HUP0302969A2 - NPY Y5 antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

NPY Y5 antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0302969A2
HUP0302969A2 HU0302969A HUP0302969A HUP0302969A2 HU P0302969 A2 HUP0302969 A2 HU P0302969A2 HU 0302969 A HU0302969 A HU 0302969A HU P0302969 A HUP0302969 A HU P0302969A HU P0302969 A2 HUP0302969 A2 HU P0302969A2
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HU
Hungary
Prior art keywords
group
general formula
alkyl
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU0302969A
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English (en)
Inventor
Kohji Hanasaki
Yasuyuki Kawanishi
Tetsuo Okada
Hideyuki Takenaka
Original Assignee
Shionogi & Co., Ltd.
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Application filed by Shionogi & Co., Ltd. filed Critical Shionogi & Co., Ltd.
Publication of HUP0302969A2 publication Critical patent/HUP0302969A2/hu
Publication of HUP0302969A3 publication Critical patent/HUP0302969A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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Abstract

A találmány tárgyát NPY Y5-receptor antagonistaként való alkalmazásraszolgáló, hatóanyagként egy általános képletű vegyületet - ahol R1alkil-, cikloalkil- vagy arilcsoport; R2 hidrogénatom vagyalkilcsoport; vagy R1 és R2 együttesen alkiléncsoport; n 1 vagy 2; Xalkilén-, alkenilén-, arilén- vagy cikloalkiléncsoport vagy kétértékűheterociklusos csoport; Y -OCONR7-, -CONR7-, -CSNR7-, -NR7CO- vagy -NR7CS- általános képletű csoport, ahol R7 hidrogénatom vagyalkilcsoport; és Z adott esetben szubsztituált alkil-, alkenil-,amino-, alkoxi-, karbociklil- vagy heterociklil-csoport - vagyprodrugszármazékát, sóját vagy szolvátját tartalmazógyógyszerkészítmények, bizonyos (I) általános képletű új vegyületek ésgyógyászati alkalmazásuk képezik. Ó
HU0302969A 1999-11-26 2000-11-21 Npyy5 antagonists, pharmaceutical compositions containing them and their use HUP0302969A3 (en)

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JP33646999 1999-11-26
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PCT/JP2000/008197 WO2001037826A1 (fr) 1999-11-26 2000-11-21 Antagonistes npyy5

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EP2014285A1 (en) 2009-01-14
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PL211888B1 (pl) 2012-07-31
ATE405257T1 (de) 2008-09-15
DK1249233T3 (da) 2008-11-17
RU2264810C2 (ru) 2005-11-27
CA2389681C (en) 2010-11-02
CA2389681A1 (en) 2001-05-31
KR20020092348A (ko) 2002-12-11
AU1418601A (en) 2001-06-04
US8115027B2 (en) 2012-02-14
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HUP0302969A3 (en) 2005-05-30
NO20022481L (no) 2002-07-26
EP1249233B9 (en) 2009-08-05
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CN101898982B (zh) 2012-07-04
US20110039802A1 (en) 2011-02-17
CY1110243T1 (el) 2015-01-14
AU780790B2 (en) 2005-04-14
ATE466573T1 (de) 2010-05-15
BR0015843A (pt) 2002-08-27
EP1249233A4 (en) 2005-04-13
ES2342344T3 (es) 2010-07-05
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