IL118201A - Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof - Google Patents

Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof

Info

Publication number
IL118201A
IL118201A IL11820196A IL11820196A IL118201A IL 118201 A IL118201 A IL 118201A IL 11820196 A IL11820196 A IL 11820196A IL 11820196 A IL11820196 A IL 11820196A IL 118201 A IL118201 A IL 118201A
Authority
IL
Israel
Prior art keywords
host cell
protein
chromatography
preparation
epo
Prior art date
Application number
IL11820196A
Other languages
English (en)
Other versions
IL118201A0 (en
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of IL118201A0 publication Critical patent/IL118201A0/xx
Priority to IL15764403A priority Critical patent/IL157644A0/xx
Publication of IL118201A publication Critical patent/IL118201A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL11820196A 1995-05-11 1996-05-09 Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof IL118201A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL15764403A IL157644A0 (en) 1995-05-11 2003-08-28 Method for the purification of a protein preparation with erythropoietin activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95107165 1995-05-11
DE19522461 1995-06-21

Publications (2)

Publication Number Publication Date
IL118201A0 IL118201A0 (en) 1996-09-12
IL118201A true IL118201A (en) 2004-12-15

Family

ID=26016131

Family Applications (2)

Application Number Title Priority Date Filing Date
IL11820196A IL118201A (en) 1995-05-11 1996-05-09 Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof
IL15764403A IL157644A0 (en) 1995-05-11 2003-08-28 Method for the purification of a protein preparation with erythropoietin activity

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL15764403A IL157644A0 (en) 1995-05-11 2003-08-28 Method for the purification of a protein preparation with erythropoietin activity

Country Status (12)

Country Link
US (2) US6399333B1 (pt)
EP (2) EP1394179B1 (pt)
JP (1) JP3061200B2 (pt)
AT (2) ATE258189T1 (pt)
AU (1) AU5817496A (pt)
CA (1) CA2220515C (pt)
DE (2) DE59610898D1 (pt)
DK (2) DK0830376T3 (pt)
ES (2) ES2211961T3 (pt)
IL (2) IL118201A (pt)
PT (2) PT830376E (pt)
WO (1) WO1996035718A1 (pt)

Families Citing this family (38)

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Publication number Priority date Publication date Assignee Title
NZ335207A (en) * 1996-11-15 2000-09-29 Genentech Inc Process to isolate recombinant human neurotrophin using hydrophobic chromatography resin
US6548296B1 (en) * 1997-07-23 2003-04-15 Roche Diagnostics Gmbh Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof
EP0986644B1 (de) * 1997-07-23 2006-10-04 Boehringer Mannheim GmbH Herstellung von erythropoietin durch endogene genaktivierung mit viralen promotoren
WO1999028346A1 (de) 1997-12-03 1999-06-10 Roche Diagnostics Gmbh Erythropoietin mit hoher spezifischer aktivität
SI1308455T1 (sl) 1998-05-06 2006-08-31 Genentech Inc Sestavek, ki obsega protitelesa anti-HER2
BR9917606A (pt) * 1998-11-06 2002-12-31 Bio Sidus S A Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento
BR9905868A (pt) * 1998-11-06 2001-01-23 Bio Sidus S A Procedimento de cultivo massivo de células de mamìfero para a obtenção de eritropoetina humana, recombinante e a eritropoetina humana recombinante obtida com tal procedimento
BR9905867A (pt) * 1998-11-06 2001-01-23 Bio Sidus S A Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula
PE20010288A1 (es) 1999-07-02 2001-03-07 Hoffmann La Roche Derivados de eritropoyetina
JP4656814B2 (ja) 2000-12-20 2011-03-23 エフ．ホフマン−ラ ロシュ アーゲー エリスロポエチンコンジュゲート
IL161909A0 (en) * 2001-11-28 2005-11-20 Sandoz Ag Method for producing a recombinant polypeptide
DE60220451T2 (de) * 2002-03-26 2008-01-24 Lek Pharmaceutical And Chemical Co. D.D. Verfahren für die herstellung eines gewünschten profils von erythropoietin glyko-isoformen
PT1428878E (pt) * 2002-12-13 2008-11-18 Bioceuticals Arzneimittel Ag Processo para a produção e purificação de eritropoietina
US20050019914A1 (en) * 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
AU2003271194A1 (en) * 2003-10-09 2005-04-21 Daewoong Co., Ltd. Process for purifying human thrombopoietin with high content of sialic acid
DE102004027816A1 (de) * 2004-06-08 2006-01-05 Bioceuticals Arzneimittel Ag Verfahren zur Reinigung von Erythropoietin
US7598356B2 (en) * 2004-07-08 2009-10-06 Board of Regents of the University of Nebraska by and on behalf of the University of Nebraska Medical Center Method for purifying a protein of the cystine-knot superfamily
CA2565209A1 (en) * 2004-11-09 2006-05-18 Usv Limited A novel process for purification of human growth harmone
BRPI0508374A (pt) * 2005-03-03 2007-07-31 Allergan Inc meios para bactéria clostrìdio e processo para obtenção de uma toxina clostrìdica
EP4155385A1 (en) 2005-12-08 2023-03-29 Amgen Inc. Improved production of glycoproteins using manganese
CN101534847A (zh) 2006-08-04 2009-09-16 普罗龙药品公司 修饰型***
EP2089424B1 (en) * 2006-12-06 2015-07-01 JCR PHARMACEUTICALS Co., LTD. Method for production of human erythropoietin
KR100988706B1 (ko) 2007-03-07 2010-10-18 한미홀딩스 주식회사 재조합 에리트로포이에틴의 신규한 정제방법
AR067537A1 (es) 2007-07-17 2009-10-14 Hoffmann La Roche Purificacion de polipeptidos pegilados
AR067536A1 (es) * 2007-07-17 2009-10-14 Hoffmann La Roche Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea
KR100900033B1 (ko) 2007-11-21 2009-06-01 한국생명공학연구원 인간 에리스로포이에틴의 정제방법
SG188143A1 (en) 2008-02-08 2013-03-28 Ambrx Inc Modified leptin polypeptides and their uses
DE102008002209A1 (de) 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur Aufreinigung von Erythropoietin
DE102008002210A1 (de) * 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Erythropoietin
WO2010034442A1 (en) 2008-09-23 2010-04-01 F. Hoffmann-La Roche Ag Purification of erythropoietin
PL2342223T3 (pl) 2008-09-26 2017-09-29 Ambrx, Inc. Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania
DE102008054716A1 (de) 2008-12-16 2010-06-17 Evonik Degussa Gmbh Inprozesskontrolle in einem Verfahren zur Herstellung von EPO
US20120177640A1 (en) 2009-07-24 2012-07-12 Josef Burg Optimizing the production of antibodies
AU2010297530B2 (en) 2009-09-23 2013-12-19 Ratiopharm Gmbh Process for the purification of recombinant human erythropoietin (EPO), EPO thus purified and pharmaceutical compositions comprising same
KR101443257B1 (ko) * 2011-10-18 2014-09-19 주식회사 종근당 낮은 등전점을 갖는 에리스로포이에틴 유사체의 정제방법
EP2970420A4 (en) * 2013-03-15 2016-08-17 Apotex Inc STABILITY OF THE ENHANCED LIQUID FORMULATION OF ERYTHROPOIETIN ALPHA VIA A PURIFICATION TREATMENT
WO2016116966A1 (en) * 2015-01-22 2016-07-28 Jcr Pharmaceuticals Co., Ltd. Method for purification of recombinant human alpha-galactosidase a from material containing contaminant host cell proteins
DK3613486T3 (da) * 2018-08-24 2021-01-04 Uga Biopharma Gmbh Metode og anlæg til rengøring af epo og/eller et epo-derivat

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
IL79176A (en) * 1985-06-20 1992-06-21 Kirin Amgen Inc Process for the recovery of erythropoietin from a fluid
US4954437A (en) 1986-09-15 1990-09-04 Integrated Genetics, Inc. Cell encoding recombinant human erythropoietin
AU4104889A (en) * 1988-09-07 1990-03-15 Bioclones (Pty) Ltd Purification of erythropoietin
DE4115722A1 (de) 1991-05-14 1992-11-19 Boehringer Mannheim Gmbh Serumfreies medium zur kultivierung von saeugerzellen

Also Published As

Publication number Publication date
DK1394179T3 (da) 2006-11-20
US6399333B1 (en) 2002-06-04
DE59611371D1 (de) 2006-09-07
PT1394179E (pt) 2006-11-30
EP0830376A1 (de) 1998-03-25
AU5817496A (en) 1996-11-29
US6471500B1 (en) 2002-10-29
JPH10506924A (ja) 1998-07-07
ATE258189T1 (de) 2004-02-15
ES2268232T3 (es) 2007-03-16
JP3061200B2 (ja) 2000-07-10
US20020146771A1 (en) 2002-10-10
EP1394179A1 (de) 2004-03-03
CA2220515A1 (en) 1996-11-14
CA2220515C (en) 2003-07-22
EP0830376B1 (de) 2004-01-21
ATE334146T1 (de) 2006-08-15
EP1394179B1 (de) 2006-07-26
WO1996035718A1 (de) 1996-11-14
IL157644A0 (en) 2004-03-28
ES2211961T3 (es) 2004-07-16
DK0830376T3 (da) 2004-05-24
IL118201A0 (en) 1996-09-12
DE59610898D1 (de) 2004-02-26
PT830376E (pt) 2004-05-31

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