BG105602A - Il-5-inhibiting 6-azauracyl derivatives - Google Patents

Il-5-inhibiting 6-azauracyl derivatives

Info

Publication number: BG105602A
Authority: BG; Bulgaria
Prior art keywords: 6alkyl; 4alkyl; optionally substituted; 4alkylc; aryl
Prior art date: 1998-12-18

Application number

BG105602A

Other languages

Bulgarian (bg)

English (en)

Inventor

Eddy Jean Freyne

Frederik DEROOSE

Jean Fernand LACRAMPE

Werner EMBRECHTS

Jerome Michel FORTIN

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-18

Filing date

2001-06-14

Publication date

2002-01-31

2001-06-14 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2002-01-31 Publication of BG105602A publication Critical patent/BG105602A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

BG105602A 1998-12-18 2001-06-14 Il-5-inhibiting 6-azauracyl derivatives BG105602A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98204336		1998-12-18
PCT/EP1999/010169 WO2000037451A1 (en)	1998-12-18	1999-12-16	Il-5 inhibiting 6-azauracil derivatives

Publications (1)

Publication Number	Publication Date
BG105602A true BG105602A (en)	2002-01-31

Family

ID=8234494

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG105602A BG105602A (en)	1998-12-18	2001-06-14	Il-5-inhibiting 6-azauracyl derivatives

Country Status (35)

Country	Link
US (1)	US6803364B1 (zh)
EP (1)	EP1140873B1 (zh)
JP (1)	JP2002533331A (zh)
KR (1)	KR100635721B1 (zh)
CN (1)	CN100343239C (zh)
AR (1)	AR021887A1 (zh)
AT (1)	ATE365723T1 (zh)
AU (1)	AU773780B2 (zh)
BG (1)	BG105602A (zh)
BR (1)	BR9916366A (zh)
CA (1)	CA2354511A1 (zh)
CO (1)	CO5150147A1 (zh)
CZ (1)	CZ20012062A3 (zh)
DE (1)	DE69936396T2 (zh)
DK (1)	DK1140873T3 (zh)
EA (1)	EA004806B1 (zh)
EE (1)	EE200100320A (zh)
ES (1)	ES2289835T3 (zh)
HK (1)	HK1042491A1 (zh)
HR (1)	HRP20010455A2 (zh)
HU (1)	HUP0104641A3 (zh)
ID (1)	ID28880A (zh)
IL (1)	IL143766A (zh)
MY (1)	MY125808A (zh)
NO (1)	NO319814B1 (zh)
NZ (1)	NZ512748A (zh)
PL (1)	PL198205B1 (zh)
PT (1)	PT1140873E (zh)
SA (1)	SA00201030B1 (zh)
SK (1)	SK8152001A3 (zh)
TR (1)	TR200101729T2 (zh)
TW (1)	TWI249530B (zh)
UA (1)	UA73107C2 (zh)
WO (1)	WO2000037451A1 (zh)
ZA (1)	ZA200104942B (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8466096B2 (en) *	2007-04-26	2013-06-18	Afton Chemical Corporation	1,3,2-dioxaphosphorinane, 2-sulfide derivatives for use as anti-wear additives in lubricant compositions
RU2523651C2 (ru) *	2012-05-22	2014-07-20	Государственное бюджетное образовательное учреждение высшего профессионального образования "Владивостокский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ВГМУ Минздравсоцразвития России)	Способ дифференцированного контроля базисного противовоспалительного лечения бронхиальной астмы у детей и подростков
RU2506045C1 (ru) *	2012-09-05	2014-02-10	Федеральное государственное бюджетное учреждение "Дальневосточный научный центр физиологии и патологии дыхания" Сибирского отделения РАМН	Способ прогнозирования достижения контроля бронхиальной астмы

Family Cites Families (17)

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DE2149645A1 (de)	1970-10-07	1972-09-14	Pfizer	2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose
US3912723A (en)	1971-03-29	1975-10-14	Pfizer	2-Phenyl-as-triazine-3,5(2H,4H)diones
US3883528A (en)	1974-04-19	1975-05-13	Pfizer	Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats
US4631278A (en)	1984-08-01	1986-12-23	Janssen Pharmaceutica N.V.	Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor
CA1244024A (en)	1984-08-01	1988-11-01	Gustaaf M. Boeckx	.alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES
GB8602342D0 (en) *	1986-01-30	1986-03-05	Janssen Pharmaceutica Nv	5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
CA1331757C (en)	1988-02-29	1994-08-30	Janssen Pharmaceutica Naamloze Vennootschap	5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
EP0476439A1 (de)	1990-09-18	1992-03-25	Bayer Ag	Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
DE4120138A1 (de)	1991-06-19	1992-12-24	Bayer Ag	Substituierte hexahydro-1,2,4-triazindione, verfahren zu ihrer herstellung, zwischenprodukte dafuer und ihre verwendung
TW263495B (zh)	1992-12-23	1995-11-21	Celltech Ltd
GB9304920D0 (en)	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
RU2146674C1 (ru)	1993-10-15	2000-03-20	Такеда Кемикал Индастриз, Лтд.	Производные триазина, способы их получения, антипротозойная композиция, добавка в пищу животных, способ ингибирования протозои у животных
TW332201B (en)	1995-04-06	1998-05-21	Janssen Pharmaceutica Nv	1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
EP0737672B1 (en)	1995-04-14	2001-10-04	Takeda Schering-Plough Animal Health K.K.	Method of producing triazine derivatives
DE69717380T2 (de) *	1996-08-30	2003-03-20	Takeda Schering Plough Animal	1,2,4-Triazin-3,5-Dionderivate als Anticoccidiosemittel
BR9811678A (pt) *	1997-07-10	2000-09-19	Janssen Pharmaceutica Nv	Derivados de 6-azauracila de inibição de il-5
ID24224A (id) *	1997-07-10	2000-07-13	Janssen Pharmaceutica Nv	Turunan-turunan 6-azaurasil sebagai inhibitor il-5

1999
- 1999-12-16 EA EA200100677A patent/EA004806B1/ru not_active IP Right Cessation
- 1999-12-16 JP JP2000589523A patent/JP2002533331A/ja not_active Withdrawn
- 1999-12-16 CN CNB998146110A patent/CN100343239C/zh not_active Expired - Fee Related
- 1999-12-16 BR BR9916366-7A patent/BR9916366A/pt not_active Application Discontinuation
- 1999-12-16 PL PL349526A patent/PL198205B1/pl not_active IP Right Cessation
- 1999-12-16 KR KR1020017006666A patent/KR100635721B1/ko not_active IP Right Cessation
- 1999-12-16 UA UA2001075132A patent/UA73107C2/uk unknown
- 1999-12-16 TR TR2001/01729T patent/TR200101729T2/xx unknown
- 1999-12-16 US US09/868,384 patent/US6803364B1/en not_active Expired - Fee Related
- 1999-12-16 DK DK99965509T patent/DK1140873T3/da active
- 1999-12-16 NZ NZ512748A patent/NZ512748A/en unknown
- 1999-12-16 ID IDW00200101295A patent/ID28880A/id unknown
- 1999-12-16 DE DE69936396T patent/DE69936396T2/de not_active Expired - Fee Related
- 1999-12-16 CZ CZ20012062A patent/CZ20012062A3/cs unknown
- 1999-12-16 PT PT99965509T patent/PT1140873E/pt unknown
- 1999-12-16 AU AU21001/00A patent/AU773780B2/en not_active Ceased
- 1999-12-16 EE EEP200100320A patent/EE200100320A/xx unknown
- 1999-12-16 EP EP99965509A patent/EP1140873B1/en not_active Expired - Lifetime
- 1999-12-16 HU HU0104641A patent/HUP0104641A3/hu unknown
- 1999-12-16 SK SK815-2001A patent/SK8152001A3/sk unknown
- 1999-12-16 WO PCT/EP1999/010169 patent/WO2000037451A1/en active IP Right Grant
- 1999-12-16 IL IL14376699A patent/IL143766A/xx not_active IP Right Cessation
- 1999-12-16 AT AT99965509T patent/ATE365723T1/de not_active IP Right Cessation
- 1999-12-16 ES ES99965509T patent/ES2289835T3/es not_active Expired - Lifetime
- 1999-12-16 CA CA002354511A patent/CA2354511A1/en not_active Abandoned
- 1999-12-17 AR ARP990106512A patent/AR021887A1/es not_active Application Discontinuation
- 1999-12-17 TW TW088122197A patent/TWI249530B/zh not_active IP Right Cessation
- 1999-12-17 MY MYPI99005536A patent/MY125808A/en unknown
- 1999-12-17 CO CO99079022A patent/CO5150147A1/es unknown
2000
- 2000-03-05 SA SA00201030A patent/SA00201030B1/ar unknown
2001
- 2001-06-14 BG BG105602A patent/BG105602A/xx unknown
- 2001-06-15 ZA ZA200104942A patent/ZA200104942B/en unknown
- 2001-06-15 NO NO20012987A patent/NO319814B1/no unknown
- 2001-06-15 HR HR20010455A patent/HRP20010455A2/hr not_active Application Discontinuation
2002
- 2002-06-03 HK HK02104206.0A patent/HK1042491A1/zh unknown

Also Published As

Publication number	Publication date
CZ20012062A3 (cs)	2002-03-13
TWI249530B (en)	2006-02-21
NO319814B1 (no)	2005-09-19
MY125808A (en)	2006-08-30
HRP20010455A2 (en)	2002-06-30
ID28880A (id)	2001-07-12
AU773780B2 (en)	2004-06-03
EP1140873B1 (en)	2007-06-27
PT1140873E (pt)	2007-10-10
NZ512748A (en)	2004-05-28
PL198205B1 (pl)	2008-06-30
EE200100320A (et)	2002-10-15
CO5150147A1 (es)	2002-04-29
DK1140873T3 (da)	2007-10-15
BR9916366A (pt)	2001-09-18
NO20012987D0 (no)	2001-06-15
WO2000037451A1 (en)	2000-06-29
EP1140873A1 (en)	2001-10-10
EA200100677A1 (ru)	2001-12-24
IL143766A (en)	2005-11-20
KR20010080617A (ko)	2001-08-22
ZA200104942B (en)	2002-06-18
HUP0104641A3 (en)	2003-01-28
JP2002533331A (ja)	2002-10-08
IL143766A0 (en)	2002-04-21
AU2100100A (en)	2000-07-12
AR021887A1 (es)	2002-08-07
UA73107C2 (en)	2005-06-15
NO20012987L (no)	2001-08-17
HK1042491A1 (zh)	2002-08-16
DE69936396T2 (de)	2008-06-19
CN1330643A (zh)	2002-01-09
HUP0104641A2 (hu)	2002-04-29
TR200101729T2 (tr)	2001-10-22
DE69936396D1 (de)	2007-08-09
CA2354511A1 (en)	2000-06-29
KR100635721B1 (ko)	2006-10-17
EA004806B1 (ru)	2004-08-26
SK8152001A3 (en)	2002-04-04
SA00201030B1 (ar)	2006-10-11
ATE365723T1 (de)	2007-07-15
CN100343239C (zh)	2007-10-17
US6803364B1 (en)	2004-10-12
ES2289835T3 (es)	2008-02-01

Publication	Publication Date	Title
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AP1475A (en)	2005-10-03	Trisubstituted 1, 3, 5-triazine derivatives for treatment of HIV infections.
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HUT74367A (en)	1996-12-30	Fungicidal alpha-aryl-substituted cyclic amide derivatives, fungicid compositions containing these as active ingredients and using thereof
HK1016602A1 (en)	1999-11-05	Novel pyridonecarboxylic acid derivatives or their salts, and antibacterial agent comprising the same as the active ingredient
IL101785A0 (en)	1992-12-30	Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
NZ239305A (en)	1994-08-26	4-benzyl-5-substituted isoxazole derivatives, preparation and herbicidal compositions thereof
BG105571A (en)	2002-01-31	4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
MXPA04002495A (es)	2004-05-31	Compuestos de imidazopiridin como moduladores del receptor 5-ht4.
NZ502180A (en)	2000-11-24	6-Azauracil derivatives and their use as IL-5 inhibitors
BG105602A (en)	2002-01-31	Il-5-inhibiting 6-azauracyl derivatives
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BG106784A (en)	2003-01-31	3-(4,5-dihydroisoxalole-5-yl)benzoylpyrazole
CA2352503A1 (en)	2000-06-02	Il-5 inhibiting 6-azauracil derivatives
CA2242494A1 (en)	1997-09-04	Novel n-substituted 4-((4'-aminobenzoyl)-oxymethyl)-piperidines having gastric prokinetic properties
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IL84874A (en)	1991-08-16	(((aminoalkyl)amino)-carbonyl)-di(het)areno-(b,e)(1,4)-diazepinones,their preparation and pharmaceutical compositions containing them
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PL338009A1 (en)	2000-09-25	2,4,4-three-substituted 1,3-dioxolane based antimycotic agents
NZ504299A (en)	2001-01-26	1-aza-2-alkyl-6-aryl-cycloalkane compounds, a process for their preparation and pharmaceutical compositions containing them
KR950704331A (ko)	1995-11-17	세펨 화합물 및 그의 약제학적 조성물(cephem compounds and their pharmaceutical compositions)
MY117552A (en)	2004-07-31	Novel esters of 3-hydroxy-piperidinemethanol derivatives