IT1285158B1 - Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il - Google Patents

Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il

Info

Publication number
IT1285158B1
IT1285158B1 ITRM960632A IT1285158B1 IT 1285158 B1 IT1285158 B1 IT 1285158B1 IT RM960632 A ITRM960632 A IT RM960632A IT 1285158 B1 IT1285158 B1 IT 1285158B1
Authority
IT
Italy
Prior art keywords
proteasis
serino
hepatitis
virus
activity
Prior art date
Application number
Other languages
English (en)
Inventor
Francesco Raffaele De
Anna Tramontano
Christian Steinkuhler
Andrea Urbani
Licia Tomei
Stefano Colloca
Maria Chiara Nardi
Rosa Letizia Vitale
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Priority to ITRM960632 priority Critical patent/IT1285158B1/it
Priority to JP10514467A priority patent/JP2001500735A/ja
Priority to PCT/IT1997/000228 priority patent/WO1998012308A1/en
Priority to AU43970/97A priority patent/AU4397097A/en
Priority to CA002264487A priority patent/CA2264487A1/en
Priority to EP97942190A priority patent/EP0950094A1/en
Publication of ITRM960632A1 publication Critical patent/ITRM960632A1/it
Application granted granted Critical
Publication of IT1285158B1 publication Critical patent/IT1285158B1/it

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ITRM960632 1996-09-17 1996-09-17 Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il IT1285158B1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ITRM960632 IT1285158B1 (it) 1996-09-17 1996-09-17 Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il
JP10514467A JP2001500735A (ja) 1996-09-17 1997-09-17 Ｃ型肝炎ウィルスのｎｓ３セリンプロテアーゼの活性を有する可溶性ポリペプチド、およびそれらの製造および単離法
PCT/IT1997/000228 WO1998012308A1 (en) 1996-09-17 1997-09-17 Soluble polypeptides with activity of the ns3 serine protease of hepatitis c virus, and process for their preparation and isolation
AU43970/97A AU4397097A (en) 1996-09-17 1997-09-17 Soluble polypeptides with activity of the ns3 serine protease of hepatitis c virus, and process for their preparation and isolation
CA002264487A CA2264487A1 (en) 1996-09-17 1997-09-17 Soluble polypeptides with activity of the ns3 serine protease of hepatitis c virus, and process for their preparation and isolation
EP97942190A EP0950094A1 (en) 1996-09-17 1997-09-17 Soluble polypeptides with activity of the ns3 serine protease of hepatitis c virus, and process for their preparation and isolation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM960632 IT1285158B1 (it) 1996-09-17 1996-09-17 Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il

Publications (2)

Publication Number Publication Date
ITRM960632A1 ITRM960632A1 (it) 1998-03-17
IT1285158B1 true IT1285158B1 (it) 1998-06-03

Family

ID=11404423

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM960632 IT1285158B1 (it) 1996-09-17 1996-09-17 Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il

Country Status (6)

Country Link
EP (1) EP0950094A1 (it)
JP (1) JP2001500735A (it)
AU (1) AU4397097A (it)
CA (1) CA2264487A1 (it)
IT (1) IT1285158B1 (it)
WO (1) WO1998012308A1 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806815D0 (en) * 1998-03-30 1998-05-27 Hoffmann La Roche Amino acid derivatives
IL143798A0 (en) 1999-01-08 2002-04-21 Bristol Myers Squibb Co Hepatitis c virus ns3 protease
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
PL206255B1 (pl) 2000-07-21 2010-07-30 Dendreon Corporationdendreon Corporation Inhibitor proteazy wirusa zapalenia wątroby C, zawierająca go kompozycja farmaceutyczna i zastosowanie inhibitora do wytwarzania leku do leczenia chorób związanych z HCV oraz zastosowanie do wytwarzania kompozycji do stosowania w kombinowanej terapii
HUP0303358A3 (en) 2000-07-21 2005-10-28 Schering Corp Novel peptides as ns3-serine protease inhibitors of hepatitis c virus and pharmaceutical compositions containing them
AU2004285019B9 (en) 2003-10-27 2011-11-24 Vertex Pharmaceuticals Incorporated HCV NS3-NS4A protease resistance mutants
US7705138B2 (en) 2005-11-11 2010-04-27 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants
SG178194A1 (en) 2009-07-31 2012-03-29 Baxter Int Cell culture medium for adamts protein expression

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0571554A1 (en) * 1991-01-14 1993-12-01 James N. Gamble Institute Of Medical Research Basic structural immunogenic polypeptides having epitopes for hcv, antibodies, polynucleotide sequences, vaccines and methods
US5843752A (en) * 1995-05-12 1998-12-01 Schering Corporation Soluble active hepatitis C virus protease
IT1277914B1 (it) * 1995-08-22 1997-11-12 Angeletti P Ist Richerche Bio Procedimento per produrre - in forma pura e in quantita' elevate - polipeptidi con l'attivita' proteolitica della proteasi ns3 di hcv, e

Also Published As

Publication number Publication date
JP2001500735A (ja) 2001-01-23
ITRM960632A1 (it) 1998-03-17
EP0950094A1 (en) 1999-10-20
AU4397097A (en) 1998-04-14
CA2264487A1 (en) 1998-03-26
WO1998012308A1 (en) 1998-03-26

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