HUP9801135A2 - Pirazolo[1,5-a]pirimidinek, eljárás előállításukra és alkalmazásuk - Google Patents
Pirazolo[1,5-a]pirimidinek, eljárás előállításukra és alkalmazásukInfo
- Publication number
- HUP9801135A2 HUP9801135A2 HU9801135A HUP9801135A HUP9801135A2 HU P9801135 A2 HUP9801135 A2 HU P9801135A2 HU 9801135 A HU9801135 A HU 9801135A HU P9801135 A HUP9801135 A HU P9801135A HU P9801135 A2 HUP9801135 A2 HU P9801135A2
- Authority
- HU
- Hungary
- Prior art keywords
- noch3
- general formula
- h3co
- compound
- powder
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000000843 powder Substances 0.000 abstract 4
- 239000000428 dust Substances 0.000 abstract 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000002466 imines Chemical class 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- 238000007239 Wittig reaction Methods 0.000 abstract 1
- 241000607479 Yersinia pestis Species 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- -1 ethylene, vinylene Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- OSFBJERFMQCEQY-UHFFFAOYSA-N propylidene Chemical compound [CH]CC OSFBJERFMQCEQY-UHFFFAOYSA-N 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgyát az (I) általánős képletű, új pirazőlő[1,5-a]pirimidinek - ahől n = 0 vagy 1 és m = 0, 1, 2 vagy 3; Y őxigén-, kénatőm vagy adőtt esetben szűbsztitűált iminőcsőpőrt, ezekkőmbinációja metiléncsőpőrttal vagy etilén-, vinilén- vagy etinilén-csőpőrt; R1, R2, R3, R4 és R'' hidrőgénatőm vagy az arőmás gyűrűk szőkásősszűbsztitűenseinek valamelyike, előnyösen halőgénatőm, adőtt esetbenszűbsztitűált alkil-, alkenil-, ciklőalkil-, alkőxi-, alkil-tiő-,(di)alkil-aminő-, (heterő)aril-, főrmil- vagy karbőxicsőpőrt, és R' H3CO-CO=CHOCH3, -H3CNH-CO-=CHOCH3, H3CO-CO-=NOCH3, H3CNH-CO-=NOCH3,H2N-CO-=NOCH3, HO-CO-=NOCH3, H3CO-CO-=CHCH3, H3CO-CO-=CHCH2CH3, H3C-CO-=CHOCH3, H3C-CO-=NOCH3, vagy H3CCH2-CO-=NOCH3 képletű csőpőrt, -N(OCH3)-CO2CH3, -N(CH3)-CO2CH3 vagy -N(CH2CH3)-CO2CH3 képletű csőpőrt,vagy az (R'.1)-=NOCH3, (R'.2)-=NOCH3, (R'.3)-=NOCH3 és (R'.4)-=NOCH3képletű csőpőrtők valamelyike, amelyekben fenilcsőpőrthőz kapcsőlódószénatőmőt jelez - és ezeket tartalmazó kártevőirtó készítmények, tővábbá azelőállításűkra szőlgáló eljárásők és alkalmazásűk képezik. A találmányszerint a vegyületeket egy (IIa) és (IIIa) vagy egy (IIc) és (IIIc)általánős képletű vegyület - ahől X őxigén, kénatőm vagy iminőcsőpőrt;L1 és L3 kilépőcsőpőrt - vagy egy (IIb) és (IIIb) általánős képletűvegyület - ahől L2 halőgénatőm - reagáltatásával vagy egy (IId) és(IIId), illetve (IIe) és (IIIe) általánős képletű vegyületből - ahőlp# egy triaril-főszfóniűm-halőgenid vagy dialkőxi-főszfőnát megfelelőrésze - Wittig- vagy Hőrner-Wittig-reakcióval állítják elő. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19516843 | 1995-05-09 | ||
| DE19602072 | 1996-01-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP9801135A2 true HUP9801135A2 (hu) | 1998-08-28 |
Family
ID=26014970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9801135A HUP9801135A2 (hu) | 1995-05-09 | 1996-04-26 | Pirazolo[1,5-a]pirimidinek, eljárás előállításukra és alkalmazásuk |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5902773A (hu) |
| EP (1) | EP0824533B1 (hu) |
| JP (1) | JPH11506428A (hu) |
| KR (1) | KR19990008451A (hu) |
| CN (1) | CN1183783A (hu) |
| AT (1) | ATE208778T1 (hu) |
| AU (1) | AU700001B2 (hu) |
| BR (1) | BR9608100A (hu) |
| CA (1) | CA2217778A1 (hu) |
| DE (1) | DE59608203D1 (hu) |
| HU (1) | HUP9801135A2 (hu) |
| IL (1) | IL118167A0 (hu) |
| TW (1) | TW337986B (hu) |
| WO (1) | WO1996035690A1 (hu) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19731153A1 (de) | 1997-07-21 | 1999-01-28 | Basf Ag | 2-(Pyrazolyl- und Triazolyl-3'-oxymethylen)-phenyl-isoxazolone und -triazolone, Verfahren zu ihrer Herstellung und ihre Verwendung |
| WO1999060858A1 (fr) * | 1998-05-28 | 1999-12-02 | Sumitomo Chemical Company, Limited | Composes de pyrazolopyrimidine et leur utilisation |
| US6552026B2 (en) | 1999-06-14 | 2003-04-22 | Basf Aktiengesellschaft | 6-phenyl-pyrazolopyrimidines |
| US20020061897A1 (en) | 2000-03-30 | 2002-05-23 | Elliott Richard L. | Neuropeptide Y antagonists |
| US7067520B2 (en) * | 2000-11-17 | 2006-06-27 | Ishihara Sangyo Kaisha, Ltd. | Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts |
| WO2003053976A1 (en) * | 2001-12-20 | 2003-07-03 | Biovitrum Ab | PIPAZOLO [1,5-a] PYRIMIDINE DERIVATIVES AS MODULATORS OF PPAR |
| WO2004082383A1 (en) * | 2003-03-17 | 2004-09-30 | Basf Aktiengesellschaft | Use of triazolopyrimidines for combating nematode diseases of plants |
| DE10357569A1 (de) * | 2003-12-10 | 2005-07-07 | Bayer Cropscience Ag | Pyrazolopyrimidine |
| CN101238127A (zh) * | 2005-05-20 | 2008-08-06 | 艾伦托斯制药控股公司 | 嘧啶或三嗪稠合的二环金属蛋白酶抑制剂 |
| US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| PL1973545T3 (pl) | 2005-12-23 | 2013-05-31 | Ariad Pharma Inc | Bicykliczne Związki Heteroarylowe |
| CN101967149B (zh) * | 2009-07-28 | 2013-01-16 | 北京师范大学 | 18F取代硝基标记的吡唑并[1,5-a]嘧啶类化合物及制备和应用 |
| JP2014517079A (ja) | 2011-06-22 | 2014-07-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
| TR201807740T4 (tr) | 2012-12-07 | 2018-06-21 | Vertex Pharma | ATR kinaz inhibitörü olarak 2-amino-6-fluoro-n-(5-fluoro-4-(4-(4-(oksetan-3-il)piperazin-1-karbonil)piperidin-1-il)piridin-3-il)pirazolo[1,5alfa]pirimidin-3-karboksamid. |
| US8957078B2 (en) | 2013-03-15 | 2015-02-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| US9663519B2 (en) | 2013-03-15 | 2017-05-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| US8969360B2 (en) | 2013-03-15 | 2015-03-03 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| SG11201604519PA (en) | 2013-12-06 | 2016-07-28 | Vertex Pharma | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof |
| WO2015187451A1 (en) | 2014-06-05 | 2015-12-10 | Vertex Pharmacetucals Incorporated | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof |
| LT3157566T (lt) | 2014-06-17 | 2019-08-12 | Vertex Pharmaceuticals Incorporated | Vėžio gydymo būdas, panaudojant chk1 ir atr inhibitorių derinį |
| JP7187308B2 (ja) | 2015-09-30 | 2022-12-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｄｎａ損傷剤とａｔｒ阻害剤との組み合わせを使用する、がんを処置するための方法 |
| MX2019002303A (es) | 2016-08-31 | 2019-07-15 | Agios Pharmaceuticals Inc | Inhibidores de procesos metabolicos celulares. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8617648D0 (en) * | 1986-07-18 | 1986-08-28 | Ici Plc | Fungicides |
| US4877738A (en) * | 1986-07-25 | 1989-10-31 | Wisconsin Alumni Research Foundation | Biological control of damping off and root rot and inoculum preparation therefor |
| ES2052696T5 (es) * | 1987-02-09 | 2000-03-01 | Zeneca Ltd | Fungicidas. |
| DE3825043A1 (de) * | 1988-07-20 | 1990-02-15 | Schering Ag | 3-methylsulfonyl-pyrazolo(1,5-a)pyrimidin-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider, pflanzenwuchsregulierender und fungizider wirkung |
| DK0629609T3 (da) * | 1989-05-17 | 1996-12-23 | Shionogi & Co | Fremgangsmåde til fremstilling af alkoxyiminoacetamidderivater og et mellemprodukt dertil |
-
1996
- 1996-04-26 JP JP8533705A patent/JPH11506428A/ja active Pending
- 1996-04-26 DE DE59608203T patent/DE59608203D1/de not_active Expired - Lifetime
- 1996-04-26 BR BR9608100A patent/BR9608100A/pt not_active Application Discontinuation
- 1996-04-26 AT AT96913532T patent/ATE208778T1/de not_active IP Right Cessation
- 1996-04-26 KR KR1019970707981A patent/KR19990008451A/ko active IP Right Grant
- 1996-04-26 CN CN96193780A patent/CN1183783A/zh active Pending
- 1996-04-26 HU HU9801135A patent/HUP9801135A2/hu unknown
- 1996-04-26 EP EP96913532A patent/EP0824533B1/de not_active Expired - Lifetime
- 1996-04-26 AU AU56484/96A patent/AU700001B2/en not_active Ceased
- 1996-04-26 WO PCT/EP1996/001774 patent/WO1996035690A1/de active IP Right Grant
- 1996-04-26 US US08/945,609 patent/US5902773A/en not_active Expired - Fee Related
- 1996-04-26 CA CA002217778A patent/CA2217778A1/en not_active Abandoned
- 1996-05-07 IL IL11816796A patent/IL118167A0/xx unknown
- 1996-05-09 TW TW085105501A patent/TW337986B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| BR9608100A (pt) | 1999-02-23 |
| EP0824533B1 (de) | 2001-11-14 |
| KR19990008451A (ko) | 1999-01-25 |
| IL118167A0 (en) | 1996-09-12 |
| CN1183783A (zh) | 1998-06-03 |
| JPH11506428A (ja) | 1999-06-08 |
| DE59608203D1 (de) | 2001-12-20 |
| TW337986B (en) | 1998-08-11 |
| US5902773A (en) | 1999-05-11 |
| EP0824533A1 (de) | 1998-02-25 |
| AU5648496A (en) | 1996-11-29 |
| ATE208778T1 (de) | 2001-11-15 |
| CA2217778A1 (en) | 1996-11-14 |
| WO1996035690A1 (de) | 1996-11-14 |
| AU700001B2 (en) | 1998-12-17 |
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