IN2012DN00801A - - Google Patents

Download PDF

Info

Publication number: IN2012DN00801A
Authority: IN; India
Prior art keywords: adamts; expression; methods; useful; proteins
Prior art date: 2009-07-31

Application number

Other languages

English (en)

Inventor

Grillberger Leopold

Spenger Alexandra

Hasslacher Meinhard

Grillberger Rana

Reiter Manfred

Original Assignee

Baxter Int

Baxter Healthcare Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-07-31

Filing date

2010-07-30

Publication date

2015-06-26

2010-07-30 Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int

2015-06-26 Publication of IN2012DN00801A publication Critical patent/IN2012DN00801A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/22—Zinc; Zn chelators
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/95—Protein-free medium and culture conditions
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/99—Serum-free medium
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)

IN801DEN2012 2009-07-31 2010-07-30 IN2012DN00801A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US23047709P	2009-07-31	2009-07-31
PCT/US2010/044020 WO2011014838A1 (en)	2009-07-31	2010-07-30	Cell culture medium for adamts protein expression

Publications (1)

Publication Number	Publication Date
IN2012DN00801A true IN2012DN00801A (pt)	2015-06-26

Family

ID=42668009

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN801DEN2012 IN2012DN00801A (pt)	2009-07-31	2010-07-30

Country Status (22)

Country	Link
US (7)	US8313926B2 (pt)
EP (1)	EP2459702B1 (pt)
JP (5)	JP5451884B2 (pt)
KR (5)	KR101756354B1 (pt)
CN (2)	CN104962539B (pt)
AU (1)	AU2010278751B2 (pt)
BR (2)	BR112012002151B1 (pt)
CA (1)	CA2769361A1 (pt)
CO (1)	CO6501191A2 (pt)
EA (1)	EA023193B1 (pt)
ES (1)	ES2583258T3 (pt)
HK (1)	HK1171790A1 (pt)
HR (1)	HRP20160783T1 (pt)
HU (1)	HUE029110T2 (pt)
IN (1)	IN2012DN00801A (pt)
MX (2)	MX2012001261A (pt)
NZ (1)	NZ597727A (pt)
PL (1)	PL2459702T3 (pt)
PT (1)	PT2459702T (pt)
SG (1)	SG178194A1 (pt)
SI (1)	SI2459702T1 (pt)
WO (1)	WO2011014838A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5451884B2 (ja) *	2009-07-31	2014-03-26	バクスター・インターナショナル・インコーポレイテッド	Ａｄａｍｔｓタンパク質発現のための細胞培養培地
CN103097522A (zh) *	2010-07-08	2013-05-08	巴克斯特国际公司	在细胞培养物中生产重组adamts13的方法
WO2013006479A2 (en)	2011-07-01	2013-01-10	Amgen Inc.	Mammalian cell culture
ES2633960T3 (es)	2012-10-15	2017-09-26	Bristol-Myers Squibb Company	Procesos de cultivo de células de mamífero para la producción de proteínas
WO2014159831A1 (en)	2013-03-13	2014-10-02	Merck Sharp & Dohme Corp.	Adapted lepidopteran insect cells for the production of recombinant proteins
US9217168B2 (en)	2013-03-14	2015-12-22	Momenta Pharmaceuticals, Inc.	Methods of cell culture
AR095196A1 (es) *	2013-03-15	2015-09-30	Regeneron Pharma	Medio de cultivo celular libre de suero
WO2015055324A1 (en) *	2013-10-14	2015-04-23	Ares Trading S.A	New medium for high performance mammalian fed-batch cultures
JP6695814B2 (ja)	2014-06-04	2020-05-20	アムジエン・インコーポレーテツド	哺乳類細胞培養物を回収するための方法
KR101867134B1 (ko) *	2015-03-23	2018-06-12	한양대학교 산학협력단	포유류 세포를 이용하여 목적 물질을 고효율로 생산하기 위한 세포 배양 배지, 이를 이용한 세포 배양 방법 및 목적 물질의 생산 방법
BR112017024579A2 (pt) *	2015-05-22	2018-07-31	Dupont Nutrition Biosci Aps	acetolactato descarboxilase
TW202340452A (zh)	2015-08-04	2023-10-16	美商再生元醫藥公司	補充牛磺酸之細胞培養基及用法
EP3493830A1 (en)	2016-08-04	2019-06-12	Baxalta Incorporated	Use of adamts13 for treating, ameliorating and/or preventing vaso-occlusive crisis in sickle cell disease, acute lung injury and/or acute respiratory distress syndrome
FI3535388T3 (fi) *	2016-11-04	2023-06-14	Takeda Pharmaceuticals Co	Adeno-assosioituneen viruksen puhdistusmenetelmiä
CN110914293A (zh) *	2017-07-06	2020-03-24	里珍纳龙药品有限公司	用于制备糖蛋白的细胞培养工艺
US11391725B2 (en) *	2018-03-16	2022-07-19	Genzyme Corporation	Methods for improving cell viability in a production bioreactor
EP3807408A4 (en) *	2018-06-18	2022-03-30	Synthetic Biologics, Inc.	METHODS OF MAKING ALKALINE PHOSPHATASE AGENTS
IL302538A (en)	2019-12-06	2023-07-01	Regeneron Pharma	Anti-VEGF protein preparations and methods for their production
CN115836126A (zh)	2020-04-02	2023-03-21	武田药品工业株式会社	Adamts13变体、组合物及其用途
CN115835904A (zh)	2020-05-22	2023-03-21	武田药品工业有限公司	用于治疗和诊断冠状病毒疾病并发症的adamts13组合物和方法
WO2021246557A1 (ko) *	2020-06-05	2021-12-09	주식회사 프로앱텍	특정한 갯수의 알부민이 연결된 요산산화효소-알부민 복합체 및 이의 제조 방법
CN111808822B (zh) *	2020-07-02	2024-01-12	北京百普赛斯生物科技股份有限公司	细胞培养用补料液及提高重组hek293细胞蛋白表达量的方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4797368A (en)	1985-03-15	1989-01-10	The United States Of America As Represented By The Department Of Health And Human Services	Adeno-associated virus as eukaryotic expression vector
US5139941A (en)	1985-10-31	1992-08-18	University Of Florida Research Foundation, Inc.	AAV transduction vectors
US5250421A (en)	1986-01-03	1993-10-05	Genetics Institute, Inc.	Method for producing factor VIII:C-type proteins
JPH0753104B2 (ja) *	1989-02-28	1995-06-07	秀明山田	細菌の培養法
CZ280901B6 (cs)	1988-10-06	1996-05-15	Hideaki Yamada	Způsob kultivace bakterií
GB9022545D0 (en)	1990-10-17	1990-11-28	Wellcome Found	Culture medium
EP1213030B1 (en)	1994-11-10	2009-04-22	Baxter Healthcare SA	Method for producing biologicals in protein-free culture
CA2211630A1 (en)	1995-02-23	1996-08-29	Quest International B.V.	Peptides for tissue and cell culture media
US6013516A (en)	1995-10-06	2000-01-11	The Salk Institute For Biological Studies	Vector and method of use for nucleic acid delivery to non-dividing cells
EP2243827B2 (en)	1996-08-30	2017-11-22	Life Technologies Corporation	Serum-free mammalian cell culture medium, and uses thereof
IT1285158B1 (it)	1996-09-17	1998-06-03	Angeletti P Ist Richerche Bio	Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il
UA59375C2 (uk)	1996-10-07	2003-09-15	Солюшіа Інк.	Суміш для гідроксилювання, спосіб гідроксилювання ароматичних сполук та спосіб одержання фенолу
AU4751697A (en)	1996-10-10	1998-05-05	Douglas Danner	Animal cell culture media comprising plant-derived nutrients
US5804420A (en)	1997-04-18	1998-09-08	Bayer Corporation	Preparation of recombinant Factor VIII in a protein free medium
US6475725B1 (en)	1997-06-20	2002-11-05	Baxter Aktiengesellschaft	Recombinant cell clones having increased stability and methods of making and using the same
AT407255B (de)	1997-06-20	2001-02-26	Immuno Ag	Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US5994136A (en)	1997-12-12	1999-11-30	Cell Genesys, Inc.	Method and means for producing high titer, safe, recombinant lentivirus vectors
US6406909B1 (en)	1998-07-10	2002-06-18	Chugai Seiyaku Kabushiki Kaisha	Serum-free medium for culturing animal cells
AT409379B (de)	1999-06-02	2002-07-25	Baxter Ag	Medium zur protein- und serumfreien kultivierung von zellen
US6926894B2 (en) *	2000-11-22	2005-08-09	Baxter Aktiengesellschaft	Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
US7670839B2 (en)	2002-12-23	2010-03-02	Fuji Film Manufacturing Europe B.V.	Process for coating cell-culture support
AU2005248299A1 (en) *	2004-04-16	2005-12-08	Wyeth	ADAMTS-8 proteins and uses thereof
US20060094104A1 (en)	2004-10-29	2006-05-04	Leopold Grillberger	Animal protein-free media for cultivation of cells
JP2007174948A (ja) *	2005-12-27	2007-07-12	Noritsu Koki Co Ltd	酵素水製造装置
JP4880997B2 (ja) *	2005-12-28	2012-02-22	アルフレッサファーマ株式会社	Ａｄａｍｔｓ１３の安定化方法
ES2474573T3 (es)	2006-01-04	2014-07-09	Baxter International Inc	Medio de cultivo celular sin oligop�ptidos
BRPI0622214A2 (pt) *	2006-12-22	2012-01-03	Springer Carrier Ltda	unidade de condicionamento de ar e mÉtodo de misturar ar em uma unidade de condicionamento de ar
US20090067805A1 (en)	2007-09-10	2009-03-12	Victor Company Of Japan, Limited	Recording and reproducing device
EP2574676B1 (en) *	2007-12-27	2017-08-30	Baxalta GmbH	Cell culture processes
JP5451884B2 (ja) *	2009-07-31	2014-03-26	バクスター・インターナショナル・インコーポレイテッド	Ａｄａｍｔｓタンパク質発現のための細胞培養培地

2010
- 2010-07-30 JP JP2012523110A patent/JP5451884B2/ja active Active
- 2010-07-30 BR BR112012002151-6A patent/BR112012002151B1/pt active IP Right Grant
- 2010-07-30 EP EP10740810.6A patent/EP2459702B1/en active Active
- 2010-07-30 KR KR1020157033595A patent/KR101756354B1/ko active IP Right Grant
- 2010-07-30 CA CA2769361A patent/CA2769361A1/en not_active Abandoned
- 2010-07-30 IN IN801DEN2012 patent/IN2012DN00801A/en unknown
- 2010-07-30 HU HUE10740810A patent/HUE029110T2/en unknown
- 2010-07-30 PL PL10740810.6T patent/PL2459702T3/pl unknown
- 2010-07-30 CN CN201510186244.8A patent/CN104962539B/zh active Active
- 2010-07-30 ES ES10740810.6T patent/ES2583258T3/es active Active
- 2010-07-30 AU AU2010278751A patent/AU2010278751B2/en active Active
- 2010-07-30 MX MX2012001261A patent/MX2012001261A/es active IP Right Grant
- 2010-07-30 US US12/847,999 patent/US8313926B2/en active Active
- 2010-07-30 WO PCT/US2010/044020 patent/WO2011014838A1/en active Application Filing
- 2010-07-30 KR KR1020157009715A patent/KR101574056B1/ko active IP Right Grant
- 2010-07-30 NZ NZ597727A patent/NZ597727A/xx unknown
- 2010-07-30 CN CN201080042028.1A patent/CN102549145B/zh active Active
- 2010-07-30 KR KR1020177018298A patent/KR101808496B1/ko active IP Right Grant
- 2010-07-30 KR KR1020177035177A patent/KR101912552B1/ko active IP Right Grant
- 2010-07-30 EA EA201270224A patent/EA023193B1/ru not_active IP Right Cessation
- 2010-07-30 KR KR1020127005425A patent/KR101573972B1/ko active IP Right Grant
- 2010-07-30 BR BR122021005965-9A patent/BR122021005965B1/pt active IP Right Grant
- 2010-07-30 PT PT107408106T patent/PT2459702T/pt unknown
- 2010-07-30 SI SI201031238A patent/SI2459702T1/sl unknown
- 2010-07-30 SG SG2012006839A patent/SG178194A1/en unknown
2012
- 2012-01-27 MX MX2013009470A patent/MX344970B/es unknown
- 2012-02-27 CO CO12033821A patent/CO6501191A2/es unknown
- 2012-09-19 US US13/622,939 patent/US8759026B2/en active Active
- 2012-12-06 HK HK12112610.1A patent/HK1171790A1/zh unknown
2014
- 2014-05-13 US US14/276,819 patent/US9127265B2/en active Active
2015
- 2015-07-23 US US14/807,745 patent/US9441216B2/en active Active
2016
- 2016-05-06 JP JP2016093240A patent/JP6511007B2/ja active Active
- 2016-07-04 HR HRP20160783TT patent/HRP20160783T1/hr unknown
- 2016-08-09 US US15/232,626 patent/US10072254B2/en active Active
2018
- 2018-01-26 JP JP2018011373A patent/JP6567707B2/ja active Active
- 2018-09-08 US US16/125,688 patent/US10724024B2/en active Active
2019
- 2019-07-31 JP JP2019141485A patent/JP6883071B2/ja active Active
2020
- 2020-06-16 US US16/903,185 patent/US11254921B2/en active Active
2021
- 2021-05-07 JP JP2021079239A patent/JP7083059B2/ja active Active

Also Published As

Publication number	Publication date
US10072254B2 (en)	2018-09-11
JP2021112210A (ja)	2021-08-05
EA023193B1 (ru)	2016-05-31
HUE029110T2 (en)	2017-02-28
JP5936232B2 (ja)	2016-06-22
AU2010278751B2 (en)	2014-05-15
JP2018093881A (ja)	2018-06-21
JP6511007B2 (ja)	2019-05-08
EA201270224A1 (ru)	2012-09-28
US8313926B2 (en)	2012-11-20
US20130071906A1 (en)	2013-03-21
KR20120046301A (ko)	2012-05-09
BR112012002151A2 (pt)	2020-03-03
EP2459702B1 (en)	2016-05-04
CN104962539A (zh)	2015-10-07
HRP20160783T1 (hr)	2016-08-12
ES2583258T3 (es)	2016-09-20
KR20170081747A (ko)	2017-07-12
US20190071660A1 (en)	2019-03-07
US20140329294A1 (en)	2014-11-06
SG178194A1 (en)	2012-03-29
US11254921B2 (en)	2022-02-22
HK1171790A1 (zh)	2013-04-05
JP2013500724A (ja)	2013-01-10
PT2459702T (pt)	2016-08-02
JP2016144471A (ja)	2016-08-12
AU2010278751A1 (en)	2012-02-09
KR101574056B1 (ko)	2015-12-02
JP6567707B2 (ja)	2019-08-28
CO6501191A2 (es)	2012-08-15
NZ597727A (en)	2013-08-30
EP2459702A1 (en)	2012-06-06
BR112012002151B1 (pt)	2021-07-06
JP7083059B2 (ja)	2022-06-09
KR101912552B1 (ko)	2018-10-26
KR101808496B1 (ko)	2017-12-12
US20110086413A1 (en)	2011-04-14
US20150329848A1 (en)	2015-11-19
JP5451884B2 (ja)	2014-03-26
JP2019201661A (ja)	2019-11-28
US20170051270A1 (en)	2017-02-23
US9441216B2 (en)	2016-09-13
WO2011014838A1 (en)	2011-02-03
BR122021005965B1 (pt)	2022-01-25
MX344970B (es)	2017-01-12
CA2769361A1 (en)	2011-02-03
JP6883071B2 (ja)	2021-06-09
US8759026B2 (en)	2014-06-24
US20200308566A1 (en)	2020-10-01
KR101756354B1 (ko)	2017-07-26
PL2459702T3 (pl)	2016-12-30
JP2014061005A (ja)	2014-04-10
MX2012001261A (es)	2012-05-22
KR20170140411A (ko)	2017-12-20
CN102549145B (zh)	2015-05-20
US9127265B2 (en)	2015-09-08
KR20150138425A (ko)	2015-12-09
SI2459702T1 (sl)	2016-11-30
US10724024B2 (en)	2020-07-28
KR101573972B1 (ko)	2015-12-02
CN104962539B (zh)	2019-09-17
CN102549145A (zh)	2012-07-04
KR20150044981A (ko)	2015-04-27

Publication	Publication Date	Title
IN2012DN00801A (pt)	2015-06-26
MX2010000348A (es)	2010-04-12	Cultivo de celulas madre pluripotentes individuales.
MX2013003681A (es)	2013-11-20	Ácidos nucleicos manipulados y métodos de uso de los mismos.
IN2012DN03825A (pt)	2015-08-28
SG10201405377XA (en)	2014-12-30	Compositions and methods for antibodies targeting complement protein c5
MX2018016021A (es)	2020-09-02	Composiciones y metodos que comprenden variante de enzima lipolitica.
MX339402B (es)	2016-05-25	Composiciones y metodos que comprenden variantes de serina proteasa.
EA201200091A1 (ru)	2012-07-30	Штаммы talaromyces и ферментные композиции
WO2010129294A3 (en)	2011-04-21	Small molecules supporting pluripotent cell growth and methods thereof
WO2010141801A3 (en)	2011-03-31	Reprogramming t cells and hematophietic cells
MX2016001315A (es)	2016-04-07	Variantes de enzimas.
MX2009005655A (es)	2009-10-21	Composiciones y usos de un polipeptido alfa-amilasa del bacilo de la especie 195.
MX2012005782A (es)	2012-08-03	Procedimientos, composiciones y kits de liofilizacion.
PH12015502408A1 (en)	2018-03-26	Purification of iduronate-2-sulfatase
WO2009137778A3 (en)	2010-06-17	Methods and compositions for genetically engineering clostridia species
WO2008085962A3 (en)	2008-10-02	Cell culture methods for producing recombinant proteins in the presence of reduced levels of one or more contaminants
DE602006017882D1 (de)	2010-12-09	Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine
WO2009058451A3 (en)	2009-06-18	Neuronal progenitor cells and methods of derivation and purification of neuronal progenitor cells from embryonic stem cells
EP2597949A4 (en)	2014-01-15	SUBMIKROMETERZUSAMMENSETZUNGEN
GB2500552A (en)	2013-09-25	Stable lactase drops
EP1885867A4 (en)	2009-01-14	NEW PROCEDURES
MX2009008903A (es)	2009-09-24	Composiciones de limpieza que comprenden alfa-galactosidasa.
WO2009034436A3 (en)	2009-05-28	'hematopoietic cells that express tmcc-1'
MX2010007695A (es)	2010-08-11	Medios resistentes a abrasion.
TN2011000041A1 (en)	2012-09-05	Compositions and methods for antibodies targeting complement protein c5