation d'application de téléphone mobile
EP3596060B1 (fr) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG Nouveaux composés bicycliques utilisés en tant qu'inhibiteurs d'atx
KR20190129924A (ko) 2017-03-16 2019-11-20 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물
ES2747768T3 (es) 2017-03-20 2020-03-11 Forma Therapeutics Inc Composiciones de pirrolopirrol como activadores de quinasa de piruvato (PKR)

Also Published As

Publication number Publication date
CL2014003136A1 (es) 2015-02-27
MA37756A1 (fr) 2018-01-31
PL2861566T3 (pl) 2017-06-30
EP2861566B1 (fr) 2016-12-21
DK2861566T3 (en) 2017-02-27
MX358310B (es) 2018-08-14
MY180688A (en) 2020-12-07
CA2872213A1 (fr) 2013-12-19
PE20150230A1 (es) 2015-02-06
PH12014502697B1 (en) 2015-01-26
MX2014015049A (es) 2015-03-03
AU2013276617A1 (en) 2014-11-20
TWI633087B (zh) 2018-08-21
US9493486B2 (en) 2016-11-15
HK1202545A1 (en) 2015-10-02
SI2861566T1 (sl) 2017-03-31
AU2013276617B2 (en) 2017-12-14
US20150099734A1 (en) 2015-04-09
ES2618703T3 (es) 2017-06-22
AU2013276617B9 (en) 2018-03-29
PT2861566T (pt) 2017-02-08
JP2015519380A (ja) 2015-07-09
AR091416A1 (es) 2015-02-04
RS55717B1 (sr) 2017-07-31
EP2861566A1 (fr) 2015-04-22
IL235826A (en) 2017-07-31
HUE030526T2 (en) 2017-05-29
CY1118860T1 (el) 2018-01-10
KR20150023373A (ko) 2015-03-05
NZ702334A (en) 2016-11-25
JP6258928B2 (ja) 2018-01-10
TW201402545A (zh) 2014-01-16
SG11201407534PA (en) 2014-12-30
EA201492223A1 (ru) 2015-03-31
PH12014502697A1 (en) 2015-01-26
CR20140501A (es) 2014-12-02
WO2013186159A1 (fr) 2013-12-19
CN104364239A (zh) 2015-02-18
BR112014030473A2 (pt) 2017-06-27
MA37756B1 (fr) 2018-09-28
IL235826A0 (en) 2015-02-01
US10633384B2 (en) 2020-04-28
CN104364239B (zh) 2017-08-25
US20170029425A1 (en) 2017-02-02
HRP20161774T1 (hr) 2017-02-24
US20200207769A1 (en) 2020-07-02
CO7121325A2 (es) 2014-11-20
LT2861566T (lt) 2017-02-10

Similar Documents

Publication Publication Date Title
PH12014502697B1 (en) New diazaspirocycloalkane and azaspirocycloalkane
IN2015DN00960A (fr)
PH12016501192A1 (en) Tetrahydropyridopyrazines modulators of gpr6
MX358376B (es) Nuevos derivados dihidroquinolina-2-ona.
PH12016500643A1 (en) New octahydro - cyclobuta [1,2-c;3,4-c`] dipyrrol -2- yl
PH12014501179B1 (en) New bicyclic dihydroisoquinoline-1-one derivatives
MX2018001890A (es) Compuestos biciclicos como inhibidores de autotaxina (atx).
MY169267A (en) New aryl-quinoline derivatives
MX2014014531A (es) Derivados de aminoquinazolina y piridopirimidina.
MX341456B (es) Amino-quinolinas como inhibidores de cinasa.
EA201590887A1 (ru) Композиция
MX2015007097A (es) Nuevas fenil-piridinas/pirazinas bi-anulares para el tratamiento de cancer.
MX2015001099A (es) Nuevos derivados biciclicos de piridina.
MX2012008141A (es) Compuestos y metodos.
MX2015016332A (es) Inhibidores de alk biciclicos fusionados.
MX2015014470A (es) Analogos de combretastatina.
MX2013009388A (es) Nuevos compuestos de azaespirodecanona como inhibidores de lipasa sensible a hormonas (hsl).
MX2013009386A (es) Nuevos compuestos de azaespirodecanona.
MX346980B (es) Nuevos compuestos de hexahidrociclopentapirrolona, hexahidropirrolopirrolona, octahidropirrolopiridinona y octahidropiridinona.
MX2013013021A (es) Nuevos compuestos de hexahidropirroloimidazolona.
MX2015009377A (es) Compuestos radiomarcados.
MX2014008856A (es) Derivados de imidazolilcetona como inhibidores de aldosterona sintasa.
PH12018500406A1 (en) Bicyclic compounds as atx inhibitors
IN2013DE03592A (fr)