HUP0102723A2 - Új difenilkarbamid-származékok, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények - Google Patents
Új difenilkarbamid-származékok, eljárás előállításukra és ezeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP0102723A2 HUP0102723A2 HU0102723A HUP0102723A HUP0102723A2 HU P0102723 A2 HUP0102723 A2 HU P0102723A2 HU 0102723 A HU0102723 A HU 0102723A HU P0102723 A HUP0102723 A HU P0102723A HU P0102723 A2 HUP0102723 A2 HU P0102723A2
- Authority
- HU
- Hungary
- Prior art keywords
- optionally substituted
- group
- alkyl
- hydrogen atom
- atom
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- GWEHVDNNLFDJLR-UHFFFAOYSA-N 1,3-diphenylurea Chemical class C=1C=CC=CC=1NC(=O)NC1=CC=CC=C1 GWEHVDNNLFDJLR-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- -1 nitro- Chemical class 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
A találmány tárgya (I) általános képletű vegyületek, ezekenantiomerjei és diasztereoizomerjei, valamint gyógyszerészetilegelfogadható savval vagy bázissal kialakított addíciós sói, ahol aképletben R1, R2, R3 és R4 jelentése egymástól függetlenülhidrogénatom, halogénatom vagy alkil-, alkoxi-, hidroxil-, ciano-,adott esetben szubsztituált aminocsoport, nitro-, karboxil-, alkoxi-karbonil-, adott esetben szubsztituált amino-karbonil-csoport vagykarbamoilcsoport; L1 és L2 jelentése hidrogénatom vagy együtt -CH2-CH2- csoportot képeznek; X1 jelentése az aromás gyűrűn 2- vagy 3-helyzetben egy kötés, és ebben az esetben X2 jelentése hidrogénatom,halogénatom, alkil-, alkoxi-, hidroxil-, nitro- vagy cianocsoport,vagy adott esetben szubsztituált aminocsoport; vagy X1 és X2 együtt akét kapcsolódó szénatommal az aromás gyűrű 2-, 3- vagy 4-helyzetébenegy 4-7 szénatomos cikloalkilcsoportot képez, ahol egy vagy két -CH2-csoport a cikloalkilgyűrűben adott esetben egy oxigénatommal vagy egyNH-csoporttal helyettesítve lehet, és ahol a cikloalkilgyűrű egyszénatomja G csoporttal szubsztituált; X3 jelentése hidrogénatom,halogénatom, alkil-, alkoxi-, hidroxil-, nitro- vagy cianocsoport,vagy adott esetben szubsztituált aminocsoport; G jelentése (G1), (G2),(G3) és (G4) általános képletű csoport közül megválasztott, ahol aszaggatott vonal jelentése adott esetben jelen lévő kettős kötés; Alkjelentése lineáris vagy elágazó 1-6 szénatomos alkiléncsoport; nértéke 0 vagy 1; T3 jelentése alkilcsoport, adott esetbenszubsztituált arilcsoport, adott esetben szubsztituált aril-alkil-csoport, adott esetben szubsztituált heteroarilcsoport vagy adottesetben szubsztituált heteroaril-alkil-csoport; T4 jelentésealkilcsoport, adott esetben szubsztituált arilcsoport, adott esetbenszubsztituált aril-alkil-csoport, adott esetben szubsztituáltheteroarilcsoport és adott esetben szubsztituált heteroaril-alkil-csoport. A találmány tárgya továbbá eljárás a fenti vegyületekelőállítására. A találmány tárgykörébe tartoznak továbbá gyógyászatikészítmények, amelyek legalább egy fenti vegyületet tartalmaznak, ésamelyek kettős a2/5-HT2c antagonistaként hasznosak. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0008378A FR2810979B1 (fr) | 2000-06-29 | 2000-06-29 | Nouveaux derives de diphenyluree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU0102723D0 HU0102723D0 (en) | 2001-08-28 |
| HUP0102723A2 true HUP0102723A2 (hu) | 2002-03-28 |
| HUP0102723A3 HUP0102723A3 (en) | 2002-11-28 |
Family
ID=8851854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0102723A HUP0102723A3 (en) | 2000-06-29 | 2001-06-29 | New diphenylurea derivatives, process for their preparation and pharmaceutical compositions containing them |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6784183B2 (hu) |
| EP (1) | EP1170288B9 (hu) |
| JP (1) | JP3933889B2 (hu) |
| KR (1) | KR100485018B1 (hu) |
| CN (1) | CN1241916C (hu) |
| AR (1) | AR033379A1 (hu) |
| AT (1) | ATE273283T1 (hu) |
| AU (1) | AU780022B2 (hu) |
| BR (1) | BR0102607A (hu) |
| CA (1) | CA2352405C (hu) |
| DE (1) | DE60104776T2 (hu) |
| DK (1) | DK1170288T3 (hu) |
| EA (1) | EA005128B1 (hu) |
| ES (1) | ES2227088T3 (hu) |
| FR (1) | FR2810979B1 (hu) |
| HK (1) | HK1042698B (hu) |
| HU (1) | HUP0102723A3 (hu) |
| NO (1) | NO320310B1 (hu) |
| NZ (1) | NZ512658A (hu) |
| PL (1) | PL348392A1 (hu) |
| PT (1) | PT1170288E (hu) |
| SI (1) | SI1170288T1 (hu) |
| TR (1) | TR200402069T4 (hu) |
| ZA (1) | ZA200105394B (hu) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10139416A1 (de) * | 2001-08-17 | 2003-03-06 | Aventis Pharma Gmbh | Aminoalkyl substituierte aromatische Bicyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| TW200306783A (en) * | 2002-04-29 | 2003-12-01 | Fmc Corp | Pesticidal heterocycles |
| US20060229335A1 (en) * | 2002-12-24 | 2006-10-12 | Bradley Teegarden | Diarylamine and arylheteroarylamine pyrazole derivatives as modulators of 5ht2a |
| CA2767153A1 (en) * | 2003-02-20 | 2004-09-02 | Encysive Pharmaceuticals Inc. | Phenylenediamine urotensin-ii receptor antagonists and ccr-9 antagonists |
| DE602004000260T2 (de) * | 2003-07-22 | 2006-08-24 | Arena Pharmaceuticals, Inc., San Diego | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
| FR2859723B1 (fr) * | 2003-09-16 | 2005-10-21 | Servier Lab | Nouveaux derives de benzoindoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP4795242B2 (ja) * | 2003-09-25 | 2011-10-19 | ドムペ・ファ．ル．マ・ソチエタ・ペル・アツィオーニ | アミジン及びその誘導体並びにそれを含有する医薬組成物 |
| CA2559038C (en) * | 2004-03-23 | 2013-09-10 | Arena Pharmaceuticals, Inc. | Processes for preparing substituted n-aryl-n'-[3-(1h-pyrazol-5-yl) phenyl] ureas and intermediates thereof |
| PE20061130A1 (es) * | 2004-11-19 | 2007-01-05 | Arena Pharm Inc | Derivados de 3-fenil-pirazol como moduladores del receptor de serotonina 5-ht2a |
| US20080015223A1 (en) * | 2004-12-03 | 2008-01-17 | Arena Pharmaceuticals, Inc. | Pyrazole Derivatives as Modulators of the 5-Ht2a Serotonin Receptor Useful for the Treatment of Disorders Related Thereto |
| PL1858877T3 (pl) | 2005-01-14 | 2014-08-29 | Gilead Connecticut Inc | 1,3 podstawione diarylem moczniki jako modulatory aktywności kinazy |
| CA2594563A1 (en) * | 2005-01-19 | 2006-07-27 | Arena Pharmaceuticals, Inc. | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis or treatment of progressive multifocal leukoencephalopathy |
| US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| CA2646081C (en) | 2006-05-18 | 2017-06-27 | Arena Pharmaceuticals, Inc. | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-ht2a serotonin receptor |
| ES2536762T3 (es) | 2006-05-18 | 2015-05-28 | Arena Pharmaceuticals, Inc. | Aminas primarias y sus derivados como moduladores del receptor de la serotonina 5-HT2A útiles para el tratamiento de trastornos relacionados con este |
| EP3395816A1 (en) | 2006-05-18 | 2018-10-31 | Arena Pharmaceuticals, Inc. | Ethers, secondary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| CN100390150C (zh) * | 2006-06-05 | 2008-05-28 | 吴汝林 | 盐酸咪唑苯脲的制备方法 |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| CA2678072A1 (en) | 2007-02-13 | 2008-08-21 | Schering Corporation | Functionally selective alpha2c adrenoreceptor agonists |
| ATE530547T1 (de) | 2007-02-13 | 2011-11-15 | Schering Corp | Derivate und analoge von chroman als funktionell selektive alpha2c-adrenorezeptor-agonisten |
| WO2009023253A2 (en) | 2007-08-15 | 2009-02-19 | Arena Pharmaceuticals Inc. | IMIDAZO[L,2-α]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO |
| US20110021538A1 (en) * | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| ES2666324T3 (es) * | 2008-10-28 | 2018-05-04 | Arena Pharmaceuticals, Inc. | Composiciones de un modulador del receptor de serotonina 5-HT2A útiles para el tratamiento de trastornos relacionados con el mismo |
| WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
| US8980891B2 (en) | 2009-12-18 | 2015-03-17 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| PT2970155T (pt) * | 2013-03-15 | 2018-07-02 | Bristol Myers Squibb Co | Inibidores de indoleamina 2,3-dioxigenase (ido) |
| JP2018516992A (ja) | 2015-06-12 | 2018-06-28 | アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ | レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体 |
| RU2018103338A (ru) | 2015-07-15 | 2019-08-15 | Аксовант Сайенсиз Гмбх | Производные диарил- и арилгетероарилмочевины для профилактики и лечения галлюцинаций, ассоциированных с нейродегенеративным заболеванием |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6238192B2 (hu) * | 1979-08-23 | 1987-08-17 | Caterpillar Tractor Co | |
| GB9313913D0 (en) * | 1993-07-06 | 1993-08-18 | Smithkline Beecham Plc | Novel compounds |
| JPH09504004A (ja) * | 1993-08-20 | 1997-04-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５ｈｔ１ｄレセプター拮抗薬用アミドおよび尿素誘導体 |
| GB9420999D0 (en) * | 1994-10-18 | 1994-12-07 | Smithkline Beecham Plc | Novel compounds |
| WO1998024785A1 (en) * | 1996-12-02 | 1998-06-11 | Fujisawa Pharmaceutical Co., Ltd. | Indole-urea derivatives with 5-ht antagonist properties |
| JP2001526643A (ja) * | 1997-04-18 | 2001-12-18 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５ｈｔ１ａ、５ｈｔ１ｂおよび５ｈｔ１ｄ受容体アンタゴニスト活性を合わせ持つ化合物を含む二環式アリールまたは二環式複素環 |
-
2000
- 2000-06-29 FR FR0008378A patent/FR2810979B1/fr not_active Expired - Fee Related
-
2001
- 2001-06-27 KR KR10-2001-0036983A patent/KR100485018B1/ko not_active IP Right Cessation
- 2001-06-27 AR ARP010103052A patent/AR033379A1/es active IP Right Grant
- 2001-06-28 NZ NZ512658A patent/NZ512658A/xx unknown
- 2001-06-28 NO NO20013254A patent/NO320310B1/no not_active IP Right Cessation
- 2001-06-28 JP JP2001195947A patent/JP3933889B2/ja not_active Expired - Fee Related
- 2001-06-28 EA EA200100600A patent/EA005128B1/ru not_active IP Right Cessation
- 2001-06-29 BR BR0102607-0A patent/BR0102607A/pt not_active Application Discontinuation
- 2001-06-29 CA CA002352405A patent/CA2352405C/fr not_active Expired - Fee Related
- 2001-06-29 ZA ZA200105394A patent/ZA200105394B/xx unknown
- 2001-06-29 US US09/896,278 patent/US6784183B2/en not_active Expired - Fee Related
- 2001-06-29 ES ES01401712T patent/ES2227088T3/es not_active Expired - Lifetime
- 2001-06-29 CN CNB011232757A patent/CN1241916C/zh not_active Expired - Fee Related
- 2001-06-29 DK DK01401712T patent/DK1170288T3/da active
- 2001-06-29 AU AU54144/01A patent/AU780022B2/en not_active Ceased
- 2001-06-29 HU HU0102723A patent/HUP0102723A3/hu unknown
- 2001-06-29 EP EP01401712A patent/EP1170288B9/fr not_active Expired - Lifetime
- 2001-06-29 SI SI200130180T patent/SI1170288T1/ unknown
- 2001-06-29 PL PL01348392A patent/PL348392A1/xx not_active Application Discontinuation
- 2001-06-29 DE DE60104776T patent/DE60104776T2/de not_active Expired - Lifetime
- 2001-06-29 AT AT01401712T patent/ATE273283T1/de not_active IP Right Cessation
- 2001-06-29 TR TR2004/02069T patent/TR200402069T4/xx unknown
- 2001-06-29 PT PT01401712T patent/PT1170288E/pt unknown
-
2002
- 2002-05-31 HK HK02104086.5A patent/HK1042698B/zh not_active IP Right Cessation
-
2004
- 2004-06-07 US US10/862,546 patent/US7026357B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0102723A2 (hu) | Új difenilkarbamid-származékok, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények | |
| HUP0400636A2 (hu) | Azetidinszármazékokat tartalmazó gyógyszerkészítmények, új azetidinszármazékok és előállításuk | |
| HUP0303756A2 (hu) | 1-Aril- vagy 1-alkilszulfonil-heterociklobenzazolok és eljárás ezek elõállítására és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0401982A2 (hu) | Indolizinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
| HUP0302487A2 (hu) | Új mandulasavszármazékok és felhasználásuk trombin inhibitorokként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| IL151172A0 (en) | Amine derivatives, their preparation and use as bax modulators | |
| TR200100238T2 (tr) | Yeni sübstitüe edilmiş pirazol türevleri | |
| HUP0203657A2 (hu) | Heterociklusos vegyületek és eljárások a szívgyengeség és más rendellenességek kezelésére | |
| HUP0100601A2 (hu) | N-tartalmú biciklusos vegyületek, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| CA2167673A1 (en) | Condensed benzazepine derivative and pharmaceutical composition thereof | |
| HUP0002843A2 (hu) | Új béta-karbolin-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények | |
| HUP0302193A2 (hu) | 1,4-Diazabiciklo[3.2.2]nonán-benzoxazol,-benzotiazol és -benzimidazol-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények | |
| TR200000725T2 (tr) | Bir monoamin oksidaz inhibitörü ve h5-HT1B antagonistinin bileşimi | |
| MXPA02012569A (es) | Ftalidas substituidas novedosas, un procedimiento para su preparacion y las composiciones farmaceuticas que contienen a las mismas. | |
| HUP0301553A2 (hu) | Gyógyászati készítmények és alkalmazásuk neurológiai rendellenességek kezelésére | |
| ATE246177T1 (de) | Katecholhydrazon-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die diese enthalten | |
| WO2003080631A3 (en) | Plasma carboxypeptidase b inhibitors | |
| NO955328D0 (no) | Pyridazin-derivater | |
| AP1396A (en) | 1-Trifluoromethyl-4-hydroxy-7-piperidinylaminomethylchroman derivatives. | |
| WO2001022951A3 (en) | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of multiple sclerosis | |
| HUP0203384A2 (hu) | Eljárás ketiminek előállítására | |
| ATE288899T1 (de) | Substituierte alkylaminopyridazinonderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen | |
| HK1075656A1 (en) | New piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds | |
| HUP0204444A2 (en) | Phenyl- and pyridyl-tetrahydro-pyridines, process for their preparation and pharmaceutical compositions containing them | |
| HUP0000783A2 (hu) | N-(piridinil-amino)-izoindolinok és származékaik, eljárás előállításukra, e vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |