AR012675A1 - Acidos diaminocarboxilicos sustituidos, compuestos intermediarios, procedimiento para la preparacion de dichos compuestos, medicamentos, uso dedichos compuestos para la preparacion de medicamentos y procedimiento para la preparacion de un medicamento - Google Patents

Acidos diaminocarboxilicos sustituidos, compuestos intermediarios, procedimiento para la preparacion de dichos compuestos, medicamentos, uso dedichos compuestos para la preparacion de medicamentos y procedimiento para la preparacion de un medicamento

Info

Publication number
AR012675A1
AR012675A1 ARP980102140A ARP980102140A AR012675A1 AR 012675 A1 AR012675 A1 AR 012675A1 AR P980102140 A ARP980102140 A AR P980102140A AR P980102140 A ARP980102140 A AR P980102140A AR 012675 A1 AR012675 A1 AR 012675A1
Authority
AR
Argentina
Prior art keywords
alkyl
preparation
compounds
phenyl
medicines
Prior art date
Application number
ARP980102140A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19719585A external-priority patent/DE19719585A1/de
Priority claimed from DE19719428A external-priority patent/DE19719428A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of AR012675A1 publication Critical patent/AR012675A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Acidos diaminocarboxílicos que comprende la formula (I) y/o una forma estereoisomera del compuesto de la formula (I) y/o una sal fisiologicamentecompatible del compuesto de la formula (I), en donde R1 representa: 1)fenilo, 2)fenilo que estás ustituido, una o dos veces con 2.1) alquilo (C1-7), lineal,cíclico o ramificado, 2.2) -OH, 2.3) alquil (C1-6)-C(O)-O-, 2.4) alquil (C1-6) -O-, 2.5)alquil (C1-6)-O-alquil (C1-4)-O- 2.6) halogeno, 2.7) -CF3, 2.8) -CN,2.9)- NO2, 2.10) HO-C(O)-,2.11) a lquil (C1-6)-O-C(O)-, 2.12) metilendioxo, 2.13) R4-(R5)N-C(O)-, 2.14) R4-(R5)N-, o un compuesto heteroaromático delsiguiente grupo 3.1 a 3.16, que no está sustituido o que está sustituido tal como se describe en los apartados 2.1 a2.14; 3.1) pirrol, 3.2) pirazol, 3.3)imidazol, 3.4) triazol, 3.5) tiofeno, 3.6) tiazol, 3.7) oxazol, 3.8) isoxazol, 3.9)piridina, 3.10) pirimidina, 3.11) indol, 3.12) benzotiofeno, 3.13)bencimidazol, 3.14) benzoxazol o 3.16) bentriazol, R2, R4 y R5son iguales o diferentes y representan 1) un átomo de hidrogeno, 2) alquilo (C1-6), 3)HO-C(o)- alquilo (C1-6), 4) fenil-(CH2)0-, en donde fenilo está no sustituido o está sustituido una o dos veces tal como se describe en los apartados 2.1 a2.14,y o represe nta el numero entero cero, 1 o 2, 5) picolilo, o 6) R4 y R5, junto con el grupo amino dispuesto en el anillo, forman un anillo de 4 a 7miembros, en donde eventualmente uno de los átomos de carbono está reemplazado por -O-, -S- o -NH,R3 y G son ig uales o diferentes y representan 1) un átomode hidrogeno, 2) alquilo (C1-6)-, en donde alquilo es lineal, ramificado o cíclico, 3) alquenilo (C1-6)-, 4) fenil -(CH2)m-, en donde fenilo está nosustituido o está sustituido uno o dosveces tal como se describe en los apartados 2.1 a 2.14, y m es el numero entero cero, 1, 2 o 3, 5) heteroaril
ARP980102140A 1997-05-09 1998-05-07 Acidos diaminocarboxilicos sustituidos, compuestos intermediarios, procedimiento para la preparacion de dichos compuestos, medicamentos, uso dedichos compuestos para la preparacion de medicamentos y procedimiento para la preparacion de un medicamento AR012675A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19719585A DE19719585A1 (de) 1997-05-09 1997-05-09 Substituierte Diaminocarbonsäuren
DE19719428A DE19719428A1 (de) 1997-05-12 1997-05-12 Substituierte Diaminocarbonsäuren

Publications (1)

Publication Number Publication Date
AR012675A1 true AR012675A1 (es) 2000-11-08

Family

ID=26036417

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980102140A AR012675A1 (es) 1997-05-09 1998-05-07 Acidos diaminocarboxilicos sustituidos, compuestos intermediarios, procedimiento para la preparacion de dichos compuestos, medicamentos, uso dedichos compuestos para la preparacion de medicamentos y procedimiento para la preparacion de un medicamento

Country Status (18)

Country Link
US (2) US6159995A (es)
EP (1) EP0877019B1 (es)
JP (1) JP4177484B2 (es)
KR (1) KR19980086893A (es)
AR (1) AR012675A1 (es)
AT (1) ATE210639T1 (es)
AU (1) AU736700B2 (es)
BR (1) BR9801604A (es)
CA (1) CA2237052A1 (es)
CZ (1) CZ143998A3 (es)
DE (1) DE59802394D1 (es)
DK (1) DK0877019T3 (es)
ES (1) ES2165640T3 (es)
HU (1) HUP9801045A3 (es)
ID (1) ID20809A (es)
PL (1) PL326218A1 (es)
PT (1) PT877019E (es)
TR (1) TR199800818A3 (es)

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DE19719621A1 (de) * 1997-05-09 1998-11-12 Hoechst Ag Sulfonylaminocarbonsäuren
US6410580B1 (en) 1998-02-04 2002-06-25 Novartis Ag Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
CN1195735C (zh) * 1998-02-04 2005-04-06 诺瓦提斯公司 抑制使基质退化的金属蛋白酶的磺酰氨基衍生物
CN1304402A (zh) * 1998-04-03 2001-07-18 三共株式会社 磺酰胺衍生物
ATE227295T1 (de) 1998-07-16 2002-11-15 Aventis Pharma Gmbh Phosphin- und phosphonsäurederivate als arzneimittel
CZ20013155A3 (cs) 1999-03-03 2002-01-16 The Procter & Gamble Company Inhibitory metaloproteas
EP1165501A1 (en) * 1999-03-03 2002-01-02 The Procter & Gamble Company Alkenyl- and alkynyl-containing metalloprotease inhibitors
GB9918684D0 (en) 1999-08-09 1999-10-13 Novartis Ag Organic compounds
GB0103303D0 (en) * 2001-02-09 2001-03-28 Novartis Ag Organic compounds
US6506786B2 (en) * 2001-02-13 2003-01-14 Pharmacor Inc. HIV protease inhibitors based on amino acid derivatives
WO2002072577A2 (en) * 2001-03-14 2002-09-19 Novartis Ag Azacycloalkyl substituted acetic acid derivatives for use as mmp inhibitors.
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
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PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
GB0221246D0 (en) * 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
GB0412553D0 (en) 2004-06-04 2004-07-07 Univ Aberdeen Therapeutic agents for the treatment of bone conditions
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0401762D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
US7388008B2 (en) * 2004-08-02 2008-06-17 Ambrilia Biopharma Inc. Lysine based compounds
SE0403086D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
SE0403085D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
US7576222B2 (en) 2004-12-28 2009-08-18 Wyeth Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase
WO2006114001A1 (en) * 2005-04-27 2006-11-02 Ambrilia Biopharma Inc. Method for improving pharmacokinetics of protease inhibitors and protease inhibitor precursors
CA2632095A1 (en) * 2005-11-30 2007-06-07 Ambrilia Biopharma Inc. Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation
US8410300B2 (en) * 2006-09-21 2013-04-02 Taimed Biologics, Inc. Protease inhibitors
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
ES2576643T3 (es) 2007-03-09 2016-07-08 Second Genome, Inc. Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos
GB0705400D0 (en) 2007-03-21 2007-05-02 Univ Aberdeen Therapeutic compounds andm their use
GB0817207D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd therapeutic apsac compounds and their use
GB0817208D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd Therapeutic apsap compounds and their use
GB201311361D0 (en) 2013-06-26 2013-08-14 Pimco 2664 Ltd Compounds and their therapeutic use
LT3262028T (lt) 2014-12-17 2022-01-10 Pimco 2664 Limited N-(4-hidroksi-4-metil-cikloheksil)-4-fenil-benzensulfonamido ir n-(-4-hidroksi-4-metil-cikloheksil)-4-(2-piridil)-benzensulfonamido junginiai ir jų terapinis panaudojimas
US11289654B2 (en) 2016-12-22 2022-03-29 Guangzhou Chinaray Optoelectronic Materials Ltd. Polymers containing furanyl crosslinkable groups and uses thereof

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Also Published As

Publication number Publication date
ID20809A (id) 1999-03-11
JP4177484B2 (ja) 2008-11-05
US6159995A (en) 2000-12-12
JPH11228529A (ja) 1999-08-24
AU736700B2 (en) 2001-08-02
BR9801604A (pt) 1999-06-08
ES2165640T3 (es) 2002-03-16
HU9801045D0 (en) 1998-07-28
EP0877019A1 (de) 1998-11-11
TR199800818A2 (xx) 1998-11-23
ATE210639T1 (de) 2001-12-15
PL326218A1 (en) 1998-11-23
CZ143998A3 (cs) 1998-11-11
HUP9801045A2 (hu) 1999-06-28
CA2237052A1 (en) 1998-11-09
TR199800818A3 (tr) 1998-11-23
KR19980086893A (ko) 1998-12-05
AU6482498A (en) 1998-11-12
US6355673B1 (en) 2002-03-12
PT877019E (pt) 2002-05-31
DK0877019T3 (da) 2002-04-08
DE59802394D1 (de) 2002-01-24
HUP9801045A3 (en) 2000-09-28
EP0877019B1 (de) 2001-12-12

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