HUP0301607A2 - Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0301607A2
HUP0301607A2 HU0301607A HUP0301607A HUP0301607A2 HU P0301607 A2 HUP0301607 A2 HU P0301607A2 HU 0301607 A HU0301607 A HU 0301607A HU P0301607 A HUP0301607 A HU P0301607A HU P0301607 A2 HUP0301607 A2 HU P0301607A2
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HU
Hungary
Prior art keywords
anatgonist
pharmaceutical compositions
nitrogen atoms
heterocyclic compound
group
Prior art date
Application number
HU0301607A
Other languages
English (en)
Inventor
David J. Blythin
Xiao Chen
Sunil Paliwal
John J. Piwinski
Gregory A. Reichard
Neng-Yang Shih
Ho-Jane Shue
Dong Xiao
Original Assignee
Schering Corp.
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Publication date
Application filed by Schering Corp. filed Critical Schering Corp.
Publication of HUP0301607A2 publication Critical patent/HUP0301607A2/hu
Publication of HUP0301607A3 publication Critical patent/HUP0301607A3/hu

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    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Abstract

A találmány tárgyát az általános képletű vegyületek - ahol előnyösenR1, R3, R4 és R7 hidrogénatom; R2 hidrogénatom vagy metil- vagyhidroxi-metil-csoport: X1 oxigénatom vagy adott esetben szubsztituáltiminocsoport; Ar1 és Ar2 szubsztituált fenilcsoport; n értéke 1 vagy2; általános képletű csoportok valamelyike, ahol X2 oxigén- vagykénatom vagy -NR5- általános képletű csoport, Y oxo-, tioxo- vagyadott esetben szubsztituált iminocsoport, és Y1, R4 és R5 különféleszubsztituensek; és R6 jelentése hidrogénatom vagy hidroxicsoport - ésgyógyszerészetileg elfogadható sóik, ezeket, valamint adott esetbenegy szelektív szerotonin reuptake inhibitort is tartalmanógyógyszerkészítmények és alkalmazásuk képezik. Ó
HU0301607A 1999-12-17 2000-12-14 Heterocyclic compound containing nitrogen atoms having selective neurokinin anatgonist effect pharmaceutical compositions containing them and their use HUP0301607A3 (en)

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