BR9812480A - "preparação farmacêutica compreendendo clodronato como ingrediente ativo e celulose microcristalina como excipiente, processo de fabricação e uso de celulose microcristalina siliciada na fabricação de dita preparação farmacêutica" - Google Patents

"preparação farmacêutica compreendendo clodronato como ingrediente ativo e celulose microcristalina como excipiente, processo de fabricação e uso de celulose microcristalina siliciada na fabricação de dita preparação farmacêutica"

Info

Publication number
BR9812480A
BR9812480A BR9812480-3A BR9812480A BR9812480A BR 9812480 A BR9812480 A BR 9812480A BR 9812480 A BR9812480 A BR 9812480A BR 9812480 A BR9812480 A BR 9812480A
Authority
BR
Brazil
Prior art keywords
pharmaceutical preparation
microcrystalline cellulose
manufacture
excipient
active ingredient
Prior art date
Application number
BR9812480-3A
Other languages
English (en)
Inventor
Veli-Matti Lehtola
Eeva-Maria Susanne Rantala
Pertti Tapani Rantala
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of BR9812480A publication Critical patent/BR9812480A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)

Abstract

"PREPARAçãO FARMACêUTICA COMPREENDENDO CLODRONATO COMO INGREDIENTE ATIVO E CELULOSE MICROCRISTALINA COMO EXCIPIENTE, PROCESSO DE FABRICAçãO E USO DE CELULOSE MICROCRISTALINA SILICIADA NA FABRICAçãO DE DITA PREPARAçãO FARMACêUTICA". O objeto da presente invenção é uma preparação farmacêutica para uso oral, especialmente um comprimido, que como ingrediente ativo contém um sal farmacologicamente aceitável de ácido diclorometileno bisfosfónico, ou seja, um clodronato, especialmente clodronato dissódico e que, como excipiente, contém celulose microcristalina siliciada. Outros objetos da invenção são um processo para fabricação de dita preparação farmacêutca e o uso de celulose microcristalina siliciada para a fabricação de dita preparação farmacêutica.
BR9812480-3A 1997-09-19 1998-09-18 "preparação farmacêutica compreendendo clodronato como ingrediente ativo e celulose microcristalina como excipiente, processo de fabricação e uso de celulose microcristalina siliciada na fabricação de dita preparação farmacêutica" BR9812480A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI973733A FI109088B (fi) 1997-09-19 1997-09-19 Tabletti ja menetelmä sen valmistamiseksi
PCT/FI1998/000735 WO1999015155A1 (en) 1997-09-19 1998-09-18 Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient

Publications (1)

Publication Number Publication Date
BR9812480A true BR9812480A (pt) 2000-09-26

Family

ID=8549561

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812480-3A BR9812480A (pt) 1997-09-19 1998-09-18 "preparação farmacêutica compreendendo clodronato como ingrediente ativo e celulose microcristalina como excipiente, processo de fabricação e uso de celulose microcristalina siliciada na fabricação de dita preparação farmacêutica"

Country Status (31)

Country Link
EP (1) EP1027037B1 (pt)
JP (1) JP3589977B2 (pt)
KR (1) KR20010024184A (pt)
CN (1) CN1124130C (pt)
AT (1) ATE255410T1 (pt)
AU (1) AU737738B2 (pt)
BG (1) BG64886B1 (pt)
BR (1) BR9812480A (pt)
CA (1) CA2301185C (pt)
CZ (1) CZ298675B6 (pt)
DE (3) DE69820287T2 (pt)
DK (1) DK1027037T3 (pt)
EA (1) EA002331B1 (pt)
EE (1) EE04218B1 (pt)
ES (1) ES2212341T3 (pt)
FI (1) FI109088B (pt)
HK (1) HK1031325A1 (pt)
HR (1) HRP20000142B1 (pt)
HU (1) HU226118B1 (pt)
ID (1) ID24423A (pt)
IL (1) IL135130A (pt)
IS (1) IS5404A (pt)
NO (1) NO327728B1 (pt)
NZ (1) NZ503766A (pt)
PL (1) PL191166B1 (pt)
PT (1) PT1027037E (pt)
SI (1) SI1027037T1 (pt)
SK (1) SK284088B6 (pt)
TR (1) TR200000722T2 (pt)
UA (1) UA73078C2 (pt)
WO (1) WO1999015155A1 (pt)

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Also Published As

Publication number Publication date
EE04218B1 (et) 2004-02-16
JP2001517616A (ja) 2001-10-09
PT1027037E (pt) 2004-04-30
JP3589977B2 (ja) 2004-11-17
FI109088B (fi) 2002-05-31
AU9268598A (en) 1999-04-12
CZ298675B6 (cs) 2007-12-19
FI973733A (fi) 1999-03-20
NO20001417D0 (no) 2000-03-17
DE29824938U1 (de) 2003-07-31
DE69820287D1 (de) 2004-01-15
ATE255410T1 (de) 2003-12-15
EE200000096A (et) 2000-12-15
UA73078C2 (uk) 2005-06-15
NO327728B1 (no) 2009-09-14
AU737738B2 (en) 2001-08-30
HK1031325A1 (en) 2001-06-15
DE1027037T1 (de) 2002-11-28
PL191166B1 (pl) 2006-03-31
BG104265A (en) 2000-11-30
DK1027037T3 (da) 2004-03-15
EP1027037A1 (en) 2000-08-16
HRP20000142A2 (en) 2000-06-30
SK3932000A3 (en) 2000-11-07
CA2301185C (en) 2006-11-28
ES2212341T3 (es) 2004-07-16
NZ503766A (en) 2002-02-01
EP1027037B1 (en) 2003-12-03
KR20010024184A (ko) 2001-03-26
SK284088B6 (sk) 2004-09-08
NO20001417L (no) 2000-05-19
EA200000317A1 (ru) 2000-10-30
DE69820287T2 (de) 2004-10-14
BG64886B1 (bg) 2006-08-31
HUP0004383A2 (hu) 2001-08-28
CZ2000787A3 (cs) 2000-08-16
IL135130A0 (en) 2001-05-20
ID24423A (id) 2000-07-20
CN1270516A (zh) 2000-10-18
WO1999015155A1 (en) 1999-04-01
HU226118B1 (en) 2008-04-28
FI973733A0 (fi) 1997-09-19
IL135130A (en) 2004-09-27
CN1124130C (zh) 2003-10-15
SI1027037T1 (en) 2004-04-30
HRP20000142B1 (en) 2004-06-30
PL339290A1 (en) 2000-12-04
TR200000722T2 (tr) 2000-11-21
EA002331B1 (ru) 2002-04-25
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IS5404A (is) 2000-03-14
CA2301185A1 (en) 1999-04-01

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