HUP0203657A2 - Heterociklusos vegyületek és eljárások a szívgyengeség és más rendellenességek kezelésére - Google Patents

Heterociklusos vegyületek és eljárások a szívgyengeség és más rendellenességek kezelésére

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Publication number
HUP0203657A2
HUP0203657A2 HU0203657A HUP0203657A HUP0203657A2 HU P0203657 A2 HUP0203657 A2 HU P0203657A2 HU 0203657 A HU0203657 A HU 0203657A HU P0203657 A HUP0203657 A HU P0203657A HU P0203657 A2 HUP0203657 A2 HU P0203657A2
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HU
Hungary
Prior art keywords
alkyl
group
optionally
nrocr
conr2
Prior art date
Application number
HU0203657A
Other languages
English (en)
Inventor
John A. Lewicki
David Y. Lin
Babu J. Mavunkel
John J. Perumattam
George F. Schreiner
Original Assignee
Scios Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/128,137 external-priority patent/US6130235A/en
Priority claimed from US09/275,176 external-priority patent/US6340685B1/en
Application filed by Scios Inc. filed Critical Scios Inc.
Publication of HUP0203657A2 publication Critical patent/HUP0203657A2/hu
Publication of HUP0203657A3 publication Critical patent/HUP0203657A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

A találmány tárgyát az (a) és (b) jelű általános képlettel jellemzettvegyületek és azok gyógyszerészetileg elfogadható sói képezik, ahol Z1és Z2 mindegyikének jelentése egymástól függetlenül CR4 vagy N; aholminden R4 jelentése egymástól függetlenül H vagy 1-6 szénatomos alkilvagy arilcsoport, mely alkil- vagy arilcsoportok tetszőlegesen egyvagy több heteroatomot tartalmaznak, mely O, S vagy N lehet, éstetszőlegesen egy vagy több halogénatom, OR, SR, NR2, RCO, COOR,CONR2, OOCR vagy NROCR szubsztituenst tartalmaznak, ahol R jelentésehidrogénatom vagy 1-6 szénatomos alkilcsoport, vagy egy vagy több CNvagy =O, vagy egy vagy több, tetszőlegesen 1-2 heteroatomot tartalmazóalifás vagy aromás 5- vagy 6-tagú gyűrű szubsztituensttartalmazhatnak; R1 jelentése az (I) általános képletű vegyület, aholX1 jelentése CO vagy annak egy izosztere; m értéke 0 vagy 1; Yjelentése tetszőlegesen szubsztituált alkil-, tetszőlegesenszubsztituált aril-, vagy tetszőlegesen szubsztituált arilalkil-csoport, vagy két Y együttesen egy 2-3 szénatomos alkilénhidatalkothat; n értéke 0, 1 vagy 2; Z3 jelentése CH vagy N; X2 jelentéseCH, CH2 vagy annak egy izosztere; és Ar egy vagy két fenilrészletbőláll, melyek közvetlenül kapcsolódnak az X2-csoporthoz, és amelyektetszőlegesen halogén-, nitro-, 1-6 szénatomos alkil-, 1-6 szénatomosalkenil-, 1-6 szénatomos alkinil-, CN- vagy CF3 szubsztituenst, vagyRCO, COOR, CONR2, NR2, OR, SR, OOCR vagy NROCR szubsztituensttartalmaznak, ahol R jelentése hidrogénatom vagy 1-6 szénatomosalkilcsoport, vagy fenilcsoport szubsztituenst tartalmaznak, mely magais tetszőlegesen a fent felsorolt szubsztituenseket tartalmazhatja; R2jelentése H, vagy 1-6 szénatomos alkil- vagy arilcsoport, mely alkil-vagy arilcsoportok mindegyike tetszőlegesen egy vagy több halogénatom,OR, SR, NR, RCO, COOR, CONR2, OOCR vagy NROCR szubsztituensttartalmazhat, ahol R jelentése hidrogénatom vagy 1-6 szénatomos alkil-vagy 1-6 szénatomos alkinilcsoport, vagy egy vagy több CN vagy =Oszubsztituenst tartalmazhat, vagy egy vagy több alifás vagy aromás 5-vagy 6-tagú gyűrűt, melyek tetszőlegesen 1-2 heteroatomottartalmaznak; R3 jelentése hidrogénatom, halogénatom, NO2, 1-6szénatomos alkil-, 1-6 szénatomos alkenil-, 1-6 szénatomos alkinil-,CN, OR, SR, NR2, RCO, COOR, CONR2, OOCR vagy NROCR csoport, ahol Rjelentése hidrogénatom vagy 1-6 szénatomos alkilcsoport. Ezek avegyületek a p38a kináz szelektív inhibitorai. Ó
HU0203657A 1998-05-22 1999-05-21 Heterocyclic compounds and methods to treat cardiac failure and other disorders HUP0203657A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8653198P 1998-05-22 1998-05-22
US09/128,137 US6130235A (en) 1998-05-22 1998-08-03 Compounds and methods to treat cardiac failure and other disorders
US09/275,176 US6340685B1 (en) 1998-05-22 1999-03-24 Compounds and methods to treat cardiac failure and other disorders
PCT/US1999/011222 WO1999061426A1 (en) 1998-05-22 1999-05-21 Heterocyclic compounds and methods to treat cardiac failure and other disorders

Publications (2)

Publication Number Publication Date
HUP0203657A2 true HUP0203657A2 (hu) 2003-03-28
HUP0203657A3 HUP0203657A3 (en) 2005-03-29

Family

ID=46203611

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203657A HUP0203657A3 (en) 1998-05-22 1999-05-21 Heterocyclic compounds and methods to treat cardiac failure and other disorders

Country Status (16)

Country Link
EP (1) EP1080078B1 (hu)
JP (1) JP2002516314A (hu)
KR (1) KR100605140B1 (hu)
CN (1) CN1229351C (hu)
AT (1) ATE316961T1 (hu)
AU (2) AU769465B2 (hu)
BR (1) BR9911069A (hu)
CA (1) CA2332459A1 (hu)
DE (1) DE69929689T2 (hu)
ES (1) ES2258331T3 (hu)
HK (1) HK1034707A1 (hu)
HU (1) HUP0203657A3 (hu)
NO (1) NO320299B1 (hu)
NZ (1) NZ508790A (hu)
PL (1) PL346345A1 (hu)
WO (1) WO1999061426A1 (hu)

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ATE316961T1 (de) 2006-02-15
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WO1999061426A1 (en) 1999-12-02
NO20005881D0 (no) 2000-11-21
CA2332459A1 (en) 1999-12-02
HUP0203657A3 (en) 2005-03-29
HK1034707A1 (en) 2001-11-02
KR100605140B1 (ko) 2006-07-28
KR20010070946A (ko) 2001-07-28
NO20005881L (no) 2001-01-09
NO320299B1 (no) 2005-11-21
CN1305464A (zh) 2001-07-25
JP2002516314A (ja) 2002-06-04
DE69929689D1 (de) 2006-04-13
EP1080078A1 (en) 2001-03-07
AU769465B2 (en) 2004-01-29
BR9911069A (pt) 2001-02-06
CN1229351C (zh) 2005-11-30
AU4092099A (en) 1999-12-13
EP1080078B1 (en) 2006-02-01
PL346345A1 (en) 2002-02-11
DE69929689T2 (de) 2006-11-02
ES2258331T3 (es) 2006-08-16

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