EE04854B1 - Oksabispidiinühendid, nende valmistamise meetod ning ravimvorm kasutamiseks südame arütmia raviks ja profülaktikaks - Google Patents

Oksabispidiinühendid, nende valmistamise meetod ning ravimvorm kasutamiseks südame arütmia raviks ja profülaktikaks

Info

Publication number: EE04854B1
Authority: EE; Estonia
Prior art keywords: prophylaxis; formulations; treatment; methods; cardiac arrhythmias
Prior art date: 1999-10-18

Application number

EEP200200203A

Other languages

English (en)

Estonian (et)

Inventor

Bj�re Annika

Bj�rsne Magnus

Cladingboel David

Hoffmann Kurt-J�rgen

Pavey John

Pont�n Fritiof

Strandlund Gert

Svensson Peder

Thomson Colin

Wilstermann Michael

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-18

Filing date

2000-10-13

Publication date

2007-06-15

2000-10-13 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2003-06-16 Publication of EE200200203A publication Critical patent/EE200200203A/xx

2007-06-15 Publication of EE04854B1 publication Critical patent/EE04854B1/xx

Links

206010003119 arrhythmia Diseases 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
238000009472 formulation Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
238000011321 prophylaxis Methods 0.000 title 1
238000011282 treatment Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

EEP200200203A 1999-10-18 2000-10-13 Oksabispidiinühendid, nende valmistamise meetod ning ravimvorm kasutamiseks südame arütmia raviks ja profülaktikaks EE04854B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9903759A SE9903759D0 (sv)	1999-10-18	1999-10-18	Pharmaceutically active compounds
PCT/SE2000/001994 WO2001028992A2 (en)	1999-10-18	2000-10-13	New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Publications (2)

Publication Number	Publication Date
EE200200203A EE200200203A (et)	2003-06-16
EE04854B1 true EE04854B1 (et)	2007-06-15

Family

ID=20417401

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200200203A EE04854B1 (et)	1999-10-18	2000-10-13	Oksabispidiinühendid, nende valmistamise meetod ning ravimvorm kasutamiseks südame arütmia raviks ja profülaktikaks

Country Status (41)

Country	Link
US (6)	US6559143B1 (sv)
EP (2)	EP1559717A3 (sv)
JP (3)	JP3973906B2 (sv)
KR (1)	KR100796142B1 (sv)
CN (2)	CN100379743C (sv)
AP (1)	AP1536A (sv)
AR (2)	AR026064A1 (sv)
AT (1)	ATE292134T1 (sv)
AU (1)	AU769513B2 (sv)
BG (1)	BG65785B1 (sv)
BR (1)	BR0014804A (sv)
CA (1)	CA2386910A1 (sv)
CO (1)	CO5271655A1 (sv)
CU (1)	CU23210A3 (sv)
CZ (1)	CZ20021328A3 (sv)
DE (1)	DE60019158T2 (sv)
DK (1)	DK1235831T3 (sv)
EA (1)	EA005319B1 (sv)
EE (1)	EE04854B1 (sv)
ES (1)	ES2239047T3 (sv)
HK (1)	HK1049003B (sv)
HR (1)	HRP20020336B1 (sv)
HU (1)	HUP0204085A3 (sv)
IL (5)	IL149108A0 (sv)
IS (2)	IS2224B (sv)
MX (1)	MXPA02003848A (sv)
MY (1)	MY130661A (sv)
NO (1)	NO327977B1 (sv)
NZ (2)	NZ518156A (sv)
OA (1)	OA12067A (sv)
PL (1)	PL354970A1 (sv)
PT (1)	PT1235831E (sv)
RS (1)	RS50760B (sv)
SE (1)	SE9903759D0 (sv)
SI (1)	SI1235831T1 (sv)
SK (1)	SK286723B6 (sv)
TR (1)	TR200201059T2 (sv)
TW (1)	TWI283680B (sv)
UA (1)	UA75052C2 (sv)
WO (1)	WO2001028992A2 (sv)
ZA (1)	ZA200202575B (sv)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI229674B (en)	1998-12-04	2005-03-21	Astra Pharma Prod	Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) *	1999-06-16	1999-06-16	Astra Ab	Pharmaceutically active compounds
SE9903759D0 (sv)	1999-10-18	1999-10-18	Astra Ab	Pharmaceutically active compounds
AR030756A1 (es) *	2000-10-02	2003-09-03	Astrazeneca Ab	Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
TWI259836B (en) *	2001-04-12	2006-08-11	Astrazeneca Ab	Modified release formulation suitable for antiarrhythmic compounds
SE0101329D0 (sv) *	2001-04-12	2001-04-12	Astrazeneca Ab	Pharmaceutical formulation
SE0101327D0 (sv) *	2001-04-12	2001-04-12	Astrazeneca Ab	New crystalline forms
SE0101323D0 (sv) *	2001-04-12	2001-04-12	Astrazeneca Ab	New process
SE0101324D0 (sv) *	2001-04-12	2001-04-12	Astrazeneca Ab	New process
CN1589272A (zh) *	2001-11-22	2005-03-02	阿斯特拉曾尼卡有限公司	从2－氨甲基－2,3－二氢噁嗪化合物制备2－或－9－氧杂－3 , 7－二氮杂双环(3.3.1)壬烷化合物的方法,其中间体,及制备这些中间体的方法
SE0201374D0 (sv) *	2002-05-06	2002-05-06	Astrazeneca Ab	Pharmaceutical combination
SE0201373D0 (sv) *	2002-05-06	2002-05-06	Astrazeneca Ab	Combination therapy
SE0201662D0 (sv) *	2002-05-31	2002-05-31	Astrazeneca Ab	Pharmaceutical combination
GB0223712D0 (en) *	2002-10-14	2002-11-20	Astrazeneca Ab	Chemical intermediate
SE0401539D0 (sv) *	2004-06-15	2004-06-15	Astrazeneca Ab	New compounds
SE0401540D0 (sv) *	2004-06-15	2004-06-15	Astrazeneca Ab	New compounds
KR20080021114A (ko) *	2005-06-13	2008-03-06	아스트라제네카 아베	심부정맥의 치료를 위한 신규한 옥사비스피딘 화합물
AU2006259938B2 (en) *	2005-06-20	2010-07-01	Astrazeneca Ab	Process for the preparation of sulfonic acid salts of oxabispidines
CA2610089A1 (en) *	2005-06-20	2006-12-28	Astrazeneca Ab	Process for the preparation of n,n´- disubstituted oxabispidines
MX2007016498A (es) *	2005-06-20	2008-03-04	Astrazeneca Ab	Proceso para la preparacion de 3,7-dihidroxi-1,5-diazaciclooctanos .
WO2006137772A1 (en) *	2005-06-20	2006-12-28	Astrazeneca Ab	New physical form of n,n´- disubstituted oxabispidines
CN1330636C (zh) *	2005-09-26	2007-08-08	鲁南制药集团股份有限公司	盐酸替罗非班中间体的合成方法
TW200734342A (en) *	2005-12-15	2007-09-16	Astrazeneca Ab	New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) *	2008-07-03	2010-02-01	Targacept Inc	Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) *	2011-10-05	2014-09-10	John Royce	Method and apparatus for cleaning a filter
CN105073728A (zh)	2013-03-15	2015-11-18	全球血液疗法股份有限公司	化合物及其用于调节血红蛋白的用途
EA201992707A1 (ru)	2013-11-18	2020-06-30	Глобал Блад Терапьютикс, Инк.	Соединения и их применения для модуляции гемоглобина
US10231970B2 (en)	2014-09-30	2019-03-19	NV Heterocycles	Methods of producing heteropolycycles via bis-epoxidation

Family Cites Families (23)

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Publication number	Priority date	Publication date	Assignee	Title
US3196154A (en)	1962-05-17	1965-07-20	Sterling Drug Inc	3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en)	1967-03-29	1970-03-31	Du Pont	Polyamides from heterocyclic diamines
CH488048A (de)	1969-06-12	1970-03-31	Inventa Ag	Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
JPS5772977A (en) *	1980-10-23	1982-05-07	Dainippon Ink & Chem Inc	Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de)	1981-03-27	1982-10-07	Basf Ag, 6700 Ludwigshafen	Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
US4533713A (en) *	1983-05-06	1985-08-06	Minnesota Mining And Manufacturing Company	Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
FI67320C (fi) *	1983-05-09	1985-03-11	Partek Ab	Foerfarande och glidgjutanordning foer gjutning av betongstycken
JPS6284070A (ja)	1985-10-07	1987-04-17	Kanegafuchi Chem Ind Co Ltd	新規なグリシジル化合物及びその製造法
JPS6284071A (ja) *	1985-10-07	1987-04-17	Kanegafuchi Chem Ind Co Ltd	新規グリシジル化合物及びその製造方法
DE3732094A1 (de)	1987-09-24	1989-04-06	Basf Ag	Bispidinderivate als klasse iii-antiarrhythmika
US5140033A (en)	1989-04-03	1992-08-18	Bayer Aktiengesellschaft	Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en)	1989-11-13	1992-05-05	Board Of Regents Of Oklahoma State University	Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
FR2664270B1 (fr) *	1990-07-09	1994-04-08	Norsolor Sa	Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres.
JP2602745B2 (ja) *	1991-06-26	1997-04-23	花王株式会社	フレキシブルディスク用センターハブのピッキング装置
US5468858A (en) *	1993-10-28	1995-11-21	The Board Of Regents Of Oklahoma State University Physical Sciences	N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
US5831099A (en)	1995-03-10	1998-11-03	The United States Of America As Represented By The Secretary Of The Army	Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9704709D0 (sv) *	1997-12-17	1997-12-17	Astra Ab	Pharmaceutically active compounds
SE9803517D0 (sv) *	1998-10-15	1998-10-15	Astra Ab	Pharmaceutical preparation
RU2254333C2 (ru)	1999-04-09	2005-06-20	Астразенека Аб	Производные адамантана, способ их получения, фармацевтическая композиция на их основе и способы лечения
SE9902270D0 (sv) *	1999-06-16	1999-06-16	Astra Ab	Pharmaceutically active compounds
SE9903759D0 (sv)	1999-10-18	1999-10-18	Astra Ab	Pharmaceutically active compounds
SE9904765D0 (sv) *	1999-12-23	1999-12-23	Astra Ab	Pharmaceutically-useful compounds
AR030756A1 (es) *	2000-10-02	2003-09-03	Astrazeneca Ab	Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

1999
- 1999-10-18 SE SE9903759A patent/SE9903759D0/sv unknown
2000
- 2000-10-06 TW TW089120910A patent/TWI283680B/zh not_active IP Right Cessation
- 2000-10-13 BR BR0014804-0A patent/BR0014804A/pt not_active IP Right Cessation
- 2000-10-13 CN CNB00816231XA patent/CN100379743C/zh not_active Expired - Fee Related
- 2000-10-13 AT AT00971960T patent/ATE292134T1/de not_active IP Right Cessation
- 2000-10-13 WO PCT/SE2000/001994 patent/WO2001028992A2/en active Application Filing
- 2000-10-13 CA CA002386910A patent/CA2386910A1/en not_active Abandoned
- 2000-10-13 CN CNA2008100058488A patent/CN101265262A/zh active Pending
- 2000-10-13 SI SI200030681T patent/SI1235831T1/xx unknown
- 2000-10-13 HU HU0204085A patent/HUP0204085A3/hu unknown
- 2000-10-13 JP JP2001531792A patent/JP3973906B2/ja not_active Expired - Fee Related
- 2000-10-13 RS YUP-294/02A patent/RS50760B/sr unknown
- 2000-10-13 EE EEP200200203A patent/EE04854B1/xx not_active IP Right Cessation
- 2000-10-13 AU AU10691/01A patent/AU769513B2/en not_active Ceased
- 2000-10-13 UA UA2002043168A patent/UA75052C2/uk unknown
- 2000-10-13 OA OA1200200113A patent/OA12067A/en unknown
- 2000-10-13 IL IL14910800A patent/IL149108A0/xx unknown
- 2000-10-13 DK DK00971960T patent/DK1235831T3/da active
- 2000-10-13 EP EP05006781A patent/EP1559717A3/en not_active Withdrawn
- 2000-10-13 EA EA200200390A patent/EA005319B1/ru not_active IP Right Cessation
- 2000-10-13 EP EP00971960A patent/EP1235831B1/en not_active Expired - Lifetime
- 2000-10-13 KR KR1020027004902A patent/KR100796142B1/ko not_active IP Right Cessation
- 2000-10-13 TR TR2002/01059T patent/TR200201059T2/xx unknown
- 2000-10-13 AP APAP/P/2002/002471A patent/AP1536A/en active
- 2000-10-13 SK SK506-2002A patent/SK286723B6/sk not_active IP Right Cessation
- 2000-10-13 MX MXPA02003848A patent/MXPA02003848A/es active IP Right Grant
- 2000-10-13 ES ES00971960T patent/ES2239047T3/es not_active Expired - Lifetime
- 2000-10-13 NZ NZ518156A patent/NZ518156A/en unknown
- 2000-10-13 PL PL00354970A patent/PL354970A1/xx not_active Application Discontinuation
- 2000-10-13 NZ NZ531260A patent/NZ531260A/en unknown
- 2000-10-13 CZ CZ20021328A patent/CZ20021328A3/cs unknown
- 2000-10-13 DE DE60019158T patent/DE60019158T2/de not_active Expired - Lifetime
- 2000-10-13 PT PT00971960T patent/PT1235831E/pt unknown
- 2000-10-16 US US09/688,251 patent/US6559143B1/en not_active Expired - Fee Related
- 2000-10-16 MY MYPI20004850A patent/MY130661A/en unknown
- 2000-10-17 CO CO00078740A patent/CO5271655A1/es not_active Application Discontinuation
- 2000-10-17 AR ARP000105452A patent/AR026064A1/es active IP Right Grant
2002
- 2002-04-02 ZA ZA200202575A patent/ZA200202575B/en unknown
- 2002-04-05 BG BG106588A patent/BG65785B1/bg unknown
- 2002-04-11 IL IL149108A patent/IL149108A/en not_active IP Right Cessation
- 2002-04-11 IL IL183854A patent/IL183854A0/en unknown
- 2002-04-16 CU CU20020079A patent/CU23210A3/es not_active IP Right Cessation
- 2002-04-16 HR HR20020336A patent/HRP20020336B1/xx not_active IP Right Cessation
- 2002-04-17 NO NO20021811A patent/NO327977B1/no not_active IP Right Cessation
- 2002-04-17 IS IS6346A patent/IS2224B/is unknown
- 2002-12-12 US US10/317,195 patent/US7164017B2/en not_active Expired - Fee Related
2003
- 2003-02-18 HK HK03101241.2A patent/HK1049003B/zh not_active IP Right Cessation
- 2003-04-02 AR ARP030101150A patent/AR039226A2/es unknown
2006
- 2006-03-22 US US11/385,833 patent/US7772229B2/en not_active Expired - Fee Related
- 2006-03-22 US US11/385,861 patent/US20060166980A1/en not_active Abandoned
- 2006-08-23 JP JP2006226089A patent/JP2006342182A/ja active Pending
- 2006-12-18 US US11/640,417 patent/US7351821B2/en not_active Expired - Fee Related
- 2006-12-27 IS IS8586A patent/IS8586A/is unknown
2007
- 2007-03-28 JP JP2007083302A patent/JP2007204486A/ja active Pending
- 2007-06-11 IL IL183853A patent/IL183853A0/en unknown
- 2007-06-11 IL IL183852A patent/IL183852A0/en unknown
2009
- 2009-09-01 US US12/585,029 patent/US20090326221A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20030153564A1 (en)	2003-08-14
BG65785B1 (bg)	2009-11-30
JP3973906B2 (ja)	2007-09-12
IS2224B (is)	2007-04-15
US7772229B2 (en)	2010-08-10
SI1235831T1 (sv)	2005-08-31
CU23210A3 (es)	2007-06-20
HRP20020336A2 (en)	2004-02-29
SK5062002A3 (en)	2002-11-06
AP2002002471A0 (en)	2002-06-30
CN100379743C (zh)	2008-04-09
NZ531260A (en)	2005-08-26
IL183853A0 (en)	2009-02-11
HUP0204085A3 (en)	2006-01-30
AU769513B2 (en)	2004-01-29
PL354970A1 (en)	2004-03-22
EP1559717A2 (en)	2005-08-03
AR026064A1 (es)	2002-12-26
OA12067A (en)	2006-05-04
IS6346A (is)	2002-04-17
PT1235831E (pt)	2005-06-30
HUP0204085A2 (hu)	2003-04-28
IS8586A (is)	2006-12-27
IL149108A (en)	2009-12-24
EA200200390A1 (ru)	2002-10-31
HRP20020336B1 (en)	2006-02-28
YU29402A (sh)	2004-12-31
ES2239047T3 (es)	2005-09-16
US7164017B2 (en)	2007-01-16
RS50760B (sr)	2010-08-31
MXPA02003848A (es)	2002-10-23
BG106588A (en)	2003-01-31
JP2007204486A (ja)	2007-08-16
KR100796142B1 (ko)	2008-01-21
AR039226A2 (es)	2005-02-09
EP1235831B1 (en)	2005-03-30
WO2001028992A3 (en)	2001-09-13
EE200200203A (et)	2003-06-16
NZ518156A (en)	2004-05-28
DE60019158T2 (de)	2006-02-02
CN101265262A (zh)	2008-09-17
CO5271655A1 (es)	2003-04-30
CZ20021328A3 (cs)	2002-09-11
US20070117799A1 (en)	2007-05-24
NO20021811L (no)	2002-06-06
US6559143B1 (en)	2003-05-06
HK1049003A1 (en)	2003-04-25
UA75052C2 (en)	2006-03-15
AP1536A (en)	2006-01-09
JP2006342182A (ja)	2006-12-21
MY130661A (en)	2007-07-31
US7351821B2 (en)	2008-04-01
SE9903759D0 (sv)	1999-10-18
ATE292134T1 (de)	2005-04-15
IL183854A0 (en)	2009-02-11
DK1235831T3 (da)	2005-06-27
TWI283680B (en)	2007-07-11
TR200201059T2 (tr)	2002-09-23
US20060166980A1 (en)	2006-07-27
EA005319B1 (ru)	2005-02-24
ZA200202575B (en)	2003-09-23
DE60019158D1 (de)	2005-05-04
EP1559717A3 (en)	2009-04-29
EP1235831A2 (en)	2002-09-04
NO20021811D0 (no)	2002-04-17
CA2386910A1 (en)	2001-04-26
JP2003512352A (ja)	2003-04-02
IL149108A0 (en)	2002-11-10
WO2001028992A2 (en)	2001-04-26
BR0014804A (pt)	2002-06-11
HK1049003B (zh)	2005-09-09
CN1399639A (zh)	2003-02-26
AU1069101A (en)	2001-04-30
KR20020038956A (ko)	2002-05-24
SK286723B6 (sk)	2009-04-06
US20090326221A1 (en)	2009-12-31
NO327977B1 (no)	2009-11-02
IL183852A0 (en)	2009-02-11
US20060166979A1 (en)	2006-07-27

Legal Events

Date	Code	Title	Description
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2011-06-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20101013

Publication	Publication Date	Title
EE04854B1 (et)	2007-06-15	Oksabispidiinühendid, nende valmistamise meetod ning ravimvorm kasutamiseks südame arütmia raviks ja profülaktikaks
EE200300504A (et)	2003-12-15	3,7-diasabitsüklo[3.3.1]preparaadid, nende valmistamise meetod ja nimetatud preparaatide kasutaminesüdame arütmiate profülaktikas või ravis
EE200200305A (et)	2003-06-16	Südame arütmiate ravis kasutatavad uued asabitsüklooktaani derivaadid
EE200300364A (et)	2003-10-15	3,7-diasabitsüklo[3,3,0]oktaanid ja nende kasutamine südame arütmiate ravis
PL364047A1 (en)	2004-12-13	New oxabispidine compound useful in the treatment of cardiac arrhythmias
EE200300495A (et)	2003-12-15	3,7-diasabitsüklo[3.3.1]preparaadid, nende valmistamise meetod ja nimetatud preparaatide kasutaminesüdame arütmiate profülaktikas või ravis
EE200300506A (et)	2004-02-16	3,7-diasabitsüklo[3.3.1]preparaadid, nende valmistamise meetod ja nimetatud preparaatide kasutaminesüdame arütmiate profülaktikas või ravis
EE200300013A (et)	2004-10-15	Bispidiini uued ühendid ning nende kasutamine südame arütmia ravis
IL146754A0 (en)	2002-07-25	New bispidine compounds useful in the treatment of cardiac arrhythmias
IL146752A0 (en)	2002-07-25	New bispidine compounds useful in the treatment of cardiac arrhythmias
IL146753A0 (en)	2002-07-25	New bispidine compounds useful in the treatment of cardiac arrhythmias
PT1192156E (pt)	2004-06-30	Novos compostos de bispidina uteis no tratamento de arritmias cardiacas
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