IL135130A - A pharmaceutical preparation containing claudronate as an active ingredient and microcrystalline cellulose that has undergone silification as an excipient - Google Patents

A pharmaceutical preparation containing claudronate as an active ingredient and microcrystalline cellulose that has undergone silification as an excipient

Info

Publication number: IL135130A
Authority: IL; Israel
Prior art keywords: microcrystalline cellulose; clodronate; silicified microcrystalline; tablets; pharmaceutical preparation
Prior art date: 1997-09-19

Application number

IL13513098A

Other languages

English (en)

Hebrew (he)

Other versions

IL135130A0 (en

Inventor

Veli-Matti Lehtola

Eeva-Maria Susanne Rantala

Pertti Tapani Rantala

Original Assignee

Schering Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-19

Filing date

1998-09-18

Publication date

2004-09-27

1998-09-18 Application filed by Schering Oy filed Critical Schering Oy

2001-05-20 Publication of IL135130A0 publication Critical patent/IL135130A0/xx

2004-09-27 Publication of IL135130A publication Critical patent/IL135130A/en

Links

ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 title claims abstract description 44
GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 title claims abstract description 43
239000000825 pharmaceutical preparation Substances 0.000 title claims abstract description 14
229960002286 clodronic acid Drugs 0.000 title description 38
239000000546 pharmaceutical excipient Substances 0.000 title description 17
239000004480 active ingredient Substances 0.000 title description 4
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 30
229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 22
239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 22
229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 22
235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 22
239000000377 silicon dioxide Substances 0.000 claims abstract description 14
235000012239 silicon dioxide Nutrition 0.000 claims abstract description 14
239000013543 active substance Substances 0.000 claims abstract description 9
150000003839 salts Chemical class 0.000 claims abstract description 6
239000008184 oral solid dosage form Substances 0.000 claims abstract 2
238000002360 preparation method Methods 0.000 claims description 27
238000000034 method Methods 0.000 claims description 19
238000004519 manufacturing process Methods 0.000 claims description 12
HJKBJIYDJLVSAO-UHFFFAOYSA-L clodronic acid disodium salt Chemical compound [Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O HJKBJIYDJLVSAO-UHFFFAOYSA-L 0.000 claims description 11
230000008569 process Effects 0.000 claims description 11
238000005550 wet granulation Methods 0.000 claims description 9
239000002775 capsule Substances 0.000 claims description 7
238000007907 direct compression Methods 0.000 claims description 6
239000007884 disintegrant Substances 0.000 claims description 5
238000007908 dry granulation Methods 0.000 claims description 5
239000000314 lubricant Substances 0.000 claims description 3
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 2
239000003826 tablet Substances 0.000 description 56
239000000203 mixture Substances 0.000 description 21
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 16
239000008117 stearic acid Substances 0.000 description 12
235000021355 Stearic acid Nutrition 0.000 description 11
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 11
XWHPUCFOTRBMGS-UHFFFAOYSA-L disodium clodronate tetrahydrate Chemical compound O.O.O.O.[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O XWHPUCFOTRBMGS-UHFFFAOYSA-L 0.000 description 10
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 9
239000008187 granular material Substances 0.000 description 9
235000019359 magnesium stearate Nutrition 0.000 description 9
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 9
239000003795 chemical substances by application Substances 0.000 description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
230000008901 benefit Effects 0.000 description 5
239000000843 powder Substances 0.000 description 4
239000007909 solid dosage form Substances 0.000 description 4
229920002472 Starch Polymers 0.000 description 3
239000006186 oral dosage form Substances 0.000 description 3
239000002245 particle Substances 0.000 description 3
239000002994 raw material Substances 0.000 description 3
239000008107 starch Substances 0.000 description 3
235000019698 starch Nutrition 0.000 description 3
239000002253 acid Substances 0.000 description 2
FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
239000003814 drug Substances 0.000 description 2
239000000945 filler Substances 0.000 description 2
239000012467 final product Substances 0.000 description 2
238000009472 formulation Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
239000000047 product Substances 0.000 description 2
210000002784 stomach Anatomy 0.000 description 2
239000000126 substance Substances 0.000 description 2
208000006386 Bone Resorption Diseases 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
229920002785 Croscarmellose sodium Polymers 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
208000037147 Hypercalcaemia Diseases 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
208000001132 Osteoporosis Diseases 0.000 description 1
229920001800 Shellac Polymers 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
229940081735 acetylcellulose Drugs 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
-1 acryl Chemical group 0.000 description 1
230000002411 adverse Effects 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
230000024279 bone resorption Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229910001424 calcium ion Inorganic materials 0.000 description 1
230000003913 calcium metabolism Effects 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002301 cellulose acetate Polymers 0.000 description 1
229940081734 cellulose acetate phthalate Drugs 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
229910052681 coesite Inorganic materials 0.000 description 1
239000008119 colloidal silica Substances 0.000 description 1
239000007891 compressed tablet Substances 0.000 description 1
229910052906 cristobalite Inorganic materials 0.000 description 1
229960005168 croscarmellose Drugs 0.000 description 1
229960000913 crospovidone Drugs 0.000 description 1
239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 1
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
239000013078 crystal Substances 0.000 description 1
235000013681 dietary sucrose Nutrition 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000008103 glucose Substances 0.000 description 1
229960001031 glucose Drugs 0.000 description 1
235000001727 glucose Nutrition 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
230000000148 hypercalcaemia Effects 0.000 description 1
208000030915 hypercalcemia disease Diseases 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
229960001855 mannitol Drugs 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
125000005641 methacryl group Chemical group 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000008188 pellet Substances 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
239000008213 purified water Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
239000004208 shellac Substances 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
229910052682 stishovite Inorganic materials 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
150000004685 tetrahydrates Chemical class 0.000 description 1
238000011282 treatment Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229910052905 tridymite Inorganic materials 0.000 description 1
125000005591 trimellitate group Chemical group 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
238000009736 wetting Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Rheumatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Orthopedic Medicine & Surgery (AREA)
Inorganic Chemistry (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)

IL13513098A 1997-09-19 1998-09-18 A pharmaceutical preparation containing claudronate as an active ingredient and microcrystalline cellulose that has undergone silification as an excipient IL135130A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI973733A FI109088B (fi)	1997-09-19	1997-09-19	Tabletti ja menetelmä sen valmistamiseksi
PCT/FI1998/000735 WO1999015155A1 (en)	1997-09-19	1998-09-18	Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient

Publications (2)

Publication Number	Publication Date
IL135130A0 IL135130A0 (en)	2001-05-20
IL135130A true IL135130A (en)	2004-09-27

Family

ID=8549561

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13513098A IL135130A (en)	1997-09-19	1998-09-18	A pharmaceutical preparation containing claudronate as an active ingredient and microcrystalline cellulose that has undergone silification as an excipient

Country Status (31)

Country	Link
EP (1)	EP1027037B1 (ja)
JP (1)	JP3589977B2 (ja)
KR (1)	KR20010024184A (ja)
CN (1)	CN1124130C (ja)
AT (1)	ATE255410T1 (ja)
AU (1)	AU737738B2 (ja)
BG (1)	BG64886B1 (ja)
BR (1)	BR9812480A (ja)
CA (1)	CA2301185C (ja)
CZ (1)	CZ298675B6 (ja)
DE (3)	DE69820287T2 (ja)
DK (1)	DK1027037T3 (ja)
EA (1)	EA002331B1 (ja)
EE (1)	EE04218B1 (ja)
ES (1)	ES2212341T3 (ja)
FI (1)	FI109088B (ja)
HK (1)	HK1031325A1 (ja)
HR (1)	HRP20000142B1 (ja)
HU (1)	HU226118B1 (ja)
ID (1)	ID24423A (ja)
IL (1)	IL135130A (ja)
IS (1)	IS5404A (ja)
NO (1)	NO327728B1 (ja)
NZ (1)	NZ503766A (ja)
PL (1)	PL191166B1 (ja)
PT (1)	PT1027037E (ja)
SI (1)	SI1027037T1 (ja)
SK (1)	SK284088B6 (ja)
TR (1)	TR200000722T2 (ja)
UA (1)	UA73078C2 (ja)
WO (1)	WO1999015155A1 (ja)

Families Citing this family (86)

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US6395303B1 (en)	1996-06-10	2002-05-28	Edward Mendell Co., Inc.	Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
SE9901272D0 (sv) *	1999-04-09	1999-04-09	Astra Ab	New improved formulation
SE9903345D0 (sv)	1999-09-17	1999-09-17	Astra Pharma Prod	Novel process
DE10006125C2 (de) *	2000-02-11	2003-08-28	Kallies Feinchemie Ag	Modifizierte Mikrocellulose
US6399101B1 (en)	2000-03-30	2002-06-04	Mova Pharmaceutical Corp.	Stable thyroid hormone preparations and method of making same
CN1272013C (zh) *	2000-06-20	2006-08-30	诺瓦提斯公司	二膦酸盐在制备用于治疗骨更新异常增加的病症的药物中的应用
SI1591122T1 (sl) *	2000-06-20	2013-02-28	Novartis Ag	Postopek za aplikacijo bisfosfonatov
US6753017B2 (en)	2001-11-07	2004-06-22	Jrs Pharma Lp	Process for preparing dry extracts
WO2003047551A1 (en) *	2001-11-29	2003-06-12	Penwest Pharmaceutical Company	Agglomerated particles including an active agent coprocessed with silicified microcrystalline cellulose
GB0209265D0 (en)	2002-04-23	2002-06-05	Novartis Ag	Organic compounds
US20040109889A1 (en)	2002-12-04	2004-06-10	Bunick Frank J.	Surface treatment composition for soft substrates
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
US8491930B2 (en) *	2008-04-23	2013-07-23	Farmasierra Manufacturing, S.L.	Pharmaceutical formulation containing ibuprofen and codeine
US8603527B2 (en) *	2010-10-25	2013-12-10	Signal Pharmaceuticals, Llc	Pharmaceutical formulations of a substituted diaminopurine
MX370785B (es) *	2012-02-07	2020-01-06	Biogen Ma Inc	Composiciones farmacéuticas que contienen fumarato de dimetilo.
US10028969B2 (en)	2012-05-14	2018-07-24	Antecip Bioventures Ii Llc	Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US9655908B2 (en)	2012-05-14	2017-05-23	Antecip Bioventures Ii Llc	Neridronic acid molecular complex for treating complex regional pain syndrome
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US9820999B2 (en)	2012-05-14	2017-11-21	Antecip Bioventures Ii Llc	Neridronic acid for treating complex regional pain syndrome
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US20150051175A1 (en) *	2012-05-14	2015-02-19	Antecip Bioventures Ii Llc	Co-Administration of Steroids and Zoledronic Acid to Prevent and Treat Pain
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1997
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1998
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Publication number	Publication date
EE04218B1 (et)	2004-02-16
JP2001517616A (ja)	2001-10-09
PT1027037E (pt)	2004-04-30
JP3589977B2 (ja)	2004-11-17
FI109088B (fi)	2002-05-31
AU9268598A (en)	1999-04-12
CZ298675B6 (cs)	2007-12-19
FI973733A (fi)	1999-03-20
NO20001417D0 (no)	2000-03-17
DE29824938U1 (de)	2003-07-31
DE69820287D1 (de)	2004-01-15
ATE255410T1 (de)	2003-12-15
EE200000096A (et)	2000-12-15
UA73078C2 (uk)	2005-06-15
NO327728B1 (no)	2009-09-14
AU737738B2 (en)	2001-08-30
HK1031325A1 (en)	2001-06-15
DE1027037T1 (de)	2002-11-28
PL191166B1 (pl)	2006-03-31
BG104265A (en)	2000-11-30
DK1027037T3 (da)	2004-03-15
EP1027037A1 (en)	2000-08-16
HRP20000142A2 (en)	2000-06-30
SK3932000A3 (en)	2000-11-07
CA2301185C (en)	2006-11-28
ES2212341T3 (es)	2004-07-16
NZ503766A (en)	2002-02-01
EP1027037B1 (en)	2003-12-03
KR20010024184A (ko)	2001-03-26
SK284088B6 (sk)	2004-09-08
NO20001417L (no)	2000-05-19
EA200000317A1 (ru)	2000-10-30
DE69820287T2 (de)	2004-10-14
BG64886B1 (bg)	2006-08-31
HUP0004383A2 (hu)	2001-08-28
CZ2000787A3 (cs)	2000-08-16
IL135130A0 (en)	2001-05-20
ID24423A (id)	2000-07-20
CN1270516A (zh)	2000-10-18
WO1999015155A1 (en)	1999-04-01
HU226118B1 (en)	2008-04-28
FI973733A0 (fi)	1997-09-19
CN1124130C (zh)	2003-10-15
BR9812480A (pt)	2000-09-26
SI1027037T1 (en)	2004-04-30
HRP20000142B1 (en)	2004-06-30
PL339290A1 (en)	2000-12-04
TR200000722T2 (tr)	2000-11-21
EA002331B1 (ru)	2002-04-25
HUP0004383A3 (en)	2006-06-28
IS5404A (is)	2000-03-14
CA2301185A1 (en)	1999-04-01

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CA2301185C (en)	2006-11-28	Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient
JP7216055B2 (ja)	2023-01-31	医薬組成物
JP6092936B2 (ja)	2017-03-08	口腔内崩壊錠の製造方法
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HU224983B1 (en)	2006-05-29	Swallow tablet comprising paracetamol
JPH08208484A (ja)	1996-08-13	セファクロル含有医薬配合物
FI96480C (fi)	1996-07-10	Menetelmä pitkävaikutteisen moniraetabletin valmistamiseksi
EP0319074B1 (en)	1992-01-29	Pharmaceutical composition and process for its preparation
US20030211150A1 (en)	2003-11-13	Immediate release tablet containing naproxen sodium
JP6328138B2 (ja)	2018-05-23	Ｎ−［５−［２−（３，５−ジメトキシフェニル）エチル］−２ｈ−ピラゾール−３−イル］−４−［（３ｒ，５ｓ）−３，５−ジメチルピペラジン−１−イル］ベンズアミドの医薬製剤
MXPA00002290A (en)	2001-05-07	Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient
KR100589483B1 (ko)	2006-06-14	아목시실린 및 클라불란산 또는 그의 염의 혼합물 함유분산정제 및 그의 제조방법
KR20060058415A (ko)	2006-05-30	아목시실린 및 클라불란산 또는 그의 염의 혼합물 함유조성물 및 그의 제조방법