HUP9903758A2 - Benzoxazinon dopamin D4 receptor antagonisták és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Benzoxazinon dopamin D4 receptor antagonisták és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9903758A2 HUP9903758A2 HU9903758A HUP9903758A HUP9903758A2 HU P9903758 A2 HUP9903758 A2 HU P9903758A2 HU 9903758 A HU9903758 A HU 9903758A HU P9903758 A HUP9903758 A HU P9903758A HU P9903758 A2 HUP9903758 A2 HU P9903758A2
- Authority
- HU
- Hungary
- Prior art keywords
- benzoxazinone
- dopamine
- same
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- HQQTZCPKNZVLFF-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-one Chemical compound C1=CC=C2ONC(=O)CC2=C1 HQQTZCPKNZVLFF-UHFFFAOYSA-N 0.000 title 1
- 229940124243 Dopamine D4 receptor antagonist Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
(I) vagy (II) általánős képletű vegyületek, amelyekben R1 és R2jelentése egymástól függetlenül hidrőgénatőm vagy 1-6 szénatőmősalkilcsőpőrt; X jelentése N-atőm vagy CH-csőpőrt; és R3 jelentésefenilcsőpőrt, naftil-, heterőaril-, helyettesített fenil-,helyettesített naftil- vagy helyettesített heterőarilcsőpőrt,amelyekben minden helyettesítő egymástól függetlenül hidrőgénatőm, 1-6szénatőmős alkőxicsőpőrt, 1-6 szénatőmős alkilcsőpőrt, -CN, -CF3 vagyszűlfamidőcsőpőrt és ezek gyógyszerészetileg elfőgadható sói,észterei, amidjai és előgyógyszerei közül kerülnek ki, a dőpamin D4receptőrők antagőnistái. ŕ
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1838396P | 1996-05-29 | 1996-05-29 | |
| US4020897P | 1997-03-06 | 1997-03-06 | |
| PCT/US1997/008524 WO1997045419A1 (en) | 1996-05-29 | 1997-05-20 | Benzoxazinone dopamine d4 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9903758A2 true HUP9903758A2 (hu) | 2000-06-28 |
| HUP9903758A3 HUP9903758A3 (en) | 2000-07-28 |
Family
ID=26691052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9903758A HUP9903758A3 (en) | 1996-05-29 | 1997-05-20 | Benzoxazinone dopamine d4 receptor antagonists and pharmaceutical compositions containing the same |
Country Status (37)
| Country | Link |
|---|---|
| EP (1) | EP0906294B1 (hu) |
| JP (1) | JP2000511534A (hu) |
| KR (1) | KR20000016151A (hu) |
| CN (1) | CN1074764C (hu) |
| AR (1) | AR008372A1 (hu) |
| AT (1) | ATE231846T1 (hu) |
| AU (1) | AU731104B2 (hu) |
| BG (1) | BG64049B1 (hu) |
| BR (1) | BR9709630A (hu) |
| CA (1) | CA2253406A1 (hu) |
| CO (1) | CO4940505A1 (hu) |
| CZ (1) | CZ384698A3 (hu) |
| DE (1) | DE69718786T2 (hu) |
| DK (1) | DK0906294T3 (hu) |
| EA (1) | EA001486B1 (hu) |
| EE (1) | EE03686B1 (hu) |
| ES (1) | ES2191180T3 (hu) |
| GE (1) | GEP20012389B (hu) |
| HK (1) | HK1019737A1 (hu) |
| HN (1) | HN1997000075A (hu) |
| HR (1) | HRP970301B1 (hu) |
| HU (1) | HUP9903758A3 (hu) |
| ID (1) | ID17266A (hu) |
| IL (1) | IL126895A (hu) |
| NO (1) | NO312296B1 (hu) |
| NZ (1) | NZ332737A (hu) |
| PA (1) | PA8431101A1 (hu) |
| PE (1) | PE69398A1 (hu) |
| PL (1) | PL330195A1 (hu) |
| PT (1) | PT906294E (hu) |
| RO (1) | RO120845B1 (hu) |
| SI (1) | SI0906294T1 (hu) |
| SK (1) | SK282703B6 (hu) |
| SV (1) | SV1997000047A (hu) |
| TW (1) | TW542833B (hu) |
| UY (1) | UY24569A1 (hu) |
| WO (1) | WO1997045419A1 (hu) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6177422B1 (en) | 1996-05-29 | 2001-01-23 | Warner-Lambert Company | Benzoxazinone dopamine D4 receptor antagonists |
| GB9801392D0 (en) * | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| WO2000000489A2 (en) * | 1998-06-30 | 2000-01-06 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl)benzodioxane and 6-(4-arylalkylpiperazin-1-yl)chromane derivatives: dopamine receptor subtype specific ligands |
| US6291463B1 (en) | 1998-06-30 | 2001-09-18 | Neurogen Corporation | 1-(Benzothiazol-2-yl)-4-(1-phenylmethyl) piperazines: dopamine receptor subtype specific ligands |
| US6177566B1 (en) | 1998-06-30 | 2001-01-23 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands |
| EP1089990A1 (en) * | 1998-06-30 | 2001-04-11 | Neurogen Corporation | 1-(benzothiazol-2-yl)-4-(1-phenylmethyl)piperazines: dopamine receptor subtype specific ligands |
| DE19844291A1 (de) | 1998-09-18 | 2000-03-23 | Schering Ag | Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| BR0114881A (pt) | 2000-10-26 | 2003-09-30 | Smithkline Beecham Plc | Derivados de benzoxazinona, sua preparação e uso |
| GB0203804D0 (en) | 2002-02-18 | 2002-04-03 | Glaxo Group Ltd | Compounds |
| GB0209244D0 (en) * | 2002-04-23 | 2002-06-05 | Glaxo Group Ltd | Compounds |
| GB0227240D0 (en) * | 2002-11-21 | 2002-12-31 | Glaxo Group Ltd | Compounds |
| ES2232292B1 (es) * | 2003-07-30 | 2006-11-01 | Laboratorios Del Dr. Esteve, S.A. | Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos. |
| CN100455573C (zh) * | 2005-11-11 | 2009-01-28 | 华东理工大学 | 一种制备1,4-苯并噁唑嗪-3-酮化合物的微波合成方法 |
| KR200482995Y1 (ko) | 2015-08-19 | 2017-03-23 | 이현진 | 물 공급부를 구비하는 얼음 트레이 |
| CN115232154A (zh) * | 2021-04-23 | 2022-10-25 | 上海翰森生物医药科技有限公司 | 杂环类衍生物抑制剂、其制备方法和应用 |
| WO2023207283A1 (en) * | 2022-04-28 | 2023-11-02 | Ningbo Newbay Technology Development Co., Ltd | Compounds as parp1 inhibitiors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4613598A (en) * | 1984-03-13 | 1986-09-23 | Mitsubishi Chemical Industries Limited | Piperazine derivatives and their acid addition salts |
| EP0233728A1 (en) * | 1986-02-11 | 1987-08-26 | Takeda Chemical Industries, Ltd. | 1,4-Benzoxazine derivatives their production and use |
| NZ254784A (en) * | 1992-08-06 | 1996-11-26 | Smithkline Beecham Plc | Substituted 5-phenyl pyrrole derivatives and medicaments |
-
1997
- 1997-05-20 GE GEAP19974623A patent/GEP20012389B/en unknown
- 1997-05-20 WO PCT/US1997/008524 patent/WO1997045419A1/en not_active Application Discontinuation
- 1997-05-20 AT AT97925651T patent/ATE231846T1/de not_active IP Right Cessation
- 1997-05-20 NZ NZ332737A patent/NZ332737A/en unknown
- 1997-05-20 CA CA002253406A patent/CA2253406A1/en not_active Abandoned
- 1997-05-20 SK SK1627-98A patent/SK282703B6/sk unknown
- 1997-05-20 HU HU9903758A patent/HUP9903758A3/hu unknown
- 1997-05-20 IL IL12689597A patent/IL126895A/en not_active IP Right Cessation
- 1997-05-20 PT PT97925651T patent/PT906294E/pt unknown
- 1997-05-20 JP JP09542647A patent/JP2000511534A/ja not_active Ceased
- 1997-05-20 EP EP97925651A patent/EP0906294B1/en not_active Expired - Lifetime
- 1997-05-20 PL PL97330195A patent/PL330195A1/xx unknown
- 1997-05-20 DE DE69718786T patent/DE69718786T2/de not_active Expired - Fee Related
- 1997-05-20 DK DK97925651T patent/DK0906294T3/da active
- 1997-05-20 BR BR9709630A patent/BR9709630A/pt not_active Application Discontinuation
- 1997-05-20 RO RO98-01622A patent/RO120845B1/ro unknown
- 1997-05-20 SI SI9730482T patent/SI0906294T1/xx unknown
- 1997-05-20 CZ CZ983846A patent/CZ384698A3/cs unknown
- 1997-05-20 EA EA199800987A patent/EA001486B1/ru not_active IP Right Cessation
- 1997-05-20 CN CN97195015A patent/CN1074764C/zh not_active Expired - Fee Related
- 1997-05-20 KR KR1019980709719A patent/KR20000016151A/ko not_active Application Discontinuation
- 1997-05-20 EE EE9800417A patent/EE03686B1/xx not_active IP Right Cessation
- 1997-05-20 ES ES97925651T patent/ES2191180T3/es not_active Expired - Lifetime
- 1997-05-20 AU AU30727/97A patent/AU731104B2/en not_active Ceased
- 1997-05-22 HN HN1997000075A patent/HN1997000075A/es unknown
- 1997-05-27 AR ARP970102249A patent/AR008372A1/es unknown
- 1997-05-28 SV SV1997000047A patent/SV1997000047A/es not_active Application Discontinuation
- 1997-05-28 CO CO97029474A patent/CO4940505A1/es unknown
- 1997-05-28 PE PE1997000432A patent/PE69398A1/es not_active Application Discontinuation
- 1997-05-28 TW TW086107221A patent/TW542833B/zh active
- 1997-05-28 UY UY24569A patent/UY24569A1/es not_active Application Discontinuation
- 1997-05-28 PA PA19978431101A patent/PA8431101A1/es unknown
- 1997-05-28 ID IDP971778A patent/ID17266A/id unknown
- 1997-05-29 HR HR970301A patent/HRP970301B1/xx not_active IP Right Cessation
-
1998
- 1998-11-26 BG BG102959A patent/BG64049B1/bg unknown
- 1998-11-27 NO NO19985531A patent/NO312296B1/no not_active IP Right Cessation
-
1999
- 1999-10-28 HK HK99104867A patent/HK1019737A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |