IL141063A - Derivatives of pyrrolidine-2-carboxylic acid and piperidine-2-carboxylic acids and pharmaceutical compositions comprising said derivatives for treating infertility - Google Patents

Derivatives of pyrrolidine-2-carboxylic acid and piperidine-2-carboxylic acids and pharmaceutical compositions comprising said derivatives for treating infertility

Info

Publication number
IL141063A
IL141063A IL14106399A IL14106399A IL141063A IL 141063 A IL141063 A IL 141063A IL 14106399 A IL14106399 A IL 14106399A IL 14106399 A IL14106399 A IL 14106399A IL 141063 A IL141063 A IL 141063A
Authority
IL
Israel
Prior art keywords
derivatives
pyrrolidine
piperidine
pharmaceutical compositions
carboxylic acid
Prior art date
Application number
IL14106399A
Other languages
English (en)
Other versions
IL141063A0 (en
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of IL141063A0 publication Critical patent/IL141063A0/xx
Publication of IL141063A publication Critical patent/IL141063A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL14106399A 1998-08-07 1999-08-05 Derivatives of pyrrolidine-2-carboxylic acid and piperidine-2-carboxylic acids and pharmaceutical compositions comprising said derivatives for treating infertility IL141063A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9571298P 1998-08-07 1998-08-07
PCT/US1999/017755 WO2000008015A2 (en) 1998-08-07 1999-08-05 Fsh mimetics for the treatment of infertility

Publications (2)

Publication Number Publication Date
IL141063A0 IL141063A0 (en) 2002-02-10
IL141063A true IL141063A (en) 2005-06-19

Family

ID=22253270

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14106399A IL141063A (en) 1998-08-07 1999-08-05 Derivatives of pyrrolidine-2-carboxylic acid and piperidine-2-carboxylic acids and pharmaceutical compositions comprising said derivatives for treating infertility

Country Status (12)

Country Link
US (3) US6235755B1 (xx)
EP (1) EP1102763B1 (xx)
JP (1) JP4511042B2 (xx)
AR (1) AR021755A1 (xx)
AT (2) ATE279407T1 (xx)
AU (1) AU772373B2 (xx)
CA (1) CA2339018A1 (xx)
DE (2) DE69931975T2 (xx)
ES (2) ES2228084T3 (xx)
IL (1) IL141063A (xx)
PT (2) PT1102763E (xx)
WO (1) WO2000008015A2 (xx)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025355A (en) * 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6297233B1 (en) 1999-02-09 2001-10-02 Bristol-Myers Squibb Company Lactam inhibitors of FXa and method
DE60120940T2 (de) * 2000-03-27 2007-01-25 Applied Research Systems Ars Holding N.V. Pyrrolidin-derivate verwendbar als bax-inhibitoren
WO2001074769A1 (en) * 2000-03-27 2001-10-11 Applied Research Systems Ars Holding N.V. Pharmaceutically active pyrrolidine derivatives as bax inhibitors
GB0010757D0 (en) 2000-05-05 2000-06-28 Astrazeneca Ab Chemical compounds
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
IL156811A0 (en) * 2001-01-19 2004-02-08 Pharmacopeia Inc Bisaryl derivatives and pharmaceutical compositions containing the same
US6900213B2 (en) 2001-01-19 2005-05-31 Pharmacopeia Drug Discovery, Inc. Bisaryl derivatives having FSH modulatory activity
EA005974B1 (ru) 2001-02-23 2005-08-25 Мерк Энд Ко., Инк. N-замещенные неарильные гетероциклические антагонисты nmda/nr2b
US7259157B2 (en) 2001-04-03 2007-08-21 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
KR20030096348A (ko) * 2001-05-05 2003-12-24 스미스클라인비이참피이엘시이 Ｎ-아로일 시클릭 아민
GB0115862D0 (en) * 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
ES2260458T3 (es) * 2001-07-02 2006-11-01 Akzo Nobel N.V. Derivados de tetrahidroquinolina.
GB0121941D0 (en) 2001-09-11 2001-10-31 Astrazeneca Ab Chemical compounds
JP2005515974A (ja) * 2001-10-22 2005-06-02 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 卵胞形成のためのゴナドドロピン
AU2003299124A1 (en) 2002-09-20 2004-04-23 Laboratoires Serono Sa Piperazine derivatives and methods of use
CN100404508C (zh) * 2002-12-20 2008-07-23 欧加农股份有限公司 四氢喹啉衍生物
CN100386318C (zh) * 2002-12-20 2008-05-07 欧加农股份有限公司 四氢喹啉衍生物及其作为fsh受体调节剂的用途
TWI322012B (en) 2002-12-20 2010-03-21 Organon Nv Tetrahydroquinoline derivatives
TWI306855B (en) 2002-12-20 2009-03-01 Organon Nv Tetrahydroquinoline derivatives
UA88879C2 (xx) * 2003-09-02 2009-12-10 Эплайд Рисерч Системз Эрс Холдинг Н.В. Мутант глікозилування fsh$мутант гликозилирование
EP1711610A2 (en) * 2004-01-28 2006-10-18 Syntonix Pharmaceuticals, Inc. HETERODIMERIC FOLLICLE STIMULATING HORMONE-Fc (FSH-Fc) FUSION PROTEINS FOR THE TREATMENT OF INFERTILITY
US7691848B2 (en) 2005-03-02 2010-04-06 Wyeth Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists
JPWO2006095922A1 (ja) * 2005-03-10 2008-08-21 京都薬品工業株式会社 テトラヒドロイソキノリン化合物およびその医薬用途
UA92008C2 (xx) 2005-05-04 2010-09-27 Н.В. Органон 4-феніл-5-оксо-1,4,5,6,7,8-гексагідрохінолінпохідні для лікування безплідності$4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолинпроизводные для лечения бесплодия
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92009C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
WO2006117023A1 (en) 2005-05-04 2006-11-09 N.V. Organon Dihydropyridine derivatives
CA2607882A1 (en) 2005-05-12 2006-11-23 Wyeth Pyrrolobenzodiazepines and heterocyclic carboxamide derivatives as follicle stimulating hormone receptor (fsh-r) antagonists
CA2609714A1 (en) 2005-06-09 2006-12-21 Wyeth Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists
US20090018142A9 (en) * 2006-05-02 2009-01-15 Zhengping Zhuang Use of phosphatases to treat tumors overexpressing N-CoR
AU2007254165A1 (en) * 2006-05-17 2007-11-29 Forschungsverbund Berlin E.V. Pyrimidine low molecular weight ligands for modulating hormone receptors
EP2081905B1 (en) 2006-07-28 2012-09-12 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor
CN101662939B (zh) 2007-02-06 2015-11-25 利克斯特生物技术公司 氧杂双环庚烷和氧杂双环庚烯，它们的制备及用途
CA2700857C (en) 2007-10-01 2016-08-02 John S. Kovach Hdac inhibitors
WO2009061652A1 (en) 2007-11-07 2009-05-14 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
WO2010005782A1 (en) 2008-07-10 2010-01-14 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the cb2 receptor
EP2318005B1 (en) 2008-08-01 2017-11-01 Lixte Biotechnology, Inc. Neuroprotective agents for the prevention and treatment of neurodegenerative diseases
WO2010147612A1 (en) 2009-06-18 2010-12-23 Lixte Biotechnology, Inc. Methods of modulating cell regulation by inhibiting p53
US8227473B2 (en) 2008-08-01 2012-07-24 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
BRPI0919172A2 (pt) 2008-09-25 2015-12-15 Boehringer Ingelheim Int compostos os quais modulam seletivamente o receptor de cb2
EP2387567B1 (en) 2009-01-14 2014-06-11 The Salk Institute for Biological Studies Compounds that protect against amyloid diseases
WO2010096371A2 (en) 2009-02-18 2010-08-26 Boehringer Ingelheim International Gmbh Heterocyclic compounds which modulate the cb2 receptor
TWI461426B (zh) * 2009-05-27 2014-11-21 Merck Sharp & Dohme （二氫）咪唑並異〔５，１－ａ〕喹啉類
US8071587B2 (en) 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
WO2010147791A1 (en) * 2009-06-16 2010-12-23 Boehringer Ingelheim International Gmbh Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor
US8431564B2 (en) 2009-07-29 2013-04-30 Merck Sharp & Dohme B.V. Ring-annulated dihydropyrrolo[2,1-α]isoquinolines
TW201116531A (en) 2009-07-29 2011-05-16 Organon Nv Ring-annulated dihydropyrrolo[2,1-a]isoquinolines
TW201116515A (en) 2009-07-31 2011-05-16 Organon Nv Dihydrobenzoindazoles
RU2569063C2 (ru) 2009-09-01 2015-11-20 Катабэйсис Фармасьютикалз, Инк. Конъюгаты жирных кислот и ниацина и их применение
USRE46608E1 (en) 2009-09-01 2017-11-14 Catabasis Pharmaceuticals, Inc. Fatty acid niacin conjugates and their uses
EP2480544A1 (en) 2009-09-22 2012-08-01 Boehringer Ingelheim International GmbH Compounds which selectively modulate the cb2 receptor
JP2013517271A (ja) 2010-01-15 2013-05-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
WO2011109324A1 (en) 2010-03-05 2011-09-09 Boehringer Ingelheim International Gmbh Tetrazole compounds which selectively modulate the cb2 receptor
US8846936B2 (en) 2010-07-22 2014-09-30 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the CB2 receptor
WO2013006308A2 (en) 2011-07-01 2013-01-10 Merck Patent Gmbh Dihydropyrazoles
WO2013012848A1 (en) 2011-07-18 2013-01-24 Merck Patent Gmbh Benzamides
JP6219844B2 (ja) * 2012-01-10 2017-10-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 卵胞刺激ホルモンの調節因子としてのベンズアミド誘導体
CN104114544A (zh) 2012-02-08 2014-10-22 默克专利有限公司 用作***受体激动剂的氘化噻唑烷酮类似物
EP2983661B1 (en) 2013-04-09 2024-05-29 Lixte Biotechnology, Inc. Formulations of oxabicycloheptanes and oxabicycloheptenes
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
EP3013823B1 (en) 2013-06-24 2017-11-01 Merck Patent GmbH Imidazole compounds as modulators of fshr and uses thereof
US10081637B2 (en) 2013-06-24 2018-09-25 Merck Patent Gmbh Pyrazole compounds as modulators of FSHR and uses thereof
US11433047B2 (en) * 2015-10-09 2022-09-06 Neurotheryx Canada Ltd. Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases
WO2019084037A1 (en) * 2017-10-26 2019-05-02 University Of Puerto Rico NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTICANCER AGENTS AND ANTI-MIGRATORY AGENTS
MX2022004874A (es) 2019-10-25 2022-05-13 Gilead Sciences Inc Compuestos de modulacion de glp-1r.
EP4247804A1 (en) 2020-11-20 2023-09-27 Gilead Sciences, Inc. Polyheterocyclic glp-1 r modulating compounds
CR20230495A (es) 2021-04-21 2023-11-30 Gilead Sciences Inc Compuestos moduladores del glp-ir carboxibenzimidazólicos.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947569A (en) * 1972-04-12 1976-03-30 American Home Products Corporation Process for preparing the releasing hormone of luteinizing hormone (LH) and of follicle stimulating hormone (FSH), salts and compositions thereof, and intermediates therefor
JPS5331669A (en) * 1976-09-06 1978-03-25 Kissei Pharmaceut Co Ltd Novel n-acylpiperidinecaroxyanilide derivatives and their preparation
US4800432A (en) * 1986-10-24 1989-01-24 The Grass Valley Group, Inc. Video Difference key generator
DE3636278A1 (de) * 1986-10-24 1988-05-05 Hoechst Ag Herbizide mittel auf der basis von cyclischen (alpha)-iminocarbon-saeureaniliden sowie neue (alpha)-iminocarbonsaeureanilide und verfahren zu ihrer herstellung
US5071823A (en) 1988-10-12 1991-12-10 Mitsubishi Paper Mills Limited Image-receiving sheet for transfer recording
DE3842010A1 (de) * 1988-12-14 1990-06-21 Hoechst Ag Kompetitive gonadoliberin-antagonisten
DE59309867D1 (de) * 1992-09-03 1999-12-16 Boehringer Ingelheim Pharma Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
US5455229A (en) * 1992-12-23 1995-10-03 Eli Lilly And Company Method for minimizing and containing ischemic and reperfusion injury
PE45195A1 (es) * 1994-03-03 1996-01-17 Boehringer Ingelheim Kg Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene
SI20424A (sl) * 1998-03-05 2001-06-30 Agouron Pharmaceuticals, Inc. Nepeptidna GnRH sredstva

Also Published As

Publication number Publication date
US6653338B2 (en) 2003-11-25
DE69931975D1 (de) 2006-07-27
IL141063A0 (en) 2002-02-10
PT1380582E (pt) 2006-08-31
WO2000008015A3 (en) 2000-05-11
AR021755A1 (es) 2002-08-07
DE69921147T2 (de) 2005-02-24
JP4511042B2 (ja) 2010-07-28
AU5393199A (en) 2000-02-28
ATE279407T1 (de) 2004-10-15
DE69931975T2 (de) 2006-10-05
US6235755B1 (en) 2001-05-22
ES2261844T3 (es) 2006-11-16
ATE329911T1 (de) 2006-07-15
JP2002522433A (ja) 2002-07-23
EP1102763B1 (en) 2004-10-13
PT1102763E (pt) 2005-01-31
ES2228084T3 (es) 2005-04-01
US6423723B1 (en) 2002-07-23
WO2000008015A2 (en) 2000-02-17
EP1102763A2 (en) 2001-05-30
AU772373B2 (en) 2004-04-22
US20020147345A1 (en) 2002-10-10
CA2339018A1 (en) 2000-02-17
DE69921147D1 (de) 2004-11-18

Similar Documents

Publication Publication Date Title
IL141063A (en) Derivatives of pyrrolidine-2-carboxylic acid and piperidine-2-carboxylic acids and pharmaceutical compositions comprising said derivatives for treating infertility
HUP0101653A3 (en) Fatty acid derivatives of bile acids and bile acid derivatives and pharmaceutical compositions thereof
EP1045636A4 (en) PHARMACEUTICAL COMPOSITIONS AND METHOD OF USING THE SAME FOR TREATING FAILURE MYOCARDIAL TISSUES
HUP0000739A3 (en) Alkyl and heterocyclic carboxylic acid derivatives containing alkylsulfonylamino group, pharmaceutical compositions thereof and combined pharmaceutical compositions treating bone loss
HUP0100178A3 (en) Tetrahydro-naphtiridinyl-imidazolydinyl-carboxylic acid derivatives and pharmaceutical compositions thereof
IL161833A0 (en) Pharmaceutical compositions and usethereof for thetreatment of psychotic diseases
IL113625A0 (en) Amino acid derivatives processes for their preparation and pharmaceutical compositions containing them and their use
HUP0900417A3 (en) Polymorphs of donepezil hydrochloride and process for production and pharmaceutical compositions containing them
HK1037303A1 (en) Compositions and methods for treatment of mitochondrial diseases
IL123986A0 (en) Antithombotic agents process for their preparation and pharmaceutical compositions comprising them
EP1021177A4 (en) COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF VASCULAR DEGENERATIVE DISEASES
NZ250762A (en) Five-membered-heterocyclic carboxylic acid derivatives and pharmaceutical compositions
HUP0105160A3 (en) Complex of ras-farnesyltransferase inhibitor and sulfobutylether-7-betha-cyclodextrin or 2-hydroxypropyl-betha-cyclodextrin and method for its preparation and pharmaceutical compositions containing them
HUP0104762A3 (en) Pharmaceutical moxifloxacin compositions and process for their preparation
ZA988016B (en) Compounds methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
IL139658A0 (en) Pharmaceutical compositions for treatment and prophylaxis and method for their preparation
PL316528A1 (en) Pharmaceutic compositions and drugs for prevetion and treatment of endothelial disorders
IL123927A (en) Propanolamine derivatives processes for their preparation and pharmaceutical composition comprising them
GB2343117B (en) Benzimidazole pharmaceutical composition and process of preparation
IL118250A0 (en) 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof and pharmaceutical compositions containing them
PL341221A1 (en) Derivatives of phenylaminoalkyl carboxylic acid and pharmacological compositions containing them
HUP9700810A3 (en) Acids and esters of diosmetin and pharmaceutical compositions containing them
HUP9800970A3 (en) Process for producing pharmaceutical compositions containing heptapeptide somatostatin derivatives of neurogene- and non-neurogene-antiflogistic and analgesic activity and peptidomimetica
HUP9904705A3 (en) N-substituted azaheterocyclic carboxylic acid derivatives and pharmaceutical compositions containing them
HUP0004223A3 (en) 4-oxo-butynic acids and pharmaceutical composition containing them as active agent

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees