BR9914355A - Derivados de mononitrato de isosorbida e sua utilização como agentes vasodilatadores com tolerância reduzida - Google Patents

Derivados de mononitrato de isosorbida e sua utilização como agentes vasodilatadores com tolerância reduzida

Info

Publication number
BR9914355A
BR9914355A BR9914355-0A BR9914355A BR9914355A BR 9914355 A BR9914355 A BR 9914355A BR 9914355 A BR9914355 A BR 9914355A BR 9914355 A BR9914355 A BR 9914355A
Authority
BR
Brazil
Prior art keywords
group
reduced tolerance
isosorbide mononitrate
vasodilating agents
alkyl group
Prior art date
Application number
BR9914355-0A
Other languages
English (en)
Other versions
BR9914355B1 (pt
Inventor
Jose Repolles Moliner
Francisco Pubill Coy
Lydia Cabeza Llorente
Marcelli Carbo Banus
Cristina Negrie Rofes
Juan Antonio Cerda Riudavets
Alicia Ferrer Siso
Marek W Radomski
Eduardo Salas Perez-Rasilla
Juan Martinez Bonnin
Original Assignee
Lacer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer Sa filed Critical Lacer Sa
Publication of BR9914355A publication Critical patent/BR9914355A/pt
Publication of BR9914355B1 publication Critical patent/BR9914355B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

<B>"DERIVADOS DE MONONITRATO DE ISOSORBIDA E SUA UTILIZAçãO COMO AGENTES VASODILATADORES COM TOLERâNCIA REDUZIDA"<D>. A presente invenção descreve novos compostos derivados de mononitrato de isosorbida e seus sais farmaceuticamente aceitáveis, que apresentam uma atividade vasodilatadora com um reduzido efeito de tolerância, tendo a fórmula geral (I), em que A e B representam individualmente quaisquer dos grupos NO~ 2~ e Z-CO-R, em que Z representa um átomo de oxigênio ou enxofre e R representa um grupo C~ 1~-C~ 4~ alquila, um grupo arila ou um grupo aralquila opcionalmente substituídos, ou o grupo (a), onde R¹ é hidrogênio ou um grupo C~ 1~-C~ 4~ alquila, um grupo arila ou um grupo aralquila eventualmente substituídos, com a condição de que um dentre A ou B é sempre -ONO~ 2~, mas nunca os dois ao mesmo tempo, e quando Z for um átomo de enxofre, R será um grupo C~ 1~-C~ 4~ alquila, um grupo arila ou um grupo aralquila eventualmente substituído e quando Z for um átomo de oxigênio, R será o grupo (a).
BRPI9914355-0A 1998-10-07 1999-10-04 Derivados de mononitrato de isosorbida e sua utilização como agentes vasodilatadores com tolerância reduzida BR9914355B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP9802076 1998-10-07
ES009802076A ES2142773B1 (es) 1998-10-07 1998-10-07 Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
PCT/ES1999/000316 WO2000020420A1 (es) 1998-10-07 1999-10-04 Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia disminuida

Publications (2)

Publication Number Publication Date
BR9914355A true BR9914355A (pt) 2001-06-26
BR9914355B1 BR9914355B1 (pt) 2014-10-21

Family

ID=8305360

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9914355-0A BR9914355B1 (pt) 1998-10-07 1999-10-04 Derivados de mononitrato de isosorbida e sua utilização como agentes vasodilatadores com tolerância reduzida

Country Status (40)

Country Link
US (2) US20010051735A1 (pt)
EP (1) EP1120419B1 (pt)
JP (1) JP4659214B2 (pt)
KR (1) KR100641801B1 (pt)
CN (1) CN1096465C (pt)
AP (1) AP1555A (pt)
AR (1) AR020538A1 (pt)
AT (1) ATE323707T1 (pt)
AU (1) AU762724B2 (pt)
BG (1) BG65135B1 (pt)
BR (1) BR9914355B1 (pt)
CA (1) CA2346010C (pt)
CO (1) CO5180544A1 (pt)
CU (1) CU23162A3 (pt)
CZ (1) CZ294551B6 (pt)
DE (2) DE69930949T2 (pt)
DK (1) DK1120419T3 (pt)
EA (1) EA003360B1 (pt)
EE (1) EE04374B1 (pt)
ES (2) ES2142773B1 (pt)
GB (1) GB2359810B (pt)
GE (1) GEP20043162B (pt)
GT (1) GT199900173A (pt)
HR (1) HRP20010256B1 (pt)
HU (1) HUP0103937A3 (pt)
ID (1) ID29946A (pt)
IL (2) IL142391A0 (pt)
IS (1) IS2312B (pt)
NO (1) NO328584B1 (pt)
NZ (1) NZ510855A (pt)
OA (1) OA11661A (pt)
PA (1) PA8483901A1 (pt)
PE (1) PE20001083A1 (pt)
PL (1) PL200028B1 (pt)
PT (1) PT1120419E (pt)
RS (1) RS50112B (pt)
TR (1) TR200100961T2 (pt)
WO (1) WO2000020420A1 (pt)
YU (1) YU25201A (pt)
ZA (1) ZA200102836B (pt)

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ES2258365B1 (es) * 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (en) * 2006-12-28 2008-07-09 Lacer, S.A. Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
ES2332565B1 (es) * 2007-01-23 2010-10-21 Lacer, S.A. Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios.
IE20070934A1 (en) 2007-12-21 2009-06-24 Trinity College Dublin Efficient aspirin prodrugs
JP5587790B2 (ja) 2008-01-09 2014-09-10 アミュラ セラピューティクス リミティド 化合物
ES2393049T3 (es) * 2008-02-07 2012-12-18 Nicox S.A. Compuestos donantes de óxido nítrico
EP2149576A1 (en) * 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
EP2149577B1 (en) 2008-07-22 2011-04-27 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2177216A1 (en) * 2008-10-13 2010-04-21 Lacer, S.A. Use of dianhydrohexite mononitrate derivatives as healing agents
WO2010055138A1 (en) * 2008-11-14 2010-05-20 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2199294A1 (en) 2008-12-19 2010-06-23 Lacer, S.A. New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
ES2423939T3 (es) * 2009-09-10 2013-09-25 Cognis Ip Management Gmbh Derivados de isosorburo gliceril éter y su empleo en aplicaciones de uso doméstico
DK2515899T3 (en) 2009-12-23 2016-08-15 Arca Biopharma Inc METHODS AND COMPOSITIONS FOR CARDIOVASCULAR DISEASES AND CONDITIONS
CN102241687A (zh) * 2011-05-23 2011-11-16 中国人民解放军第四军医大学 抗缺血/再灌注损伤的药物
WO2013060673A1 (en) 2011-10-24 2013-05-02 Nicox S.A. Quinone based nitric oxide donating compounds
KR20150123324A (ko) * 2013-03-05 2015-11-03 아처 다니엘 미드랜드 캄파니 이소헥시드 모노트리플레이트 및 이의 합성 방법
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds
CN104650108B (zh) * 2013-11-18 2017-05-24 富力 连翘脂素硫酸酯及其衍生物、制备方法及其应用
CN105461731B (zh) * 2014-08-07 2017-05-24 富力 连翘脂素布洛芬酯、其制备及其应用

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IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ES2142773B1 (es) 2001-01-01
KR100641801B1 (ko) 2006-11-02
GT199900173A (es) 2001-03-30
ES2142773A1 (es) 2000-04-16
GB0111172D0 (en) 2001-06-27
AP2001002128A0 (en) 2001-06-30
NO328584B1 (no) 2010-03-22
EA003360B1 (ru) 2003-04-24
PL347030A1 (en) 2002-03-11
CZ294551B6 (cs) 2005-01-12
BR9914355B1 (pt) 2014-10-21
KR20010088848A (ko) 2001-09-28
PL200028B1 (pl) 2008-11-28
CN1322205A (zh) 2001-11-14
PA8483901A1 (es) 2000-09-29
HUP0103937A3 (en) 2003-11-28
CN1096465C (zh) 2002-12-18
NO20011778D0 (no) 2001-04-06
ATE323707T1 (de) 2006-05-15
IL142391A0 (en) 2002-03-10
DE69930949D1 (de) 2006-05-24
CA2346010C (en) 2010-01-12
EE200100207A (et) 2002-06-17
HUP0103937A2 (hu) 2002-02-28
AU762724B2 (en) 2003-07-03
EA200100422A1 (ru) 2001-10-22
US6858632B2 (en) 2005-02-22
CO5180544A1 (es) 2002-07-30
PT1120419E (pt) 2006-07-31
YU25201A (sh) 2003-04-30
DK1120419T3 (da) 2006-07-03
JP2002526544A (ja) 2002-08-20
IL142391A (en) 2007-07-24
IS5910A (is) 2001-03-29
NZ510855A (en) 2004-02-27
ES2257871T3 (es) 2006-08-01
HRP20010256A2 (en) 2002-04-30
US20030225134A1 (en) 2003-12-04
EP1120419B1 (en) 2006-04-19
CU23162A3 (es) 2006-07-18
CA2346010A1 (en) 2000-04-13
NO20011778L (no) 2001-04-06
AU6204199A (en) 2000-04-26
AP1555A (en) 2006-01-18
RS50112B (sr) 2009-03-25
WO2000020420A1 (es) 2000-04-13
PE20001083A1 (es) 2000-11-28
ZA200102836B (en) 2002-09-25
US20010051735A1 (en) 2001-12-13
DE19983612T1 (de) 2001-09-27
TR200100961T2 (tr) 2003-02-21
EP1120419A1 (en) 2001-08-01
HRP20010256B1 (en) 2009-08-31
DE69930949T2 (de) 2006-12-28
IS2312B (is) 2007-11-15
BG65135B1 (bg) 2007-03-30
JP4659214B2 (ja) 2011-03-30
OA11661A (en) 2004-12-08
AR020538A1 (es) 2002-05-15
BG105417A (en) 2001-12-29
EE04374B1 (et) 2004-10-15
GEP20043162B (en) 2004-01-26
ID29946A (id) 2001-10-25
CZ20011257A3 (cs) 2001-08-15
GB2359810A (en) 2001-09-05
GB2359810B (en) 2003-12-03

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 21/10/2014, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.