AR021887A1 - Drogas moderadas inhibidoras de il-5 - Google Patents
Drogas moderadas inhibidoras de il-5Info
- Publication number
- AR021887A1 AR021887A1 ARP990106512A ARP990106512A AR021887A1 AR 021887 A1 AR021887 A1 AR 021887A1 AR P990106512 A ARP990106512 A AR P990106512A AR P990106512 A ARP990106512 A AR P990106512A AR 021887 A1 AR021887 A1 AR 021887A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- aryl
- het3
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se refiere a los compuestos de la formula (1), un N-oxido, una sal de adicion farmacéuticamente aceptable, una amina cuaternaria o su formaestereoquímicamente isomérica, donde p es de 0 a 4; q es de 0 a 5; X es O, S; NR3 o un enlace directo; o -X-R2es CN; R1 es H, OH, halo, NH2, mono- odi(alquilo C1-4)NH2, alquilo C1-6, alquil C1-6-O, cicloalquilo C3-7, arilo, arilalquilo C1-6, NH2alquilo C1-4, mono- o di(alquil C1-4)NH2alquilo C1-4 o mono- odi(alquil C1-4)NH2alquilo C1-4NH2; R2 es arilo,Het1, cicloalquilo opcionalmente sustituido, alquilo C1-6 opcionalmente sustituido; R3 es H o alquilo C1-4; R4y R5 son -C(=O)-Z-R14, alquilo C1-6, halo, polihaloalquilo C1-6, OH, mercapto, alquil C1-6-O, alquiltio C1-6, alquil C1-6C(=O)O, arilo,ciano, ni tro, Het3, R6,NR7R8 o alquilo C1-4 sustituido con -C(=O)-Z-R14, Het3, R6 o NR7R8; Z es O, S, NH, -CH2-O- o -CH2-S-; R14 es H, acilo C1-20, alquilo C1-20 opcionalmentesustituido, alquenilo C3-20 opcionalmente sustituido, alquinilo C3-20,cicloalquilo C3-7, polihaloalquilo C1-20, Het5, fenilo; o R14 es un radical que contieneoxígeno; arilo es fenilo opcionalmente sustituido; Het1, Het2, Het3 y Het5 son heterociclos opcionalmente sustituidos; Het4 es un heterociclo monocíclico; siR2es diferente de NH2C(=O), alquilo C1-6OC(=O)alquilo C1-6; y R11 es diferente de COOH, alquilo C1-4OC(=O), NH2C(=O), alquilo C1-4NH2C(=O), OHalquilo C1-4NH2C(=O), alquilo C1-4C(=O)NH2C(=O), cicloalquilo C3-7NH2C(=O); y R7, R8, R9, R10, R12, R13, R15y R16 son difere ntes de alquilo C1-4C(=O)Oalquilo C1-4C(=O),OHalquilo C1-4C(=O); y Het3 es diferente de un heterociclo monocíclico sustituido con COOH o alquilo C1-4C(=O); y los compuestos de la formula (1) contienen almenos una porcion -C(=O)-Z-R14; a los procesos para su preparacion y composiciones que los comprenden. Además se refiere a su uso como medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98204336 | 1998-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021887A1 true AR021887A1 (es) | 2002-08-07 |
Family
ID=8234494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106512A AR021887A1 (es) | 1998-12-18 | 1999-12-17 | Drogas moderadas inhibidoras de il-5 |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6803364B1 (es) |
| EP (1) | EP1140873B1 (es) |
| JP (1) | JP2002533331A (es) |
| KR (1) | KR100635721B1 (es) |
| CN (1) | CN100343239C (es) |
| AR (1) | AR021887A1 (es) |
| AT (1) | ATE365723T1 (es) |
| AU (1) | AU773780B2 (es) |
| BG (1) | BG105602A (es) |
| BR (1) | BR9916366A (es) |
| CA (1) | CA2354511A1 (es) |
| CO (1) | CO5150147A1 (es) |
| CZ (1) | CZ20012062A3 (es) |
| DE (1) | DE69936396T2 (es) |
| DK (1) | DK1140873T3 (es) |
| EA (1) | EA004806B1 (es) |
| EE (1) | EE200100320A (es) |
| ES (1) | ES2289835T3 (es) |
| HK (1) | HK1042491A1 (es) |
| HR (1) | HRP20010455A2 (es) |
| HU (1) | HUP0104641A3 (es) |
| ID (1) | ID28880A (es) |
| IL (1) | IL143766A (es) |
| MY (1) | MY125808A (es) |
| NO (1) | NO319814B1 (es) |
| NZ (1) | NZ512748A (es) |
| PL (1) | PL198205B1 (es) |
| PT (1) | PT1140873E (es) |
| SA (1) | SA00201030B1 (es) |
| SK (1) | SK8152001A3 (es) |
| TR (1) | TR200101729T2 (es) |
| TW (1) | TWI249530B (es) |
| UA (1) | UA73107C2 (es) |
| WO (1) | WO2000037451A1 (es) |
| ZA (1) | ZA200104942B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8466096B2 (en) * | 2007-04-26 | 2013-06-18 | Afton Chemical Corporation | 1,3,2-dioxaphosphorinane, 2-sulfide derivatives for use as anti-wear additives in lubricant compositions |
| RU2523651C2 (ru) * | 2012-05-22 | 2014-07-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Владивостокский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ВГМУ Минздравсоцразвития России) | Способ дифференцированного контроля базисного противовоспалительного лечения бронхиальной астмы у детей и подростков |
| RU2506045C1 (ru) * | 2012-09-05 | 2014-02-10 | Федеральное государственное бюджетное учреждение "Дальневосточный научный центр физиологии и патологии дыхания" Сибирского отделения РАМН | Способ прогнозирования достижения контроля бронхиальной астмы |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2149645A1 (de) | 1970-10-07 | 1972-09-14 | Pfizer | 2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose |
| US3912723A (en) | 1971-03-29 | 1975-10-14 | Pfizer | 2-Phenyl-as-triazine-3,5(2H,4H)diones |
| US3883528A (en) | 1974-04-19 | 1975-05-13 | Pfizer | Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats |
| CA1244024A (en) | 1984-08-01 | 1988-11-01 | Gustaaf M. Boeckx | .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES |
| US4631278A (en) | 1984-08-01 | 1986-12-23 | Janssen Pharmaceutica N.V. | Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor |
| GB8602342D0 (en) * | 1986-01-30 | 1986-03-05 | Janssen Pharmaceutica Nv | 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones |
| CA1331757C (en) | 1988-02-29 | 1994-08-30 | Janssen Pharmaceutica Naamloze Vennootschap | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
| EP0476439A1 (de) | 1990-09-18 | 1992-03-25 | Bayer Ag | Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung |
| DE4120138A1 (de) | 1991-06-19 | 1992-12-24 | Bayer Ag | Substituierte hexahydro-1,2,4-triazindione, verfahren zu ihrer herstellung, zwischenprodukte dafuer und ihre verwendung |
| TW263495B (es) | 1992-12-23 | 1995-11-21 | Celltech Ltd | |
| GB9304920D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| TW403741B (en) | 1993-10-15 | 2000-09-01 | Takeda Chemical Industries Ltd | Triazine derivative, production and use thereof |
| TW332201B (en) | 1995-04-06 | 1998-05-21 | Janssen Pharmaceutica Nv | 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives |
| EP0737672B1 (en) | 1995-04-14 | 2001-10-04 | Takeda Schering-Plough Animal Health K.K. | Method of producing triazine derivatives |
| DE69717380T2 (de) | 1996-08-30 | 2003-03-20 | Takeda Schering Plough Animal | 1,2,4-Triazin-3,5-Dionderivate als Anticoccidiosemittel |
| ID24390A (id) * | 1997-07-10 | 2000-07-13 | Janssen Pharmaceutica Nv | Turunan-turunan 6-azaurasil penghambat il-5 |
| PL337875A1 (en) | 1997-07-10 | 2000-09-11 | Janssen Pharmaceutica Nv | Derivatives of 6-azauracil as il-5 inhibitors |
-
1999
- 1999-12-16 UA UA2001075132A patent/UA73107C2/uk unknown
- 1999-12-16 PL PL349526A patent/PL198205B1/pl not_active IP Right Cessation
- 1999-12-16 IL IL14376699A patent/IL143766A/xx not_active IP Right Cessation
- 1999-12-16 SK SK815-2001A patent/SK8152001A3/sk unknown
- 1999-12-16 ID IDW00200101295A patent/ID28880A/id unknown
- 1999-12-16 US US09/868,384 patent/US6803364B1/en not_active Expired - Fee Related
- 1999-12-16 BR BR9916366-7A patent/BR9916366A/pt not_active Application Discontinuation
- 1999-12-16 PT PT99965509T patent/PT1140873E/pt unknown
- 1999-12-16 KR KR1020017006666A patent/KR100635721B1/ko not_active IP Right Cessation
- 1999-12-16 EE EEP200100320A patent/EE200100320A/xx unknown
- 1999-12-16 CZ CZ20012062A patent/CZ20012062A3/cs unknown
- 1999-12-16 AT AT99965509T patent/ATE365723T1/de not_active IP Right Cessation
- 1999-12-16 CN CNB998146110A patent/CN100343239C/zh not_active Expired - Fee Related
- 1999-12-16 CA CA002354511A patent/CA2354511A1/en not_active Abandoned
- 1999-12-16 NZ NZ512748A patent/NZ512748A/en unknown
- 1999-12-16 ES ES99965509T patent/ES2289835T3/es not_active Expired - Lifetime
- 1999-12-16 WO PCT/EP1999/010169 patent/WO2000037451A1/en active IP Right Grant
- 1999-12-16 JP JP2000589523A patent/JP2002533331A/ja not_active Withdrawn
- 1999-12-16 AU AU21001/00A patent/AU773780B2/en not_active Ceased
- 1999-12-16 HU HU0104641A patent/HUP0104641A3/hu unknown
- 1999-12-16 DE DE69936396T patent/DE69936396T2/de not_active Expired - Fee Related
- 1999-12-16 TR TR2001/01729T patent/TR200101729T2/xx unknown
- 1999-12-16 EP EP99965509A patent/EP1140873B1/en not_active Expired - Lifetime
- 1999-12-16 EA EA200100677A patent/EA004806B1/ru not_active IP Right Cessation
- 1999-12-16 DK DK99965509T patent/DK1140873T3/da active
- 1999-12-17 MY MYPI99005536A patent/MY125808A/en unknown
- 1999-12-17 TW TW088122197A patent/TWI249530B/zh not_active IP Right Cessation
- 1999-12-17 CO CO99079022A patent/CO5150147A1/es unknown
- 1999-12-17 AR ARP990106512A patent/AR021887A1/es not_active Application Discontinuation
-
2000
- 2000-03-05 SA SA00201030A patent/SA00201030B1/ar unknown
-
2001
- 2001-06-14 BG BG105602A patent/BG105602A/xx unknown
- 2001-06-15 ZA ZA200104942A patent/ZA200104942B/en unknown
- 2001-06-15 HR HR20010455A patent/HRP20010455A2/hr not_active Application Discontinuation
- 2001-06-15 NO NO20012987A patent/NO319814B1/no unknown
-
2002
- 2002-06-03 HK HK02104206.0A patent/HK1042491A1/zh unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |