HUP9801045A2 - Szulfonil-amino-karbonsav-származékok, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents

Szulfonil-amino-karbonsav-származékok, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra

Info

Publication number
HUP9801045A2
HUP9801045A2 HU9801045A HUP9801045A HUP9801045A2 HU P9801045 A2 HUP9801045 A2 HU P9801045A2 HU 9801045 A HU9801045 A HU 9801045A HU P9801045 A HUP9801045 A HU P9801045A HU P9801045 A2 HUP9801045 A2 HU P9801045A2
Authority
HU
Hungary
Prior art keywords
oxygen
phenyl
atom
substituted
sulfur atom
Prior art date
Application number
HU9801045A
Other languages
English (en)
Inventor
Günter Billen
Burkhard Haase
Bernhard Neises
Manfred Schudok
Wilfried Schwab
Werner Thorwart
Original Assignee
Hoechst Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19719585A external-priority patent/DE19719585A1/de
Priority claimed from DE19719428A external-priority patent/DE19719428A1/de
Application filed by Hoechst Ag. filed Critical Hoechst Ag.
Publication of HU9801045D0 publication Critical patent/HU9801045D0/hu
Publication of HUP9801045A2 publication Critical patent/HUP9801045A2/hu
Publication of HUP9801045A3 publication Critical patent/HUP9801045A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Furan Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány tárgyát képezik az (I) általánős képletű vegyületek, azelőállításűkra szőlgáló eljárás alkalmazásűk és a vegyületekettartalmazó gyógyszerkészítmények. R1 jelentése adőtt esetbenszűbsztitűált fenilcsőpőrt; adőtt esetben szűbsztitűált heterőarőmásgyűrűs csőpőrt; R2 jelentése hidrőgénatőm; alkil-, alkőxicsőpőrtők;szűbsztitűált vagy szűbsztitűálatlan fenil-alkil- vagy fenilcsőpőrt;R3 és G azőnősak vagy különbözők, és jelentésük hidrőgénatőm; alkil-,alkenil-, fenil-, heterőarilcsőpőrt, ahől a fenil- ésheterőarilcsőpőrt szűbsztitűálatlan, vagy mőnő- vagy diszűbsztitűáltlehet; A jelentése kővalens kémiai kötés, őxigénatőm, vinilén- vagyvinilcsőpőrt; B jelentése kötés vagy kétvegyértékű alkilénlánc; Djelentése alkilénlánc, ahől a lánctagők száma 1-6, és egy láncatőmőtadőtt esetben őxigén- vagy kénatőm vagy -NH- csőpőrt helyettesíthet;és X jelentése etenilcsőpőrt, őxigén- vagy kénatőm. A találmányszerinti vegyületek gátőlják a matrixőt lebőntó matrix-metallőprőteinázők aktivitását, közelebbről gátőlják a sztrőmelizin(MMP-3) és a neűtrőfil kőllagenáz (MMP 8) enzimek működését, s ígyelsősőrban pőrcszövet kárősődásainak kezelésére alkalmazhatók. ŕ
HU9801045A 1997-05-09 1998-05-08 Sulfonyl-amino-carboxylic acid derivatives, use thereof, pharmaceutical compositions containing them and process for their preparation HUP9801045A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19719585A DE19719585A1 (de) 1997-05-09 1997-05-09 Substituierte Diaminocarbonsäuren
DE19719428A DE19719428A1 (de) 1997-05-12 1997-05-12 Substituierte Diaminocarbonsäuren

Publications (3)

Publication Number Publication Date
HU9801045D0 HU9801045D0 (en) 1998-07-28
HUP9801045A2 true HUP9801045A2 (hu) 1999-06-28
HUP9801045A3 HUP9801045A3 (en) 2000-09-28

Family

ID=26036417

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801045A HUP9801045A3 (en) 1997-05-09 1998-05-08 Sulfonyl-amino-carboxylic acid derivatives, use thereof, pharmaceutical compositions containing them and process for their preparation

Country Status (18)

Country Link
US (2) US6159995A (hu)
EP (1) EP0877019B1 (hu)
JP (1) JP4177484B2 (hu)
KR (1) KR19980086893A (hu)
AR (1) AR012675A1 (hu)
AT (1) ATE210639T1 (hu)
AU (1) AU736700B2 (hu)
BR (1) BR9801604A (hu)
CA (1) CA2237052A1 (hu)
CZ (1) CZ143998A3 (hu)
DE (1) DE59802394D1 (hu)
DK (1) DK0877019T3 (hu)
ES (1) ES2165640T3 (hu)
HU (1) HUP9801045A3 (hu)
ID (1) ID20809A (hu)
PL (1) PL326218A1 (hu)
PT (1) PT877019E (hu)
TR (1) TR199800818A3 (hu)

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DE19719621A1 (de) * 1997-05-09 1998-11-12 Hoechst Ag Sulfonylaminocarbonsäuren
US6410580B1 (en) 1998-02-04 2002-06-25 Novartis Ag Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
PL342009A1 (en) * 1998-02-04 2001-05-07 Novartis Ag Sulphonylamine derivatives capable to inhibit extracellular substance degrading metaloproteinases
AU756248B2 (en) * 1998-04-03 2003-01-09 Sankyo Company Limited Sulfonamide derivatives
CA2337828C (en) * 1998-07-16 2010-08-17 Aventis Pharma Deutschland Gmbh Phosphinic and phosphonic acid derivatives used as pharmaceuticals
KR20010102486A (ko) * 1999-03-03 2001-11-15 데이비드 엠 모이어 알케닐- 및 알키닐-함유 메탈로프로테아제 저해제
NZ513830A (en) 1999-03-03 2001-09-28 Procter & Gamble Dihetero-substituted metalloprotease inhibitors
GB9918684D0 (en) 1999-08-09 1999-10-13 Novartis Ag Organic compounds
GB0103303D0 (en) 2001-02-09 2001-03-28 Novartis Ag Organic compounds
US6506786B2 (en) * 2001-02-13 2003-01-14 Pharmacor Inc. HIV protease inhibitors based on amino acid derivatives
EP1373262B1 (en) * 2001-03-14 2010-05-12 Novartis AG Azacycloalkyl substituted acetic acid derivatives for use as mmp inhibitors
SE0100903D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0103710D0 (sv) * 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
GB0221246D0 (en) * 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
GB0412553D0 (en) 2004-06-04 2004-07-07 Univ Aberdeen Therapeutic agents for the treatment of bone conditions
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0401762D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
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SE0403085D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
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TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
DK2124562T3 (en) 2007-03-09 2016-08-01 Second Genome Inc BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof
GB0705400D0 (en) 2007-03-21 2007-05-02 Univ Aberdeen Therapeutic compounds andm their use
GB0817208D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd Therapeutic apsap compounds and their use
GB0817207D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd therapeutic apsac compounds and their use
GB201311361D0 (en) 2013-06-26 2013-08-14 Pimco 2664 Ltd Compounds and their therapeutic use
HRP20211877T1 (hr) 2014-12-17 2022-03-04 Pimco 2664 Limited Spojevi n-(4-hidroksi-4-metil-cikloheksil)-4-fenil-benzensulfonamida i n-(4-hidroksi-4-metil-cikloheksil)-4- (2-piridil)-benzensulfonamida i njihova terapijska uporaba
CN109790136B (zh) 2016-12-22 2024-01-12 广州华睿光电材料有限公司 含呋喃交联基团的聚合物及其应用

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Also Published As

Publication number Publication date
BR9801604A (pt) 1999-06-08
HU9801045D0 (en) 1998-07-28
TR199800818A2 (xx) 1998-11-23
DE59802394D1 (de) 2002-01-24
CZ143998A3 (cs) 1998-11-11
ES2165640T3 (es) 2002-03-16
US6159995A (en) 2000-12-12
AR012675A1 (es) 2000-11-08
EP0877019A1 (de) 1998-11-11
HUP9801045A3 (en) 2000-09-28
KR19980086893A (ko) 1998-12-05
PT877019E (pt) 2002-05-31
JP4177484B2 (ja) 2008-11-05
ID20809A (id) 1999-03-11
DK0877019T3 (da) 2002-04-08
JPH11228529A (ja) 1999-08-24
TR199800818A3 (tr) 1998-11-23
ATE210639T1 (de) 2001-12-15
PL326218A1 (en) 1998-11-23
US6355673B1 (en) 2002-03-12
EP0877019B1 (de) 2001-12-12
AU736700B2 (en) 2001-08-02
CA2237052A1 (en) 1998-11-09
AU6482498A (en) 1998-11-12

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