IL143766A - Il-5 inhibiting 6-azauracil derivatives - Google Patents

Il-5 inhibiting 6-azauracil derivatives

Info

Publication number: IL143766A
Authority: IL; Israel
Prior art keywords: inhibiting; azauracil derivatives; azauracil; derivatives
Prior art date: 1998-12-18

Application number

IL14376699A

Other languages

English (en)

Other versions

IL143766A0 (en

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-18

Filing date

1999-12-16

Publication date

2005-11-20

1999-12-16 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2002-04-21 Publication of IL143766A0 publication Critical patent/IL143766A0/xx

2005-11-20 Publication of IL143766A publication Critical patent/IL143766A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

IL14376699A 1998-12-18 1999-12-16 Il-5 inhibiting 6-azauracil derivatives IL143766A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98204336		1998-12-18
PCT/EP1999/010169 WO2000037451A1 (en)	1998-12-18	1999-12-16	Il-5 inhibiting 6-azauracil derivatives

Publications (2)

Publication Number	Publication Date
IL143766A0 IL143766A0 (en)	2002-04-21
IL143766A true IL143766A (en)	2005-11-20

Family

ID=8234494

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14376699A IL143766A (en)	1998-12-18	1999-12-16	Il-5 inhibiting 6-azauracil derivatives

Country Status (35)

Country	Link
US (1)	US6803364B1 (zh)
EP (1)	EP1140873B1 (zh)
JP (1)	JP2002533331A (zh)
KR (1)	KR100635721B1 (zh)
CN (1)	CN100343239C (zh)
AR (1)	AR021887A1 (zh)
AT (1)	ATE365723T1 (zh)
AU (1)	AU773780B2 (zh)
BG (1)	BG105602A (zh)
BR (1)	BR9916366A (zh)
CA (1)	CA2354511A1 (zh)
CO (1)	CO5150147A1 (zh)
CZ (1)	CZ20012062A3 (zh)
DE (1)	DE69936396T2 (zh)
DK (1)	DK1140873T3 (zh)
EA (1)	EA004806B1 (zh)
EE (1)	EE200100320A (zh)
ES (1)	ES2289835T3 (zh)
HK (1)	HK1042491A1 (zh)
HR (1)	HRP20010455A2 (zh)
HU (1)	HUP0104641A3 (zh)
ID (1)	ID28880A (zh)
IL (1)	IL143766A (zh)
MY (1)	MY125808A (zh)
NO (1)	NO319814B1 (zh)
NZ (1)	NZ512748A (zh)
PL (1)	PL198205B1 (zh)
PT (1)	PT1140873E (zh)
SA (1)	SA00201030B1 (zh)
SK (1)	SK8152001A3 (zh)
TR (1)	TR200101729T2 (zh)
TW (1)	TWI249530B (zh)
UA (1)	UA73107C2 (zh)
WO (1)	WO2000037451A1 (zh)
ZA (1)	ZA200104942B (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8466096B2 (en) *	2007-04-26	2013-06-18	Afton Chemical Corporation	1,3,2-dioxaphosphorinane, 2-sulfide derivatives for use as anti-wear additives in lubricant compositions
RU2523651C2 (ru) *	2012-05-22	2014-07-20	Государственное бюджетное образовательное учреждение высшего профессионального образования "Владивостокский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ВГМУ Минздравсоцразвития России)	Способ дифференцированного контроля базисного противовоспалительного лечения бронхиальной астмы у детей и подростков
RU2506045C1 (ru) *	2012-09-05	2014-02-10	Федеральное государственное бюджетное учреждение "Дальневосточный научный центр физиологии и патологии дыхания" Сибирского отделения РАМН	Способ прогнозирования достижения контроля бронхиальной астмы

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2149645A1 (de)	1970-10-07	1972-09-14	Pfizer	2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose
US3912723A (en)	1971-03-29	1975-10-14	Pfizer	2-Phenyl-as-triazine-3,5(2H,4H)diones
US3883528A (en)	1974-04-19	1975-05-13	Pfizer	Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats
US4631278A (en)	1984-08-01	1986-12-23	Janssen Pharmaceutica N.V.	Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor
CA1244024A (en)	1984-08-01	1988-11-01	Gustaaf M. Boeckx	.alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES
GB8602342D0 (en) *	1986-01-30	1986-03-05	Janssen Pharmaceutica Nv	5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
CA1331757C (en)	1988-02-29	1994-08-30	Janssen Pharmaceutica Naamloze Vennootschap	5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
EP0476439A1 (de)	1990-09-18	1992-03-25	Bayer Ag	Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
DE4120138A1 (de)	1991-06-19	1992-12-24	Bayer Ag	Substituierte hexahydro-1,2,4-triazindione, verfahren zu ihrer herstellung, zwischenprodukte dafuer und ihre verwendung
TW263495B (zh)	1992-12-23	1995-11-21	Celltech Ltd
GB9304920D0 (en)	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
RU2146674C1 (ru)	1993-10-15	2000-03-20	Такеда Кемикал Индастриз, Лтд.	Производные триазина, способы их получения, антипротозойная композиция, добавка в пищу животных, способ ингибирования протозои у животных
TW332201B (en)	1995-04-06	1998-05-21	Janssen Pharmaceutica Nv	1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
EP0737672B1 (en)	1995-04-14	2001-10-04	Takeda Schering-Plough Animal Health K.K.	Method of producing triazine derivatives
DE69717380T2 (de) *	1996-08-30	2003-03-20	Takeda Schering Plough Animal	1,2,4-Triazin-3,5-Dionderivate als Anticoccidiosemittel
BR9811678A (pt) *	1997-07-10	2000-09-19	Janssen Pharmaceutica Nv	Derivados de 6-azauracila de inibição de il-5
ID24224A (id) *	1997-07-10	2000-07-13	Janssen Pharmaceutica Nv	Turunan-turunan 6-azaurasil sebagai inhibitor il-5

1999
- 1999-12-16 EA EA200100677A patent/EA004806B1/ru not_active IP Right Cessation
- 1999-12-16 JP JP2000589523A patent/JP2002533331A/ja not_active Withdrawn
- 1999-12-16 CN CNB998146110A patent/CN100343239C/zh not_active Expired - Fee Related
- 1999-12-16 BR BR9916366-7A patent/BR9916366A/pt not_active Application Discontinuation
- 1999-12-16 PL PL349526A patent/PL198205B1/pl not_active IP Right Cessation
- 1999-12-16 KR KR1020017006666A patent/KR100635721B1/ko not_active IP Right Cessation
- 1999-12-16 UA UA2001075132A patent/UA73107C2/uk unknown
- 1999-12-16 TR TR2001/01729T patent/TR200101729T2/xx unknown
- 1999-12-16 US US09/868,384 patent/US6803364B1/en not_active Expired - Fee Related
- 1999-12-16 DK DK99965509T patent/DK1140873T3/da active
- 1999-12-16 NZ NZ512748A patent/NZ512748A/en unknown
- 1999-12-16 ID IDW00200101295A patent/ID28880A/id unknown
- 1999-12-16 DE DE69936396T patent/DE69936396T2/de not_active Expired - Fee Related
- 1999-12-16 CZ CZ20012062A patent/CZ20012062A3/cs unknown
- 1999-12-16 PT PT99965509T patent/PT1140873E/pt unknown
- 1999-12-16 AU AU21001/00A patent/AU773780B2/en not_active Ceased
- 1999-12-16 EE EEP200100320A patent/EE200100320A/xx unknown
- 1999-12-16 EP EP99965509A patent/EP1140873B1/en not_active Expired - Lifetime
- 1999-12-16 HU HU0104641A patent/HUP0104641A3/hu unknown
- 1999-12-16 SK SK815-2001A patent/SK8152001A3/sk unknown
- 1999-12-16 WO PCT/EP1999/010169 patent/WO2000037451A1/en active IP Right Grant
- 1999-12-16 IL IL14376699A patent/IL143766A/xx not_active IP Right Cessation
- 1999-12-16 AT AT99965509T patent/ATE365723T1/de not_active IP Right Cessation
- 1999-12-16 ES ES99965509T patent/ES2289835T3/es not_active Expired - Lifetime
- 1999-12-16 CA CA002354511A patent/CA2354511A1/en not_active Abandoned
- 1999-12-17 AR ARP990106512A patent/AR021887A1/es not_active Application Discontinuation
- 1999-12-17 TW TW088122197A patent/TWI249530B/zh not_active IP Right Cessation
- 1999-12-17 MY MYPI99005536A patent/MY125808A/en unknown
- 1999-12-17 CO CO99079022A patent/CO5150147A1/es unknown
2000
- 2000-03-05 SA SA00201030A patent/SA00201030B1/ar unknown
2001
- 2001-06-14 BG BG105602A patent/BG105602A/xx unknown
- 2001-06-15 ZA ZA200104942A patent/ZA200104942B/en unknown
- 2001-06-15 NO NO20012987A patent/NO319814B1/no unknown
- 2001-06-15 HR HR20010455A patent/HRP20010455A2/hr not_active Application Discontinuation
2002
- 2002-06-03 HK HK02104206.0A patent/HK1042491A1/zh unknown

Also Published As

Publication number	Publication date
CZ20012062A3 (cs)	2002-03-13
TWI249530B (en)	2006-02-21
NO319814B1 (no)	2005-09-19
MY125808A (en)	2006-08-30
HRP20010455A2 (en)	2002-06-30
ID28880A (id)	2001-07-12
AU773780B2 (en)	2004-06-03
EP1140873B1 (en)	2007-06-27
PT1140873E (pt)	2007-10-10
NZ512748A (en)	2004-05-28
PL198205B1 (pl)	2008-06-30
EE200100320A (et)	2002-10-15
CO5150147A1 (es)	2002-04-29
DK1140873T3 (da)	2007-10-15
BR9916366A (pt)	2001-09-18
NO20012987D0 (no)	2001-06-15
WO2000037451A1 (en)	2000-06-29
EP1140873A1 (en)	2001-10-10
EA200100677A1 (ru)	2001-12-24
KR20010080617A (ko)	2001-08-22
ZA200104942B (en)	2002-06-18
HUP0104641A3 (en)	2003-01-28
JP2002533331A (ja)	2002-10-08
IL143766A0 (en)	2002-04-21
AU2100100A (en)	2000-07-12
AR021887A1 (es)	2002-08-07
UA73107C2 (en)	2005-06-15
NO20012987L (no)	2001-08-17
HK1042491A1 (zh)	2002-08-16
DE69936396T2 (de)	2008-06-19
CN1330643A (zh)	2002-01-09
HUP0104641A2 (hu)	2002-04-29
TR200101729T2 (tr)	2001-10-22
DE69936396D1 (de)	2007-08-09
CA2354511A1 (en)	2000-06-29
KR100635721B1 (ko)	2006-10-17
EA004806B1 (ru)	2004-08-26
SK8152001A3 (en)	2002-04-04
SA00201030B1 (ar)	2006-10-11
ATE365723T1 (de)	2007-07-15
CN100343239C (zh)	2007-10-17
US6803364B1 (en)	2004-10-12
BG105602A (en)	2002-01-31
ES2289835T3 (es)	2008-02-01

Legal Events

Date	Code	Title	Description
2006-02-21	FF	Patent granted
2010-11-30	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
PL346155A1 (en)	2002-01-28	1h-imidazopyridine derivatives
PL345540A1 (en)	2001-12-17	Thiobenzimidazole derivatives
HRP990011B1 (en)	2004-12-31	Benzosulfone derivatives
IL140284A0 (en)	2002-02-10	Adenosine derivatives
GB9910384D0 (en)	1999-07-07	Alpha-ketoamide derivatives
IL133916A0 (en)	2001-04-30	Il-5 inhibiting 6-azauracil derivatives
IL147976A0 (en)	2002-09-12	Interleukin-5 inhibiting 6-azauracil derivatives
EG23802A (en)	2007-08-22	2-Phenylpyran-4-one derivatives
ZA200101830B (en)	2002-06-05	Piperidine derivatives.
GB9827729D0 (en)	1999-02-10	Thieno-indole derivatives
IL133915A0 (en)	2001-04-30	6-azauracil derivatives as il-5 inhibitors
IL143766A0 (en)	2002-04-21	Il-5 inhibiting 6-azauracil derivatives
IL143530A0 (en)	2002-04-21	Pyridazinone derivatives
ZA98576B (en)	1998-07-23	Gemcitabine derivatives
EP1061912A4 (en)	2003-01-02	PHENANTHROFURANDERIVATE
IL139276A0 (en)	2001-11-25	Cyclohexenondioxthio chromanoyl derivatives
ATE289596T1 (de)	2005-03-15	Il-5 hemmende 6-azauracilderivate
HK1042478A1 (zh)	2002-08-16	2-氧代-2h-喹啉衍生物
GB9816279D0 (en)	1998-09-23	Arylthiazolidinedione derivatives
SI1051395T1 (sl)	2007-08-31	N-hidroksiformamidni derivati