IL149108A0 - New oxabispidine compounds useful in the treatment of cardiac arrhythmias - Google Patents

New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Info

Publication number
IL149108A0
IL149108A0 IL14910800A IL14910800A IL149108A0 IL 149108 A0 IL149108 A0 IL 149108A0 IL 14910800 A IL14910800 A IL 14910800A IL 14910800 A IL14910800 A IL 14910800A IL 149108 A0 IL149108 A0 IL 149108A0
Authority
IL
Israel
Prior art keywords
treatment
compounds useful
cardiac arrhythmias
oxabispidine compounds
new
Prior art date
Application number
IL14910800A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IL149108A0 publication Critical patent/IL149108A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL14910800A 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias IL149108A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds
PCT/SE2000/001994 WO2001028992A2 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Publications (1)

Publication Number Publication Date
IL149108A0 true IL149108A0 (en) 2002-11-10

Family

ID=20417401

Family Applications (5)

Application Number Title Priority Date Filing Date
IL14910800A IL149108A0 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias
IL183854A IL183854A0 (en) 1999-10-18 2002-04-11 New oxabispidine compounds useful in the treatment of cardiac arrhythmias
IL149108A IL149108A (en) 1999-10-18 2002-04-11 Oxabispidine compounds, process for their preparation, pharmaceutical compositions comprising them and use thereof in the preparation of a medicament for the treatment of arrhythmia
IL183852A IL183852A0 (en) 1999-10-18 2007-06-11 New oxabispidine compounds useful in the treatment of cardiac arrhythmias
IL183853A IL183853A0 (en) 1999-10-18 2007-06-11 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL183854A IL183854A0 (en) 1999-10-18 2002-04-11 New oxabispidine compounds useful in the treatment of cardiac arrhythmias
IL149108A IL149108A (en) 1999-10-18 2002-04-11 Oxabispidine compounds, process for their preparation, pharmaceutical compositions comprising them and use thereof in the preparation of a medicament for the treatment of arrhythmia
IL183852A IL183852A0 (en) 1999-10-18 2007-06-11 New oxabispidine compounds useful in the treatment of cardiac arrhythmias
IL183853A IL183853A0 (en) 1999-10-18 2007-06-11 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Country Status (41)

Country Link
US (6) US6559143B1 (sv)
EP (2) EP1559717A3 (sv)
JP (3) JP3973906B2 (sv)
KR (1) KR100796142B1 (sv)
CN (2) CN101265262A (sv)
AP (1) AP1536A (sv)
AR (2) AR026064A1 (sv)
AT (1) ATE292134T1 (sv)
AU (1) AU769513B2 (sv)
BG (1) BG65785B1 (sv)
BR (1) BR0014804A (sv)
CA (1) CA2386910A1 (sv)
CO (1) CO5271655A1 (sv)
CU (1) CU23210A3 (sv)
CZ (1) CZ20021328A3 (sv)
DE (1) DE60019158T2 (sv)
DK (1) DK1235831T3 (sv)
EA (1) EA005319B1 (sv)
EE (1) EE04854B1 (sv)
ES (1) ES2239047T3 (sv)
HK (1) HK1049003B (sv)
HR (1) HRP20020336B1 (sv)
HU (1) HUP0204085A3 (sv)
IL (5) IL149108A0 (sv)
IS (2) IS2224B (sv)
MX (1) MXPA02003848A (sv)
MY (1) MY130661A (sv)
NO (1) NO327977B1 (sv)
NZ (2) NZ518156A (sv)
OA (1) OA12067A (sv)
PL (1) PL354970A1 (sv)
PT (1) PT1235831E (sv)
RS (1) RS50760B (sv)
SE (1) SE9903759D0 (sv)
SI (1) SI1235831T1 (sv)
SK (1) SK286723B6 (sv)
TR (1) TR200201059T2 (sv)
TW (1) TWI283680B (sv)
UA (1) UA75052C2 (sv)
WO (1) WO2001028992A2 (sv)
ZA (1) ZA200202575B (sv)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
SE0101327D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
CA2465840A1 (en) * 2001-11-22 2003-06-05 Duncan Michael Gill Process for the preparation of 2-or-9-oxa-3, 7-diazabicyclo (3.3.1) nonanes from 2-aminomethyl-2, 3-dihydrooxazines, intermediates therefore, and processes for preparing such intermediates
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401539D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
CN101243093A (zh) * 2005-06-13 2008-08-13 阿斯利康(瑞典)有限公司 用于治疗心律不齐的新型氧杂双哌啶化合物
AU2006259937A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of N,N'- disubstituted oxabispidines
US20100160626A1 (en) * 2005-06-20 2010-06-24 Astrazeneca Ab Process For The Preparation Of 3,7-Dihydroxy-1,5-Diazacyclooctanes
EP1896487A4 (en) * 2005-06-20 2010-03-31 Astrazeneca Ab PROCESS FOR THE PREPARATION OF OXABISPIDINE SULFONIC ACID SALTS
AR053901A1 (es) * 2005-06-20 2007-05-23 Astrazeneca Ab Formas fisicas de oxabispidinas n,n'- disustituidas
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
MX2015011445A (es) 2013-03-15 2016-04-20 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulacion de la hemoglobina.
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US10231970B2 (en) 2014-09-30 2019-03-19 NV Heterocycles Methods of producing heteropolycycles via bis-epoxidation

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196154A (en) * 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
JPS5772977A (en) * 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) * 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
FI67320C (fi) * 1983-05-09 1985-03-11 Partek Ab Foerfarande och glidgjutanordning foer gjutning av betongstycken
JPS6284071A (ja) * 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規グリシジル化合物及びその製造方法
JPS6284070A (ja) * 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規なグリシジル化合物及びその製造法
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5140033A (en) 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
FR2664270B1 (fr) * 1990-07-09 1994-04-08 Norsolor Sa Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres.
JP2602745B2 (ja) * 1991-06-26 1997-04-23 花王株式会社 フレキシブルディスク用センターハブのピッキング装置
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
US5831099A (en) * 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
HUP0202214A3 (en) 1999-04-09 2002-12-28 Astrazeneca Ab Adamantane derivatives, preparation and use thereof
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
SE9904765D0 (sv) * 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Also Published As

Publication number Publication date
BR0014804A (pt) 2002-06-11
ES2239047T3 (es) 2005-09-16
US20060166979A1 (en) 2006-07-27
MXPA02003848A (es) 2002-10-23
SK5062002A3 (en) 2002-11-06
CU23210A3 (es) 2007-06-20
AR039226A2 (es) 2005-02-09
AR026064A1 (es) 2002-12-26
IS6346A (is) 2002-04-17
IS2224B (is) 2007-04-15
DE60019158T2 (de) 2006-02-02
WO2001028992A2 (en) 2001-04-26
HUP0204085A2 (hu) 2003-04-28
NO20021811D0 (no) 2002-04-17
CN100379743C (zh) 2008-04-09
TWI283680B (en) 2007-07-11
SK286723B6 (sk) 2009-04-06
AU1069101A (en) 2001-04-30
DE60019158D1 (de) 2005-05-04
EP1235831A2 (en) 2002-09-04
IL183853A0 (en) 2009-02-11
JP2006342182A (ja) 2006-12-21
ATE292134T1 (de) 2005-04-15
JP2007204486A (ja) 2007-08-16
EA005319B1 (ru) 2005-02-24
US20060166980A1 (en) 2006-07-27
CO5271655A1 (es) 2003-04-30
EE04854B1 (et) 2007-06-15
EE200200203A (et) 2003-06-16
YU29402A (sh) 2004-12-31
IL149108A (en) 2009-12-24
SI1235831T1 (sv) 2005-08-31
UA75052C2 (en) 2006-03-15
CN1399639A (zh) 2003-02-26
US20090326221A1 (en) 2009-12-31
AP2002002471A0 (en) 2002-06-30
HK1049003A1 (en) 2003-04-25
ZA200202575B (en) 2003-09-23
US7164017B2 (en) 2007-01-16
BG65785B1 (bg) 2009-11-30
NO20021811L (no) 2002-06-06
US7351821B2 (en) 2008-04-01
CN101265262A (zh) 2008-09-17
RS50760B (sr) 2010-08-31
IS8586A (is) 2006-12-27
EA200200390A1 (ru) 2002-10-31
US20070117799A1 (en) 2007-05-24
KR100796142B1 (ko) 2008-01-21
JP2003512352A (ja) 2003-04-02
HRP20020336B1 (en) 2006-02-28
HK1049003B (zh) 2005-09-09
DK1235831T3 (da) 2005-06-27
HUP0204085A3 (en) 2006-01-30
EP1559717A3 (en) 2009-04-29
OA12067A (en) 2006-05-04
HRP20020336A2 (en) 2004-02-29
MY130661A (en) 2007-07-31
JP3973906B2 (ja) 2007-09-12
SE9903759D0 (sv) 1999-10-18
NZ518156A (en) 2004-05-28
US6559143B1 (en) 2003-05-06
AU769513B2 (en) 2004-01-29
BG106588A (en) 2003-01-31
NZ531260A (en) 2005-08-26
CA2386910A1 (en) 2001-04-26
US20030153564A1 (en) 2003-08-14
PL354970A1 (en) 2004-03-22
US7772229B2 (en) 2010-08-10
IL183852A0 (en) 2009-02-11
AP1536A (en) 2006-01-09
IL183854A0 (en) 2009-02-11
EP1559717A2 (en) 2005-08-03
TR200201059T2 (tr) 2002-09-23
CZ20021328A3 (cs) 2002-09-11
WO2001028992A3 (en) 2001-09-13
PT1235831E (pt) 2005-06-30
NO327977B1 (no) 2009-11-02
EP1235831B1 (en) 2005-03-30
KR20020038956A (ko) 2002-05-24

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