EA200100422A1 - Производные мононитрата изосорбида и их использование в качестве сосудорасширяющих агентов с пониженной толерантностью - Google Patents

Производные мононитрата изосорбида и их использование в качестве сосудорасширяющих агентов с пониженной толерантностью

Info

Publication number
EA200100422A1
EA200100422A1 EA200100422A EA200100422A EA200100422A1 EA 200100422 A1 EA200100422 A1 EA 200100422A1 EA 200100422 A EA200100422 A EA 200100422A EA 200100422 A EA200100422 A EA 200100422A EA 200100422 A1 EA200100422 A1 EA 200100422A1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
substituted
derivatives
vasculating
isonsorbide
Prior art date
Application number
EA200100422A
Other languages
English (en)
Other versions
EA003360B1 (ru
Inventor
Хосе Репольес Молинер
Франсиско Пубиль Кой
Лидия Кабеса Льоренте
Марсель.ли Карбо Банус
Кристина Негрье Рофес
Хуан Антонио Серда Риудаветс
Алисия Феррер Сисо
Марек В. Радомски
Эдуардо Салас Перес-Расилья
Хуан Мартинес Боннин
Original Assignee
Ласер, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ласер, С.А. filed Critical Ласер, С.А.
Publication of EA200100422A1 publication Critical patent/EA200100422A1/ru
Publication of EA003360B1 publication Critical patent/EA003360B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

Новые производные мононитрата изосорбида и его фармацевтически приемлемых солей, которые обладают сосудорасширяющей активностью с пониженным эффектом толерантности, формулы (I)в которой A и B, каждый независимо, представляет любую из групп -ONOи -Z-CO-R, где Z представляет атом кислорода или атом серы и R представляет C-C-алкильную группу, арильную группу или аралкильную группу, иногда замещенную, или группув которой Rпредставляет водород или C-C-алкильную группу, арильную группу или аралкильную группу, иногда замещенную, при условии, что один из A или B всегда представляет -ONO, но никогда оба из них не являются данной группой одновременно; когда Z представляет атом серы, R представляет C-C-алкильную группу, арильную группу или аралкильную группу, иногда замещенную; и когда Z представляет атом кислорода, R представляет группуМеждународная заявка была опубликована вместе с отчетом о международном поиске.
EA200100422A 1998-10-07 1999-10-04 Производные мононитрата изосорбида и их использование в качестве сосудорасширяющих агентов с пониженной толерантностью EA003360B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009802076A ES2142773B1 (es) 1998-10-07 1998-10-07 Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
PCT/ES1999/000316 WO2000020420A1 (es) 1998-10-07 1999-10-04 Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia disminuida

Publications (2)

Publication Number Publication Date
EA200100422A1 true EA200100422A1 (ru) 2001-10-22
EA003360B1 EA003360B1 (ru) 2003-04-24

Family

ID=8305360

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100422A EA003360B1 (ru) 1998-10-07 1999-10-04 Производные мононитрата изосорбида и их использование в качестве сосудорасширяющих агентов с пониженной толерантностью

Country Status (40)

Country Link
US (2) US20010051735A1 (ru)
EP (1) EP1120419B1 (ru)
JP (1) JP4659214B2 (ru)
KR (1) KR100641801B1 (ru)
CN (1) CN1096465C (ru)
AP (1) AP1555A (ru)
AR (1) AR020538A1 (ru)
AT (1) ATE323707T1 (ru)
AU (1) AU762724B2 (ru)
BG (1) BG65135B1 (ru)
BR (1) BR9914355B1 (ru)
CA (1) CA2346010C (ru)
CO (1) CO5180544A1 (ru)
CU (1) CU23162A3 (ru)
CZ (1) CZ294551B6 (ru)
DE (2) DE19983612T1 (ru)
DK (1) DK1120419T3 (ru)
EA (1) EA003360B1 (ru)
EE (1) EE04374B1 (ru)
ES (2) ES2142773B1 (ru)
GB (1) GB2359810B (ru)
GE (1) GEP20043162B (ru)
GT (1) GT199900173A (ru)
HR (1) HRP20010256B1 (ru)
HU (1) HUP0103937A3 (ru)
ID (1) ID29946A (ru)
IL (2) IL142391A0 (ru)
IS (1) IS2312B (ru)
NO (1) NO328584B1 (ru)
NZ (1) NZ510855A (ru)
OA (1) OA11661A (ru)
PA (1) PA8483901A1 (ru)
PE (1) PE20001083A1 (ru)
PL (1) PL200028B1 (ru)
PT (1) PT1120419E (ru)
RS (1) RS50112B (ru)
TR (1) TR200100961T2 (ru)
WO (1) WO2000020420A1 (ru)
YU (1) YU25201A (ru)
ZA (1) ZA200102836B (ru)

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ES2258365B1 (es) * 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (en) * 2006-12-28 2008-07-09 Lacer, S.A. Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
ES2332565B1 (es) * 2007-01-23 2010-10-21 Lacer, S.A. Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios.
IE20070934A1 (en) 2007-12-21 2009-06-24 Trinity College Dublin Efficient aspirin prodrugs
JP5587790B2 (ja) 2008-01-09 2014-09-10 アミュラ セラピューティクス リミティド 化合物
WO2009098113A1 (en) * 2008-02-07 2009-08-13 Nicox S.A. Nitric oxide donor compounds
EP2149576A1 (en) * 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
EP2149577B1 (en) * 2008-07-22 2011-04-27 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2177216A1 (en) * 2008-10-13 2010-04-21 Lacer, S.A. Use of dianhydrohexite mononitrate derivatives as healing agents
WO2010055138A1 (en) * 2008-11-14 2010-05-20 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2199294A1 (en) * 2008-12-19 2010-06-23 Lacer, S.A. New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
ES2423939T3 (es) * 2009-09-10 2013-09-25 Cognis Ip Management Gmbh Derivados de isosorburo gliceril éter y su empleo en aplicaciones de uso doméstico
WO2011079273A2 (en) 2009-12-23 2011-06-30 Arca Biopharma, Inc. Methods and compositions for cardiovascular diseases and conditions
CN102241687A (zh) * 2011-05-23 2011-11-16 中国人民解放军第四军医大学 抗缺血/再灌注损伤的药物
CN103739499B (zh) 2011-10-24 2016-09-07 尼科斯科学爱尔兰公司 醌基一氧化氮供体化合物
EP2964653A4 (en) * 2013-03-05 2016-11-30 Archer Daniels Midland Co ISOHEXIDE MONOTRIFLATES AND PROCESS FOR THEIR SYNTHESIS
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds
CN104650108B (zh) * 2013-11-18 2017-05-24 富力 连翘脂素硫酸酯及其衍生物、制备方法及其应用
CN105461731B (zh) * 2014-08-07 2017-05-24 富力 连翘脂素布洛芬酯、其制备及其应用

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DE3248548A1 (de) * 1982-12-29 1984-07-05 Heinrich Mack Nachf., 7918 Illertissen Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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CA2014520C (en) 1989-04-17 1996-07-16 Fumio Suzuki Hexitol derivatives
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FR2680173A1 (fr) * 1991-08-07 1993-02-12 Hoechst Lab Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .
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IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
HUP0103937A2 (hu) 2002-02-28
TR200100961T2 (tr) 2003-02-21
AP2001002128A0 (en) 2001-06-30
CN1096465C (zh) 2002-12-18
IL142391A (en) 2007-07-24
EP1120419A1 (en) 2001-08-01
HRP20010256B1 (en) 2009-08-31
YU25201A (sh) 2003-04-30
EP1120419B1 (en) 2006-04-19
PE20001083A1 (es) 2000-11-28
BR9914355A (pt) 2001-06-26
JP2002526544A (ja) 2002-08-20
EA003360B1 (ru) 2003-04-24
BR9914355B1 (pt) 2014-10-21
WO2000020420A1 (es) 2000-04-13
US20030225134A1 (en) 2003-12-04
ES2257871T3 (es) 2006-08-01
OA11661A (en) 2004-12-08
AU6204199A (en) 2000-04-26
IS2312B (is) 2007-11-15
HUP0103937A3 (en) 2003-11-28
NZ510855A (en) 2004-02-27
PT1120419E (pt) 2006-07-31
CA2346010A1 (en) 2000-04-13
NO20011778L (no) 2001-04-06
DK1120419T3 (da) 2006-07-03
NO20011778D0 (no) 2001-04-06
NO328584B1 (no) 2010-03-22
IS5910A (is) 2001-03-29
GB2359810A (en) 2001-09-05
AP1555A (en) 2006-01-18
HRP20010256A2 (en) 2002-04-30
DE69930949D1 (de) 2006-05-24
DE19983612T1 (de) 2001-09-27
IL142391A0 (en) 2002-03-10
CZ20011257A3 (cs) 2001-08-15
GT199900173A (es) 2001-03-30
CO5180544A1 (es) 2002-07-30
GB2359810B (en) 2003-12-03
CU23162A3 (es) 2006-07-18
KR20010088848A (ko) 2001-09-28
CZ294551B6 (cs) 2005-01-12
PL200028B1 (pl) 2008-11-28
GEP20043162B (en) 2004-01-26
US20010051735A1 (en) 2001-12-13
PL347030A1 (en) 2002-03-11
KR100641801B1 (ko) 2006-11-02
ES2142773A1 (es) 2000-04-16
DE69930949T2 (de) 2006-12-28
JP4659214B2 (ja) 2011-03-30
EE04374B1 (et) 2004-10-15
EE200100207A (et) 2002-06-17
GB0111172D0 (en) 2001-06-27
PA8483901A1 (es) 2000-09-29
AR020538A1 (es) 2002-05-15
ATE323707T1 (de) 2006-05-15
BG65135B1 (bg) 2007-03-30
ES2142773B1 (es) 2001-01-01
RS50112B (sr) 2009-03-25
US6858632B2 (en) 2005-02-22
CN1322205A (zh) 2001-11-14
ID29946A (id) 2001-10-25
CA2346010C (en) 2010-01-12
BG105417A (en) 2001-12-29
ZA200102836B (en) 2002-09-25
AU762724B2 (en) 2003-07-03

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