PT1380582E - Mimeticos de fsg para o tratamento da infertilidade - Google Patents

Mimeticos de fsg para o tratamento da infertilidade

Info

Publication number
PT1380582E
PT1380582E PT03023514T PT03023514T PT1380582E PT 1380582 E PT1380582 E PT 1380582E PT 03023514 T PT03023514 T PT 03023514T PT 03023514 T PT03023514 T PT 03023514T PT 1380582 E PT1380582 E PT 1380582E
Authority
PT
Portugal
Prior art keywords
fsg
infertility
mimetics
treatment
fsg mimetics
Prior art date
Application number
PT03023514T
Other languages
English (en)
Inventor
El Tayer Nabil
Magar Sharad
Reddy Adulla
Buckler David
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of PT1380582E publication Critical patent/PT1380582E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
PT03023514T 1998-08-07 1999-08-08 Mimeticos de fsg para o tratamento da infertilidade PT1380582E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9571298P 1998-08-07 1998-08-07

Publications (1)

Publication Number Publication Date
PT1380582E true PT1380582E (pt) 2006-08-31

Family

ID=22253270

Family Applications (2)

Application Number Title Priority Date Filing Date
PT99939686T PT1102763E (pt) 1998-08-07 1999-08-05 Mimeticos fsh para o tratamento da infertilidade
PT03023514T PT1380582E (pt) 1998-08-07 1999-08-08 Mimeticos de fsg para o tratamento da infertilidade

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT99939686T PT1102763E (pt) 1998-08-07 1999-08-05 Mimeticos fsh para o tratamento da infertilidade

Country Status (12)

Country Link
US (3) US6235755B1 (pt)
EP (1) EP1102763B1 (pt)
JP (1) JP4511042B2 (pt)
AR (1) AR021755A1 (pt)
AT (2) ATE279407T1 (pt)
AU (1) AU772373B2 (pt)
CA (1) CA2339018A1 (pt)
DE (2) DE69921147T2 (pt)
ES (2) ES2261844T3 (pt)
IL (1) IL141063A (pt)
PT (2) PT1102763E (pt)
WO (1) WO2000008015A2 (pt)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025355A (en) * 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
EP1156803A4 (en) 1999-02-09 2004-03-17 Bristol Myers Squibb Co FXA LACTAM INHIBITORS AND METHOD
UA74362C2 (uk) * 2000-03-27 2005-12-15 Еплайд Рісьорч Системз Ерс Холдінг Н.В. Фармацевтично активні похідні піролідину
US7018988B2 (en) 2000-03-27 2006-03-28 Applied Research Systems Ars Holding N.V. Pharmaceutically active pyrrolidine derivatives as Bax inhibitors
GB0010757D0 (en) 2000-05-05 2000-06-28 Astrazeneca Ab Chemical compounds
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
DE60201415T2 (de) * 2001-01-19 2006-02-09 Pharmacopeia, Inc. Bisarylderivate mit fsh rezeptor modulierender aktivität
US6900213B2 (en) 2001-01-19 2005-05-31 Pharmacopeia Drug Discovery, Inc. Bisaryl derivatives having FSH modulatory activity
US7217716B2 (en) 2001-02-23 2007-05-15 Merck & Co., Inc. N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists
WO2002080928A1 (en) 2001-04-03 2002-10-17 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
HUP0400048A3 (en) 2001-05-05 2008-10-28 Smithkline Beecham Plc N-aroyl cyclic amines and pharmaceutical compositions containing them
GB0115862D0 (en) * 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
JP4523273B2 (ja) * 2001-07-02 2010-08-11 ナームローゼ・フエンノートチヤツプ・オルガノン テトラヒドロキノリン誘導体
GB0121941D0 (en) 2001-09-11 2001-10-31 Astrazeneca Ab Chemical compounds
DK1438336T3 (da) * 2001-10-22 2006-10-02 Applied Research Systems Gonadotropiner til follikeldannelse
WO2004031182A1 (en) * 2002-09-20 2004-04-15 Applied Research Systems Ars Holding N.V. Piperazine derivatives and methods of use
CN100404508C (zh) * 2002-12-20 2008-07-23 欧加农股份有限公司 四氢喹啉衍生物
CN100386318C (zh) * 2002-12-20 2008-05-07 欧加农股份有限公司 四氢喹啉衍生物及其作为fsh受体调节剂的用途
TWI306855B (en) * 2002-12-20 2009-03-01 Organon Nv Tetrahydroquinoline derivatives
TWI322012B (en) * 2002-12-20 2010-03-21 Organon Nv Tetrahydroquinoline derivatives
UA88879C2 (en) * 2003-09-02 2009-12-10 Эплайд Рисерч Системз Эрс Холдинг Н.В. Fsh glycosylation mutant
AU2005207960A1 (en) * 2004-01-28 2005-08-11 Syntonix Pharmaceuticals, Inc. Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility
US7691848B2 (en) 2005-03-02 2010-04-06 Wyeth Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists
JPWO2006095922A1 (ja) * 2005-03-10 2008-08-21 京都薬品工業株式会社 テトラヒドロイソキノリン化合物およびその医薬用途
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92008C2 (en) 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
UA92009C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
SI1879866T1 (sl) 2005-05-04 2011-06-30 Organon Nv Dihidropiridinski derivati
BRPI0609677A2 (pt) 2005-05-12 2011-10-18 Wyeth Corp composto ou um sal farmaceuticamente aceitável do mesmo, e, método para a preparação de um composto
JP2008543765A (ja) 2005-06-09 2008-12-04 ワイス 卵胞刺激ホルモンレセプターアンタゴニストとしてのピロロベンゾジアゼピンピリジンカルボキサミドおよび誘導体
US20090018142A9 (en) * 2006-05-02 2009-01-15 Zhengping Zhuang Use of phosphatases to treat tumors overexpressing N-CoR
JP2009537551A (ja) * 2006-05-17 2009-10-29 アメリカ合衆国 ホルモン受容体を調節するためのピリミジン低分子量リガンド
JP5448164B2 (ja) 2006-07-28 2014-03-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体を変調する化合物
CN101662939B (zh) 2007-02-06 2015-11-25 利克斯特生物技术公司 氧杂双环庚烷和氧杂双环庚烯,它们的制备及用途
EP2200439B1 (en) * 2007-10-01 2017-03-22 Lixte Biotechnology, Inc. Hdac inhibitors
EP2217565B1 (en) 2007-11-07 2013-05-22 Boehringer Ingelheim International GmbH Compounds which modulate the cb2 receptor
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
WO2010005782A1 (en) 2008-07-10 2010-01-14 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the cb2 receptor
EP2318005B1 (en) 2008-08-01 2017-11-01 Lixte Biotechnology, Inc. Neuroprotective agents for the prevention and treatment of neurodegenerative diseases
WO2010147612A1 (en) 2009-06-18 2010-12-23 Lixte Biotechnology, Inc. Methods of modulating cell regulation by inhibiting p53
US8227473B2 (en) 2008-08-01 2012-07-24 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
AP2011005674A0 (en) 2008-09-25 2011-04-30 Boehringer Ingelheim Int Sulfonyl compounds which selectively modulate the CB2 receptor.
AU2010204723A1 (en) * 2009-01-14 2011-08-18 The Salk Institute For Biological Studies Methods for screening and compounds that protect against amyloid diseases
US8889670B2 (en) 2009-02-18 2014-11-18 Boehringer Ingelheim International Gmbh Heterocyclic compounds which modulate the CB2 receptor
US8071587B2 (en) 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
TWI461426B (zh) * 2009-05-27 2014-11-21 Merck Sharp & Dohme (二氫)咪唑並異〔5,1-a〕喹啉類
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
EP2443107B1 (en) 2009-06-16 2018-08-08 Boehringer Ingelheim International GmbH Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor
US8431564B2 (en) 2009-07-29 2013-04-30 Merck Sharp & Dohme B.V. Ring-annulated dihydropyrrolo[2,1-α]isoquinolines
TW201116531A (en) 2009-07-29 2011-05-16 Organon Nv Ring-annulated dihydropyrrolo[2,1-a]isoquinolines
TW201116515A (en) 2009-07-31 2011-05-16 Organon Nv Dihydrobenzoindazoles
JP5802209B2 (ja) 2009-09-01 2015-10-28 カタバシス ファーマシューティカルズ,インコーポレイテッド 脂肪酸ナイアシン抱合体およびそれらの使用
USRE46608E1 (en) 2009-09-01 2017-11-14 Catabasis Pharmaceuticals, Inc. Fatty acid niacin conjugates and their uses
US8383651B2 (en) 2009-09-22 2013-02-26 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
WO2011088015A1 (en) 2010-01-15 2011-07-21 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
JP5746228B2 (ja) 2010-03-05 2015-07-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体を選択的に調節するテトラゾール化合物
EP2595959B1 (en) 2010-07-22 2015-11-04 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor
ES2796774T3 (es) 2011-07-01 2020-11-30 Merck Patent Gmbh Dihidropirazoles, composiciones farmacéuticas de los mismos y su uso para el tratamiento de trastornos de fertilidad
AU2012284184B2 (en) 2011-07-18 2017-03-09 Merck Patent Gmbh Benzamides
ES2663972T3 (es) * 2012-01-10 2018-04-17 Merck Patent Gmbh Derivados de benzamida como moduladores de la hormona folículo estimulante
EP2812320B1 (en) 2012-02-08 2018-03-07 Merck Patent GmbH Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor
EP2983661A4 (en) 2013-04-09 2016-12-21 Lixte Biotechnology Inc FORMULATIONS OF OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
ES2657979T3 (es) 2013-06-24 2018-03-07 Merck Patent Gmbh Compuestos de imidazol como moduladores de FSHR y sus usos
AU2014302712B2 (en) 2013-06-24 2018-11-29 Merck Patent Gmbh Pyrazole compounds as modulators of FSHR and uses thereof
US11433047B2 (en) * 2015-10-09 2022-09-06 Neurotheryx Canada Ltd. Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases
WO2019084037A1 (en) 2017-10-26 2019-05-02 University Of Puerto Rico NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTICANCER AGENTS AND ANTI-MIGRATORY AGENTS
EP4048664A1 (en) 2019-10-25 2022-08-31 Gilead Sciences, Inc. Glp-1r modulating compounds
WO2022109182A1 (en) 2020-11-20 2022-05-27 Gilead Sciences, Inc. Polyheterocyclic glp-1 r modulating compounds
CR20230495A (es) 2021-04-21 2023-11-30 Gilead Sciences Inc Compuestos moduladores del glp-ir carboxibenzimidazólicos.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947569A (en) * 1972-04-12 1976-03-30 American Home Products Corporation Process for preparing the releasing hormone of luteinizing hormone (LH) and of follicle stimulating hormone (FSH), salts and compositions thereof, and intermediates therefor
JPS5331669A (en) * 1976-09-06 1978-03-25 Kissei Pharmaceut Co Ltd Novel n-acylpiperidinecaroxyanilide derivatives and their preparation
US4800432A (en) * 1986-10-24 1989-01-24 The Grass Valley Group, Inc. Video Difference key generator
DE3636278A1 (de) * 1986-10-24 1988-05-05 Hoechst Ag Herbizide mittel auf der basis von cyclischen (alpha)-iminocarbon-saeureaniliden sowie neue (alpha)-iminocarbonsaeureanilide und verfahren zu ihrer herstellung
US5071823A (en) 1988-10-12 1991-12-10 Mitsubishi Paper Mills Limited Image-receiving sheet for transfer recording
DE3842010A1 (de) * 1988-12-14 1990-06-21 Hoechst Ag Kompetitive gonadoliberin-antagonisten
SK65094A3 (en) * 1992-09-03 1995-03-08 Boehringer Ingelheim Kg Aminoacid derivatives, process for producing the same and pharmaceutical compositions containing these derivatives
US5455229A (en) * 1992-12-23 1995-10-03 Eli Lilly And Company Method for minimizing and containing ischemic and reperfusion injury
PE45195A1 (es) * 1994-03-03 1996-01-17 Boehringer Ingelheim Kg Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene
JP2002505318A (ja) * 1998-03-05 2002-02-19 アゴーロン・ファーマシューティカルズ・インコーポレイテッド 非ペプチドGnRH因子

Also Published As

Publication number Publication date
DE69921147D1 (de) 2004-11-18
EP1102763B1 (en) 2004-10-13
ATE279407T1 (de) 2004-10-15
EP1102763A2 (en) 2001-05-30
JP2002522433A (ja) 2002-07-23
ES2261844T3 (es) 2006-11-16
ES2228084T3 (es) 2005-04-01
AU772373B2 (en) 2004-04-22
US20020147345A1 (en) 2002-10-10
DE69921147T2 (de) 2005-02-24
CA2339018A1 (en) 2000-02-17
JP4511042B2 (ja) 2010-07-28
PT1102763E (pt) 2005-01-31
WO2000008015A3 (en) 2000-05-11
US6423723B1 (en) 2002-07-23
WO2000008015A2 (en) 2000-02-17
IL141063A (en) 2005-06-19
AR021755A1 (es) 2002-08-07
US6235755B1 (en) 2001-05-22
US6653338B2 (en) 2003-11-25
AU5393199A (en) 2000-02-28
ATE329911T1 (de) 2006-07-15
DE69931975T2 (de) 2006-10-05
DE69931975D1 (de) 2006-07-27
IL141063A0 (en) 2002-02-10

Similar Documents

Publication Publication Date Title
PT1380582E (pt) Mimeticos de fsg para o tratamento da infertilidade
DE69915462D1 (de) Sehr leistungsstarker objektcache
BR9706949A (pt) Composições desinfetantes e processos para desinfecção de superfícies
BR9711530A (pt) Combina-Æo de terapia para tratamento de psicoses
DE69719519D1 (de) Kraniotomie abdecktuch
BR9706945A (pt) Composições desinfetantes e processos para disinfecção de superfícies
BR9709726A (pt) Inibição da captação de serotonina
PT1144395E (pt) Derivados de 2-aminobenzoxazinona para o tratamento da obesidade
PT977748E (pt) Derivados benzopirano substituidos para o tratamento de inflamacao
DE69722540D1 (de) Chirurgischer Klemmmechanismus
NO20004688L (no) Terapi ved østrogenassosierte lidelser
IS4812A (is) Samsett meðferð fyrir beingisnun
BR9707609A (pt) Composição para desinfecção
PT1147083E (pt) Derivados de arilpiperazinil-ciclohexilindole para o tratamento da depressao
PT1077940E (pt) 4-fenilpiperidinas novas para o tratamento de dermatoses pruriginosas
DE69707539T2 (de) UV-Bestrahlungsgerät
PT1143977E (pt) Derivados de 2-oxibenzoxazinona para o tratamento da obesidade
BR9710534A (pt) Tratamento da superf¡cie de metal
BR9706553A (pt) Recipiente para tratamento de gás
PT1206436E (pt) Retinoides para o tratamento de enfisema
BR9707610A (pt) Composições desinfetantes e processos para desinfecção de superfícies
BR9707699A (pt) Composições desinfetantes e processos para desinfetar superfícies
ID17723A (id) Senyawa untuk pengobatan
ID27214A (id) Triazolopiridina untuk pengobatan gangguan trombosis
PT1100499E (pt) Utilizacao de eletriptano para a prevencao da recorrencia da enxaqueca