IL142391A0 - Derivatives of isosorbid mononitrate, utilization as vasodilator agents with reduced tolerance - Google Patents

Derivatives of isosorbid mononitrate, utilization as vasodilator agents with reduced tolerance

Info

Publication number
IL142391A0
IL142391A0 IL14239199A IL14239199A IL142391A0 IL 142391 A0 IL142391 A0 IL 142391A0 IL 14239199 A IL14239199 A IL 14239199A IL 14239199 A IL14239199 A IL 14239199A IL 142391 A0 IL142391 A0 IL 142391A0
Authority
IL
Israel
Prior art keywords
utilization
derivatives
reduced tolerance
vasodilator agents
isosorbid mononitrate
Prior art date
Application number
IL14239199A
Other languages
English (en)
Original Assignee
Lacer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer Sa filed Critical Lacer Sa
Publication of IL142391A0 publication Critical patent/IL142391A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
IL14239199A 1998-10-07 1999-10-04 Derivatives of isosorbid mononitrate, utilization as vasodilator agents with reduced tolerance IL142391A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009802076A ES2142773B1 (es) 1998-10-07 1998-10-07 Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
PCT/ES1999/000316 WO2000020420A1 (es) 1998-10-07 1999-10-04 Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia disminuida

Publications (1)

Publication Number Publication Date
IL142391A0 true IL142391A0 (en) 2002-03-10

Family

ID=8305360

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14239199A IL142391A0 (en) 1998-10-07 1999-10-04 Derivatives of isosorbid mononitrate, utilization as vasodilator agents with reduced tolerance
IL142391A IL142391A (en) 1998-10-07 2001-04-03 History of isosorbide mononitrate and their use as improved vasodilators

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL142391A IL142391A (en) 1998-10-07 2001-04-03 History of isosorbide mononitrate and their use as improved vasodilators

Country Status (40)

Country Link
US (2) US20010051735A1 (cs)
EP (1) EP1120419B1 (cs)
JP (1) JP4659214B2 (cs)
KR (1) KR100641801B1 (cs)
CN (1) CN1096465C (cs)
AP (1) AP1555A (cs)
AR (1) AR020538A1 (cs)
AT (1) ATE323707T1 (cs)
AU (1) AU762724B2 (cs)
BG (1) BG65135B1 (cs)
BR (1) BR9914355B1 (cs)
CA (1) CA2346010C (cs)
CO (1) CO5180544A1 (cs)
CU (1) CU23162A3 (cs)
CZ (1) CZ294551B6 (cs)
DE (2) DE19983612T1 (cs)
DK (1) DK1120419T3 (cs)
EA (1) EA003360B1 (cs)
EE (1) EE04374B1 (cs)
ES (2) ES2142773B1 (cs)
GB (1) GB2359810B (cs)
GE (1) GEP20043162B (cs)
GT (1) GT199900173A (cs)
HR (1) HRP20010256B1 (cs)
HU (1) HUP0103937A3 (cs)
ID (1) ID29946A (cs)
IL (2) IL142391A0 (cs)
IS (1) IS2312B (cs)
NO (1) NO328584B1 (cs)
NZ (1) NZ510855A (cs)
OA (1) OA11661A (cs)
PA (1) PA8483901A1 (cs)
PE (1) PE20001083A1 (cs)
PL (1) PL200028B1 (cs)
PT (1) PT1120419E (cs)
RS (1) RS50112B (cs)
TR (1) TR200100961T2 (cs)
WO (1) WO2000020420A1 (cs)
YU (1) YU25201A (cs)
ZA (1) ZA200102836B (cs)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2258365B1 (es) * 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (en) * 2006-12-28 2008-07-09 Lacer, S.A. Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
ES2332565B1 (es) * 2007-01-23 2010-10-21 Lacer, S.A. Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios.
IE20070934A1 (en) 2007-12-21 2009-06-24 Trinity College Dublin Efficient aspirin prodrugs
WO2009087379A2 (en) 2008-01-09 2009-07-16 Amura Therapeutics Limited Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases
WO2009098113A1 (en) * 2008-02-07 2009-08-13 Nicox S.A. Nitric oxide donor compounds
EP2149576A1 (en) * 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
EP2149577B1 (en) * 2008-07-22 2011-04-27 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2177216A1 (en) * 2008-10-13 2010-04-21 Lacer, S.A. Use of dianhydrohexite mononitrate derivatives as healing agents
WO2010055138A1 (en) * 2008-11-14 2010-05-20 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2199294A1 (en) 2008-12-19 2010-06-23 Lacer, S.A. New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
ES2423939T3 (es) * 2009-09-10 2013-09-25 Cognis Ip Management Gmbh Derivados de isosorburo gliceril éter y su empleo en aplicaciones de uso doméstico
DK2515899T3 (en) 2009-12-23 2016-08-15 Arca Biopharma Inc METHODS AND COMPOSITIONS FOR CARDIOVASCULAR DISEASES AND CONDITIONS
CN102241687A (zh) * 2011-05-23 2011-11-16 中国人民解放军第四军医大学 抗缺血/再灌注损伤的药物
CN103687843B (zh) 2011-10-24 2016-11-16 尼科斯科学爱尔兰公司 醌基一氧化氮供体化合物
CA2902009A1 (en) * 2013-03-05 2014-09-12 Archer Daniels Midland Company Isohexide monotriflates and process for synthesis thereof
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds
CN104650108B (zh) * 2013-11-18 2017-05-24 富力 连翘脂素硫酸酯及其衍生物、制备方法及其应用
CN105461731B (zh) * 2014-08-07 2017-05-24 富力 连翘脂素布洛芬酯、其制备及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1356374A (fr) 1963-02-12 1964-03-27 Machine à fonctions multiples pour le travail du bois
GB1356374A (en) 1971-04-29 1974-06-12 American Home Prod Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol
US3886196A (en) 1973-02-07 1975-05-27 Phillips Petroleum Co Magnesium-aluminum-silicate-phosphate catalysts for ammonialytic cleavage of lactams to form omega-aminonitriles
DE3028289C2 (de) * 1980-07-25 1986-11-27 Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe 2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE3248548A1 (de) * 1982-12-29 1984-07-05 Heinrich Mack Nachf., 7918 Illertissen Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3421072A1 (de) 1984-06-06 1985-12-12 Heinrich Mack Nachf., 7918 Illertissen 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3602067A1 (de) 1986-01-24 1987-07-30 Mack Chem Pharm 2,6-dioxabicyclo(3.3.0)octan-derivate, ihre herstellung und verwendung als arzneimittel
DE3606634A1 (de) 1986-02-28 1987-09-03 Mack Chem Pharm Isohexid-nucleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IT1204571B (it) * 1987-05-08 1989-03-10 Chiesi Farma Spa Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche
DE3741005A1 (de) 1987-12-03 1989-06-15 Mack Chem Pharm Aminopropanol-derivate von 1,4:3,6-dianhydro-hexit-nitraten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JP2628756B2 (ja) * 1988-09-15 1997-07-09 シュバルツファルマ アクチェンゲゼルシャフト 新規有機ニトレート及びそれらの製造方法
US5428061A (en) 1988-09-15 1995-06-27 Schwarz Pharma Ag Organic nitrates and method for their preparation
US4891373A (en) * 1988-11-23 1990-01-02 Pfizer Inc. Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments
CA2014520C (en) 1989-04-17 1996-07-16 Fumio Suzuki Hexitol derivatives
NL9001955A (nl) * 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
FR2680173A1 (fr) 1991-08-07 1993-02-12 Hoechst Lab Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .
US5665766A (en) * 1992-07-30 1997-09-09 Cal International Limited Ester of an organic nitrate and a salicylate
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
WO2000020420A1 (es) 2000-04-13
AU6204199A (en) 2000-04-26
PL347030A1 (en) 2002-03-11
DE69930949D1 (de) 2006-05-24
BR9914355B1 (pt) 2014-10-21
NO328584B1 (no) 2010-03-22
ATE323707T1 (de) 2006-05-15
TR200100961T2 (tr) 2003-02-21
GB2359810A (en) 2001-09-05
CU23162A3 (es) 2006-07-18
GT199900173A (es) 2001-03-30
KR20010088848A (ko) 2001-09-28
GB0111172D0 (en) 2001-06-27
HUP0103937A2 (hu) 2002-02-28
YU25201A (sh) 2003-04-30
IS5910A (is) 2001-03-29
IS2312B (is) 2007-11-15
NO20011778L (no) 2001-04-06
DE69930949T2 (de) 2006-12-28
EE04374B1 (et) 2004-10-15
GEP20043162B (en) 2004-01-26
KR100641801B1 (ko) 2006-11-02
NZ510855A (en) 2004-02-27
CA2346010C (en) 2010-01-12
ES2257871T3 (es) 2006-08-01
CA2346010A1 (en) 2000-04-13
IL142391A (en) 2007-07-24
EP1120419A1 (en) 2001-08-01
HRP20010256B1 (en) 2009-08-31
CO5180544A1 (es) 2002-07-30
US20010051735A1 (en) 2001-12-13
JP2002526544A (ja) 2002-08-20
AR020538A1 (es) 2002-05-15
PE20001083A1 (es) 2000-11-28
ID29946A (id) 2001-10-25
RS50112B (sr) 2009-03-25
EE200100207A (et) 2002-06-17
AU762724B2 (en) 2003-07-03
EP1120419B1 (en) 2006-04-19
CZ294551B6 (cs) 2005-01-12
BR9914355A (pt) 2001-06-26
CN1096465C (zh) 2002-12-18
BG105417A (en) 2001-12-29
NO20011778D0 (no) 2001-04-06
DK1120419T3 (da) 2006-07-03
HUP0103937A3 (en) 2003-11-28
US20030225134A1 (en) 2003-12-04
JP4659214B2 (ja) 2011-03-30
CN1322205A (zh) 2001-11-14
BG65135B1 (bg) 2007-03-30
OA11661A (en) 2004-12-08
AP1555A (en) 2006-01-18
HRP20010256A2 (en) 2002-04-30
CZ20011257A3 (cs) 2001-08-15
AP2001002128A0 (en) 2001-06-30
ES2142773A1 (es) 2000-04-16
ZA200102836B (en) 2002-09-25
DE19983612T1 (de) 2001-09-27
PA8483901A1 (es) 2000-09-29
EA003360B1 (ru) 2003-04-24
PT1120419E (pt) 2006-07-31
GB2359810B (en) 2003-12-03
PL200028B1 (pl) 2008-11-28
ES2142773B1 (es) 2001-01-01
US6858632B2 (en) 2005-02-22
EA200100422A1 (ru) 2001-10-22

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Legal Events

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